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Visualizing diffusion tensor images of the mouse spinal cord

D.H. Laidlaw, E.T. Ahrens, D. Kremers, M.J. Avalos, R.E. Jacobs, C. Readhead
Proceedings Visualization '98 (Cat. No.98CB36276)  
We demonstrate the methods on images of the mouse spinal cord.  ...  The visualizations show significant differences between spinal cords from mice suffering from Experimental Allergic Encephalomyelitis (EAE) and spinal cords from wild-type mice.  ...  Additional support was provided by NSF (ASC-89-20219) as part of the NSF STC for Computer Graphics and Scientific Visualization, by the DOE (DE-FG03-92ER25134) as part of the Center for Research in Computational  ... 
doi:10.1109/visual.1998.745294 dblp:conf/visualization/LaidlawAKAJR98 fatcat:nek7kdpbh5cl3idbpqkbupgao4

Structural insights into the rodent CNS via diffusion tensor imaging

Jiangyang Zhang, Manisha Aggarwal, Susumu Mori
2012 Trends in Neurosciences  
Diffusion tensor imaging (DTI) is a useful tool for studying anatomy and pathology in the rodent central nervous system (CNS).The unique tissue contrasts provided by DTI are well suited for monitoring  ...  Significant progress has also been made in combining DTI results with data acquired using other imaging modalities to enhance our understanding of the rodent CNS.  ...  Acknowledgments The authors are supported by National Institutes of Health grants R21NS059529 (J.Z.), R21NS065306 (J.Z.), R01NS070909 (J.Z.), R01AG20012 (S.M.), and R01EB003543 (S.M.).  ... 
doi:10.1016/j.tins.2012.04.010 pmid:22651954 pmcid:PMC3591520 fatcat:gl7yufkx2bcshc33tbtq67eh24

Diffusion tensor imaging of white matter pathology in the mouse brain

Jiangyang Zhang
2010 Imaging in Medicine  
studies that involve diffusion tensor imaging of rodent brain and spinal cord. keywords: brain n diffusion tensor imaging n mouse n MrI n pathology n spinal cord n white matter  ...  Diffusion tensor imaging of white matter pathology in the mouse brain review Diffusion tensor imaging has been increasingly used for studying white matter pathology in rodent models of neurological diseases  ...  l || : Parallel diffusivity; l^: Perpendicular diffusivity; FA: Fractional anisotropy. Table 2 . 2 selected diffusion tensor imaging studies of mouse and rat brain or spinal cord.  ... 
doi:10.2217/iim.10.60 pmid:21643525 pmcid:PMC3105628 fatcat:7z4rrj4xyfdttb352feaszfrvy

Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice

Xiaojie Wang, Matthew F. Cusick, Yong Wang, Peng Sun, Jane E. Libbey, Kathryn Trinkaus, Robert S. Fujinami, Sheng-Kwei Song
2014 NMR in Biomedicine  
Diffusion tensor imaging-derived directional diffusivity and anisotropy indices have been applied to characterize white matter disorders.  ...  Recently, a novel diffusion basis spectrum imaging has been developed to quantitatively assess axonal injury, demyelination, and inflammation in a mouse model of inflammatory demyelination.  ...  A sagittal image of the mouse vertebral column was acquired using a gradient echo sequence to visualize vertebral discs, as references to plan the target axial images.  ... 
doi:10.1002/nbm.3129 pmid:24816651 pmcid:PMC4071074 fatcat:5tslqbdv3bdc5ki3skybjypmr4

Assessing neuraxial microstructural changes in a transgenic mouse model of early stage Amyotrophic Lateral Sclerosis by ultra‐high field MRI and diffusion tensor metrics

Rodolfo G. Gatto, Carina Weissmann, Manish Amin, Ariel Finkielsztein, Ronen Sumagin, Thomas H. Mareci, Osvaldo D. Uchitel, Richard L. Magin
2020 Animal Models and Experimental Medicine  
In this work, we propose the use of diffusion tensor imaging (DTI) metrics to assess specific ultrastructural changes in the central nervous system during the early neurodegenerative stages of ALS.  ...  Changes in diffusion tensor shape were observed in this animal model at the early, nonsymptomatic stages of ALS.  ...  planes of diffusion tensors are associated to tissue complexity in the spinal cord of the ALS mouse.  ... 
doi:10.1002/ame2.12112 pmid:32613171 pmcid:PMC7323706 fatcat:litjdxhi2jbqrp3w2rj4dr3iwq

