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Random laser with intrinsically uncomplicated fabrication processes, high spectral radiance, anglefree emission, and conformal onto freeform surfaces is in principle ideal for a variety of applications, ranging from lighting to identification systems. In this work, a white random laser (White-RL) with high-purity and high-stability is designed, fabricated, and demonstrated via the cost-effective materials (e.g., organic laser dyes) and simple methods (e.g., all-solution process anddoi:10.1038/s41598-018-21228-w pmid:29426912 pmcid:PMC5807428 fatcat:f5jixmewwjfctlgoci34mx4xsq
more »... d structures). Notably, the wavelength, linewidth, and intensity of White-RL are nearly isotropic, nevertheless hard to be achieved in any conventional laser systems. Dynamically fine-tuning colour over a broad visible range is also feasible by on-chip integration of three free-standing monochromatic laser films with selective pumping scheme and appropriate colour balance. With these schematics, White-RL shows great potential and high application values in high-brightness illumination, full-field imaging, full-colour displays, visible-colour communications, and medical biosensing. The hope of next-generation illuminants goes on the application of random laser. As an unconventional laser system, random laser is naturally endowed with two key superiorities, namely, laser-level intensity and broad-angular emissions 1-4 , which are mutually exclusive in thermal light sources, light-emitting-diodes (LEDs), and lasers. Nowadays, white LEDs, undoubtedly, lead the mainstream lighting marketplace 5,6 . The current standard of white LEDs is dominated by the high-brightness InGaN blue LEDs integrated with wavelength-downconverting phosphors, which have been introduced the highest luminous efficacy of all white light source 7 . However, the recognized limitation in InGaN blue LEDs was not able to be overcome: A nonthermal drop in efficiency under increasing input energy density. The "efficiency drop" restricts operation only under relatively low input energy densities, which is a stark contrast with the motive for producing more photons per unit area of the LEDs chips (i.e., reducing the cost per lumen of the illuminations) 8 . Lasers, with higher efficiency and output than LEDs or thermal light sources, are potential and promising alternatives 9,10 . Multi-wavelength lasers spanning the full visible spectrum have been significantly addressed in the state-of-the-art optical technologies. Previous prototypes of simultaneous red, green, and blue (RGB) emissions include a flute-type hollow-cathode He-CD laser, an Ar-Kr mixed gas laser, a cascaded optical superlattice for wavelength conversion, a combination of inorganic semiconductor laser diodes and a second harmonic Nd3þ-doped yttrium aluminum garnet (Nd: YAG), a monolithic multisegment ZnCdSSe-based semiconductor nanosheet, a single-chip dye-doped polymer, and so on 11-16 . However, there remains several significant challenges that the integration, operation, and production of nonlinear optical processes of laser modules are somewhat bulky, costly, and intricate. Besides, the constructions of conventional lasers in a single chip or a film, in which intentional gratings, waveguides, and resonators need to be precisely designed and constructed, are arduous techniques. The last and the worst, directionality, a significant nature of lasers, sets a hurdle for lighting, imaging, and display uses. These shortcomings create and promote interests in developing a strong-luminous and high-efficiency light source with competitive cost, simple design, compact size, and low spatial coherent emission. A white random laser (White-RL) is a promising and feasible approach. Such unconventional laser lases when multiple light scattering in the disordered materials lets the gain surpass the loss 2,4 . Notably, random laser systems can generate spatially incoherent and laser-level radiation, in contrast to those existing illuminant modules (e.g., incandescent bulb, LEDs, superluminescent diodes, and broadband lasers). This angle-free emission is in principle ideal for not only general lighting (e.g., laser headlights) but also consumer products (e.g., spotlight, laser display, and digital laser projector) and even imaging applications (e.g., full-field microscopy and medical sensing). Additionally, based on the unique mechanism, random lasers hold limitless potential beyond the scope of conventional lasers, bringing new possibilities and innovative designs to advanced illuminants 3,17-20 . Since
