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Water-Based Suspensions of Iron Oxide Nanoparticles with Electrostatic or Steric Stabilization by Chitosan: Fabrication, Characterization and Biocompatibility

Galina Kurlyandskaya, Larisa Litvinova, Alexander Safronov, Valeria Schupletsova, Irina Tyukova, Olga Khaziakhmatova, Galina Slepchenko, Kristina Yurova, Elena Cherempey, Nikita Kulesh, Ricardo Andrade, Igor Beketov (+1 others)
2017 Sensors  
Stabilized water-based suspensions were fabricated using electrostatic or steric stabilization by the natural polymer chitosan.  ...  Suspensions with and without chitosan enhanced the secretion of cytokines by a 24-h culture of HBMLs compared to a control without MNPs.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/s17112605 pmid:29137198 pmcid:PMC5712992 fatcat:2z4fjkrkljan5frfuxb2u7vtue

Shining Light on Chitosan: A Review on the Usage of Chitosan for Photonics and Nanomaterials Research

Sreekar Marpu, Erin Benton
2018 International Journal of Molecular Sciences  
Highlighted in this review are the different works involving some of the above-mentioned molecular-nano systems that are prepared or stabilized using the CS polymer.  ...  The biocompatibility and biodegradability of CS have helped researchers identify its utility in the delivery of therapeutic agents, tissue engineering, wound healing, and more.  ...  We would also like to thank Brooke Otten and Kortney Melancon for their helpful suggestions with the tile of the manuscript and the schematic illustration. We would also like to thank Mohammad A.  ... 
doi:10.3390/ijms19061795 pmid:29914214 pmcid:PMC6032264 fatcat:xyfi2mkdkndfdgi34whsmon67y

Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications [chapter]

Kessily B. Rufato, Juliana P. Galdino, Kamila S. Ody, Antonio G.B. Pereira, Elisangela Corradini, Alessandro F. Martins, Alexandre T. Paulino, André R. Fajardo, Fauze A. Aouada, Felipe A. La Porta, Adley F. Rubira, Edvani C. Muniz
2018 Hydrogels [Working Title]  
This chapter is an attempt for updating and joining the plenty of available information regarding the preparation, characterization, and biomedical application of hydrogels based on chitosan and chitosan  ...  Such physical interactions arise due to the presence of (i) groups with opposite electrical charges (electrostatic interactions, as in the case of polyelectrolyte complexes or PECs) and (ii) dipolar or  ...  Hydrogels based on electrostatic interaction of the cationic CS and the anionic heparin and poly(γ-glutamic acid) were successfully prepared and characterized.  ... 
doi:10.5772/intechopen.81811 fatcat:rfm5uo762vb7hdiglvgjmekkzy

Development of Chitosan Functionalized Magnetic Nanoparticles with Bioactive Compounds

Gordana Hojnik Podrepšek, Željko Knez, Maja Leitgeb
2020 Nanomaterials  
In this study, magnetic maghemite nanoparticles, which belong to the group of metal oxides, were functionalized with chitosan, a non-toxic, hydrophilic, biocompatible, biodegradable biopolymer with anti-bacterial  ...  Furthermore, after activation of chitosan functionalized maghemite nanoparticles with glutaraldehyde (GA) or pentaethylenehexamine (PEHA), immobilization studies of enzyme cholesterol oxidase (ChOx) and  ...  Acknowledgments: The authors acknowledge the Slovenian Research Agency and Ministry of Education, Science, and Sport, Slovenia. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/nano10101913 pmid:32992815 pmcid:PMC7599998 fatcat:uikzrr3u2famtdplsumkdzekja

Chitosan/Graphene Oxide Composite Films and Their Biomedical and Drug Delivery Applications: A Review