Diffusion tensor imaging of mouse brain stem and cervical spinal cord

Joong Hee Kim, Justin Haldar, Zhi-Pei Liang, Sheng-Kwei Song
2009 Journal of Neuroscience Methods  
In vivo diffusion tensor imaging measurements of the mouse brain stem and cervical spinal cord are presented.  ...  The cervical spinal cord white matter showed similar tissue characteristics as seen in the thoracic cord.  ...  Acknowledgements This study was supported in part by National Institute of Health NS047592, and the University of Missouri Spinal Cord Injuries Research Program.  ... 
doi:10.1016/j.jneumeth.2008.09.005 pmid:18834905 pmcid:PMC2637387 fatcat:ip4ou3cnpzcxtiq25ajqab4yru

In vivo diffusion tensor imaging of thoracic and cervical rat spinal cord at 7 T

Kishore V. Mogatadakala, Ponnada A. Narayana
2009 Magnetic Resonance Imaging  
In vivo diffusion tensor imaging (DTI) of rat cervical and thoracic spinal cord was performed using a three element phased array coil at 7T.  ...  The DWI images were tensor encoded and diffusion tensor metrics, fractional anisotropy (FA), mean diffusivity (MD), and longitudinal diffusivity (λ P ) and transverse diffusivity (λ ⊥ ), were determined  ...  Because of the curvature of the spinal cord, the manufacturer supplied shimming routines do not work well for spinal cord imaging.  ... 
doi:10.1016/j.mri.2009.05.002 pmid:19520537 pmcid:PMC2763029 fatcat:v7xciniifrhclikofk5uoqiv4y

Diffusion Tensor Imaging of the Spinal Cord

Aditya Vedantam, Michael B. Jirjis, Brian D. Schmit, Marjorie C. Wang, John L. Ulmer, Shekar N. Kurpad
2014 Neurosurgery  
Diffusion tensor imaging (DTI) provides a measure of the directional diffusion of water molecules in tissues.  ...  Interestingly, changes in DTI indices are visualized in regions of the cord, which appear normal on conventional MRI and are remote from the site of cord compression.  ...  protocols have allowed for useable diffusion images of the spinal cord.  ... 
doi:10.1227/neu.0000000000000171 pmid:24064483 pmcid:PMC4986512 fatcat:kgwatz26fbd2ri3wyyybyuw2e4

Towards a microMRI atlas of mouse development

R.E. Jacobs, E.T. Ahrens, M.E. Dickinson, D. Laidlaw
1999 Computerized Medical Imaging and Graphics  
Diffusion weighted imaging, diffusion tensor imaging, and multi-valued data sets are presented as examples of uniquely MR methods of obtaining anatomical information.  ...  This study investigates the potential of microscopic Magnetic Resonance Imaging to obtain information for 3D digital atlases of mouse development using fixed samples.  ...  Acknowledgements This work was supported by the Beckman Institute at Caltech, by the Human Brain Project with contributions from the National Institute on Drug Abuse, the National Institute of Mental Health  ... 
doi:10.1016/s0895-6111(98)00059-7 pmid:10091864 fatcat:dz7nohpsdnedxaflo6piiufx7e

In Vivo Tracing of Neural Tracts in the Intact and Injured Spinal Cord of Marmosets by Diffusion Tensor Tractography

K. Fujiyoshi, M. Yamada, M. Nakamura, J. Yamane, H. Katoh, K. Kitamura, K. Kawai, S. Okada, S. Momoshima, Y. Toyama, H. Okano
2007 Journal of Neuroscience  
Previous advances in magnetic resonance imaging technology have led to the development of diffusion tensor tractography (DTT) as a potential modality to perform in vivo tracing of axonal fibers.  ...  in the injured spinal cord.  ...  Results DTT of intact and injured spinal cords in postmortem common marmosets Based on the data from in vivo highresolution diffusion tensor MR images of postmortem common marmoset spinal cords ( Fig  ... 
doi:10.1523/jneurosci.3354-07.2007 pmid:17978040 pmcid:PMC6673369 fatcat:dxs5uyockjhvdnzdxi6l52d3yy

