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Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modelling

Mark E. Bastin, Susana Muñoz Maniega, Karen J. Ferguson, Laura J. Brown, Joanna M. Wardlaw, Alasdair M.J. MacLullich, Jonathan D. Clayden
2010 NeuroImage  
These data therefore suggest that brain atrophy and white matter lesions play a significant role in driving regional patterns of age-related changes in white matter tract shape and integrity.  ...  Here we examine how brain atrophy and white matter lesions affect correlations between tract shape, tract integrity and age in a range of frontal and non-frontal tracts in 90 non-demented subjects aged  ...  Acknowledgements White matter structure in the ageing brain  ... 
doi:10.1016/j.neuroimage.2010.02.036 pmid:20568062 pmcid:PMC3763188 fatcat:jcxuyyaajjahbkehkwyxnncvzy

Lesion activity and chronic demyelination are the major determinants of brain atrophy in MS

Chenyu Wang, Michael H. Barnett, Con Yiannikas, Joshua Barton, John Parratt, Yuyi You, Stuart L. Graham, Alexander Klistorner
2019 Neurology: Neuroimmunology & Neuroinflammation  
To evaluate the combined effect of lesion activity and pathologic processes occurring in both chronically demyelinated lesions and normal-appearing white matter (NAWM) on brain atrophy in MS.  ...  [29] [30] [31] However, fibrillary gliosis, which developed during the initial (acute) inflammatory stage of lesion formation, 32 is likely to support the structural integrity of established lesions  ...  The multifactorial mechanism of brain atrophy observed in this study may explain the shortcomings of existing diseasemodifying therapies, which radically diminish the formation of new inflammatory lesions  ... 
doi:10.1212/nxi.0000000000000593 pmid:31454773 pmcid:PMC6705629 fatcat:rp3kz55qzvgddmtrtphwhcwcai

The measurement and clinical relevance of brain atrophy in multiple sclerosis

Robert A Bermel, Rohit Bakshi
2006 Lancet Neurology  
Progressive loss of brain tissue bulk can be detected in vivo in a sensitive and reproducible manner by MRI. Clinical studies have shown that brain atrophy begins early in the disease course.  ...  be explained by conventional lesion assessments.  ...  Acknowledgments RB was supported by research grants from the National Institutes of Health (NIH-NINDS 1 K23 NS42379-01), National Multiple Sclerosis Society (RG 3258A2/1; RG 3574A1), and National Science  ... 
doi:10.1016/s1474-4422(06)70349-0 pmid:16426992 fatcat:ewe5yzbmuzasthsfsdn3jwnnve

Gray Matter Atrophy Is Primarily Related to Demyelination of Lesions in Multiple Sclerosis: A Diffusion Tensor Imaging MRI Study

Eszter Tóth, Nikoletta Szabó, Gergõ Csete, András Király, Péter Faragó, Tamás Spisák, Krisztina Bencsik, László Vécsei, Zsigmond T. Kincses
2017 Frontiers in Neuroanatomy  
deep white matter and the gray matter atrophy.  ...  The PLS analysis revealed a combination of demyelination-like diffusion parameters (higher mean and radial diffusivity in patients) in the lesions and in the non-lesioned periventricular white matter,  ...  ACKNOWLEDGMENTS This paper was supported by the "Neuroscience Research Group of the Hungarian Academy of Sciences and University of Szeged, " the National Brain Research Program (Grant No.  ... 
doi:10.3389/fnana.2017.00023 pmid:28424595 pmcid:PMC5372801 fatcat:ogfke5gvg5agbcmbyktumcuupi

Cerebral correlates of declarative memory dysfunctions in early traumatic brain injury

J M Serra-Grabulosa
2005 Journal of Neurology, Neurosurgery and Psychiatry  
Hippocampal atrophy, white matter loss, and memory impairment remain until adolescence.  ...  Volumes of grey matter, white matter, cerebrospinal fluid (CSF), hippocampus, and caudate nuclei were measured.  ...  ACKNOWLEDGMENTS This study was supported by grants from the Spanish Ministry of Education and Culture (DGICYT PM-98-0192), and the General Direction of Research from the Generalitat de Catalunya (1999SGR00081  ... 
doi:10.1136/jnnp.2004.027631 pmid:15608014 pmcid:PMC1739340 fatcat:g2b7axcwkfcanm3gzzxvyrsrty

In aging, is it gray or white?

