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Visual support for incremental abstraction and refinement in Ada 95

T. Dean Hendrix, James H. Cross, Larry A. Barowski, Karl S. Mathias
1998 ACM SIGAda Ada Letters  
GRASP is a software engineering tool which uniquely combines a source code diagramming technique, the control structure diagram (CSD), with other comprehension aids such as complexity visualization, syntax  ...  The synergistic combination of these features in GRASP has the potential to be a powerful aid in any activity where source code is expected to be read.  ...  VISUALIZING CONTROL STRUCTURE The CSD is the principal visualization in the GRASP environment. GRASP provides automatic generation of CSDs from Ada 95, C, C++, Java, and VHDL source code.  ... 
doi:10.1145/301687.289568 fatcat:zbmnbhyo25fprer2ctq7j7zmfe

Visual support for incremental abstraction and refinement in Ada 95

T. Dean Hendrix, James H. Cross, Larry A. Barowski, Karl S. Mathias
1998 Proceedings of the 1998 annual ACM SIGAda international conference on Ada - SIGAda '98  
GRASP is a software engineering tool which uniquely combines a source code diagramming technique, the control structure diagram (CSD), with other comprehension aids such as complexity visualization, syntax  ...  The synergistic combination of these features in GRASP has the potential to be a powerful aid in any activity where source code is expected to be read.  ...  VISUALIZING CONTROL STRUCTURE The CSD is the principal visualization in the GRASP environment. GRASP provides automatic generation of CSDs from Ada 95, C, C++, Java, and VHDL source code.  ... 
doi:10.1145/289524.289568 dblp:conf/sigada/HendrixCBM98 fatcat:wlp3d7bhuzd7tbnceijuef6lx4

Do visualizations improve program comprehensibility? experiments with control structure diagrams for Java

T. Dean Hendrix, James H. Cross, Saeed Maghsoodloo, Matthew L. McKinney
2000 ACM SIGCSE Bulletin  
Recently, the first in a series of planned comprehension experiments was performed to measure the effect of the control structure diagram (CSD) on program comprehensibility.  ...  Upper-division computer science students were asked to respond to questions regarding the structure and execution of a source code module written in Java.  ...  complex control structures to span hundreds of lines.  ... 
doi:10.1145/331795.331890 fatcat:zfak7v4bjnfojcee435wnilyli

Do visualizations improve program comprehensibility? experiments with control structure diagrams for Java

T. Dean Hendrix, James H. Cross, Saeed Maghsoodloo, Matthew L. McKinney
2000 Proceedings of the thirty-first SIGCSE technical symposium on Computer science education - SIGCSE '00  
Recently, the first in a series of planned comprehension experiments was performed to measure the effect of the control structure diagram (CSD) on program comprehensibility.  ...  Upper-division computer science students were asked to respond to questions regarding the structure and execution of a source code module written in Java.  ...  complex control structures to span hundreds of lines.  ... 
doi:10.1145/330908.331890 dblp:conf/sigcse/HendrixCMM00 fatcat:rkzk7ul32fbsveep2z3cpmz7p4

Software visualizations for improving and measuring the comprehensibility of source code

David A. Umphress, T. Dean Hendrix, James H. Cross II, Saeed Maghsoodloo
2006 Science of Computer Programming  
The Control Structure Diagram (CSD) was examined for its influence on aiding the comprehension of software source code, and the Complexity Profile Graph (CPG) was examined for its ability to measure source  ...  The CPG was found to cue the software developer to complex portions of the code that might require special attention; the CSD was found to aid in understanding specific details of the code.  ...  The authors would like to acknowledge and thank Jeong Yang for her work in CPG experiments.  ... 
doi:10.1016/j.scico.2005.10.001 fatcat:6lbc7vy64bae3jqdhll7tb5mym

Reliability prediction for the vehicles equipped with advanced driver assistance systems (ADAS) and passive safety systems (PSS)

