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Virus Variation Resource – improved response to emergent viral outbreaks

Eneida L. Hatcher, Sergey A. Zhdanov, Yiming Bao, Olga Blinkova, Eric P. Nawrocki, Yuri Ostapchuck, Alejandro A. Schäffer, J. Rodney Brister
2016 Nucleic Acids Research  
The resource is located at http://www.ncbi.nlm.nih.gov/genome/ viruses/variation/ and includes modules for seven viral groups: influenza virus, Dengue virus, West Nile virus, Ebolavirus, MERS coronavirus  ...  The Virus Variation Resource is a value-added viral sequence data resource hosted by the National Center for Biotechnology Information.  ...  to quickly provide new modules in response to emerging outbreaks and associated nucleotide sequencing efforts.  ... 
doi:10.1093/nar/gkw1065 pmid:27899678 pmcid:PMC5210549 fatcat:rmk3lbtajzed3a3nqyfz2eh3by

Local, national, and regional viral haemorrhagic fever pandemic potential in Africa: a multistage analysis

David M Pigott, Aniruddha Deshpande, Ian Letourneau, Chloe Morozoff, Robert C Reiner, Moritz U G Kraemer, Shannon E Brent, Isaac I Bogoch, Kamran Khan, Molly H Biehl, Roy Burstein, Lucas Earl (+22 others)
2017 The Lancet  
viral haemorrhagic fevers in Africa, Crimean-Congo haemorrhagic fever, Ebola virus disease, Lassa fever, and Marburg virus disease.  ...  Predicting when and where pathogens will emerge is difficult, yet, as shown by the recent Ebola and Zika epidemics, effective and timely responses are key.  ...  This work was funded by a grant from The Paul G Allen Ebola Program (grant 11878) to SIH, which also provided funding for DMP, AD, and CM.  ... 
doi:10.1016/s0140-6736(17)32092-5 pmid:29031848 pmcid:PMC5735217 fatcat:2dd7o7y53na3rk5gtzucjasjrq

Perspectives on West Africa Ebola Virus Disease Outbreak, 2013–2016

Jessica R. Spengler, Elizabeth D. Ervin, Jonathan S. Towner, Pierre E. Rollin, Stuart T. Nichol
2016 Emerging Infectious Diseases  
The magnitude of the outbreak was not attributable to a substantial change of the virus.  ...  Continued efforts during the outbreak and in preparation for future outbreak response should involve identifying the reservoir, improving in-country detection and response capacity, conducting survivor  ...  We also acknowledge and commend the international response to the EVD outbreak in West Africa and thank the other members of CDC's Viral Special Pathogens Branch, Division of High-Consequence Pathogens  ... 
doi:10.3201/eid2206.160021 pmid:27070842 pmcid:PMC4880067 fatcat:t4wgfa2afzbtnoieoda5lg7wpq

Emerging Viral Diseases: Confronting Threats with New Technologies

H. D. Marston, G. K. Folkers, D. M. Morens, A. S. Fauci
2014 Science Translational Medicine  
Here too, research advances have greatly improved responses to emerging viruses.  ...  Real-time reverse transcription PCR, a quantitative RNA-based technology, has been developed and deployed in outbreaks, including Ebola virus disease outbreaks in Africa Technology Application to emerging  ... 
doi:10.1126/scitranslmed.3009872 pmid:25210060 fatcat:mhzauowapfchdaxlnzscnb2may

Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology

Angela L. Rasmussen, Michael G. Katze
2016 Cell Host and Microbe  
As genomic technologies become more accessible, these methods will redefine how emerging viruses are studied and outbreaks are contained.  ...  Here we review the existing and emerging genomic technologies that are enabling systems epidemiology and systems virology and making it possible to respond rapidly to emerging viruses such as Zika.  ...  approaches to rapidly facilitate a more comprehensive understanding of emergent viruses and the host response to the pathogen.  ... 
doi:10.1016/j.chom.2016.04.016 pmid:27173929 pmcid:PMC7104983 fatcat:qysjwtkef5gujiliuc5t266o64

