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Multispectral brain morphometry in Tourette syndrome persisting into adulthood

Bogdan Draganski, Davide Martino, Andrea E. Cavanna, Chloe Hutton, Michael Orth, Mary M. Robertson, Hugo D. Critchley, Richard S. Frackowiak
2010 Brain  
White matter analysis revealed changes in fibre coherence in patients with Tourette syndrome within anterior parts of the corpus callosum.  ...  Patients with Tourette syndrome showed relative grey matter volume reduction in orbitofrontal, anterior cingulate and ventrolateral prefrontal cortices bilaterally.  ...  Acknowledgements We thank all the participants in our study and the radiographers at the Functional Imaging Laboratory for their assistance acquiring the data.  ... 
doi:10.1093/brain/awq300 pmid:21071387 pmcid:PMC2995885 fatcat:s2ecns3zorbuzmggf6gvhrtybi

Altered structural connectivity of cortico-striato-pallido-thalamic networks in Gilles de la Tourette syndrome

Yulia Worbe, Linda Marrakchi-Kacem, Sophie Lecomte, Romain Valabregue, Fabrice Poupon, Pamela Guevara, Alan Tucholka, Jean-François Mangin, Marie Vidailhet, Stephane Lehericy, Andreas Hartmann, Cyril Poupon
2014 Brain  
In patients with Gilles de la Tourette syndrome compared to control subjects, we found white matter abnormalities in neuronal pathways connecting the cerebral cortex, the basal ganglia and the thalamus  ...  Taken together, our data showed widespread structural abnormalities in cortico-striato-pallido-thalamic white matter pathways in patients with Gilles de la Tourette, which likely result from abnormal brain  ...  Y.W. was supported by l'Association Française du syndrome de Gilles de la Tourette and by Lilly Institute.  ... 
doi:10.1093/brain/awu311 pmid:25392196 pmcid:PMC4306818 fatcat:zjugq4ohrvcr3o6nfex5bgrywu

Early white-matter abnormalities of the ventral frontostriatal pathway in fragile X syndrome

2009 Developmental Medicine & Child Neurology  
Aberrant white-matter structure was localized in the left ventral frontostriatal pathway.  ...  METHOD-In this study, we used a diffusion tensor imaging (DTI) tractography approach to reconstruct white-matter fibers in the ventral frontostriatal pathway in young males with fragile X syndrome (n=17  ...  We observed structural abnormalities in fragile X syndrome in the ventral but not the dorsal frontostriatal pathway.  ... 
doi:10.1111/j.1469-8749.2009.03295.x pmid:19416325 pmcid:PMC2715437 fatcat:3y6zyhgx6ndz7m2xuimm2ytak4

Altered topology of structural brain networks in patients with Gilles de la Tourette syndrome

E. Schlemm, B. Cheng, F. Fischer, C. Hilgetag, C. Gerloff, G. Thomalla
2017 Scientific Reports  
In addition, extended abnormalities and disorganized activation beyond sensorimotor regions have been detected by functional MRI in language, paralimbic, insular or executive circuits 10-12 .  ...  Gilles de la Tourette syndrome is a neurodevelopmental disorder characterized by tics.  ...  Acknowledgements The research leading to these results has received funding from the German Research Foundation (DFG), SFB 936 "Multi-site Communication in the Brain" (Projects A1, C1, C2, Z3).  ... 
doi:10.1038/s41598-017-10920-y pmid:28878322 pmcid:PMC5587563 fatcat:jh4myec7vzemzpodnbd2f6tira

PET Neuroimaging: Insights on Dystonia and Tourette Syndrome and Potential Applications

