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A Programmable High-Voltage Compliance Neural Stimulator for Deep Brain Stimulation in Vivo
2015
Sensors
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Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. ...
The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. ...
Acknowledgments This study was supported in part by the Ministry of Science and Technology, Taiwan, under grant No. 103-2221-E-182-070,102-2218-E-182-003, 102-2221-E-010-011-MY3, and 101-2622-E-010-002 ...
doi:10.3390/s150612700
pmid:26029954
pmcid:PMC4507613
fatcat:duwcavmmjvczxokez4wmtsu3se
A CMOS-based neural implantable optrode for optogenetic stimulation and electrical recording
2015
2015 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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The neural interface has two clusters of stimulation and recording sites. ...
The system includes circuits for controlling the optical stimulations; recording local field potentials (LFPs); and onboard diagnostics. ...
The authors would like to acknowledge the CANDO project (www.cando.ac.uk), CSC scheme and GBCET scholarship. ...
doi:10.1109/biocas.2015.7348357
dblp:conf/biocas/ZhaoDRSD0C15
fatcat:y5izmxqltzcjtctmwd3hvgz5wi
MagNI: A Magnetoelectrically Powered and Controlled Wireless Neurostimulating Implant
2020
IEEE Transactions on Biomedical Circuits and Systems
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2021 pre-print arXiv:2107.02995v1 fatcat:dw5mi7guuvg2zfolgspdjxhh3u
Thanks to low tissue absorption, low misalignment sensitivity and high power transfer efficiency, the ME effect enables safe delivery of high power levels (a few milliwatts) at low resonant frequencies ...
The system delivers fully programmable bi-phasic current-controlled stimulation with patterns covering 0.05-to-1.5-mA amplitude, 64-to-512-s pulse width and 0-to-200-Hz repetition frequency for neurostimulation ...
We would also like to thank Soonyoung Kim for the culturing and handling of Hydra and useful discussions of Hydra biology. ...
doi:10.1109/tbcas.2020.3037862
pmid:33180732
pmcid:PMC8712272
fatcat:zjx4a6lwibc5fgdrgtyxukhrfq
A Fully Integrated Sensor-Brain-Machine Interface System for Restoring Somatosensation
2020
IEEE Sensors Journal
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2020 pre-print arXiv:2010.15081v1 fatcat:kl2gvhov2rgvhkcle53pm2jlva
The electrogoniometer integrates an ultra low-power digital signal processor (DSP) for real-time joint angle measurement. The neural interface enables bidirectional neural stimulation and recording. ...
Recent advances in direct neural control of paralyzed arms present new requirements for miniaturized, low-power sensor systems. ...
The stimulator has two modes: in the high-current mode, the output current range is 0-2048µA with a programmable step current of 32µA; in the low-current mode, the output current range is 0-255µA with ...
doi:10.1109/jsen.2020.3030899
fatcat:dvynmwcegjhsdhvru7lpdx5g2q
A Compact Large Voltage-Compliance High Output-Impedance Programmable Current Source for Implantable Microstimulators
2005
IEEE Transactions on Biomedical Engineering
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This approach improves stimulation efficiency, extends power supply lifetime, and saves chip area especially when the stimulation current level is high in the milliampere range. ...
The VCR current source achieves large voltage compliance, up to 97% of the supply voltage, while maintaining high output impedance in the 100 M range to keep the stimulus current constant within 1% of ...
Wise and Dr. W. J. Heetderks for their guidance. This work was done using the WIMS-NSF-ERC shared facilities. ...
doi:10.1109/tbme.2004.839797
pmid:15651568
fatcat:a5akugnsf5davhx5b3zhylul7m
A Dual Mode Pulsed Electro-Magnetic Cell Stimulator Produces Acceleration of Myogenic Differentiation
2013
Recent Patents on Biotechnology
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This paper presents the design and test of a dual-mode electric and magnetic biological stimulator (EM-Stim). ...
The device is fully programmable, portable and easy to use, and can run from a battery or a power supply. The device can generate magnetic fields of up to 1.6 mT and output voltages of +/−40 V. ...
Grand Opportunities (GO) NIAMS 1RC2AR058962-01 to MB, and an NIH P01 National Institutes of Aging grant AG039355-01A1 to LFB and MB. ...
doi:10.2174/1872208311307010007
pmid:23445453
pmcid:PMC3815741
fatcat:oaqh7fyg6jfapbiexkyhbrrckm
A programmable closed-loop recording and stimulating wireless system for behaving small laboratory animals
2014
Scientific Reports
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Regarding the possibility of directly stimulating the brain, deep brain stimulation (DBS) is a well-established procedure in the treatment of tremor associated with the Parkinson disease and multiple sclerosis ...
although a new generation of bi-directional systems aimed at combining neural signal recording and real-time processing with electrical stimulation for closed-loop applications is emerging 10-13 . ...
Acknowledgments We acknowledge the financial support of the SI-CODE project of the Future and Emerging Technologies (FET) programme within the Seventh Framework Programme for Research of the European Commission ...
doi:10.1038/srep05963
pmid:25096831
pmcid:PMC4123143
fatcat:bgliecdnr5fxpd4ztvalkdbj54
A chronic generalized bi-directional brain–machine interface
2011
Journal of Neural Engineering
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The custom integrated micropower sensor and interface circuits facilitate extended operation in a power-limited device. ...