Alan Peters, Douglas L. Rosene
2003 Journal of Comparative Neurology  
The article by Marner et al. in this issue of the Journal of Comparative Neurology reports that there is an extensive loss of myelinated fibers from the white matter of the human cerebral hemispheres during  ...  in white matter.  ...  Other MRI studies have examined the frequency of small white matter lesions with age.  ... 
doi:10.1002/cne.10715 pmid:12794738 fatcat:efqt37godjbqhhammgyf5wqosi

Relating Imaging Indices of White Matter Integrity and Volume in Healthy Older Adults

C. E. Hugenschmidt, A. M. Peiffer, R. A. Kraft, R. Casanova, A. R. Deibler, J. H. Burdette, J. A. Maldjian, P. J. Laurienti
2007 Cerebral Cortex  
In the current study, structural MRI techniques were used to identify the relationship between white matter integrity and decreased volume in healthy aging adults.  ...  The data demonstrated that white matter atrophy did in fact account for differences in some areas, but significant FA decreases remained across much of the white matter after adjusting for atrophy.  ...  Thus, efforts to explain age-related cognitive changes increasingly focus on modifications in synaptic remodeling and white matter integrity (Bartzokis 2004) .  ... 
doi:10.1093/cercor/bhm080 pmid:17575289 fatcat:rugzwagpr5d7zi35iyqerppe5u

Role of White Matter Hyperintensities and Related Risk Factors in Vascular Cognitive Impairment: A Review

Yiyi Chen, Xing Wang, Ling Guan, Yilong Wang
2021 Biomolecules  
White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging markers of cerebral small-vessel disease, which is prevalent in older individuals and closely associated with the  ...  Because the underlying pathological processes and biomarkers of WMHs and their development in cognitive impairment remain uncertain, progress in prevention and treatment is lagging.  ...  relationship between the integrity of white matter and WMHs can at least partly explain the presence of extensive WMHs in patients without symptoms.  ... 
doi:10.3390/biom11081102 pmid:34439769 pmcid:PMC8391787 fatcat:gzewdeuki5bk7lcdsd33s74k3e

White matter abnormalities and Virchow Robin spaces in patients with psychotic disorders

Osman Ozdemir, Pinar Ozdemir, Vedat Cilingir, Mehmet Bulut, Damla Timucin
2014 Disease and Molecular Medicine  
The patient sample comprised 24 patients with psychotic disorders who had white matter abnormalities on MRI.  ...  In this study, we aimed to present white matter abnormalities and Virchow Robin spaces in patients with psychotic disorders and to discuss possible underlying mechanisms.  ...  Thickening of the vessel wall and reduction in lumen size can induce loss of autoregulation and chronic hypoperfusion leading to white matter lesions.  ... 
doi:10.5455/dmm.20140510085049 fatcat:n4qzvf6ja5euxlpodjuqohoi2u

The Fornix in Health and Disease: An Imaging Review

Adam G. Thomas, Panos Koumellis, Robert A. Dineen
2011 Radiographics  
It is also important to assess its integrity in any disease process where there is white matter tract involvement to explain the origin of potentially distressing symptoms.  ...  By using quantitative fiber tracking, an age-dependent reduction in forniceal integrity has been demonstrated in healthy aging (13) .  ...  Page 1115 Forniceal atrophy together with other secondary signs of MTS such as mammillary atrophy, temporal horn dilatation, and thinning of the collateral white matter are used as secondary signs in equivocal  ... 
doi:10.1148/rg.314105729 pmid:21768242 fatcat:5xnpmfutmrb4zof2vbvrecmf7y

