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A Programmable High-Voltage Compliance Neural Stimulator for Deep Brain Stimulation in Vivo

Cihun-Siyong Gong, Hsin-Yi Lai, Sy-Han Huang, Yu-Chun Lo, Nicole Lee, Pin-Yuan Chen, Po-Hsun Tu, Chia-Yen Yang, James Lin, You-Yin Chen
2015 Sensors  
Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders.  ...  The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure.  ...  Acknowledgments This study was supported in part by the Ministry of Science and Technology, Taiwan, under grant No. 103-2221-E-182-070,102-2218-E-182-003, 102-2221-E-010-011-MY3, and 101-2622-E-010-002  ... 
doi:10.3390/s150612700 pmid:26029954 pmcid:PMC4507613 fatcat:duwcavmmjvczxokez4wmtsu3se

A CMOS-based neural implantable optrode for optogenetic stimulation and electrical recording

Hubin Zhao, Fahimeh Dehkhoda, Reza Ramezani, Danil Sokolov, Patrick Degenaar, Yan Liu, Timothy Constandinou
2015 2015 IEEE Biomedical Circuits and Systems Conference (BioCAS)  
The neural interface has two clusters of stimulation and recording sites.  ...  The system includes circuits for controlling the optical stimulations; recording local field potentials (LFPs); and onboard diagnostics.  ...  The authors would like to acknowledge the CANDO project (, CSC scheme and GBCET scholarship.  ... 
doi:10.1109/biocas.2015.7348357 dblp:conf/biocas/ZhaoDRSD0C15 fatcat:y5izmxqltzcjtctmwd3hvgz5wi

MagNI: A Magnetoelectrically Powered and Controlled Wireless Neurostimulating Implant

Zhanghao Yu, Joshua C. Chen, Fatima T. Alrashdan, Benjamin W. Avants, Yan He, Amanda Singer, Jacob T. Robinson, Kaiyuan Yang
2020 IEEE Transactions on Biomedical Circuits and Systems  
Thanks to low tissue absorption, low misalignment sensitivity and high power transfer efficiency, the ME effect enables safe delivery of high power levels (a few milliwatts) at low resonant frequencies  ...  The system delivers fully programmable bi-phasic current-controlled stimulation with patterns covering 0.05-to-1.5-mA amplitude, 64-to-512-s pulse width and 0-to-200-Hz repetition frequency for neurostimulation  ...  We would also like to thank Soonyoung Kim for the culturing and handling of Hydra and useful discussions of Hydra biology.  ... 
doi:10.1109/tbcas.2020.3037862 pmid:33180732 pmcid:PMC8712272 fatcat:zjx4a6lwibc5fgdrgtyxukhrfq

A Fully Integrated Sensor-Brain-Machine Interface System for Restoring Somatosensation

Xilin Liu, Hongjie Zhu, Tian Qiu, Srihari Y. Sritharan, Dengteng Ge, Shu Yang, Milin Zhang, Andrew G. Richardson, Timothy H. Lucas, Nader Engheta, Jan Van der Spiegel
2020 IEEE Sensors Journal  
The electrogoniometer integrates an ultra low-power digital signal processor (DSP) for real-time joint angle measurement. The neural interface enables bidirectional neural stimulation and recording.  ...  Recent advances in direct neural control of paralyzed arms present new requirements for miniaturized, low-power sensor systems.  ...  The stimulator has two modes: in the high-current mode, the output current range is 0-2048µA with a programmable step current of 32µA; in the low-current mode, the output current range is 0-255µA with  ... 
doi:10.1109/jsen.2020.3030899 fatcat:dvynmwcegjhsdhvru7lpdx5g2q

A Compact Large Voltage-Compliance High Output-Impedance Programmable Current Source for Implantable Microstimulators

M. Ghovanloo, K. Najafi
2005 IEEE Transactions on Biomedical Engineering  
This approach improves stimulation efficiency, extends power supply lifetime, and saves chip area especially when the stimulation current level is high in the milliampere range.  ...  The VCR current source achieves large voltage compliance, up to 97% of the supply voltage, while maintaining high output impedance in the 100 M range to keep the stimulus current constant within 1% of  ...  Wise and Dr. W. J. Heetderks for their guidance. This work was done using the WIMS-NSF-ERC shared facilities.  ... 
doi:10.1109/tbme.2004.839797 pmid:15651568 fatcat:a5akugnsf5davhx5b3zhylul7m