Pierpaolo Alongi, Leonardo Iaccarino, Daniela Perani
2014 Frontiers in Neurology  
Gilles de la Tourette syndrome (GTS) is a childhood-onset neuropsychiatric developmental disorder characterized by motor and phonic tics, which could progress to behavioral changes.  ...  PET techniques are of considerable value in detecting functional and molecular abnormalities in vivo, according to the adopted radioligands.  ...  Similarly, DTI-based studies in GTS yielded clear evidence of reduced microstructural integrity of white matter extending beyond motor pathways.  ... 
doi:10.3389/fneur.2014.00183 pmid:25295029 pmcid:PMC4171987 fatcat:rbbueewfpbatdncy54dfjestd4

A Bayesian Account of the Sensory-Motor Interactions Underlying Symptoms of Tourette Syndrome

Charlotte L. Rae, Hugo D. Critchley, Anil K. Seth
2019 Frontiers in Psychiatry  
Tourette syndrome is a hyperkinetic movement disorder.  ...  Our model integrates behavioural, neuroimaging, and computational approaches to provide mechanistic insight into the pathophysiological basis of Tourette syndrome.  ...  FEATURES OF TOURETTE SYNDROME TS presents a multifaceted set of phenomenological features (3) ( Table 1) .  ... 
doi:10.3389/fpsyt.2019.00029 pmid:30890965 pmcid:PMC6412155 fatcat:vxtedaglvzgzvitxsbvno5jkqm

Diffuse alterations in grey and white matter associated with cognitive impairment in Shwachman–Diamond syndrome: Evidence from a multimodal approach

Sandra Perobelli, Franco Alessandrini, Giada Zoccatelli, Elena Nicolis, Alberto Beltramello, Baroukh M. Assael, Marco Cipolli
2015 NeuroImage: Clinical  
Diffusion tensor imaging was used to assess brain white matter. The Tract-based Spatial Statistics package and probabilistic tractography were used to characterize white matter pathways.  ...  identified six abnormal clusters of white matter fibres in the fronto-callosal, right fronto-external capsulae, left fronto-parietal, right pontine, temporo-mesial and left anterior-medial-temporal regions  ...  Acknowledgements The study was supported by a grant (n. 0409) from the Italian Shwachman Syndrome Association (AISS).  ... 
doi:10.1016/j.nicl.2015.02.014 pmid:25844324 pmcid:PMC4375735 fatcat:alcfmdnw4faere3ycvzjvsvxze

Toward a Symptom-Guided Neurostimulation for Gilles de la Tourette Syndrome

Nicole Pedroarena-Leal, Diane Ruge
2017 Frontiers in Psychiatry  
Therapy resistance of approximately one-third of patients with Gilles de la Tourette syndrome (GTS) requires consideration of alternative therapeutic interventions.  ...  The concept of considering the physiological basis of specific symptoms when using stimulation techniques will provide a platform for more effective non-pharmacological neuromodulation of symptoms in GTS  ...  Gilles de la Tourette syndrome patients have been treated with DBS since 1999, and approximately 48 published studies report some degree of motor tic reduction (32) .  ... 
doi:10.3389/fpsyt.2017.00029 pmid:28289393 pmcid:PMC5326794 fatcat:e3xg7bcjrfhfbkefzx2ohyacii

Tourette Syndrome and Tic Disorders: A Decade of Progress

2007 Journal of the American Academy of Child and Adolescent Psychiatry  
Objective: This is a review of progress made in the understanding of Tourette syndrome (TS) during the past decade including models of pathogenesis, state-of-the-art assessment techniques, and treatment  ...  Method: Computerized literature searches were conducted under the key words "Tourette syndrome," "Tourette disorder," and "tics." Only references from 1996Y2006 were included.  ...  disorder, Asperger`s syndrome, and TS, perhaps some final common pathways mediate abnormal prepulse inhibition in all of these diseases.  ... 
doi:10.1097/chi.0b013e318068fbcc pmid:17667475 fatcat:akoijhtxkbfwnczoc2v3cf6rfq

The neurophysiological correlates of motor tics following focal striatal disinhibition