Sara Moradi, Hamid Hamedi, Alan E. Tonelli, Martin W. King
2021 Applied Sciences  
Graphene oxide has also been considered by researchers as a non-toxic, inexpensive, and biocompatible material for wound healing applications.  ...  This review paper discusses the potential use of chitosan/graphene oxide composite films and their application in wound dressing and drug delivery systems.  ...  [43] fabricated biocompatible graphene oxide nanocomposite membranes cross-linked with chitosan, which can be used in various applications.  ... 
doi:10.3390/app11177776 fatcat:2g2ewdvzhrgspk54fgbva7h7fq

Recent Advances of Chitosan Formulations in Biomedical Applications

Mohammed A. S. Abourehab, Sheersha Pramanik, Mohamed A. Abdelgawad, Bassam M. Abualsoud, Ammar Kadi, Mohammad Javed Ansari, A. Deepak
2022 International Journal of Molecular Sciences  
Chitosan, a naturally abundant cationic polymer, is chemically composed of cellulose-based biopolymers derived by deacetylating chitin.  ...  This review article highlights the extensive research about the properties, extraction techniques, and recent developments of chitosan-based composites for drug, gene, protein, and vaccine delivery applications  ...  Acknowledgments: M.A. would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code: (22UQU4290565DSR78).  ... 
doi:10.3390/ijms231810975 pmid:36142887 fatcat:tbozeprddbawbdppdwkxvxndwm

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Veronika Mikušová, Peter Mikuš
2021 International Journal of Molecular Sciences  
Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation  ...  involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with  ...  All authors have read and agreed to the published version of the manuscript. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms22179652 pmid:34502560 pmcid:PMC8431817 fatcat:2cl5ngddk5h5tgz7pbc4sgloj4

Chitosan: A Promising Biopolymer in Drug Delivery Applications

Chinmayee Saikia, Pankaj Gogoi
2015 Journal of Molecular and Genetic Medicine  
The therapeutic index of the active agent can be enhanced by increasing its stability, solubility and bioavailability, along with specific site delivery.  ...  Various types of chitosan based drug delivery systems are surveyed to elucidate its role in different biomedical applications.  ...  Modification with nanomaterials: Metal nanoparticles such as zinc oxide, titanium dioxide, montmorrilonite, iron oxide etc. have recently been widely investigated in drug delivery applications (specially  ... 
doi:10.4172/1747-0862.s4-006 fatcat:5qxducclp5cjdbmql2aelgg6mi

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Qizhou Chen, Yi Qi, Yuwei Jiang, Weiyan Quan, Hui Luo, Kefeng Wu, Sidong Li, Qianqian Ouyang
2022 Marine Drugs  
In recent years, the demand has increased significantly in many fields and has huge application potential. Due to the poor water solubility of chitosan, its wide application is limited.  ...  The review covers the period from 1996 to 2022 and was elaborated by searching Google Scholar, PubMed, Elsevier, ACS publications, MDPI, Web of Science, Springer, and other databases.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/md20080536 pmid:36005539 pmcid:PMC9410415 fatcat:7imkz3ysdbanzd2zmjg2kkek34

Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid

Sorasitthiyanukarn, Muangnoi, Thaweesest, Bhuket, Jantaratana, Rojsitthisak, Rojsitthisak
2020 Biomolecules  
Curcumin diglutaric acid-loaded polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles (CG-PEG-CSO-SPIONs) were fabricated by co-precipitation and optimized using  ...  In addition, the CG-PEG-CSO-SPIONs could be stored dry for up to 12 weeks or in aqueous solution for up to 4 days at either 4 °C or 25 °C with no loss of stability.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/biom10010073 pmid:31906490 pmcid:PMC7023009 fatcat:ap2egyfjibhurlfnh33nbkpobu