Objectives To investigate the clinical efficacy and safety of radiofrequency ablation treatment of children with supraventricular tachycardia (PSVT). Methods Conventional cardiac electrophysiology examination was performed in 36 children with PSVT to identify PSVT pathogenesis, and to determine the ablation site. Radiofrequency ablation was performed using the temperature control method. Results Electrophysiological examination showed 22 cases of atrioventricular reentrant tachycardia (AVRT),doi:10.1136/heartjnl-2012-302920n.5 fatcat:2lxj7bou5bgzlp2afyv6zs6bki
more »... cases of atrioventricular nodal reentrant tachycardia (AVNRT) and all surgeries were successful. There were two cases of transient third degree atrioventricular block (AVB), which returned to sinus rhythm automatically, when His bundle electrode was placed. Two cases of complete right bundle branch block (CRBBB) Occurred after surgery and returned to normal after 1-2 days. One child with AVNRT (2.7%) recurred after 9 months and need re-operation to be successful. No serious complications occurred such as permanent III degree AVB and pericardial tamponade. Conclusions In the skilled interventional cardiology center, radiofrequency ablation of PSVT in children is as safe and effective as in adults. AVNRT recurrence after ablation may be related to physician fear in children with atrioventricular nodal development immaturity and more conservation for the ablation energy and ablation time in children. E222 Heart 2012;98(Suppl 2): E1-E319
Objectives To investigate the correlation of carotid atherosclerosis and serum high sensitivity C-reactive protein levels in elderly hypertensive patients Methods 102 cases of elderly patients with hypertension were selected according to the WHO/ISH hypertension diagnostic criteria. Blood was taken for quantitative detection of serum hs-CRP in the early morning and carotid ultrasound was done on the same day. Ultrasound scanning began from the beginning of the carotid artery, followed bydoi:10.1136/heartjnl-2012-302920r.10 fatcat:ncdodsyjafhghnsi2563jtfj3y
more »... on of bilateral common carotid artery, carotid bifurcation and internal carotid artery. The blood vessel wall, blood vessel diameter, medial thickness (MT), and atherosclerotic plaque were observed by two-dimensional image. The MT would be defined as thickening of the carotid intima if the thickness was greater than or equal to 0.9 mm and less than 1.3 mm. The MT would be defined as the plaque if the thickness was greater than or equal to 1.3 mm. Media thickness and (or) plaque formation in the carotid artery were determined to have carotid atherosclerosis. Results After testing, the normal group, the thickening group and the plaque group of 102 patients were accordingly 20 cases, 19 cases and 63 cases. Serum hs-CRP levels were (2.92±3.12) mg/l, (3.89±2.43) mg/l, and (5.79±4.71) mg/l accordingly in each group. The average level of serum hs-CRP in 82 cases of carotid artery atherosclerosis (thickening group and plaque group) was significantly higher than that in 20 cases without carotid atherosclerosis (5.76 ±3.24 vs 3.58±2.51 mg/l, p<0.05). Conclusions Serum hs-CRP levels in hypertensive patients with carotid atherosclerosis were significantly higher than those without carotid artery lesions, suggesting that serum hs-CRP levels have a high correlation with carotid atherosclerosis in elderly hypertensive patients and the inflammatory response may play a crucial role in the process of carotid artery atherosclerotic lesion development.
