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DALY, William G., Instructor, Institute of Technology, Northern Alberta. ... Moore and William G. Daly ff. 12 Laurent BÉLANGER, Occupational Mobility of French and English Canadian Business Leaders in the Province of Québec (Unpublished Ph.D. dissertation) E. ...doi:10.7202/028368ar fatcat:yw2b2ivde5eabkaa3kw7butfra
professor of medicine Department of Medicine, Wansbeck General Hospital, Ashington NE63 9JJ Mark Daly specialist registrar in endocrinology and diabetes Correspondence to: G Williams garethw ... Hospital Aintree, Liverpool L9 7AL Mimi Chen preregistration house officer Natt junior research assistant Susie intermediate research assistant Candy senior research assistant Gareth Williams ...doi:10.1136/bmj.321.7276.1565 pmid:11124176 pmcid:PMC27564 fatcat:d5zcb5efhbb2hitjy5uevq3oba
Cyphert-Daly, Robert M. Tighe, Loretta G. Que, Julie G. Ledford. Supervision: Julie G. Ledford. Validation: Julie G. Ledford. Visualization: William P. Pederson, Julie G. Ledford. ... nystatin (Sigma), 50 μg/ml gentamicin. ...doi:10.1371/journal.pone.0247504 pmid:33617569 pmcid:PMC7899376 fatcat:zz7z4ecjr5darnmk7355pcke2e
G. Johnson for technical assistance. ... F: Pressure gradient wave, g: Circumferential dis;ention wave, h: Velocity-gradient wave at the wall, i: Discharge wave. See text for abbreviations. ...doi:10.1161/01.res.33.2.198 pmid:4727371 fatcat:mytnaxr6bngitpwtwmc7kqzvf4
A., BURNSTOCK, G., AND WEBB, T. E.: G-protein coupled receptors B. P., WILLIAMS, C. A., AND CEELEN, P. W.: ATP-activated C. D., AND TSIEN, R. W.: A novel receptor-operated BERNE, R. ... G-protein-coupled# G-protein-coupled Nonselective pore G-protein coupled? ... .: Receptor-to-effector signaling through G proteins: roles for '3/ 7dimers as well as a subunits. Cell 71: 1069-1072, 1992. ...pmid:7938164 pmcid:PMC4976594 fatcat:omj6gy4xr5fcnhxo7criywu5jm
Protein effect SDK1 c.5540G>A p.Arg1847Gln - SIFT = tolerated (0.82)/PolyPhen = benign (0.078) NOD1 c.676G>A p.Ala226Thr - SIFT = tolerated (0.76)/PolyPhen = benign (0.008) C8orf40 c.125A>G ... p.Tyr42Cys - SIFT = deleterious (0)/PolyPhen = probably damaging (0.997) OR52N4 c.323C>G p.Thr108Ser - SIFT = tolerated (0.54)/PolyPhen = benign (0.014) DNHD1 c.100C>T p.Gln34Ter - not predictable ...doi:10.1159/000365057 pmid:25337069 pmcid:PMC4188168 fatcat:dc6mo3vlbfcrtlphxprtfqkgky
Lecture Notes in Computer Science
Acknowledgments We would like to acknowledge the work done by former members of the Möbius group: G. P. Kavanaugh, J. M. Sowder, and A. L. Williamson. ... Evc 1999, David Daly, Daniel D. Deavours, Jay M. Doyle, Aaron J. Stillman, Patrick G. Webster Figure 1 . 1 Möbius Architecture. ...doi:10.1007/3-540-46429-8_25 fatcat:y7retbl2w5cfxdszrtxujgymny
Although high-functioning individuals with autistic disorder (i.e. autism and Asperger syndrome) are of normal intelligence, they have life-long abnormalities in social communication and emotional behaviour. However, the biological basis of social difficulties in autism is poorly understood. Facial expressions help shape behaviour, and we investigated if high-functioning people with autistic disorder show neurobiological differences from controls when processing emotional facial expressions. Wedoi:10.1093/brain/123.11.2203 pmid:11050021 fatcat:cqnf4mh7fjc4tf656jk4kdmgta
more »... used functional MRI to investigate brain activity in nine adults with autistic disorder (mean age ⍨ standard deviation 37 ⍨ 7 years; IQ 102 ⍨ 15) and nine controls (27 ⍨ 7 years; IQ 116 ⍨ 10) when explicitly (consciously) and implicitly (unconsciously) processing Abbreviations: BOLD ϭ blood oxygenation level-dependent; fMRI ϭ functional MRI; FPQ ϭ fundamental power quotient; ICD ϭ International Classification of Disease; WAIS-R ϭ Wechsler Adult Intelligence Scale-Revised
and Purpose-The World Health Organization has emphasized the importance of international populationbased data for unbiased surveillance of stroke incidence and outcome. To date, few such studies have been conducted using recommended gold-standard ascertainment methods. We conducted a large, population-based stroke study in Dublin, Ireland. Methods-Using gold-standard ascertainment methods, individuals with stroke and transient ischemic attack occurring over a 12-month period (December 1,doi:10.1161/strokeaha.111.645721 pmid:22693134 fatcat:i7hxu5lt4rfktj6x3hgwujbqiu