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

Rabia Javed, Muhammad Zia, Sania Naz, Samson O. Aisida, Noor ul Ain, Qiang Ao
2020 Journal of Nanobiotechnology  
The capping ligands stabilize the interface where nanoparticles interact with their medium of preparation. Specific structural features of nanoparticles are attributed to capping on their surface.  ...  AbstractCapping agents are of utmost importance as stabilizers that inhibit the over-growth of nanoparticles and prevent their aggregation/coagulation in colloidal synthesis.  ...  Acknowledgements Rabia Javed and Samson Olatubosun Aisida acknowledge the International Postdoctoral Exchange Fellowship by CMU and NCP-TWAS Postdoc Fellowship award (NCP-CAAD/TWAS_Fellow8408) respectively  ... 
doi:10.1186/s12951-020-00704-4 pmid:33225973 pmcid:PMC7682049 fatcat:notn7lli3rbx7nmgijvzhdgedm

Surface Modification of Nanoparticles Used in Biomedical Applications [chapter]

Evrim Umut
2013 Modern Surface Engineering Treatments  
The stability of a magnetic colloidal suspension results from the equilibrium between attractive (magnetic dipol-dipol, van der Waals) and repulsive (electrostatic, steric) forces [57] .  ...  of water/organic solvent based suspensions/ solutions (ferrofluids) prepared with MNPs ii) providing biocompatibility of MNPs by preventing any toxic ion leakage from magnetic core into the biological  ... 
doi:10.5772/55746 fatcat:4wrg2ruxmbf55lei56kfwvj5cu

Application of Iron Magnetic Nanoparticles in Protein Immobilization

Jiakun Xu, Jingjing Sun, Yuejun Wang, Jun Sheng, Fang Wang, Mi Sun
2014 Molecules  
This review provides an updated and integrated focus on the fabrication and characterization of suitable magnetic iron nanoparticle-based nano-active materials for protein immobilization.  ...  Various modification methods have been developed to produce biocompatible magnetic nanoparticles for protein immobilization.  ...  An iron oxide nanoparticles-chitosan composite based glucose biosensor was developed by Kaushik et al. [168] .  ... 
doi:10.3390/molecules190811465 pmid:25093986 fatcat:nkhqhj6jvbb6pa4vseze32n5km

Significance of Capping Agents of Colloidal Nanoparticles from the Perspective of Drug and Gene Delivery, Bioimaging, and Biosensing: An Insight

Rabia Javed, Anila Sajjad, Sania Naz, Humna Sajjad, Qiang Ao
2022 International Journal of Molecular Sciences  
The over-growth and coagulation of nanoparticles is prevented using capping agents by the production of stearic effect that plays a pivotal role in stabilizing the interface.  ...  This strategy of coating the nanoparticles' surface with capping agents is an emerging trend in assembling multipurpose nanoparticles that is beneficial for improving their physicochemical and biological  ...  [64] reported a new technique for the production of iron oxide nanoparticles (IONPs) capped by EDTA based on the one-pot electrodeposition method, and these NPs showed acceptable characteristics for  ... 
doi:10.3390/ijms231810521 pmid:36142435 fatcat:5whdwlkamjcfle3ore3mdiqwfi

Preparation of Novel Poly(hydroxyethyl methacrylate-co-glycidyl methacrylate)-Grafted Core-Shell Magnetic Chitosan Microspheres and Immobilization of Lactase

Wei Zhao, Rui-Jin Yang, Ting-Ting Qian, Xiao Hua, Wen-Bin Zhang, Wendy Katiyo
2013 International Journal of Molecular Sciences  
The application of HG-MCM in immobilization of lactase showed that the immobilized enzyme presented higher storage, pH and thermal stability compared to the free enzyme.  ...  The HG-MCM presented a core-shell structure and regular spherical shape with poly(hydroxyethyl methacrylate-co-glycidyl methacrylate) grafted onto the chitosan layer coating the Fe 3 O 4 cores.  ...  Acknowledgments The authors gratefully acknowledge the financial support provided by Project 31000829 of the National Natural Science Foundation of PR China, the Project BK2010148 of Jiangsu Provincial  ... 
doi:10.3390/ijms140612073 pmid:23743822 pmcid:PMC3709774 fatcat:ysci3pihwrhpbpc3qnh4m5kvje
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