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Why voxel-based morphometric analysis should be used with great caution when characterizing group differences

Christos Davatzikos
2004 NeuroImage  
In this commentary we describe why voxel-based statistics, which are commonly used to construct statistical parametric maps, are very limited in characterizing morphological differences between groups,  ...  A variety of voxel-based morphometric analysis methods have been adopted by the neuroimaging community in the recent years.  ...  Since whole-brain analysis with fine spatial detail based on manual outlining is prohibitively costly for all practical purposes, voxel-based morphometric analysis (VBMA) has been enthusiastically embraced  ... 
doi:10.1016/j.neuroimage.2004.05.010 pmid:15325347 fatcat:vkf2zrex5vdmjbinfyfnzuiuaq

Brain Structure and Meditation: How Spiritual Practice Shapes the Brain [chapter]

Ulrich Ott, Britta K. Hölzel, Dieter Vaitl
2011 Studies in neuroscience, consciousness and spirituality  
This contribution narratively reviews recent morphometric studies that compared experienced meditators with matched controls.  ...  Meditation practices can be conceived as specific types of mental training with measureable effects on the function and structure of the human brain.  ...  In particular, the lack of an age-related decline in gray matter has to be interpreted with great caution since people with cognitive impairments are likely to discontinue meditation practice.  ... 
doi:10.1007/978-94-007-2079-4_9 fatcat:nz5goyqq7bdvjh43i6inrsch6e

Decoding the perception of pain from fMRI using multivariate pattern analysis

Kay H. Brodersen, Katja Wiech, Ekaterina I. Lomakina, Chia-shu Lin, Joachim M. Buhmann, Ulrike Bingel, Markus Ploner, Klaas Enno Stephan, Irene Tracey
2012 NeuroImage  
Using multivariate analyses on different spatial scales, we investigated the predictive capacity of fMRI data for decoding whether a stimulus had been perceived as painful.  ...  Our results demonstrate that the neural representation of (near-threshold) pain is spatially distributed and can be best described at an intermediate spatial scale.  ...  The authors wish to thank Thomas Nichols for insightful discussions on permutation tests and Jonathan Brooks for sharing somatotopic analysis results.  ... 
doi:10.1016/j.neuroimage.2012.08.035 pmid:22922369 pmcid:PMC3532598 fatcat:ab4zbd6affdsvdhxtfe5ece3eu

Cortical Grey Matter and Subcortical White Matter Brain Microstructural Changes in Schizophrenia Are Localised and Age Independent: A Case-Control Diffusion Tensor Imaging Study

Chiara Chiapponi, Fabrizio Piras, Federica Piras, Sabrina Fagioli, Carlo Caltagirone, Gianfranco Spalletta, Stefano L. Sensi
2013 PLoS ONE  
It is still unknown whether the structural brain impairments that characterize schizophrenia (SZ) worsen during the lifetime.  ...  White matter fractional anisotropy decreased in the entire age range spanned (18-65 years) in both SZ and HC and was significantly lower in younger patients with SZ, with no interaction (age by diagnosis  ...  Various processes may be responsible for the lower WM anisotropy in SZ and caution should be taken before drawing any conclusions [17] .  ... 
doi:10.1371/journal.pone.0075115 pmid:24124469 pmcid:PMC3790776 fatcat:fiynrgiufrakbgzvh7zd6wde6i

Age-at-Death Estimation of Fetuses and Infants in Forensic Anthropology: A New "Coupling" Method to Detect Biases Due to Altered Growth Trajectories

Mélissa Niel, Kathia Chaumoître, Pascal Adalian
2022 Biology  
The pars basilaris shapes, quantified by elliptic Fourier analysis, were grouped into consensus stages to characterize the maturation process along increasing age groups.  ...  The coupling between maturation and growth in the age estimation of young individuals with altered growth processes was analyzed in this study, whereby the age was determined using a geometric morphometrics  ...  must be considered with great caution.  ... 
doi:10.3390/biology11020200 pmid:35205067 pmcid:PMC8868630 fatcat:usgbfixx2rfhjdqbzuvgqxxwgu

Modeling & Analysis

2003 NeuroImage  
Voxels with time courses that differ in latency but are similar in other aspects will thus be grouped into the same component.  ...  the set-level and the voxel-level), when PET measurements from 7 healthy volunteers were used to characterize the changes in regional CBF associated with hand movement, which we have consistently found  ...  Consequently this technique should be used more intensively to localise epileptic foci in pharmaco-resistant patients.  ... 
doi:10.1016/s1053-8119(05)70006-9 fatcat:zff2suxcofbxvetfrwfwcxi3zm

Analysis strategies for high-resolution UHF-fMRI data

Jonathan R. Polimeni, Ville Renvall, Natalia Zaretskaya, Bruce Fischl
2018 NeuroImage  
Particular focus is placed on anatomicallyinformed analyses, including cortical surface-based analysis, which are powerful techniques that can guide each step of the analysis from preprocessing to statistical  ...  Altogether, there are both specific challenges and opportunities presented by UHF-fMRI, and the use of proper analysis strategies can help these valuable data reach their full potential.  ...  s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies.  ... 
doi:10.1016/j.neuroimage.2017.04.053 pmid:28461062 pmcid:PMC5664177 fatcat:dcrrvh4sgfcb5diw62bgbeng2a