Objectives To investigate the clinical value and safety of emergency bedside temporary cardiac pacing without X-ray fluoroscopy. Methods 63 patients were selected due to ventricular rate less than or equal to 40 times/min and (or) RR interval greater than 3.0 s caused by various diseases and associated with severe hemodynamic disorders, Adams syndrome attack or disturbance of consciousness. Subclavian vein was punctured for vasodilating sheath placement by seldinger technique without x-raydoi:10.1136/heartjnl-2012-302920n.12 fatcat:5tehdm2brfew7eqfe444cdjzai
more »... oscopy at bedside. Temporary pacing electrode was inserted into the right ventricular cavity from the sheath and success was judged by three methods based on intracardiac ECG, pacing ECG, or whether it could induce PVCs. Results Out of 63 patients, 59 cases of pacing was successful and the success rate was 93.7%. The operation time from the puncture to the successful pacing was about 2-15 min (average 4.5 min) and pacing thresholds were less than or equal to 2.0 V. The hemodynamic significantly improved, Adams syndrome attacks stopped and consciousness returned to normal in successful pacing patients. No serious complications occurred such as infective endocarditis, bleeding, pneumothorax, hemothorax and so on. Conclusions Emergency bedside temporary cardiac pacing without x-ray fluoroscopy is important rescue of severe bradycardia or cardiac arrest, particularly suitable for critically ill patients, who should not be moved and need emergency pacing. It has fast, easy and safe advantages and is indispensable means in the cardiac emergency work.
Rationale: Pilocytic astrocytoma (PA) typically shows biphasic pattern with a mixture of loose microcystic and compact regions, in which it is not uncommon to see heterogeneous morphology. However, there has not been reported in the literatures of the PA type that shows similarity to dysembryoplastic neuroepithelial tumor (DNT) in both histological morphology and immunophenotype. Patient concerns: The present study described a case of PA affecting the right temporal-occipital lobe in adoi:10.1097/md.0000000000010755 pmid:29768357 pmcid:PMC5976299 fatcat:kpyg32uwtjctpi6uwbaqhjp5zq
more »... ld male patient. Morphologically, it composed of totally distinctive microcystic pattern. The classical biphasic pattern of PA was not observed. Immunohistochemically, neuronal marker NeuN was expressed in tumor cells scattered in the background which simulated its expression morphology in DNT. However, KIAA1549-BRAF fusion gene was identified by fluorescence in situ hybridization (FISH), supporting for the diagnosis of PA. Diagnoses: DNT-like PA (WHO grade I). Interventions: The tumor was totally removed via a right temporal-occipital craniotomy. Outcomes: The patient is free of local recurrence and dissemination eleven months after surgical resection of the lesion. Lessons: We herein report a rare case of DNT-like PA. For diagnosis, KIAA1549-BRAF fusion gene should be detected under similar situation. Abbreviations: DNT = dysembryoplastic neuroepithelial tumor, FISH = fluorescence in situ hybridization, GFAP = glial fibrillary acidic protein, GG = ganglioglioma, IDH1 = isocitrate dehydrogenase 1, MRI = magnetic resonance imaging, NF1 = neurofibromatosis type 1, Olig2 = oligodendrocyte transcription factor 2, PA = pilocytic astrocytoma, PXA = pleomorphic xanthoastrocytoma.
Despite advances in pharmacotherapy, intervention devices and techniques, residual cardiovascular risks still cause a large burden on public health. Whilst most guidelines encourage achieving target levels of specific lipids and lipoproteins to reduce these risks, increasing evidence has shown that molecular modification of these lipoproteins also has a critical impact on their atherogenicity. Modification of low-density lipoprotein (LDL) by oxidation, glycation, peroxidation, apolipoproteindoi:10.3390/biomedicines9080985 fatcat:mt6enm5p3vabljfbkx3c7cshs4
more »... II adhesion, and the small dense subtype largely augment its atherogenicity. Post-translational modification by oxidation, carbamylation, glycation, and imbalance of molecular components can reduce the capacity of high-density lipoprotein (HDL) for reverse cholesterol transport. Elevated levels of triglycerides (TGs), apolipoprotein C-III and lipoprotein(a), and a decreased level of apolipoprotein A-I are closely associated with atherosclerotic cardiovascular disease. Pharmacotherapies aimed at reducing TGs, lipoprotein(a), and apolipoprotein C-III, and enhancing apolipoprotein A-1 are undergoing trials, and promising preliminary results have been reported. In this review, we aim to update the evidence on modifications of major lipid and lipoprotein components, including LDL, HDL, TG, apolipoprotein, and lipoprotein(a). We also discuss examples of translating findings from basic research to potential therapeutic targets for drug development.
