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Visualizing diffusion tensor images of the mouse spinal cord
Proceedings Visualization '98 (Cat. No.98CB36276)
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We demonstrate the methods on images of the mouse spinal cord. ...
The visualizations show significant differences between spinal cords from mice suffering from Experimental Allergic Encephalomyelitis (EAE) and spinal cords from wild-type mice. ...
Additional support was provided by NSF (ASC-89-20219) as part of the NSF STC for Computer Graphics and Scientific Visualization, by the DOE (DE-FG03-92ER25134) as part of the Center for Research in Computational ...
doi:10.1109/visual.1998.745294
dblp:conf/visualization/LaidlawAKAJR98
fatcat:nek7kdpbh5cl3idbpqkbupgao4
Structural insights into the rodent CNS via diffusion tensor imaging
2012
Trends in Neurosciences
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Diffusion tensor imaging (DTI) is a useful tool for studying anatomy and pathology in the rodent central nervous system (CNS).The unique tissue contrasts provided by DTI are well suited for monitoring ...
Significant progress has also been made in combining DTI results with data acquired using other imaging modalities to enhance our understanding of the rodent CNS. ...
Acknowledgments The authors are supported by National Institutes of Health grants R21NS059529 (J.Z.), R21NS065306 (J.Z.), R01NS070909 (J.Z.), R01AG20012 (S.M.), and R01EB003543 (S.M.). ...
doi:10.1016/j.tins.2012.04.010
pmid:22651954
pmcid:PMC3591520
fatcat:gl7yufkx2bcshc33tbtq67eh24
Diffusion tensor imaging of white matter pathology in the mouse brain
2010
Imaging in Medicine
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studies that involve diffusion tensor imaging of rodent brain and spinal cord. keywords: brain n diffusion tensor imaging n mouse n MrI n pathology n spinal cord n white matter ...
Diffusion tensor imaging of white matter pathology in the mouse brain review Diffusion tensor imaging has been increasingly used for studying white matter pathology in rodent models of neurological diseases ...
l || : Parallel diffusivity; l^: Perpendicular diffusivity; FA: Fractional anisotropy.
Table 2 . 2 selected diffusion tensor imaging studies of mouse and rat brain or spinal cord. ...
doi:10.2217/iim.10.60
pmid:21643525
pmcid:PMC3105628
fatcat:7z4rrj4xyfdttb352feaszfrvy
Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice
2014
NMR in Biomedicine
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Diffusion tensor imaging-derived directional diffusivity and anisotropy indices have been applied to characterize white matter disorders. ...
Recently, a novel diffusion basis spectrum imaging has been developed to quantitatively assess axonal injury, demyelination, and inflammation in a mouse model of inflammatory demyelination. ...
A sagittal image of the mouse vertebral column was acquired using a gradient echo sequence to visualize vertebral discs, as references to plan the target axial images. ...
doi:10.1002/nbm.3129
pmid:24816651
pmcid:PMC4071074
fatcat:5tslqbdv3bdc5ki3skybjypmr4
Assessing neuraxial microstructural changes in a transgenic mouse model of early stage Amyotrophic Lateral Sclerosis by ultra‐high field MRI and diffusion tensor metrics
2020
Animal Models and Experimental Medicine
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In this work, we propose the use of diffusion tensor imaging (DTI) metrics to assess specific ultrastructural changes in the central nervous system during the early neurodegenerative stages of ALS. ...
Changes in diffusion tensor shape were observed in this animal model at the early, nonsymptomatic stages of ALS. ...
planes of diffusion tensors are associated to tissue complexity in the spinal cord of the ALS mouse. ...
doi:10.1002/ame2.12112
pmid:32613171
pmcid:PMC7323706
fatcat:litjdxhi2jbqrp3w2rj4dr3iwq
Diffusion tensor imaging of mouse brain stem and cervical spinal cord
2009
Journal of Neuroscience Methods
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In vivo diffusion tensor imaging measurements of the mouse brain stem and cervical spinal cord are presented. ...
The cervical spinal cord white matter showed similar tissue characteristics as seen in the thoracic cord. ...
Acknowledgements This study was supported in part by National Institute of Health NS047592, and the University of Missouri Spinal Cord Injuries Research Program. ...
doi:10.1016/j.jneumeth.2008.09.005
pmid:18834905
pmcid:PMC2637387
fatcat:ip4ou3cnpzcxtiq25ajqab4yru
In vivo diffusion tensor imaging of thoracic and cervical rat spinal cord at 7 T
2009
Magnetic Resonance Imaging
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In vivo diffusion tensor imaging (DTI) of rat cervical and thoracic spinal cord was performed using a three element phased array coil at 7T. ...
The DWI images were tensor encoded and diffusion tensor metrics, fractional anisotropy (FA), mean diffusivity (MD), and longitudinal diffusivity (λ P ) and transverse diffusivity (λ ⊥ ), were determined ...
Because of the curvature of the spinal cord, the manufacturer supplied shimming routines do not work well for spinal cord imaging. ...
doi:10.1016/j.mri.2009.05.002
pmid:19520537
pmcid:PMC2763029
fatcat:v7xciniifrhclikofk5uoqiv4y
Diffusion Tensor Imaging of the Spinal Cord
2014
Neurosurgery
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Diffusion tensor imaging (DTI) provides a measure of the directional diffusion of water molecules in tissues. ...