Kevin W. McCairn, Maya Bronfeld, Katya Belelovsky, Izhar Bar-Gad
2009 Brain  
cortex; STN = subthalamic nucleus; TS = Tourette syndrome  ...  The cortico-basal ganglia pathway is involved in normal motor control and implicated in multiple movement disorders.  ...  Funding Funding for this research was provided by the Tourette Syndrome Association.  ... 
doi:10.1093/brain/awp142 pmid:19506070 fatcat:mpabuxzglreazk7hu5hrwhjz4e

White Matter Changes in OCD Revealed by Diffusion Tensor Imaging

Leonardo F. Fontenelle, Ivanei E. Bramati, Jorge Moll, Mauro V. Mendlowicz, Ricardo de Oliveira-Souza, Fernanda Tovar-Moll
2011 CNS Spectrums  
AbstractIntroductionThe aim of this study was to investigate white matter (WM) abnormalities in obsessive-compulsive disorder (OCD) and its relationship to severity of obsessive-compulsive symptoms.MethodsConventional  ...  volunteers, patients with OCD exhibited reduced FA values bilaterally in regions of the posterior limb of the IC and in the SLF and increased MD values bilaterally in the posterior limb of the IC, in  ...  in orbitofrontal cortex, the striatum, and the thalamic grey matter in patients with OCD. 3 Based on a frontal-striatal model of OCD, one might predict the existence of abnormalities in the white matter  ... 
doi:10.1017/s1092852912000260 pmid:24725386 fatcat:ykcqiaerl5gq3fx2uuxuvx2npy

ADHD: Volumetry, Motor, and Oculomotor Functions [chapter]

E. Mark Mahone
2011 Current topics in behavioral neurosciences  
The same pattern is observed in children with "pure" Tourette syndrome (TS), for whom disproportionate increases in frontal white matter and rostral corpus callosum volume were observed (compared to controls  ...  Among children with Tourette syndrome, for example, those with ADHD have motor slowing, whereas those with Tourette syndrome alone (without ADHD) do not (Schuerholz et al. 1997) .  ... 
doi:10.1007/7854_2011_146 pmid:21732239 fatcat:m7qk7lcgdzadrgltl5zxyid3yu

Cognitive control over motor output in Tourette syndrome

Jeyoung Jung, Stephen R. Jackson, Amy Parkinson, Georgina M. Jackson
2013 Neuroscience and Biobehavioral Reviews  
Tourette syndrome [TS] is a neurodevelopmental disorder characterised by chronic vocal and motor tics.  ...  Instead, we argue that PFC should be viewed as a source of facilitatory signals that bias competition in brain areas more directly involved in motor execution.  ...  Furthermore, it is highly likely that decreased intra-cortical inhibition/increased cortical excitability extends beyond motor cortex in TS to include the SMA.  ... 
doi:10.1016/j.neubiorev.2012.08.009 pmid:23017869 fatcat:iicyb6ss6fbspjv5cgekcapaha

Immune-mediated animal models of Tourette syndrome

Mady Hornig, W. Ian Lipkin
2013 Neuroscience and Biobehavioral Reviews  
An autoimmune diathesis has been proposed in Tourette syndrome (TS) and related neuropsychiatric disorders such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism and anorexia  ...  compelling evidence in support of the autoimmune hypothesis.  ...  Introduction Tourette syndrome (TS), named for the French neurologist Georges Gilles de la Tourette, is a disorder marked by persistent motor and vocal tics, high rates of neuropsychiatric comorbidity  ... 
doi:10.1016/j.neubiorev.2013.01.007 pmid:23313649 pmcid:PMC4054816 fatcat:jf7kpv5fsrghtfl4qgjzulvpki

Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement

Lynn K. Paul
2010 Journal of Neurodevelopmental Disorders  
, autism spectrum disorders, and Tourette syndrome).  ...  This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome  ...  Supported in part by grants from National Institutes of Health and the Simons Foundation.  ... 
doi:10.1007/s11689-010-9059-y pmid:21484594 pmcid:PMC3163989 fatcat:52yhjplljbcupdafzbo2jibiym
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