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Structural and Diffusion Property Alterations in Unaffected Siblings of Patients with Obsessive-Compulsive Disorder

Ziwen Peng, Feng Shi, Changzheng Shi, Guodong Miao, Qiong Yang, Wei Gao, Jason J. Wolff, Raymond C. K. Chan, Dinggang Shen, Jan Kassubek
2014 PLoS ONE  
To investigate the relationship of white matter microstructure with cortical thickness, we measure fractional anisotropy (FA) of white matter in 30 OCD patients, 19 unaffected siblings and 30 matched healthy  ...  Disrupted white matter integrity and abnormal cortical thickness are widely reported in the pathophysiology of obsessivecompulsive disorder (OCD).  ...  We selected the VBM method mainly because the abnormal white matter in the parietal lobe was found both in OCD patients and their first-degree relatives in a previous VBM-based study, which aimed to coincide  ... 
doi:10.1371/journal.pone.0085663 pmid:24489665 pmcid:PMC3904847 fatcat:qpsobrdggrdrrc3tqkkkbn46x4

Volumetric and Diffusion Abnormalities in Subcortical Nuclei of Older Adults With Cognitive Frailty

Mingyue Wan, Rui Xia, Huiying Lin, Pingting Qiu, Jianquan He, Yu Ye, Jing Tao, Lidian Chen, Guohua Zheng
2020 Frontiers in Aging Neuroscience  
Volumetric and diffusion tensor imaging (DTI) parameters of subcortical nuclei were measured with structural and DTI brain magnetic resonance imaging (MRI) and compared between groups.  ...  Conclusion: Microstructural changes occur in the subcortical nuclei of older adults with CF, and these changes are correlated with cognitive decline and physical frailty.  ...  ACKNOWLEDGMENTS We thank the participants and staff at the communities and hospitals for their work in this project, including Fujian University of Traditional Chinese Medicine Subsidiary Rehabilitation  ... 
doi:10.3389/fnagi.2020.00202 pmid:32848700 pmcid:PMC7399332 fatcat:mvujsrloibffffchzneu6cbjpu

Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T

Zhiyun Jia, Yuqing Wang, Xiaoqi Huang, Weihong Kuang, Qizhu Wu, Su Lui, John Sweeney, Qiyong Gong
2014 Journal of Psychiatry & Neuroscience  
Studies of white matter tracts in patients with a history of suicidal behaviour have shown alteration in the left anterior limb of the internal capsule (ALIC).  ...  Frontothalamic loops passing through the ALIC are abnormal in patients with depression and significantly more abnormal in depressed patients with a history of suicide attempts than in those without a history  ...  Conventional magnetic resonance imaging (MRI) studies have found white matter and grey matter hyperintensities and reduced orbitofrontal cortex grey matter volumes on scans of depressed patients with a  ... 
doi:10.1503/jpn.130023 pmid:24119793 pmcid:PMC3997602 fatcat:xvx43tmgubfblhj5pnv2w5acou

Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging

Yuqi Cheng, Jian Xu, Hongjun Yu, Binbin Nie, Na Li, Chunrong Luo, Haijun Li, Fang Liu, Yan Bai, Baoci Shan, Lin Xu, Xiufeng Xu (+1 others)
2014 PLoS ONE  
Method: In this study, 61 pairs of untreated, non-elderly, first-episode MDD patients and healthy controls (HCs) aged 18-45 years old received DTI scans.  ...  Fractional anisotropy (FA), derived from diffusion tensor imaging (DTI), has been widely used to study neuropsychiatric disorders by providing information about the brain circuitry, abnormalities of which  ...  of Zoology the Chinese Academy of Sciences for the assistance in statistical analyses.  ... 
doi:10.1371/journal.pone.0112307 pmid:25393297 pmcid:PMC4231105 fatcat:qqairiddh5fj7izupj7nxachou

Magnetic Resonance Imaging Studies on Acupuncture Therapy in Depression: A Systematic Review