Interestingly, changes in DTI indices are visualized in regions of the cord, which appear normal on conventional MRI and are remote from the site of cord compression. ...
protocols have allowed for useable diffusion images of the spinal cord. ...
doi:10.1227/neu.0000000000000171
pmid:24064483
pmcid:PMC4986512
fatcat:kgwatz26fbd2ri3wyyybyuw2e4
Towards a microMRI atlas of mouse development
1999
Computerized Medical Imaging and Graphics
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Diffusion weighted imaging, diffusion tensor imaging, and multi-valued data sets are presented as examples of uniquely MR methods of obtaining anatomical information. ...
This study investigates the potential of microscopic Magnetic Resonance Imaging to obtain information for 3D digital atlases of mouse development using fixed samples. ...
Acknowledgements This work was supported by the Beckman Institute at Caltech, by the Human Brain Project with contributions from the National Institute on Drug Abuse, the National Institute of Mental Health ...
doi:10.1016/s0895-6111(98)00059-7
pmid:10091864
fatcat:dz7nohpsdnedxaflo6piiufx7e
In Vivo Tracing of Neural Tracts in the Intact and Injured Spinal Cord of Marmosets by Diffusion Tensor Tractography
2007
Journal of Neuroscience
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Previous advances in magnetic resonance imaging technology have led to the development of diffusion tensor tractography (DTT) as a potential modality to perform in vivo tracing of axonal fibers. ...
in the injured spinal cord. ...
Results
DTT of intact and injured spinal cords in postmortem common marmosets Based on the data from in vivo highresolution diffusion tensor MR images of postmortem common marmoset spinal cords ( Fig ...
doi:10.1523/jneurosci.3354-07.2007
pmid:17978040
pmcid:PMC6673369
fatcat:dxs5uyockjhvdnzdxi6l52d3yy
Diffusion Tensor Imaging Predicts Hyperacute Spinal Cord Injury Severity
2007
Journal of Neurotrauma
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Diffusion tensor imaging predicts hyperacute spinal cord injury severity." Journal of Neurotrauma.24,6. 979-990. (2007). ...
We recently demonstrated that in vivo derived diffusion tensor imaging (DTI) parameters are sensitive and specific biomarkers for spinal cord white matter damage. ...
ACKNOWLEDGMENTS This study was supported in part by the National Multiple Sclerosis Society (CA 1012), NIH R01-NS047592, R01-AG10299, R01-DK19645, JDRF 1-2005-1085, University of Missouri Spinal Cord Injuries ...
doi:10.1089/neu.2006.0253
pmid:17600514
fatcat:sfnsuego3vanxlgxr2b3gd5qlm
Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration
2011
NeuroImage
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These results demonstrate the usefulness of MRM in visualising the ultrastructure of the mouse spinal cord. ...
Current imaging studies have concentrated on areas of the brain and spinal cord that contain mixed populations of sensory and motor neurons. ...
Acknowledgements Funding provided by the Ross Maclean Fellowship, Peter Goodenough Bequest and the Queensland Nuclear Magnetic Resonance Network. Jane Ellis for assistance with histology.
References ...
doi:10.1016/j.neuroimage.2011.06.003
pmid:21689764
fatcat:75a3z6lklrhw3pfsoovrouf7du
The role of diffusion tensor imaging in the diagnosis, prognosis, and assessment of recovery and treatment of spinal cord injury: a systematic review
2019
Neurosurgical Focus
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OBJECTIVEDiffusion tensor imaging (DTI) is an MRI tool that provides an objective, noninvasive, in vivo assessment of spinal cord injury (SCI). ...
In this imaging modality, the direction and amplitude of the diffusion of water molecules inside tissues is measured, and this diffusion can be measured using a variety of parameters. ...
Acknowledgments Except for Fig. 5 , all figures are research images that we obtained using Siemens Healthineers MR and/or CT scanners, and Figs. 6 and 7 were also processed using Siemens Healthineers ...
doi:10.3171/2019.1.focus18591
pmid:30835681
fatcat:rnavztuulfhtng5aketj5ydisi
Diffusion Tensor Imaging ofEx VivoCervical Spinal Cord Specimens: The Immediate and Long-Term Effects of Fixation on Diffusivity
2009
The Anatomical Record
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Four human cervical cords and three segments of pig vivo cervical spinal cord specimens were imaged both before and after tissue fixation using 3D multi-shot diffusion weighted imaging (ms-DWEPI). ...
Several efforts have been made to study the effect of fixation on both human and mouse tissue, with varying results. ...
Saam in Physics at University of Utah for his technical support on the temperature controlling system. ...
doi:10.1002/ar.20823
pmid:19051255
pmcid:PMC2860544
fatcat:7mhjvafasbehdlpio6trd74yh4
Diffusion Tensor Imaging at 3 Hours after Traumatic Spinal Cord Injury Predicts Long-Term Locomotor Recovery
2010
Journal of Neurotrauma
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Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recovery. ...
These studies demonstrate for the first time that axial diffusivity (ljj), derived from diffusion tensor imaging (DTI) within 3 h after SCI, accurately predicts long-term locomotor behavioral recovery ...
Acknowledgments This study was supported in part by National Institute of Health (grant NS047592), and the University of Missouri Spinal Cord Injuries Research Program. ...
doi:10.1089/neu.2009.1063
pmid:20001686
pmcid:PMC2867549
fatcat:qlkoyfm6szhmtingp2k4zmznbq
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