Correspondence: Wei Wang, Department of Medical Ultrasonics, The First The authors have no conflicts of interest to disclose. Copyright # 2016 Wolters Kluwer Health, Inc. All rights reserved. ...doi:10.1097/md.0000000000003450 pmid:27227910 pmcid:PMC4902334 fatcat:lowd32hhj5gfzikrkpp34f4nce
Results of a previous study also indicated that VEGF mediates the autocrine induction of HO-1 in macrophage (Weis et al. 2009 ). ...doi:10.1530/erc-15-0007 pmid:25876647 fatcat:yev2xivly5g3tebhorv4yapqiu
This paper presents a low-voltage low-dropout voltage (LDO) regulator achieving a high power supply rejection (PSR) performance over a wide frequency range. A simple PSR enhancing circuit (PSRE) establishing a power noise (ripple) cancellation mechanism to avoid power noise passing through the power MOS transistor. A LDO regulator adopting the proposed PSRE was designed using a 1-V 90 nm CMOS process to convert an input of 1.2 V-0.8 V to an output of 0.85 V-0.5 V at a load current range ofdoi:10.1587/elex.11.20140906 fatcat:nsh34q365rfqbnrimys7trrenu
more »... mA. Post-layout simulations show that a PSR is above −57 dB at 1 MHz while the output spike during a 0.1 mA-100 mA load transient test is only 14 mV.
The need for portable and inexpensive analytical devices for various critical issues has led researchers to seek novel materials to construct them. Soft porous materials, such as paper and sponges, are ideal candidates for fabricating such devices due to their light weight and high availability. More importantly, their great compatibility toward modifications and add-ons allows them to be customized to match different objectives. As a result, porous material-based composites have beendoi:10.3390/jcs5010035 fatcat:s5zntezvfrbpxdfqyzayftwjrm
more »... y used to construct sensing devices applied in various fields, such as point-of-care testing, environmental sensing, and human motion detection. In this article, we present fundamental thoughts on how to design a sensing device based on these interesting composite materials and provide correlated examples for reader's references. First, a rundown of devices made with porous composite materials starting from their fabrication techniques and compatible detection methods is given. Thereafter, illustrations are provided on how device function and property improvements are achieved with a delicate use of composite materials. This includes extending device lifetime by using polymer films to protect the base material, while signal readout can be enhanced by a careful selection of protective cover and the application of advanced photo image analysis techniques. In addition to chemical sensors, mechanical responsive devices based on conductive composite materials are also discussed with a focus on base material selection and platform design. We hope the ideas and discussions presented in this article can help researchers interested in designing sensing devices understand the importance and usefulness of composite materials.
P-glycoprotein affects the transport of numerous drugs including chemotherapeutic drugs vincristine sulfate (VCR) and docetaxel (DTX), and is one of the main causes for multidrug resistance. Our previous studies have shown that oxypeucedanin (OPD) can enhance the intestinal transit of puerarin and VCR. However, the underlying mechanism is unclear. This study investigated the potential mechanism by which OPD improves P-gp-mediated drug transport. Molecular docking was performed to predict thedoi:10.3390/molecules23081841 pmid:30042338 fatcat:5ey67wtu7rfz5mf7mepouaipfu
more »... ding force between OPD and P-gp and the contribution of OPD on P-gp activity. We observed the effect of OPD on the transport of VCR in MDCK-MDR1 cell monolayer and also measured the plasma pharmacokinetic parameters of DTX in the presence and absence of OPD by LC-MS/MS. Moreover, we further investigated the reversal mechanism of OPD on P-gp-mediated drug transport by determining the intracellular accumulation of Rhodamine-123 (Rh123) and P-gp ATPase activity as well as protein expression and mRNA level of P-gp. Our molecular docking results revealed that the binding force between OPD and P-gp was much lower than that between P-gp and verapamil (a P-gp substrate). The transport study in vitro indicated that OPD increased the flux of VCR across MDCK-MDR1 cell monolayer. The in vivo pharmacokinetic parameters data showed OPD increased the absorption of DTX. OPD activated P-gp ATPase activity and enhanced intracellular accumulation of Rh123 in MDCK-MDR1 cells. Western blotting and qRT-PCR outcomes indicated that OPD suppressed P-gp protein expression as well as downregulated P-gp mRNA level. Thus, OPD reverse P-gp-mediated drug transport via inhibition of P-gp activity and P-gp protein expression as well as downregulation of P-gp mRNA level. Our results suggest that OPD could reverse P-gp-mediated drug resistance in tumor cells.