One Health proof of concept: Bringing a transdisciplinary approach to surveillance for zoonotic viruses at the human-wild animal interface

Terra R. Kelly, William B. Karesh, Christine Kreuder Johnson, Kirsten V.K. Gilardi, Simon J. Anthony, Tracey Goldstein, Sarah H. Olson, Catherine Machalaba, Jonna A.K. Mazet
2017 Preventive Veterinary Medicine  
, improving our understanding of viral disease spillover from wildlife and implementing strategies for preventing and controlling emerging disease threats.  ...  Such an approach presents important opportunities to reduce the impact of disease emergence events and also to mitigate future emergence through improved cross-sectoral coordination.  ...  The contents are the responsibility of the PREDICT Consortium and do not necessarily reflect the views of USAID or the United States Government.  ... 
doi:10.1016/j.prevetmed.2016.11.023 pmid:28034593 pmcid:PMC7132382 fatcat:7xd5ov3snbe53p77c2gkaimzxi

Systems approaches to coronavirus pathogenesis

Alexandra Schäfer, Ralph S Baric, Martin T Ferris
2014 Current Opinion in Virology  
As emergent viruses may cause episodic outbreaks of disease over time, human samples are limited.  ...  The advent of systems genetic and biology resources provide new opportunities for deconvoluting the complex genetic interactions and expression networks that regulate pathogenic or protective host response  ...  Acknowledgments We wish to acknowledge SP and RG for assistance with figures.  ... 
doi:10.1016/j.coviro.2014.04.007 pmid:24842079 pmcid:PMC4076299 fatcat:q6ozyszhyvgmbbyehktwb2cgua

Harnessing DNA Synthesis to Develop Rapid Responses to Emerging and Pandemic Pathogens

Lisa M. Runco, J. Robert Coleman
2011 Journal of Pathogens  
Given the interconnected nature of our world today, emerging pathogens and pandemic outbreaks are an ever-growing threat to the health and economic stability of the global community.  ...  This is evident by the recent 2009 Influenza A (H1N1) pandemic, the SARS outbreak, as well as the ever-present threat of global bioterrorism.  ...  Acknowledgments The authors would like to thank JAMC for his support in preparing this publication. Dr.  ... 
doi:10.4061/2011/765763 pmid:23533775 pmcid:PMC3595711 fatcat:ue5fdvxwtzegxnclajftbbgy2e

Open Sources and Crowdsourcing for Combating Emerging and Reemerging Infectious Diseases

Yanfeng Yan, Huaiyu Tian, Wenyi Zhang, Di Liu, Yujun Cui, Ruifu Yang
2016 Infectious Diseases and Translational Medicine  
This process can often delay understanding the pathogenic strain responsible for an outbreak, which in turn delays the development of prevention and control strategies.  ...  Emerging infectious diseases (EIDs) could quickly cross national borders as a result of air travel, and spread disaster and panic globally within months or even days.  ...  A resource of viral genome information [25] is maintained at the NCBI, including genome sequences, variations, and analyzing tools (http://www.ncbi.nlm.nih. gov/genome/viruses/).  ... 
doi:10.11979/idtm.201603003 doaj:62cbb22d791947709d8226d84bfe36aa fatcat:ekypiu3g5zbfjbhz5hccygglam

Enlightenment from the COVID-19 Pandemic: The Roles of Environmental Factors in Future Public Health Emergency Response

Xiaolei Wang, Fengchang Wu, Xiaoli Zhao, Xiao Zhang, Junyu Wang, Lin Niu, Weigang Liang, Kenneth Mei Yee Leung, John P. Giesy
2021 Engineering  
, and after the responses to such emergencies.  ...  To improve countries' capability to respond to public health emergencies associated with viral infections such as the COVID-19 pandemic, a number of environmental factors should be considered before, during  ...  of viral outbreaks so as to improve the early-warning capabilities of PHERSs.  ... 
doi:10.1016/j.eng.2020.12.019 pmid:33747606 pmcid:PMC7955573 fatcat:uuqwxq6brjartlzjnbjuwmgte4