The fuzzy brain. Vagueness and mapping connectivity of the human cerebral cortex

Philipp Haueis
2012 Frontiers in Neuroanatomy  
conceptually useful.  ...  There, vagueness gets imported into connectivity studies since the network structure is dependent on the parcellation scheme and thresholds have to be used to delineate functional boundaries.  ...  II: Research Contexts and Combinatory Vagueness"), because it can be unclear which dimension should be prioritized when modalities point toward different boundary locations.  ... 
doi:10.3389/fnana.2012.00037 pmid:22973199 pmcid:PMC3433728 fatcat:4ns6b6pxgbap7bmjtuxnkkhrqi

The evolution of the vestibular apparatus in apes and humans

Alessandro Urciuoli, Clément Zanolli, Amélie Beaudet, Jean Dumoncel, Frédéric Santos, Salvador Moyà-Solà, David M Alba
2020 eLife  
Inferring evolutionary relationships from fossils must be done with caution, but the bony cavity that houses the inner ear – which is involved in balance and hearing and fairly common in the fossil record  ...  – has proven useful for tracing the evolution of certain groups of mammals.  ...  -2015-071318 to AU), the Generalitat de Catalunya (CERCA Programme, and consolidated research groups 2017 SGR 86 and 2017 SGR 116 GRC), and the French CNRS.  ... 
doi:10.7554/elife.51261 pmid:32122463 pmcid:PMC7054002 fatcat:s3m3tz5jpzbdzbtwp53nod3npi

Effort discounting in human nucleus accumbens

M. M. Botvinick, S. Huffstetler, J. T. McGuire
2009 Cognitive, Affective, & Behavioral Neuroscience  
We used fMRI to measure neural responses to monetary rewards in the human nucleus accumbens (NAcc), a structure previously demonstrated to encode reference-dependent reward information.  ...  A great deal of behavioral and economic research suggests that the value attached to a reward stands in inverse relation to the amount of effort required to obtain it, a principle known as effort discounting  ...  interpreted with caution.  ... 
doi:10.3758/cabn.9.1.16 pmid:19246324 pmcid:PMC2744387 fatcat:3eubg3hfsradfgxmgyi6t32pry

The Inappropriate Symmetries of Multivariate Statistical Analysis in Geometric Morphometrics

Fred L. Bookstein
2016 Evolutionary biology  
We therefore need new tools that explicitly incorporate these elements of knowledge, should they be quantitative, to break the symmetries of the classic morphometric approaches.  ...  To more powerfully organize inferences from the high-dimensional measurements that characterize so much of today's organismal biology, tomorrow's toolkit must rely neither on principal component analysis  ...  In the formula for distance, why should different variables X i enter with equal weights? In the formulas for the rotations, why should the organism care if linear combinations are orthogonal?  ... 
doi:10.1007/s11692-016-9382-7 pmid:27512236 pmcid:PMC4960290 fatcat:6ys34iv6sbfsxakfig6df3pxlq

Surface-Based and Probabilistic Atlases of Primate Cerebral Cortex

David C. Van Essen, Donna L. Dierker
2007 Neuron  
For both humans and macaque monkeys, digital brain atlases of many varieties are in widespread use, each having its own strengths and limitations.  ...  Brain atlases play an increasingly important role in neuroimaging, as they are invaluable for analysis, visualization, and comparison of results across studies.  ...  Consequently, high-dimensional VBR should be applied and interpreted with great caution as a method for reducing intersubject variability in human cerebral cortex.  ... 
doi:10.1016/j.neuron.2007.10.015 pmid:17964241 fatcat:lnihwxolkvh2hnuva45rs3ibwi

Multivariate classification of patients with Alzheimer's and dementia with Lewy bodies using high-dimensional cortical thickness measurements: an MRI surface-based morphometric study

Alexander V. Lebedev, E. Westman, M. K. Beyer, M. G. Kramberger, C. Aguilar, Z. Pirtosek, D. Aarsland
2012 Journal of Neurology  
Therefore, the results of the study IV should be interpreted with caution.  ...  Multivariate classification of patients with Alzheimer's and dementia with Lewy bodies using high-dimensional cortical thickness measurements: an MRI surface-based morphometric study.  ... 
doi:10.1007/s00415-012-6768-z pmid:23224109 fatcat:ynen6532azf2th6tqvh647glku

Resting-state functional MRI studies on infant brains: A decade of gap-filling efforts

Han Zhang, Dinggang Shen, Weili Lin
2018 NeuroImage  
The image analysis tools for neonates and young infants can be quite different from those for adults.  ...  With the anticipated availability of unprecedented high-resolution rs-fMRI and dedicated analysis pipelines from the Baby Connectome Project (BCP), it is important now to revisit previous findings and  ...  This work also uses the data from "Multi-visit Advanced Pediatric brain imaging study for characterizing structural and functional development (MAP Study)".  ... 
doi:10.1016/j.neuroimage.2018.07.004 pmid:29990581 pmcid:PMC6289773 fatcat:bxh232qww5gibgfgfy7jjbss74

Application of cone beam computed tomography in facial imaging science

Zacharias Fourie, Janalt Damstra, Yijin Ren
2012 Shanghai kou qiang yi xue = Shanghai journal of stomatology  
Since 3D cone beam computed tomography (CBCT) imaging will play an increasingly important role in orthodontics and orthognathic surgery, special emphasis should be placed on discussing CBCT applications  ...  Traditional 2D imaging has gradually being replaced by 3D images in different disciplines, particularly in the fields of orthodontics, maxillofacial surgery, plastic and reconstructive surgery, neurosurgery  ...  invalidated technology could potentially contain unacceptably high levels of measurement error, results based on such data must be interpreted with extreme caution. 1 341 A substitute for the original  ... 
pmid:22610338 fatcat:potdrqefznf4tjtceraeecbs7y
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