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Triple intersection numbers for the Paley graphs
[article]
2021
arXiv
pre-print
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We give a tight bound for the triple intersection numbers of Paley graphs. In particular, we show that any three vertices have a common neighbor in Paley graphs of order larger than 25.
arXiv:2109.03654v1
fatcat:7a6ttjrxkbhb5au4alpgk45ova
Seizures Following Cardiopulmonary Bypass
2016
The journal of extra-corporeal technology
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The heart required defibrillation with a single 10 J shock to return to sinus rhythm. The patient was slowly rewarmed to 36.5°C nasopharyngeal before bypass was discontinued. ...
There are several factors at play including the presence of significant atheromatous change in the aorta, periods of low cerebral perfusion, an open-chamber J Extra Corpor Technol. 2016;48:137-140 ...
pmid:27729707
pmcid:PMC5056684
fatcat:rurnuxlphzdj7ooeagwovx7com
An Investigation of Machine Learning Methods Applied to Structure Prediction in Condensed Matter
[article]
2014
arXiv
pre-print
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In this technique, the following Lagrangian expression is minimized: L P (W, b) = 1 2 M j=1 ||w j 2 || + C n i=1 L(u i ) (7) where C is a constant analogous to the soft margin parameter, W,b are now multi-dimensional ...
arXiv:1405.3564v1
fatcat:ekzp6fpkhrg3npqltvg2mm2qwa
Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?
2015
Toxicological Sciences
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Brouwer, Ms. K.M. Freeman, and Dr. R.L. St. Claire are employed by Qualyst Transporter Solutions, LLC. Dr. K.L.R. ...
Brouwer is a co-inventor of the sandwich-cultured hepatocyte technology for quantification of biliary excretion (B-CLEAR V R ) and related technologies, which have been licensed exclusively to Qualyst ...
doi:10.1093/toxsci/kfv231
pmid:26507107
fatcat:znw7bppobrb5zdrizvzwjwj4qa
Photophysics of perylene monoimide-labelled organocatalysts
2019
Photochemical and Photobiological Sciences
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A fluorophore-tagged organocatalyst undergoes electron transfer in polar solvents allowing to sense the presence of its free quinuclidine catalytic site.
doi:10.1039/c8pp00462e
pmid:30566162
fatcat:6lbanaf76fbtlf2xsr6e2wuy4u
Mental Health Treatment Patterns in Perinatally HIV-Infected Youth and Controls
2009
Pediatrics
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BACKGROUND-Youths perinatally infected with HIV often receive psychotropic medication and behavioral treatment for emotional and behavioral symptoms. We describe patterns of intervention for HIV-positive youth and youth in a control group in the United States.
doi:10.1542/peds.2008-2441
pmid:19596734
pmcid:PMC2764487
fatcat:7uevaey5u5hkvby25rdpauir4i
Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers
2013
Nature Communications
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Clostridium difficile is a major nosocomial pathogen and the main causative agent of antibioticassociated diarrhoea. The organism produces two potent toxins, A and B, which are its major virulence factors. These are chromosomally encoded on a region termed the pathogenicity locus (PaLoc), which also contains regulatory genes, and is absent in non-toxigenic strains. Here we show that the PaLoc can be transferred from the toxin-producing strain, 630Derm, to three non-toxigenic strains of
doi:10.1038/ncomms3601
pmid:24131955
pmcid:PMC3826655
fatcat:sixggq5evvdjnnuziq7bwmajji
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... ribotypes. One of the transconjugants is shown by cytotoxicity assay to produce toxin B at a similar level to the donor strain, demonstrating that a toxigenic C. difficile strain is capable of converting a non-toxigenic strain to a toxin producer by horizontal gene transfer. This has implications for the treatment of C. difficile infections, as non-toxigenic strains are being tested as treatments in clinical trials.