more »... vember 30, 2006 in North Dublin were identified. Disability was assessed using the modified Rankin score and stroke severity (Ͻ72 hours) by the National Institutes of Health Stroke Scale. Stroke-related deaths were confirmed by review of medical files, death certificates, pathology, and coroner's records. Crude and standardized (to European and World Health Organization standard populations) rates of incidence, risk factors, severity, and early outcome (mortality, case-fatality, disability) were calculated, assuming a Poisson distribution for the number of events. Results-Seven hundred one patients with new stroke or transient ischemic attack were ascertained (485 first-ever stroke patients, 83 recurrent stroke patients, 133 first-ever transient ischemic attack patients). Crude frequency rates (all rates per 1000 person-years) were: 1.65 (95% CI, 1.5-1.79; first-ever stroke), 0.28 (95% CI, 0.22-0.35; recurrent stroke), and 0.45 (95% CI, 0.37-0.53; first-ever transient ischemic attack). Age-adjusted stroke rates were higher than those in 9 other recent population-based samples from high-income countries. High rates of subtype-specific risk factors were observed (atrial fibrillation, 31.3% and smoking, 29.1% in ischemic stroke; warfarin use, 21.2% in primary intracerebral hemorrhage; smoking, 53.9% in subarachnoid hemorrhage; PϽ0.01 for all compared with other subtypes). Compared with recent studies, 28-day case-fatality rates for primary intracerebral hemorrhage (41%; 95% CI, 29.2%-54.1%) and subarachnoid hemorrhage (46%; 95% CI, 28.8%-64.5%) were greater in Dublin. Conclusions-Using gold-standard methods for case ascertainment, we found high incidence rates of stroke in Dublin compared with those in similar high-income countries; this is likely explained in part by high rates of subtype-specific risk factors.
Tissue-culture polystyrene plates were coated using Matrigel (Corning, NY) at a density of 0.0087 µg/cm 2 . ... All medium was supplemented with 100 U/mL Penicillin/100 µg/mL Streptomycin (Thermo Fisher Scientific, Inc., Carlsbad, CA). ...doi:10.1038/s41551-017-0096 pmid:29104816 pmcid:PMC5667681 fatcat:tas24if6krezjcu3owm4hqq34y
The Cochrane library
A C K N O W L E D G E M E N T S Our thanks to Mr Lawrence Impey who provided additional data for Impey 2003, to Dr Helen Cheyne who provided additional data for Cheyne 2003 and to Dr Fiona Williams who ... P L A I N L A N G U A G E S U M M A R Y Comparing electronic monitoring of the baby's heartbeat on a woman's admission in labour using cardiotocography (CTG) with intermittent monitoring What is the ...doi:10.1002/14651858.cd005122.pub5 pmid:28125772 pmcid:PMC6464914 fatcat:j5gggrfftvbktlobtp2pjq3tc4
Background. Increasing evidence suggests that autism is associated with abnormal white-matter (WM) anatomy and impaired brain 'connectivity'. While myelin plays a critical role in synchronized brain communication, its aetiological role in autistic symptoms has only been indirectly addressed by WM volumetric, relaxometry and diffusion tensor imaging studies. A potentially more specific measure of myelin content, termed myelin water fraction (MWF), could provide improved sensitivity to myelindoi:10.1017/s0033291714001858 pmid:25111948 fatcat:2s52qhl4zfe5lecs6l7cat7zbe
more »... ration in autism. Method. We performed a cross-sectional imaging study that compared 14 individuals with autism and 14 age-and IQ-matched controls. T 1 relaxation times (T 1 ), T 2 relaxation times (T 2 ) and MWF values were compared between autistic subjects, diagnosed using the Autism Diagnostic Interview -Revised (ADI-R), with current symptoms assessed using the Autism Diagnostic Observation Schedule (ADOS) and typical healthy controls. Correlations between T 1 , T 2 and MWF values with clinical measures [ADI-R, ADOS, and the Autism Quotient (AQ)] were also assessed. Results. Individuals with autism showed widespread WM T 1 and MWF differences compared to typical controls. Within autistic individuals, worse current social interaction skill as measured by the ADOS was related to reduced MWF although not T 1 . No significant differences or correlations with symptoms were observed with respect to T 2 . Conclusions. Autistic individuals have significantly lower global MWF and higher T 1 , suggesting widespread alteration in tissue microstructure and biochemistry. Areas of difference, including thalamic projections, cerebellum and cingulum, have previously been implicated in the disorder; however, this is the first study to specifically indicate myelin alteration in these regions.
William G. ... Simon G. Williams: analysis or interpretation of data, accepts responsibility for conduct of research and will give final approval. Sanjeev S. ...doi:10.1212/wnl.0000000000001129 pmid:25480913 pmcid:PMC4336087 fatcat:q5dz2qnxpbcvvpjjr3xkkvrdqm
vascular endothelial growth factor A (VEGF-A; 50 μg L −1 ). ... After culturing the cells for 2 d in E8BAC medium (E8 medium with Activin A (25 μg L −1 ), BMP4 (5 μg L −1 ), and CHIR 99021 (1 × 10 −6 m)), the cells were cultured in E7Vi medium (E8 medium with VEGF-A ...doi:10.1002/adhm.201801186 pmid:30565891 pmcid:PMC6601624 fatcat:x5zy4atb5zh2do2etdwfmldzlq
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