A Dual Mode Pulsed Electro-Magnetic Cell Stimulator Produces Acceleration of Myogenic Differentiation

Walter D. Leon-Salas, Hatem Rizk, Chenglin Mo, Noah Weisleder, Leticia Brotto, Eduardo Abreu, Marco Brotto
2013 Recent Patents on Biotechnology  
This paper presents the design and test of a dual-mode electric and magnetic biological stimulator (EM-Stim).  ...  The device is fully programmable, portable and easy to use, and can run from a battery or a power supply. The device can generate magnetic fields of up to 1.6 mT and output voltages of +/−40 V.  ...  Grand Opportunities (GO) NIAMS 1RC2AR058962-01 to MB, and an NIH P01 National Institutes of Aging grant AG039355-01A1 to LFB and MB.  ... 
doi:10.2174/1872208311307010007 pmid:23445453 pmcid:PMC3815741 fatcat:oaqh7fyg6jfapbiexkyhbrrckm

A programmable closed-loop recording and stimulating wireless system for behaving small laboratory animals

Gian Nicola Angotzi, Fabio Boi, Stefano Zordan, Andrea Bonfanti, Alessandro Vato
2014 Scientific Reports  
Regarding the possibility of directly stimulating the brain, deep brain stimulation (DBS) is a well-established procedure in the treatment of tremor associated with the Parkinson disease and multiple sclerosis  ...  although a new generation of bi-directional systems aimed at combining neural signal recording and real-time processing with electrical stimulation for closed-loop applications is emerging 10-13 .  ...  Acknowledgments We acknowledge the financial support of the SI-CODE project of the Future and Emerging Technologies (FET) programme within the Seventh Framework Programme for Research of the European Commission  ... 
doi:10.1038/srep05963 pmid:25096831 pmcid:PMC4123143 fatcat:bgliecdnr5fxpd4ztvalkdbj54

A chronic generalized bi-directional brain–machine interface

A G Rouse, S R Stanslaski, P Cong, R M Jensen, P Afshar, D Ullestad, R Gupta, G F Molnar, D W Moran, T J Denison
2011 Journal of Neural Engineering  
The custom integrated micropower sensor and interface circuits facilitate extended operation in a power-limited device.  ...  A bi-directional neural interface (NI) system was designed and built by incorporating a novel neural recording and processing subsystem into a commercially approved neural stimulator.  ...  Parts of this work were supported by NIH R01EB009103.  ... 
doi:10.1088/1741-2560/8/3/036018 pmid:21543839 pmcid:PMC3146241 fatcat:kof2dl7spra6jirv4mgi4yvx2i

A low-power, generic biostimulator with arbitrary pulse shape, based on a central control core

Milad Faizollah, Mousa Karimi, Amir M. Sodagar
2013 IEICE Electronics Express  
This paper reports on the design of a low-power biostimulator, capable of generating stimulus pulses with arbitrary wave shapes and programmable amplitude and timing.  ...  To wirelessly interface with the external setup, a BPSK demodulator and clock recovery circuit is used which exhibit 100% data-rate-to-carrier-frequency ratio and consumes as low as 120 μW at 2.5 Mbps.  ...  Various biomedical stimulation devices such as cochlear implants, visual prostheses, pacemakers, deep brain stimulators (DBS), and spinal cord stimulators are developed to improve the quality of daily  ... 
doi:10.1587/elex.10.20120868 fatcat:56wwoswlo5ccrguej6debtjwaq

A Fully Integrated RF-powered Energy-replenishing Current-controlled Stimulator

Sohmyung Ha, Chul Kim, Jiwoong Park, Gert Cauwenberghs, Patrick Mercier
2018 IEEE Transactions on Biomedical Circuits and Systems  
The adiabatic power rails and energy replenishment scheme enabled our stimulator to achieve an SEF of 6.0.  ...  The stimulator occupies 0.22 mm 2 in a 180 nm silicon-on-insulator process and produces differential currents up to 145 µA.  ...  Halgren, and B. McNaughton for critical input and stimulating discussions on clinical and fundamental neuroscience applications of high-density ECoG neural interfaces.  ... 
doi:10.1109/tbcas.2018.2881800 fatcat:j2ea3azvdrh2dldexw77llm7ju