A novel method for the determination of biliary clearance in humans
2004
AAPS Journal
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Biliary excretion is an important route of elimination and the biliary tract is a potential site of toxicity for many drugs and xenobiotics. Quantification of biliary excretion in healthy human volunteers is logistically challenging and is rarely defined during drug development. The current study uses a novel oroenteric tube coupled with a specialized clinical protocol to examine the pharmacokinetics of 99m Technetium (Tc-99m) mebrofenin, a compound that undergoes rapid hepatic uptake and
doi:10.1208/aapsj060433
pmid:15760098
pmcid:PMC2751229
fatcat:ovi3rrjxybfnbcxeulxgylc2za
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... ive biliary excretion. A custommade multilumen oroenteric tube was positioned in the duodenum of healthy human volunteers. Subjects were positioned under a gamma camera and 2.5 mCi of Tc-99m mebrofenin was administered intravenously. Duodenal aspirates, blood samples, and urine were collected periodically for 3 hours. Two hours after Tc-99m mebrofenin administration, the gallbladder was contracted with an intravenous infusion of cholecystokinin-8. Gamma scintigraphy was used to determine the gallbladder ejection fraction in each subject. Total systemic clearance of Tc-99m mebrofenin approximated liver blood flow (Cl total 17.3 ± 1.7 mL/min/kg), and 35% to 84% of the Tc-99m mebrofenin dose was recovered in bile. However, when the data were corrected for the gallbladder ejection fraction, 71% to 92% of the excreted Tc-99m mebrofenin dose was recovered. This novel oroenteric tube and clinical protocol provide a useful method to quantify biliary excretion of xenobiotics in healthy human volunteers.
Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease
2019
Drug Metabolism And Disposition
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We acknowledge the support provided by the Biomarkers Mass Spectrometry sub-core supported in part by NIEHS grant P30ES010126 (J. Swenberg). We thank Dr. ...
Performed data analysis: Bezençon, Beaudoin, Ito, Fu, Roth, Brock, and Brouwer. Wrote or contributed to the writing of the manuscript: Bezençon, Beaudoin, and Brouwer. ...
WT and PCK rat livers were perfused as described previously (Brouwer and Thurman, 1996; Chandra et al., 2005a) . ...
doi:10.1124/dmd.119.086785
pmid:31160314
pmcid:PMC6657211
fatcat:mudstpr7ebcnhmkygumr545vuq
Lipids are the preferred substrate of the protist Naegleria gruberi, relative of a human brain pathogen
[article]
2018
bioRxiv
pre-print
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Naegleria gruberi is a free-living non-pathogenic amoeboflagellate and relative of Naegleria fowleri, a deadly pathogen causing primary amoebic meningoencephalitis (PAM). A genomic analysis of N. gruberi exists, but physiological evidence for its core energy metabolism or in vivo growth substrates is lacking. Here we show that N. gruberi trophozoites need oxygen for normal functioning and growth and that they furthermore shun both glucose and amino acids as growth substrates. Trophozoite growth
doi:10.1101/370890
fatcat:6xfajixesfcq5kdzzabmg76hzm
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... depends mainly upon lipid oxidation via a mitochondrial branched respiratory chain, both ends of which require oxygen as final electron acceptor. Growing N. gruberi trophozoites thus have a strictly aerobic energy metabolism with a marked substrate preference for the oxidation of fatty acids. Analyses of N. fowleri genome data and comparison with those of N. gruberi indicate that N. fowleri has the same type of metabolism. Specialization to oxygen-dependent lipid breakdown represents a hitherto unprecedented metabolic strategy in protists.
Automated analysis of images in documents for intelligent document search
2009
International Journal on Document Analysis and Recognition
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: ( j); 14 v_ticket ( j) = v_ticket ( j) − 1; 15 if hasU nvisited RightConnection( j) then 16 j = Select_Right_Connection( j); The curve construction algorithm. ...
Let X h i , X l i , Y h i , Y l i represent C j i.e. C x i j = X l i − X h j . ...
doi:10.1007/s10032-009-0081-0
fatcat:myywoqxytnhfhhw44zkprz73cm
Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly
2013
Nucleic Acids Research
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The retinoic acid inducible gene-I (RIG-I)-like family of receptors is positioned at the front line of our innate cellular defence system. RIG-I detects and binds to foreign duplex RNA in the cytoplasm of both immune and non-immune cells, and initiates the induction of type I interferons and pro-inflammatory cytokines. The mechanism of RIG-I activation by doublestranded RNA (dsRNA) involves a molecular rearrangement proposed to expose the N-terminal pair of caspase activation recruitment
doi:10.1093/nar/gks1477
pmid:23325848
pmcid:PMC3597671
fatcat:ionqmf7z2rabzi3zwsjuckdfea
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... , enabling an interaction with interferon-beta promoter stimulator 1 (IPS-1) and thereby initiating downstream signalling. dsRNA is particularly stimulatory when longer than 20 bp, potentially through allowing binding of more than one RIG-I molecule. Here, we characterize full-length RIG-I and RIG-I subdomains combined with a stimulatory 29mer dsRNA using multi-angle light scattering and size-exclusion chromatography-coupled small-angle X-ray scattering, to build up a molecular model of RIG-I before and after the formation of a 2:1 protein:dsRNA assembly. We report the small-angle X-ray scattering-derived solution structure of the human apo-RIG-I and observe that on binding of RIG-I to dsRNA in a 2:1 ratio, the complex becomes highly extended and flexible. Hence, here we present the first model of the fully activated oligomeric RIG-I.
Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease
2018
Drug Metabolism And Disposition
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Performed data analysis: Beaudoin, Bezençon, Cao, Roth, Brock, Mizuno, Brouwer. Wrote or contributed to the writing of the manuscript: Beaudoin, Bezençon, Brouwer. ...
Authorship Contributions Participated in research design: Beaudoin, Roth, Brock, Brouwer. Conducted experiments: Beaudoin, Mizuno. ...
The isolated perfused liver (IPL) is a physiologically relevant ex situ model used to assess hepatobiliary drug clearance (Brouwer and Thurman, 1996) , and evaluate the hepatic transport and metabolic ...
doi:10.1124/dmd.118.083907
pmid:30504136
pmcid:PMC6338823
fatcat:ohirknetprcrrkos2v6xh5sizu
Effects of counseling techniques on patients' weight-related attitudes and behaviors in a primary care clinic
2011
Patient Education and Counseling
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Objective-Examine primary care physicians' use of counseling techniques when treating overweight and obese patients and the association with mediators of behavior change as well as change in nutrition, exercise, and weight loss attempts. Methods-We audio recorded office encounters between 40 physicians and 461 patients. Encounters were coded for physician use of selected counseling techniques using the Motivational Interviewing Treatment Integrity (MITI) scale. Patient motivation and confidence
doi:10.1016/j.pec.2011.01.024
pmid:21316897
pmcid:PMC3368547
fatcat:opyt5e3urzh47nskvf6lbkv624
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... as well as Fat and Fiber Diet score (1 to 4), Framingham Physical Activity Questionnaire (MET-minutes), and weight loss attempts (yes/no) were assessed by surveys. Generalized linear models were fit, including physician, patient, and visit level covariates. Results-Patients whose physicians were rated higher in empathy improved their Fat and Fiber intake 0.18 units (95% CI 0, 0.4). When physicians used "MI consistent" techniques, patients reported higher confidence to improve nutrition (OR 2.57, 95% CI 1.2, 5.7). Conclusion-When physicians used counseling techniques consistent with MI principles, some of their patients' weight-related attitudes and behaviors improved. Practice Implications-Physicians may not be able to employ formal MI during a clinic visit. However, use of counseling techniques consistent with MI principles, such as expression of empathy, may improve patients' weight-related attitudes and behaviors.
Meditation and Yoga Practices as Potential Adjunctive Treatment of SARS-CoV-2 Infection and COVID-19: A Brief Overview of Key Subjects
2020
Journal of Alternative and Complementary Medicine
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Editor's Note: As an acute condition quickly associated with multiple chronic susceptibilities, COVID-19 has rekindled interest in, and controversy about, the potential role of the host in disease processes. While hundreds of millions of research dollars have been funneled into drug and vaccine solutions that target the external agent, integrative practitioners tuned to enhancing immunity faced a familiar mostly unfunded task. First, go to school on the virus. Then draw from the global array of
doi:10.1089/acm.2020.0177
pmid:32579021
fatcat:vwundcifvfbvfhxfldmwglptw4
more »
... natural therapies and practices with host-enhancing or anti-viral capabilities to suggest integrative treatment strategies. The near null-set of conventional treatment options propels this investigation. In this paper, researchers from the Massachusetts Institute of Technology, University of California-San Diego, Chopra Library for Integrative Studies, and Harvard University share one such exploration. Their conclusion, that "certain meditation, yoga asana (postures), and pranayama (breathing) practices may possibly be effective adjunctive means of treating and/or preventing SARS-CoV-2 infection" underscores the importance of this rekindling. At JACM, we are pleased to have the opportunity to publish this work. We hope that it might help diminish in medicine and health the polarization that, like so much in the broader culture, seems to be an obstacle to healing.
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