The Role of the Cerebellum in Multiple Sclerosis

Katrin Weier, Brenda Banwell, Antonio Cerasa, D. Louis Collins, Anne-Marie Dogonowski, Hans Lassmann, Aldo Quattrone, Mohammad A. Sahraian, Hartwig R. Siebner, Till Sprenger
2015 Cerebellum  
Some links between the histopathological changes, the structural and functional abnormalities as captured by MRI, cerebellar dysfunction and the clinical consequences are starting to emerge and warrant  ...  There is considerable evidence of cerebellar involvement in MS based on clinical, histopathological, as well as structural and functional magnetic resonance imaging (MRI) studies.  ...  , showing myelin loss in the entire cortex and in the subcortical white matter.  ... 
doi:10.1007/s12311-014-0634-8 pmid:25578034 fatcat:eg7zmzith5c2tbw7mu5usnuyoe

Mechanisms of Neurodegeneration and Axonal Dysfunction in Progressive Multiple Sclerosis

Jorge Correale, Mariano Marrodan, María Ysrraelit
2019 Biomedicines  
Multiple Sclerosis (MS) is a major cause of neurological disability, which increases predominantly during disease progression as a result of cortical and grey matter structures involvement.  ...  Loss of axon energy provided by oligodendrocytes determines further axonal degeneration and neuronal loss. Clearly, these different mechanisms are not mutually exclusive and could act in combination.  ...  Acknowledgments: We thank the collaboration of María Inés Gaitán, and Ismael Calandri for the preparation of the figures. Conflicts of  ... 
doi:10.3390/biomedicines7010014 pmid:30791637 pmcid:PMC6466454 fatcat:kprnrmfpbnb3lm7ze5ufbzignm

Association between pathological and MRI findings in multiple sclerosis

Massimo Filippi, Maria A Rocca, Frederik Barkhof, Wolfgang Brück, Jacqueline T Chen, Giancarlo Comi, Gabriele DeLuca, Nicola De Stefano, Bradley J Erickson, Nikos Evangelou, Franz Fazekas, Jeroen JG Geurts (+5 others)
2012 Lancet Neurology  
A number of correlative pathological and MRI studies have helped to defi ne in vivo the pathological substrates of MS in focal lesions and normal-appearing white matter, not only in the brain, but also  ...  Contributors CL, BFP, FF, and BJE drafted the section on lesions. WB and JC drafted the section on normal-appearing white matter. JJG and MAR drafted the section on grey matter.  ...  Acknowledgments This paper reports the conclusions of the fi rst MRI-Path Workshop, which was held in Milan, Italy, on June 10-11, 2011, and chaired by Massimo Filippi and Hans Lassmann.  ... 
doi:10.1016/s1474-4422(12)70003-0 pmid:22441196 fatcat:wz7eyqevcrgfdp4wzmno66twzu

Tracking Changes following Spinal Cord Injury

Patrick Freund, Armin Curt, Karl Friston, Alan Thompson
2012 The Neuroscientist  
Recent evidence suggests an interesting three-way relationship between neurological deficit and changes in the spinal cord and of the brain and that, importantly, noninvasive magnetic resonance imaging  ...  Besides clinical measures of recovery, biomarkers that can detect early anatomical and functional changes might be useful in determining clinical outcome-during the course of rehabilitation and recovery-as  ...  Axonal Degeneration Assessed with DTI in the Brain As in the spinal cord, DTI measured in the brain allows one to quantify remote changes in the white matter integrity of central pathways (Basser and  ... 
doi:10.1177/1073858412449192 pmid:22730072 pmcid:PMC4107798 fatcat:urruxy2r75fh7mjbelb6yktlte

Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab

T. Button, D. Altmann, D. Tozer, C. Dalton, K. Hunter, A. Compston, A. Coles, D. Miller
2012 Multiple Sclerosis  
The magnetization transfer ratio reflects the integrity of tissue structure, including myelination and axonal density.  ...  The gradient difference in grey matter was 0.25 pu/year (p < 0.001) after age-adjustment.  ...  AC receives support from the Cambridge Biomedical Centre and The NMR Research Unit is supported by the UK MS Society and the UCLH/UCL Biomedical Research Centre, TB receives a Sackler Studentship.  ... 
doi:10.1177/1352458512444915 pmid:22492133 fatcat:w4pu24jfzncgdmpxyonnrc4iai
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