Khashayar Hojjati-Emami, Balbir S. Dhillon, Kouroush Jenab
2012 International Journal of Industrial Engineering Computations  
Further, the ADAS warning and ADAS crash avoidance components in 'Model 1'can be decomposed to sub-systems in a series structure.  ...  Warning, ADAS Crash Avoidance and Passive Systems would be broken down to components in a parallel structure.  ... 
doi:10.5267/j.ijiec.2012.08.004 fatcat:ndbcaulbcjhmxffxuyahrceye4

The impact of software engineering research on modern progamming languages

Barbara G. Ryder, Mary Lou Soffa, Margaret Burnett
2005 ACM Transactions on Software Engineering and Methodology  
This report documents this relationship by focusing on several major features of current programming languages: data and procedural abstraction, types, concurrency, exceptions, and visual programming mechanisms  ...  and ideas as demonstrated by workshop topics, special issue publications, and invited talks in the two fields.  ...  Gabriel, Bill Harrison, Andy Koenig, Barbara Liskov, Mike Mahoney, Mary Shaw, and Charles Weisert, their suggestions and comments.  ... 
doi:10.1145/1101815.1101818 fatcat:es7r5vkwbngjflyk37ekwzbdwi

Efficacy and safety of adalimumab in the treatment of non-infectious uveitis: a meta-analysis and systematic review

Shuai Ming, Kunpeng Xie, Huijuan He, Ya Li, Bo Lei
2018 Drug Design, Development and Therapy  
The pooled proportions of inflammation control were 74% (95% CI 64%-82%) and 79% (95% CI 69%-87%) in groups of 6and 12-months follow-up durations.  ...  We investigated control of inflammation, improvement of visual acuity (VA), corticosteroid-sparing effect, and adverse events (AEs) or serious adverse events.  ...  Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/dddt.s160431 pmid:30013320 pmcid:PMC6037408 fatcat:aveulvkohjho7gpnk62glkcyci

Characterization of the Proteins Involved in the DNA Repair Mechanism in M. smegmatis

Angela Di Somma, Carolina Canè, Antonio Moretta, Arianna Cirillo, Franz Cemič, Angela Duilio
2020 International Journal of Molecular Sciences  
Our results suggested the formation of a functional complex between Ogt and Ada-AlkA, which was confirmed both in silico by docking calculations and by gel filtration chromatography.  ...  We propose that this stable association allows the complex to fulfill the biological roles exerted by Ada in the homologous E. coli system.  ...  Figure 3A shows the resulting gel visualized by UV radiation and clearly displaying an Ada-AlkA-dependent shift in the electrophoresis mobility of the DNA-protein complex compared to the isolated probe  ... 
doi:10.3390/ijms21155391 pmid:32751237 fatcat:w7xsqhse4jhpzlhluqyk42ki6e

Magnitude of Cognitive Dysfunction in Adults with Type 2 Diabetes: A Meta-analysis of Six Cognitive Domains and the Most Frequently Reported Neuropsychological Tests Within Domains

Priya Palta, Andrea L.C. Schneider, Geert Jan Biessels, Pegah Touradji, Felicia Hill-Briggs
2014 Journal of the International Neuropsychological Society  
dysfunction in adults with type 2 diabetes, relative to nondiabetic controls, and to obtain effect sizes for the most commonly reported neuropsychological tests within domains.  ...  B (d = −0.39), Rey-Osterreith Complex Figure (delayed) (d = −0.38), Trails A (d = −0.34), and Stroop Part I (d = −0.28).  ...  Acknowledgments This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes Research and Training Center grant (F.H-B., grant number P60 DK079637) and  ... 
doi:10.1017/s1355617713001483 pmid:24555960 pmcid:PMC4132660 fatcat:iwdflls7rffydlbx5feop4eoka

Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays

D. J. Steger, A. Eberharter, S. John, P. A. Grant, J. L. Workman
1998 Proceedings of the National Academy of Sciences of the United States of America  
For Ada and NuA4, we demonstrate that acetylation of only histone proteins mediates enhanced transcription, suggesting that these complexes facilitate transcription at least in part by modifying histones  ...  HAT activities acetylating either histone H3 (SAGA, Ada, and NuA3) or H4 (NuA4) stimulate HIV-1 transcription from preassembled nucleosomal templates in an acetyl CoA-dependent manner.  ...  We are grateful to Zhaodan Cao of Tularik for providing recombinant p65 prepared from vaccinia virus-infected HeLa cells. We thank members of the Workman lab for many helpful discussions.  ... 
doi:10.1073/pnas.95.22.12924 pmid:9789016 pmcid:PMC23656 fatcat:7zsx2jhnzrexnizxzjfwtifywu

RAPTOR

Martin C. Carlisle, Terry A. Wilson, Jeffrey W. Humphries, Steven M. Hadfield
2005 Proceedings of the 36th SIGCSE technical symposium on Computer science education - SIGCSE '05  
Proceedings of the 33rd SIGCSE [4] Feldman, M., and Koffman E. Ada 95 Problem Solving and Symposium (March 2002), 33-42. Program Design, 3rd edition.  ...  Previously, the twelve hour algorithms block of Solving, Flowcharts. this course was taught in Ada 95 or MATLAB.  ... 
doi:10.1145/1047344.1047411 dblp:conf/sigcse/CarlisleWHH05 fatcat:6c4ay23gljgjxbr62j5lo75fke

Physico-chemical Modification of Gelatine for the Improvement of 3D Printability of Oxidized Alginate-gelatine Hydrogels Towards Cartilage Tissue Engineering

T. Kreller, T. Distler, S. Heid, S. Gerth, R. Detsch, A.R. Boccaccini
2021 Materials & design  
The authors thank Dr Joachim Kaschta for his advice and the introduction to the rheometer and Eva Hufnagel for the support of the 3D volume analysis.  ...  F: Visualized rheological behavior of modified ADA-GEL hydrogels cooling down from 37°C after 5 min and after 20 min. Left: ADA-GEL-T 70°C_6h . Second from left: ADA-GEL-T 80°C_3h .  ...  control.  ... 
doi:10.1016/j.matdes.2021.109877 fatcat:j5hvyz3zsnbyto6eh2ruroidsm

Model driven development with Ada

Andy Lapping
2004 Proceedings of the 2004 annual ACM SIGAda international conference on Ada The engineering of correct and reliable software for real-time & distributed systems using Ada and related technologies - SIGAda '04  
with rich enough specification to be able to design and implement it in Ada.  ...  The UML has proven to be the standard visual representation language capable of providing both systems and software teams with a coherent set of interchangeable artefacts that fully describe an application  ...  Almost everybody (but not everybody) agrees that a class in Ada 95 corresponds to a package containing a main type. In most of the cases the main type is declared private or with a private extension.  ... 
doi:10.1145/1032297.1032301 dblp:conf/sigada/Lapping04 fatcat:bcnuluvjhjb7rbbfuggby454qa

Pharmacokinetic-Pharmacodynamic Modelling of Systemic IL13 Blockade by Monoclonal Antibody Therapy: A Free Assay Disguised as Total

John Hood, Ignacio González-García, Nicholas White, Leeron Marshall, Vincent F. S. Dubois, Paolo Vicini, Paul G. Baverel
2021 Pharmaceutics  
The target time course was modelled as a linear combination of free target and a percentage of the drug-target complex to fit the clinical data.  ...  A sequential pharmacokinetic (PK) and pharmacodynamic (PD) model was built with Nonlinear Mixed Effects Modelling based on data from a first-in-human trial of a novel biologic, MEDI7836.  ...  The ADA screening assay was based on a bridging immunoassay format; positive control samples, screening samples, and negative control samples were incubated in the presence of biotinylated MEDI7836 and  ... 
doi:10.3390/pharmaceutics13040519 pmid:33918602 fatcat:qbjb4zbftnfi5oat6t2zxqi6wm
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