Diffusion Tensor Imaging Predicts Hyperacute Spinal Cord Injury Severity

David N. Loy, Joong Hee Kim, Mingqiang Xie, Robert E. Schmidt, Kathryn Trinkaus, Sheng-Kwei Song
2007 Journal of Neurotrauma  
Diffusion tensor imaging predicts hyperacute spinal cord injury severity." Journal of Neurotrauma.24,6. 979-990. (2007).  ...  We recently demonstrated that in vivo derived diffusion tensor imaging (DTI) parameters are sensitive and specific biomarkers for spinal cord white matter damage.  ...  ACKNOWLEDGMENTS This study was supported in part by the National Multiple Sclerosis Society (CA 1012), NIH R01-NS047592, R01-AG10299, R01-DK19645, JDRF 1-2005-1085, University of Missouri Spinal Cord Injuries  ... 
doi:10.1089/neu.2006.0253 pmid:17600514 fatcat:sfnsuego3vanxlgxr2b3gd5qlm

Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration

Gary J. Cowin, Tim J. Butler, Nyoman D. Kurniawan, Charles Watson, Robyn H. Wallace
2011 NeuroImage  
These results demonstrate the usefulness of MRM in visualising the ultrastructure of the mouse spinal cord.  ...  Current imaging studies have concentrated on areas of the brain and spinal cord that contain mixed populations of sensory and motor neurons.  ...  Acknowledgements Funding provided by the Ross Maclean Fellowship, Peter Goodenough Bequest and the Queensland Nuclear Magnetic Resonance Network. Jane Ellis for assistance with histology. References  ... 
doi:10.1016/j.neuroimage.2011.06.003 pmid:21689764 fatcat:75a3z6lklrhw3pfsoovrouf7du

The role of diffusion tensor imaging in the diagnosis, prognosis, and assessment of recovery and treatment of spinal cord injury: a systematic review

Orel A. Zaninovich, Mauricio J. Avila, Matthew Kay, Jennifer L. Becker, R. John Hurlbert, Nikolay L. Martirosyan
2019 Neurosurgical Focus  
OBJECTIVEDiffusion tensor imaging (DTI) is an MRI tool that provides an objective, noninvasive, in vivo assessment of spinal cord injury (SCI).  ...  In this imaging modality, the direction and amplitude of the diffusion of water molecules inside tissues is measured, and this diffusion can be measured using a variety of parameters.  ...  Acknowledgments Except for Fig. 5 , all figures are research images that we obtained using Siemens Healthineers MR and/or CT scanners, and Figs. 6 and 7 were also processed using Siemens Healthineers  ... 
doi:10.3171/2019.1.focus18591 pmid:30835681 fatcat:rnavztuulfhtng5aketj5ydisi

Diffusion Tensor Imaging ofEx VivoCervical Spinal Cord Specimens: The Immediate and Long-Term Effects of Fixation on Diffusivity

T.H. Kim, L. Zollinger, X.F. Shi, J. Rose, E.-K. Jeong
2009 The Anatomical Record  
Four human cervical cords and three segments of pig vivo cervical spinal cord specimens were imaged both before and after tissue fixation using 3D multi-shot diffusion weighted imaging (ms-DWEPI).  ...  Several efforts have been made to study the effect of fixation on both human and mouse tissue, with varying results.  ...  Saam in Physics at University of Utah for his technical support on the temperature controlling system.  ... 
doi:10.1002/ar.20823 pmid:19051255 pmcid:PMC2860544 fatcat:7mhjvafasbehdlpio6trd74yh4

Diffusion Tensor Imaging at 3 Hours after Traumatic Spinal Cord Injury Predicts Long-Term Locomotor Recovery

Joong H. Kim, David N. Loy, Qing Wang, Matthew D. Budde, Robert E. Schmidt, Kathryn Trinkaus, Sheng-Kwei Song
2010 Journal of Neurotrauma  
Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recovery.  ...  These studies demonstrate for the first time that axial diffusivity (ljj), derived from diffusion tensor imaging (DTI) within 3 h after SCI, accurately predicts long-term locomotor behavioral recovery  ...  Acknowledgments This study was supported in part by National Institute of Health (grant NS047592), and the University of Missouri Spinal Cord Injuries Research Program.  ... 
doi:10.1089/neu.2009.1063 pmid:20001686 pmcid:PMC2867549 fatcat:qlkoyfm6szhmtingp2k4zmznbq
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