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Neuroimaging in anxiety disorders

Kirsten Engel, Borwin Bandelow, Oliver Gruber, Dirk Wedekind
2008 Journal of neural transmission  
This may well fit into a theoretical framework of negative emotional processing as suggested by LeDoux (1996) stressing an unconscious, ''fast'' way of automatic amygdala mediated responses to potentially  ...  Domschke et al. (2006) reported correlations between distinct genetic polymorphisms of the serotonergic system and a lower activation of the right prefrontal cortex and increased activity of both amygdalae  ... 
doi:10.1007/s00702-008-0077-9 pmid:18568288 pmcid:PMC2694920 fatcat:bdgkdh6hkvftfmlouhghtr3f44

Understanding Emotions: Origins and Roles of the Amygdala

Goran Šimić, Mladenka Tkalčić, Vana Vukić, Damir Mulc, Ena Španić, Marina Šagud, Francisco E. Olucha-Bordonau, Mario Vukšić, Patrick R. Hof
2021 Biomolecules  
Feelings are conscious, emotional experiences of these activations that contribute to neuronal networks mediating thoughts, language, and behavior, thus enhancing the ability to predict, learn, and reappraise  ...  from activations of specialized neuronal populations in several parts of the cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and subcortical structures, such as the amygdala  ...  ) and the PFC (responsible for regulation of amygdala reactivity, so that hypofunction of the PFC will lead to amygdala hyperreactivity).  ... 
doi:10.3390/biom11060823 pmid:34072960 fatcat:aezpbf2jlnhgzhivxeqmyonwpu

Candidate biomarkers of suicide crisis syndrome: what to test next? A concept paper

Raffaella Calati, Charles B Nemeroff, Jorge Lopez-Castroman, Lisa J Cohen, Igor Galynker
2019 International Journal of Neuropsychopharmacology  
Affective disturbance is likely mediated by alterations in dopaminergic circuits involved in reward and anti-reward systems, as well as endogenous opioids.  ...  Nemeroff is stockholder for Xhale, Celgene, Seattle Genetics, Abbvie, OPKO Health Inc., Antares, BI Gen Holdings Inc., Corcept Therapeutics Pharmaceuticals Company, TC MSO Inc., Trends in Pharma Development  ...  The genetics of loneliness have been extensively reviewed (Goossens et al., 2015) .  ... 
doi:10.1093/ijnp/pyz063 pmid:31781761 pmcid:PMC7171927 fatcat:ligzwe2vxrgdvjypz647a33b7m

The developmental line of autonomy in the etiology, dynamics, and treatment of borderline personality disorders

RICHARD M. RYAN
2005 Development and Psychopathology  
model, that relative to controls, BPD patients had diminished capacities in controlled or effortful processing.  ...  For example, a compulsive action may be controlled but may not feel in any way truly volitional.  ... 
doi:10.1017/s0954579405050467 fatcat:e3oijenr7bbzxjmzekhi5vwpje

Individual variation in resisting temptation: Implications for addiction

Benjamin T. Saunders, Terry E. Robinson
2013 Neuroscience and Biobehavioral Reviews  
For example, when one is hungry, the incentive value of rewards and their cues is potentiated, when sated, their value is relatively diminished.  ...  While details of the relationships between these traits are currently unknown, they all share the common characteristic of being associated with hyperreactivity to environmental cues.  ... 
doi:10.1016/j.neubiorev.2013.02.008 pmid:23438893 pmcid:PMC3732519 fatcat:6qzh5kdwlzgb7kq6mog3avm3k4

The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

Craig W Berridge, Barry D Waterhouse
2003 Brain Research Reviews  
Further, in vitro, locally applied amygdala.  ...  Second messenger mediators of NE-induced 323,326,378].  ... 
doi:10.1016/s0165-0173(03)00143-7 pmid:12668290 fatcat:fxy2a7veqfapvbxyui5dqzf5cu

Abstracts from the XXIII CINP Congress, Montréal, June 23–27, 2002

2002 International Journal of Neuropsychopharmacology  
G-protein coupled receptors constitute the single largest family of cell surface receptors and mediate physiological responses to a wide variety of stimuli including hormones and neurotransmitters.  ...  amygdala, cingulate, and serotonergic neurocircuitry play a role in mediating SAD.  ...  Finally, the nucleus accumbens core and the central amygdala, together with the mesolmibic dopamine innervation of the nucleus accumbens which is regulated by the central amygdala, mediate conditioned  ... 
doi:10.1017/s1461145702003176 fatcat:25u2fa2qmve7zpljmks4tqinge