Jinhuan Zhang, Xiaoxiong Wu, Dehui Nie, Yuanyuan Zhuo, Jiaying Li, Qingmao Hu, Jinping Xu, Haibo Yu
2021 Frontiers in Psychiatry  
Accumulating studies had been performed using magnetic resonance imaging (MRI) to understand the neural mechanism of acupuncture therapy for depression.  ...  Therefore, we aim to summarize the current MRI research and provide useful information for further research by identifying papers published in English and Chinese about MRI studies on acupuncture for depression  ...  ) , obsessive-compulsive disorder (104) , and MDD (105) .  ... 
doi:10.3389/fpsyt.2021.670739 pmid:34489749 pmcid:PMC8417590 fatcat:6drbe6rperegxgl3gutowwauiq

Altered Brain Functional Asymmetry in Patients With Major Depressive Disorder Related to Gastrointestinal Symptoms

Xiaoya Fu, Yudan Ding, Jindong Chen, Feng Liu, Huabing Li, Jingping Zhao, Wenbin Guo
2022 Frontiers in Neuroscience  
perspective.MethodsResting-state functional magnetic resonance imaging was obtained in 28 healthy controls (HCs), 35 MDD patients with GI symptoms (GI-MDD patients), and 17 patients with MDD without GI  ...  ObjectiveDisrupted brain functional asymmetry has been reported in major depressive disorder (MDD). The comorbidity may be a crucial factor to this functional asymmetry.  ...  Reduced hemispheric asymmetry of white matter microstructure in autism spectrum disorder. J. Am. Acad. Child Adolesc.  ... 
doi:10.3389/fnins.2021.797598 pmid:35250436 pmcid:PMC8891942 fatcat:474gppo54fekfg63x6ol5xu4ny

Alzheimer's Disease: Risk Factors and Preventive Strategies [chapter]

Joann T. Tschanz, John C. S. Breitner
2010 Principles and Practice of Geriatric Psychiatry  
disorder 578 brain-derived neurotrophic factor (BDNF) 42, 337 depression aetiology and 619 Brain Fitness programme 398 'brain games' 400 brain imaging vascular dementia 345 white matter lesions  ...  , in physical examination 118 movement disorders, sleep-related 702 [ 18 F]MPPF-PET 260 MRI see magnetic resonance imaging (MRI) MRS see magnetic resonance spectroscopy (MRS) MTLLD1 and MTLLDII  ... 
doi:10.1002/9780470669600.ch47 fatcat:r3yhydwz5zgzlgr7fxehof64sm

The 3rd Schizophrenia International Research Society Conference, 14–18 April 2012, Florence, Italy: Summaries of oral sessions

Brandon Abbs, Rashmin M. Achalia, Adegoke O. Adelufosi, Ahmet Yiğit Aktener, Natalie J. Beveridge, Savita G. Bhakta, Rachael K. Blackman, Emre Bora, M.S. Byun, Maurice Cabanis, Ricardo Carrion, Christina A. Castellani (+25 others)
2012 Schizophrenia Research  
an update on current investigations ongoing in the field of schizophrenia research.  ...  It is hoped that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in  ...  The information in these reports and the accuracy of each statement were the sole responsibility of each rapporteur and are based on personal interpretations of what was heard.  ... 
doi:10.1016/j.schres.2012.07.024 pmid:22910407 pmcid:PMC3877922 fatcat:kjoz7q232zejnfnvpuogpobsfa

Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012

2012 International Journal of Neuropsychopharmacology  
neurodegenerative and mood disorders, in the frontal cortex of a novel brain cohort from patients with documented HIV, MDD, or HIV with MDD (HIV/ MDD) by qRT-PCR.  ...  Objective : Altered expression of neurotrophic factors has been implicated in both the pathology of human immunodeficiency virus (HIV) infection and major depressive disorder (MDD) in the brain and may  ...  Methods : Genotype effects of rs12807809 were investigated on gray matter (GM) and white matter (WM) volumes using magnetic resonance imaging (MRI) with a voxel-based morphometry (VBM) technique in a sample  ... 
doi:10.1017/s1461145712000508 fatcat:ft6ipgmb45azzjxouthbqdn43i

The 2nd Schizophrenia International Research Society Conference, 10–14 April 2010, Florence, Italy: Summaries of oral sessions

