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White matter cerebral blood flow is inversely correlated with structural and functional connectivity in the human brain

Sina Aslan, Hao Huang, Jinsoo Uh, Virendra Mishra, Guanghua Xiao, Matthias J.P. van Osch, Hanzhang Lu
2011 NeuroImage  
Previous neuroimaging studies have demonstrated the presence of cerebral blood flow (CBF) in the white matter, but have not studied its spatial distribution.  ...  An inverse correlation was again observed between tract-specific CBF and the functional connectivity.  ...  Fig. 2 : Relationship between gray matter connectivity and white matter functional and structural parameters.  ... 
doi:10.1016/j.neuroimage.2011.02.082 pmid:21385618 pmcid:PMC3085605 fatcat:gthc33nk3rgkfg4wvcmf533zqe

Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings

Robert K. McNamara, Ruth H. Asch, Diana M. Lindquist, Robert Krikorian
2017 Prostaglandins, Leukotrienes and Essential Fatty Acids  
However, limitations associated with the postmortem approach have hindered progress in our understanding of the role of PUFA in human brain structure, function, and pathology.  ...  However, direct evidence for a role of PUFA in human brain structure and function has been lacking.  ...  Acknowledgments This work was supported in part by National Institute of Health grants DK097599, MH097818, and MH107378 to R.K.M.  ... 
doi:10.1016/j.plefa.2017.05.001 pmid:28529008 pmcid:PMC5680156 fatcat:jh2wrcb7xra5nddrt6epigw54u

Anomalies of Ventriculoarterial Connections and Immature Brain Development

Nobuyuki Ishibashi, Richard A. Jonas
2016 World journal for pediatric & congenital heart surgery  
With increased survival rates, the focus of current research in the pediatric cardiac population has clearly transitioned from short-term surgical survival to the improvement of functional outcome and  ...  It is becoming clear that the etiology of neurological deficits associated with CHD is cumulative and multifactorial.  ...  from the Children's Heart Foundation, and Foglia and Hills families.  ... 
doi:10.1177/2150135116650650 pmid:27587497 pmcid:PMC5490797 fatcat:rc5m77u5xzauva4h4wh7qg4hoe

Better Correlation of Cognitive Function to White Matter Integrity than to Blood Supply in Subjects with Leukoaraiosis

Genlong Zhong, Ruiting Zhang, Yerfan Jiaerken, Xinfeng Yu, Ying Zhou, Chang Liu, Longting Lin, Lusha Tong, Min Lou
2017 Frontiers in Aging Neuroscience  
We analyzed the cerebral blood flow (CBF) by dividing the brain tissue into three regions: WMH, normal appearing white matter (NAWM) and cortex.  ...  The aim of the present study was to determine whether brain structural damage or cerebral blood supply better correlated with the global cognitive outcome in subjects with leukoaraiosis.  ...  ACKNOWLEDGMENTS Thanks to the guidance of statistical analysis from Yunxian Yu, an associate professor from the department of epidemiology and health statistics, School of Public Health, Zhejiang University  ... 
doi:10.3389/fnagi.2017.00185 pmid:28659787 pmcid:PMC5466957 fatcat:caw7wmmjrfdx5a5jekvga2ucjy

Lower Cardiac Output Is Associated with Greater White Matter Hyperintensities in Older Adults with Cardiovascular Disease

Angela L. Jefferson, David F. Tate, Athena Poppas, Adam M. Brickman, Robert H. Paul, John Gunstad, Ronald A. Cohen
2007 Journal of The American Geriatrics Society  
OBJECTIVES: To preliminarily examine the association between cardiac output, a measure of systemic blood flow, and structural brain magnetic resonance imaging indices of white matter hyperintensities (  ...  Cerebrovascular degeneration and the chronicity of hypoperfusion may exacerbate the susceptibility of white matter integrity to alterations in blood flow in older adults.  ...  dysfunction, including problems with sequencing and planning). 13 In light of the reciprocal white matter pathways connecting frontal and subcortical structures, 14 subcortical white matter damage  ... 
doi:10.1111/j.1532-5415.2007.01226.x pmid:17608877 pmcid:PMC2721459 fatcat:7eue666langslkplvfh3odojua