A bi-directional neural interface (NI) system was designed and built by incorporating a novel neural recording and processing subsystem into a commercially approved neural stimulator. ...
Parts of this work were supported by NIH R01EB009103. ...
doi:10.1088/1741-2560/8/3/036018
pmid:21543839
pmcid:PMC3146241
fatcat:kof2dl7spra6jirv4mgi4yvx2i
A low-power, generic biostimulator with arbitrary pulse shape, based on a central control core
2013
IEICE Electronics Express
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This paper reports on the design of a low-power biostimulator, capable of generating stimulus pulses with arbitrary wave shapes and programmable amplitude and timing. ...
To wirelessly interface with the external setup, a BPSK demodulator and clock recovery circuit is used which exhibit 100% data-rate-to-carrier-frequency ratio and consumes as low as 120 μW at 2.5 Mbps. ...
Various biomedical stimulation devices such as cochlear implants, visual prostheses, pacemakers, deep brain stimulators (DBS), and spinal cord stimulators are developed to improve the quality of daily ...
doi:10.1587/elex.10.20120868
fatcat:56wwoswlo5ccrguej6debtjwaq
A Fully Integrated RF-powered Energy-replenishing Current-controlled Stimulator
2018
IEEE Transactions on Biomedical Circuits and Systems
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The adiabatic power rails and energy replenishment scheme enabled our stimulator to achieve an SEF of 6.0. ...
The stimulator occupies 0.22 mm 2 in a 180 nm silicon-on-insulator process and produces differential currents up to 145 µA. ...
Halgren, and B. McNaughton for critical input and stimulating discussions on clinical and fundamental neuroscience applications of high-density ECoG neural interfaces. ...
doi:10.1109/tbcas.2018.2881800
fatcat:j2ea3azvdrh2dldexw77llm7ju
ZigBee-based Wireless Neuro-Stimulator for Improving Stroke Recovery
2010
Experimental Neurobiology
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The ZigBee is a stable platform for many low-power wireless applications. ...
The system developed here can also be beneficial as a common platform for a wide range of brain diseases and clinical care for which electric stimulation is used. ...
ACKNOWLEDGEMENTS This work was supported by the Grant of the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/ Center for Healthcare Technology Development). ...
doi:10.5607/en.2010.19.3.165
pmid:22110356
pmcid:PMC3214784
fatcat:hcpkmsa6mrdbjhc7vv6upxkhpu
IC-Based Neuro-Stimulation Environment for Arbitrary Waveform Generation
2021
Electronics
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The designed system comprises a High Voltage CMOS ASIC generating a configurable stimulating current, driven by a digital circuitry implemented on a FPGA. ...
We propose in this paper a stimulator capable of delivering arbitrary waveforms to electrodes, and suitable for non-conventional stimulation strategies. ...
With DBS, the stimulation targets are deep nuclei structures of the brain, although the underlying mechanisms have not been fully identified. ...
doi:10.3390/electronics10151867
fatcat:7kgqowr6xrbhtc5o222fotttvu
An Integrated 256-Channel Epiretinal Prosthesis
2010
IEEE Journal of Solid-State Circuits
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A mixed-mode and multiple-voltage design is applied to the stimulator for withstanding a high compliance voltage of ±10V at the output stage as well as for reducing the area of each pixel. ...
and a 256-channel stimulator to generate user programmable bi-phasic current stimuli. ...
A mixed-mode and multiplevoltage design makes it possible to achieve miniaturization and low power operation of the system. ...
doi:10.1109/jssc.2010.2055371
fatcat:fdbpce3dtnf3hengsuhmfiyimu
An Inductively Coupled Power and Data Link with Self-referenced ASK Demodulator and Wide-range LDO for Bio-implantable Devices
2017
JSTS Journal of Semiconductor Technology and Science
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For the reliable data and power delivery, a self-referenced amplitudeshift keying (ASK) demodulator and a wide-range voltage regulator are suggested and implemented in the proposed stimulator system. ...
The prototype fabricated in 0.35 um BCD process successfully transferred 1.2 Kbps data bi-directionally while supplying 4.5 mW power to internal MCU and stimulation block. ...
INTRODUCTION Deep brain stimulators have been successfully demonstrated as a clinical tool for the treatment of chronic pain and movement disorders such as Parkinson's disease [1] [2] [3] . ...
doi:10.5573/jsts.2017.17.1.120
fatcat:uqqxalvmybfrpe7oqp77gubs64
A novel charge-metering method for voltage mode neural stimulation
2012
2012 IEEE International Symposium on Circuits and Systems
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This paper presents a novel, fully-integrated circuit for achieving change-balanced voltage-mode neural stimulation based on a charge-metering technique. ...
This has been designed to deliver a maximum charge stimulus of 10.24 nC within 100 µs. Simulated results show a charge delivery error of 0.4-4% and a maximum residual charge of −73 pC. ...
) benefitting from deep brain stimulation therapy [2] . ...
doi:10.1109/iscas.2012.6271737
dblp:conf/iscas/LuanC12
fatcat:2jfgtv7zgrfyxcbb5w677plqzu
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