Moogeh Baharnoori, Cali Bartholomeusz, Aurelie A. Boucher, Lisa Buchy, Christopher Chaddock, Bonga Chiliza, Melanie Föcking, Alex Fornito, Juan A. Gallego, Hiroaki Hori, Gisele Huf, Gul A. Jabbar (+20 others)
2010 Schizophrenia Research  
Related research provided longitudinal follow-up of obsessive compulsive symptoms (OCS) in first episode SCZ (FES), predictors of recovery and treatment response in FES-spectrum disorders, and five year  ...  Current research using DTI shows a decrease in fractional anisotropy in white matter of first-episode schizophrenia patients, suggesting a disruption of white matter integrity, possibly predating the onset  ...  Dazzan investigated changes in brain volume and outcome after 6 years of treatment in 49 patients with a first psychotic episode and compared them to 49 controls (Lappin et al. in preparation) and found  ... 
doi:10.1016/j.schres.2010.09.008 pmid:20934307 pmcid:PMC4182935 fatcat:aca7cqdp35gotmhphwkqimwsre

Poster Session I

2010 Neuropsychopharmacology  
One measure of impulsive choice is delayed discounting and occurs in 26.8% of children with ADHD.  ...  Background: Attention deficit hyperactivity disorder (ADHD) is a developmental disorder wherein a subset of individuals with ADHD is at greater risk for substance use than the typical population.  ...  Methods: In the present study, we used adeno-associated viral (AAV) and promoter-driven cre-recombinase expression to selectively excise floxed p38alpha MAPK in specific cell types and brain regions to  ... 
doi:10.1038/npp.2010.216 fatcat:v3q2xjxc45b2hckv33pzz7mtee

Panel and Study Groups

2013 Neuropsychopharmacology  
In addition there are 30-76 patients with schizophrenia (depending on the brain region and assay) and 63 patients with affective disorders.  ...  GABA signaling abnormalities have been reported frequently in postmortem schizophrenia studies.  ...  Measures include: a comprehensive clinical phenotype; cortical thicknessFassessed through structural magnetic resonance imaging MRI); Diffusion tensor imaging (DTI) to assess cortical white matter tract  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

VI Sindem MEETING: Italian Association for the Study of Dementia linked to the Italian Neurological Society (SIN)

Vincenzo Bonavita, Carlo Caltagirone, Claudio Mariani, Alessandro Padovani, Elio Scarpini, Sandro Sorbi, Vincenzo Bonavita, Carlo Caltagirone, Claudio Mariani, Alessandro Padovani, Elio Scarpini, Sandro Sorbi
2011 Journal of Alzheimer's Disease  
Brain magnetic resonance imaging showed diffuse cortical and deep atrophy and nonspecific minute T2hyperintense lesions in supratentorial white matter.  ...  on computed tomography or magnetic resonance imaging (MRI) in the brains of elderly subjects, particularly in those with vascular risk factors [2] .  ...  Results: On one hand, brain damaged subjects may manifest impaired facial emotion recognition, ending in compromised social interactions.  ... 
doi:10.3233/jad-2010-1433 fatcat:owgslmgl4rdinpovt26xcvnkwe

Final Program, The 2012 International Neuropsychological Society Mid-Year Meeting/11th Nordic Meeting in Neuropsychology June 27–30, 2012 Oslo, Norway

2012 Journal of the International Neuropsychological Society  
Symposium Description: Attention deficit hyperactivity disorder (ADHD) is a developmental condition with first behavioral signs appearing in childhood and often continuing into adulthood.  ...  First, Marja Laasonen from the University of Helsinki, Finland (contact  ...  White matter microstructure and resting-state functional connectivity of task-relevant brain regions were assessed using multimodal magnetic resonance imaging.  ... 
doi:10.1017/s1355617712001063 fatcat:hvqdxc6a5jb6rfbhapoem4q72i

Joint Meeting of the FESN (Federation of the European Societies of Neuropsychology)/GNP (Gesellschaft für Neuropsychologie) September 12-14, 2013, Berlin, Germany

2013 Behavioural Neurology  
To address these is-sues, functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) were used to examine brain activation during spatial working memory retrieval and white matter  ...  using magnetic resonance imaging (MRI).  ...  Plasma markers of thrombosis have been related to white matter (WM) integrity loss and lower processing speed (Miralbell et al., 2011) .  ... 
doi:10.3233/ben-139900 pmid:28149002 pmcid:PMC5215690 fatcat:f4olin3ogfg7zlznht4ryjbtym
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