Neuroimaging in the Kleine-Levin Syndrome

Maria Engström, Francesco Latini, Anne-Marie Landtblom
2018 Current Neurology and Neuroscience Reports  
We discuss these findings based on recent research on thalamocortical networks and brain stem white matter tracts.  ...  Most studies report deviations related to cerebral perfusion, glucose metabolism, or blood-oxygen-level-dependent responses in frontotemporal areas and/or the thalamus.  ...  Uncoupling of Cerebral Blood Flow and Metabolism In healthy subjects, cerebral blood flow and metabolism are closely related, shown as regional correlation between cerebral blood flow and cerebral metabolic  ... 
doi:10.1007/s11910-018-0866-y pmid:30030664 pmcid:PMC6061192 fatcat:3bj474witfcxhgf2fxuh53czsi

Recent Advances in Neuroimaging Methods

Oury Monchi, Habib Benali, Julien Doyon, Antonio P. Strafella
2008 International Journal of Biomedical Imaging  
One issue of great debate regarding blood oxygenated level dependant (BOLD) functional MRI is its relationship to cerebral blood flow and metabolism under different conditions.  ...  However, the brain is obviously not fully connected, and consequently, they needed to determine whether a given geodesic really represents a white matter fiber tract or not.  ...  ACKNOWLEDGMENTS We would like to express our sincere gratitude to all contributing authors, reviewers, as well as the Editor Dr. Ge Wang, for making this special issue possible and successful.  ... 
doi:10.1155/2008/218582 pmid:18483610 pmcid:PMC2376048 fatcat:b46fwvcsizbz7pa5m35bntzppu

Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly

Priya Rajagopalan, Helga Refsum, Xue Hua, Arthur W. Toga, Clifford R. Jack, Michael W. Weiner, Paul M. Thompson
2013 Neurobiology of Aging  
Results-Elevated kidney biomarkers were associated with volume deficits in the white matter region of the brain.  ...  Background-Poor kidney function is associated with increased risk of cognitive decline and generalized brain atrophy.  ...  The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San  ... 
doi:10.1016/j.neurobiolaging.2012.10.022 pmid:23182131 pmcid:PMC3603573 fatcat:s7oaoxnqczcthndtccnngpadim

Structural brain alterations in heart failure: a review of the literature and implications for risk of Alzheimer's disease

Michael L. Alosco, Scott M. Hayes
2015 Heart Failure Reviews  
Based on animal research and past work in AD patients, the mechanisms for structural brain changes in HF may stem from reductions in cerebral blood flow subsequent to cardiac deficiency.  ...  Our review indicates that patients with HF exhibit greater neural atrophy and white matter microstructural alterations of nearly every region of the Papez circuit (e.g., hippocampus, cingulate gyrus, thalamus  ...  Studies in humans and rodents support the notion that cerebral hypoperfusion is one important contributor to structural brain changes in HF.  ... 
doi:10.1007/s10741-015-9488-5 pmid:25896528 pmcid:PMC5543407 fatcat:kl25uhxozfaafaf44ul4t6w4aa

Studying the topological organization of the cerebral blood flow fluctuations in resting state

Lester Melie-García, Gretel Sanabria-Diaz, Carlos Sánchez-Catasús
2013 NeuroImage  
In this paper the cerebral blood flow (CBF) in resting state obtained from SPECT imaging is employed as a hemodynamics descriptor to study the concurrent changes between brain structures and to build binarized  ...  These were anatomically distributed in frontal, limbic, occipital and parietal regions that suggest its important role in functional integration.  ...  Acknowledgments This study was supported by the Cuban Neuroscience Center and Center for Neurological Restoration (CIREN) from Havana, Cuba.  ... 
doi:10.1016/j.neuroimage.2012.08.082 pmid:22975159 fatcat:act5vfrnr5aa3d7dp2hh6zgmj4