2014 Rob Clarke Awards

2014 Physiology News  
The stimulation reproducibly resulted in unresponsiveness, amnesia and arrest of volition behaviour.  ...  Ca influx (pmol cm -2 sec -1 ) 'It became quickly apparent that reduction of Na + in the external solution greatly diminished 45 Ca efflux from the auricles.  ...  He described the fundamental properties of neurons in particular nuclei, and their synaptic inputs (dorsal raphe, nucleus accumbens, anterior cingulate cortex, central amygdala and hippocampus, with Tanaka  ... 
doi:10.36866/pn.96.7a fatcat:vx32prefqrfarmjlfm7wpruptu

Reinvigorating Actus Reus: The Case for Involuntary Actions by Veterans with Post-Traumatic Stress Disorder

Melissa Hamilton
2011
and hippocampus, PTSD patients also bear impaired functioning of the frontal cortex, which would otherwise mediate the extinction of hyperreactivity to stimuli that are actually not threatening. 212  ...  Coleman, Genetics and Responsibility: To Know the Candeub, supra note 16, at 119. 5 State v. Simpson, 53 P.3d 165, 169 (Alaska Ct.  ... 
doi:10.15779/z38zs6w fatcat:h4y5t6hpvrgnfafsrjlt2zhzri

Poster Sessions

2011 Epilepsia  
Alternatively the genetic model of ADNFLE is not representative of the whole NFLE population.  ...  Genetic and environmental mechanisms other than the known mutations may be implicated in the pathogenesis of NFLE in most cases making NFLE a multifactorial polygenic disease.  ...  This process is possibly mediated by hyperreactivity of the hypothalamic-pituitary-adrenal (HPA) axis with increased corticosterone release.  ... 
doi:10.1111/j.1528-1167.2011.03207.x fatcat:77ayxa5tcbannis7zksyeo57ju

E-Poster Presentations

2020 European psychiatry  
Also, BL patients showed amygdala deactivation in response to painful stimulation, as well as altered connectivity between left amygdala and dorsal anterior cingulate cortex.  ...  It is associated to a variety of psychophysiological alterations and a general hyperreactivity to negative emotion.  ...  Results: Despite possible pathophysiological factors which may explain the complexity of suicide in MDD, scientific evidence supposed the synergic role of genetics, exogenous and endogenous stressors (  ... 
doi:10.1192/j.eurpsy.2020.5 fatcat:vslfruegm5f2jc5dl6hu6gqnom

OFQ [chapter]

Encyclopedia of Pain  
Breakthrough pain may be spontaneous, occurring without an identifiable precipitating event, and precipitant factors, volitional and non-volitional, have been identified in more than 50% of patients.  ...  These effects can diminish the neuronal firing of peripheral sensory neurons .  ... 
doi:10.1007/978-3-540-29805-2_2903 fatcat:irnv26a3hfbhpdybfjvpdne2pm

Veterinary Psychopharmacology

Sharon Crowell-Davis, Thomas Murray
2006 unpublished
The patient had also been socially isolated by its own volition from other cats in the household.  ...  ., then the question of genetic influence is not an issue.  ... 
fatcat:bwxujeromjgmjonxwaxz2ausem

Consciousness, healing, and women's literacy practices: a feminist critique

Krista L. Nickerson
2013
Despite the gender-neutrality of the perpetrating event, however, structural inequalities that mediate norms of thinking, feeling, and behaving (as I explored in Chapter 6) also mediate social responses  ...  The amygdala (part of the limbic area), especially, can trigger an array of involuntary physiological changes in the body that prepare humans and other animals to face a perceived threat (Brand, 2000)  ... 
doi:10.13016/m24d82 fatcat:ei7fjxprgjf5jcbzurvv5rx54y

Profiling Emotion Regulation: Exploring patterns of regulation in classroom behaviour

Lysandra Sinclaire-Harding, Apollo-University Of Cambridge Repository, Apollo-University Of Cambridge Repository, David Whitebread
2018
In much the same way as genetic studies have begun to do (e.g.  ...  Selecting a different task or choosing to work with a partner at one's own volition or without the permission of the class teacher would usually have negative consequences for the student in school.  ... 
doi:10.17863/cam.18628 fatcat:lrqzb2souzfdzee6wbj4wtbvju