Emerging and Re-emerging Infectious Diseases [chapter]

Vassil St. Georgiev
2009 National Institute of Allergy and Infectious Diseases, NIH  
) Variola major (smallpox) and other related pox viruses Francisella tularensis (tularemia) Viral hemorrhagic fevers: Arenaviruses LCM, Junin virus, Machupo virus, Guanarito virus Lassa fever Bunyaviruses  ...  Research Plans and Priorities In response to the threat of emerging and re-emerging infectious diseases, NIAID has developed a strategy for addressing these issues through targeted research and training  ... 
doi:10.1007/978-1-60327-297-1_4 fatcat:rqrcbof3nrg5nkjwxj7gj5zade

International Conference on Emerging Infectious Diseases in the Pacific Rim, Bangkok, Thailand

James LeDuc
1997 Emerging Infectious Diseases  
Lessons learned from outbreaks in the last 15 years contribute to developing strategies for the mobilization of resources to respond rapidly to emerging foodborne microbial hazards.  ...  genetic variability, and genomic analysis; vaccine development; and improved vector control and fundamental strengthening of public health practices to address emerging infectious diseases including improved  ...  A session on viral hemorrhagic fevers reviewed recent Ebola virus outbreaks and the  ... 
doi:10.3201/eid0302.970229 fatcat:bbx4f5agpvhtbmtwl2nqyzj3bq

The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response

Yolanda Botti-Lodovico, Parvathy Nair, Dolo Nosamiefan, Matthew Stremlau, Stephen Schaffner, Sebastian V. Agignoae, John Oke Aiyepada, Fehintola V. Ajogbasile, George O. Akpede, Foday Alhasan, Kristian G. Andersen, Danny A. Asogun (+99 others)
2021 Viruses  
improve pandemic preparedness and response anywhere in the world.  ...  As we delved further, we conjectured that the "emerging" nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and  ...  Branco is co-founder and managing director of Zalgen Labs, a biotechnology company developing countermeasures to emerging viruses. Kristian G.  ... 
doi:10.3390/v13081605 pmid:34452470 pmcid:PMC8402630 fatcat:xjbx5qswg5bfhgafwjumo36cbe

Bat-borne virus diversity, spillover and emergence

Michael Letko, Stephanie N. Seifert, Kevin J. Olival, Raina K. Plowright, Vincent J. Munster
2020 Nature Reviews Microbiology  
to anticipate and prepare for the next viral outbreak.  ...  response and prevention efforts.  ...  K.J.O. is supported by the USAID Emerging Pandemic Threats PREDICT program, NIH/NIAID award R01AI110964 and a US Defense Threat Reduction Agency award HDTRA11710064.  ... 
doi:10.1038/s41579-020-0394-z pmid:32528128 pmcid:PMC7289071 fatcat:xnoiezq6hrhe5l6fnz7p3zjwau

Pathogenesis of Uveitis in Ebola Virus Disease Survivors: Evolving Understanding from Outbreaks to Animal Models

Caleb Hartley, J Clay Bavinger, Sanjana Kuthyar, Jessica G Shantha, Steven Yeh
2020 Microorganisms  
Ebola virus disease (EVD) and emerging infectious disease threats continue to threaten life, prosperity and global health security.  ...  Moreover, in vitro models of Ebola virus have shown permissiveness in retinal pigment epithelial cells, potentially contributing to viral persistence.  ...  The funders had no role in the design of the study; in the collection, analyses, or interpretation of the data; in the writing of the manuscript; or in the decision to publish the results.  ... 
doi:10.3390/microorganisms8040594 pmid:32325950 pmcid:PMC7232169 fatcat:oscn6seynvg5fgmvmdbzq3o7ze
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