ZigBee-based Wireless Neuro-Stimulator for Improving Stroke Recovery

Gookhwa Kim, Hyojeong Yun, Munho Ryu, Yongil Shin, Hyoungihl Kim, Yoonseok Yang
2010 Experimental Neurobiology  
The ZigBee is a stable platform for many low-power wireless applications.  ...  The system developed here can also be beneficial as a common platform for a wide range of brain diseases and clinical care for which electric stimulation is used.  ...  ACKNOWLEDGEMENTS This work was supported by the Grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/ Center for Healthcare Technology Development).  ... 
doi:10.5607/en.2010.19.3.165 pmid:22110356 pmcid:PMC3214784 fatcat:hcpkmsa6mrdbjhc7vv6upxkhpu

IC-Based Neuro-Stimulation Environment for Arbitrary Waveform Generation

Florian Kolbl, Yannick Bornat, Jonathan Castelli, Louis Regnacq, Gilles N'Kaoua, Sylvie Renaud, Noëlle Lewis
2021 Electronics  
The designed system comprises a High Voltage CMOS ASIC generating a configurable stimulating current, driven by a digital circuitry implemented on a FPGA.  ...  We propose in this paper a stimulator capable of delivering arbitrary waveforms to electrodes, and suitable for non-conventional stimulation strategies.  ...  With DBS, the stimulation targets are deep nuclei structures of the brain, although the underlying mechanisms have not been fully identified.  ... 
doi:10.3390/electronics10151867 fatcat:7kgqowr6xrbhtc5o222fotttvu

An Integrated 256-Channel Epiretinal Prosthesis

Kuanfu Chen, Zhi Yang, Linh Hoang, James Weiland, Mark Humayun, Wentai Liu
2010 IEEE Journal of Solid-State Circuits  
A mixed-mode and multiple-voltage design is applied to the stimulator for withstanding a high compliance voltage of ±10V at the output stage as well as for reducing the area of each pixel.  ...  and a 256-channel stimulator to generate user programmable bi-phasic current stimuli.  ...  A mixed-mode and multiplevoltage design makes it possible to achieve miniaturization and low power operation of the system.  ... 
doi:10.1109/jssc.2010.2055371 fatcat:fdbpce3dtnf3hengsuhmfiyimu

An Inductively Coupled Power and Data Link with Self-referenced ASK Demodulator and Wide-range LDO for Bio-implantable Devices

Byeonggyu Park, Tae-Gwon Yun, Kyongsu Lee, Jin-Ku Kang
2017 JSTS Journal of Semiconductor Technology and Science  
For the reliable data and power delivery, a self-referenced amplitudeshift keying (ASK) demodulator and a wide-range voltage regulator are suggested and implemented in the proposed stimulator system.  ...  The prototype fabricated in 0.35 um BCD process successfully transferred 1.2 Kbps data bi-directionally while supplying 4.5 mW power to internal MCU and stimulation block.  ...  INTRODUCTION Deep brain stimulators have been successfully demonstrated as a clinical tool for the treatment of chronic pain and movement disorders such as Parkinson's disease [1] [2] [3] .  ... 
doi:10.5573/jsts.2017.17.1.120 fatcat:uqqxalvmybfrpe7oqp77gubs64

A novel charge-metering method for voltage mode neural stimulation

Song Luan, Timothy G. Constandinou
2012 2012 IEEE International Symposium on Circuits and Systems  
This paper presents a novel, fully-integrated circuit for achieving change-balanced voltage-mode neural stimulation based on a charge-metering technique.  ...  This has been designed to deliver a maximum charge stimulus of 10.24 nC within 100 µs. Simulated results show a charge delivery error of 0.4-4% and a maximum residual charge of −73 pC.  ...  ) benefitting from deep brain stimulation therapy [2] .  ... 
doi:10.1109/iscas.2012.6271737 dblp:conf/iscas/LuanC12 fatcat:2jfgtv7zgrfyxcbb5w677plqzu
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