The tourism industry has become a new growth engine that closely coordinates with the financial industry and contributes to the sustainable development of local economies. This study establishes a comprehensive index system and evaluates the coupling coordination based on an integrated approach, and the dynamic relationship between tourism and finance through applying coupling coordination degree modeling, the Granger causality test, and an impulse response function based on the regionaldoi:10.3390/su10072320 fatcat:cxmdxm7cdzaofl7uzyxzvureb4
more »... ation theory and system theory. Using data from 2000 to 2016 of three tourism-based cities in China, the findings reveal heterogeneous results among the cities. Specifically, the following: (1) The coupling coordination degree between finance and tourism in Zhangjiajie increased with strong fluctuations. A one-way causality relationship existed between two subsystems, and finance continuously contributed to the growth of tourism with serious lags; (2) The coupling coordination degree between finance and tourism in Huang Shan presented a ladder-type and continuous rise. A two-way causality relationship existed between the two subsystems mentioned above, and finance influenced the growth of tourism with continuously positive or negative effects, while tourism continuously contributed to the development of finance. (3) The coupling coordination degree between finance and tourism in Sanya grew with a frequent, tiny, and fluctuating trend. A two-way causality relationship existed between the two subsystems mentioned above, and finance influenced the growth of tourism with continuously positive or negative effects, while tourism influenced the development of finance with temporary positive or negative effects.
Cancer stem cells (CSCs) are cells that drive tumorigenesis, contributing to metastasis and cancer recurrence as well as resistance to chemotherapy of oral squamous cell carcinomas (OSCC). Therefore, approaches to target CSCs become the subject of intense research for cancer therapy. In this study, we demonstrated that isoliquiritigenin, a chalcone-type flavonoid isolated from licorice root, exhibited more toxicity in oral cancer stem cells (OSCC-CSCs) compared to normal cells. Treatment ofdoi:10.18632/oncotarget.21338 pmid:29212198 pmcid:PMC5706844 fatcat:w5mhfdkqrjdgjg4tes636pehvy
more »... iquiritigenin not only inhibited the self-renewal ability but also reduced the expression of CSC markers, including the ALDH1 and CD44. In addition, the capacities of OSCC-CSCs to invade, metastasize and grow into a colony were suppressed by isoliquiritigenin. Most importantly, we showed that isoliquiritigenin potentiated chemotherapy along with downregulated expression of an ABC transporter that is associated with drug resistance, ABCG2. Moreover, a combination of isoliquiritigenin and Cisplatin significantly repressed the invasion and colony formation abilities of OSCC-CSCs. Our results suggested that administration of isoliquiritigenin reduced the protein expression of mRNA and membrane GRP78, a critical mediator of tumor biology. Overexpression of GRP78 reversed the inhibitory effect of isoliquiritigenin on OSCC-CSCs. Furthermore, isoliquiritigenin retarded the tumor growth in nude mice bearing OSCC xenografts. Taken together, these findings showed that isoliquiritigenin is an effective natural compound that can serve as an adjunct to chemotherapy for OSCC.
Overexpression of vimentin is significantly associated with HCC , and contributes to prostate cancer invasion and metastasis via Src regulation (Wei et al. 2008) . ... As TR functions are complex and tissue-and time-specific, aberrant expression of the various TR isoforms has different effects and is associated with different types of tumor or stages of C-H Liao et al ...doi:10.1677/erc-09-0050 pmid:19903741 fatcat:3vmkcqudmzgoxiv6idqymk543q
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