Multimodality MRI Findings in Patients with End-Stage Renal Disease

Hui Juan Chen, Long Jiang Zhang, Guang Ming Lu
2015 BioMed Research International  
This paper is a review that presents the MRI findings of occult brain damage in ESRD patients, outlines the applications of advanced MRI techniques, and introduces a brief perspective in this study field  ...  It is of great significance to detect the neurological complications and improve the prognosis of ESRD patients.  ...  Acknowledgments The authors express their thanks for the grants from Natural Scientific Foundation of China (30700194, 81171313, 81322020, and 81230032 to Long Jiang Zhang) and Program for New Century  ... 
doi:10.1155/2015/697402 pmid:26064943 pmcid:PMC4434172 fatcat:izp5tx4rdzafnbgjxxc23en6va

Association of White Matter Hyperintensities and Cardiovascular Disease

Francesco Moroni, Enrico Ammirati, Atticus H. Hainsworth, Paolo G. Camici
2020 Circulation Cardiovascular Imaging  
The diagnosis of cerebral SVD is largely based on brain magnetic resonance imaging, with white matter hyperintensities, microbleeds, and brain atrophy reflecting key structural changes.  ...  Coronary microcirculation cannot be visualized in vivo in humans, and functional information can be deduced by measuring the coronary flow reserve.  ...  D, Small penetrating arteries exhibiting cerebral small vessel disease, human brain subcortical white matter. Green: fibrous connective tissue, Masson trichrome stained section. Bar=100 microns.  ... 
doi:10.1161/circimaging.120.010460 pmid:33232175 fatcat:fxmhdnmkybg5jeodvd77jfqjfm

Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI

Catherine Foster, Jessica J. Steventon, Daniel Helme, Valentina Tomassini, Richard G. Wise
2020 Frontiers in Physiology  
Gray matter cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) were quantified in a sample of young adults within a normal fitness range.  ...  This cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in the healthy brain.  ...  Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. J.  ... 
doi:10.3389/fphys.2020.00360 pmid:32372976 pmcid:PMC7187806 fatcat:m25dkzh3tfa4lf4v6evrovrexi

Advances in multimodal magnetic resonance imaging of vascular mild cognitive impairment

Zhi-Qi Wang, Yan-Qing Han
2019 Journal of Hainan Medical University  
As a widely used imaging method, multimode magnetic resonance imaging can evaluate the brain structure and function of patients with VaMCI noninvasively and explore the relationship between brain structure  ...  , function and cognitive function change.  ...  Some studies have found that chronic deficiency of local cerebral blood flow can lead to local gray matter (GM) atrophy [4] [5] [6] .  ... 
doaj:8362f89dd33d48d2abc6e8a07c608b8f fatcat:3x3tsryp6jdyvpyyrtxlrrj6pi

Using Magnetic Resonance Imaging in the Early Detection of Alzheimer's Disease [chapter]

Emily J., Manus J., Brandon A.
2013 Understanding Alzheimer's Disease  
Cerebral blood flow Cerebral blood flow is a measurement of the rate of tissue perfusion, usually measured by the amount of blood that reaches a tissue per unit time mL blood per g tissue per minute [  ...  "t the times selected for T imaging, there is a high amount of contrast between gray and white matter and therefore T weighted imaging is useful for viewing structural changes in the brain Figure c .  ...  Regional cerebral perfusion in patients with "lzheimer's disease and mild cognitive impairment effect of "POE Epsilon allele. Neuroradiology. Jul. .  ... 
doi:10.5772/54445 fatcat:lyc7fm7kfnh3njaadtflsgctte
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