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A kiss to set the rhythm
2016
eLife
Preserved Fulltext
Copyright Shruti and Prevot. ...
Associated Laboratory, Institut National de la Santé et de la Recherche Mé dicale, Université de Lille, Unité Mixte de Recherche 1172, Lille, France sonal.shruti@inserm.fr http://orcid.org/0000-0002-4258-6164 Vincent ...
doi:10.7554/elife.19823
pmid:27558594
pmcid:PMC4999308
fatcat:ezokxzwkxndotdl5xy7gkgamoe
Les tanycytes hypothalamiques
2014
M S.Médecine Sciences
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Prévot, page 624 de ce numéro
Églantine Balland, Vincent Prévot Inserm, équipe développement et plasticité du cerveau postnatal, Centre de recherche Jean-Pierre Aubert, Inserm U837, bâtiment Biserte, ...
Prévot 1 , Fanny Langlet 1Figure 1. ...
doi:10.1051/medsci/20143006009
pmid:25014450
fatcat:useznbmoyfg47pdpu6fpoxbxcq
Hypothalamic microRNAs flip the switch for fertility
2017
OncoTarget
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Hypothalamic microRNAs flip the switch for fertility Andrea Messina and Vincent Prevot Reproduction, in mammals, is finely regulated by the hypothalamic-pituitary-gonadal axis (HPG) and driven, by a complex ...
doi:10.18632/oncotarget.14646
pmid:28099896
pmcid:PMC5354699
fatcat:ceolu7vlfnd47g3r2erwp7kq2m
GnRH Neurons Directly Listen to the Periphery
2011
Endocrinology
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Les micro-ARN
2017
M S.Médecine Sciences
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Prevot ...
doi:10.1051/medsci/20173305014
pmid:28612726
fatcat:ri3qmj5rlfhudcphjcixxoqcva
Reproductive function during chronodisruption: Model of shiftwork in rodents
2020
Endocrinology
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L'hormone anti-müllerienne
2016
M S.Médecine Sciences
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4. Picard C, Mathieu AL, Hasan U, et al. Inherited anomalies of innate immune receptors in pediatriconset inflammatory diseases. Autoimmun Rev 2015 ; 14 : 1147-53. 5. Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008 ; 134 : 587-98. 2. Hung T, Pratt GA, Sundararaman B, et al. The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression. Science 2015 ; 350 : 455-9. 3. Crow YJ, Manel N.
doi:10.1051/medsci/20163205005
pmid:27225911
fatcat:6hymji4o4na3pbvjanrwhv3ht4
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... s syndrome and the type I interferonopathies. Nat Rev Immunol 2015 ; 15 : 429-40. RÉFÉRENCES 1. Terrier B, Mouthon L. Lupus érythémateux systémique : traitements par anticorps monoclonaux et molécules recombinantes. Med Sci (Paris) 2013 ; 29 : 65-73.
L'IRM hypothalamique, un nouvel outil diagnostique dans l'anorexie mentale ?
2020
M S.Médecine Sciences
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When Size Matters: How Astrocytic Processes Shape Metabolism
2017
Cell Metabolism
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The hypothalamic control of metabolism appears to be a puzzle that cannot be explained by neuronal function alone. Zhang and colleagues (2017) add a few new pieces by demonstrating that astrocytes critically modulate neural circuits controling energy homeostasis through nutritional-status-dependent morphological plasticity and IKKβ/NF-κB signaling, which modulate extracellular neurotransmitter bioavailability. Main body Key to the regulation of energy homeostasis is the control by hypothalamic
doi:10.1016/j.cmet.2017.04.016
pmid:28467945
fatcat:2yng33n6ojhvnkusunypvkj5qy
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... eurons of numerous neuroendocrine functions that integrate metabolic feedback and adapt the response of the organism to physiological demands (Jais and Bruning, 2017). However, it is
Plasticité de la barrière hémato-hypothalamique
2014
M S.Médecine Sciences
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Prévot,
page 624 de ce numéro
c'est la place des jonctions serrées, qui
sont sur les cellules endothéliales ou sur
les tanycytes. ...
Prévot,
page 624 de ce numéro
Les tanycytes sont la source du VEGFA
impliqué dans les fenestrations
endothéliales
Nos travaux ont montré que les tany-
cytes synthétisent et sécrètent le VEGFA
qui ...
doi:10.1051/medsci/20143006010
pmid:25014451
fatcat:fbn3fzmqr5fqzdjbqwbydzfn4i
Hypothalamic structural and functional imbalances in anorexia nervosa
2019
Neuroendocrinology
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The hypothalamus contains integrative systems that support life, including physiological processes such as food intake, energy expenditure and reproduction. Here, we show that anorexia nervosa patients, contrary to normal weight and constitutionally lean individuals, respond with a paradoxical reduction in hypothalamic levels of glutamate/glutamine (Glx) upon feeding. This reversal of the Glx response is associated with decreased wiring in the arcuate nucleus and increased connectivity in the
doi:10.1159/000503147
pmid:31484186
fatcat:wbfixh5e5vh77lh3vhriuzi6n4
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... teral hypothalamic area, which are involved in the regulation on a variety of physiological and behavioral functions including the control of food intake and energy balance. The identification of distinct hypothalamic neurochemical dysfunctions and associated structural variations in anorexia nervosa paves the way for the development of new diagnostic and treatment strategies in conditions associated with abnormal body mass index and a maladaptive response to negative energy balance.
Female sexual behavior in mice is controlled by kisspeptin neurons
2018
Nature Communications
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Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural circuits driving this orchestration in the brain have, however, remained elusive. Here, we demonstrate that neurons controlling ovulation in the mammalian brain are at the core of a branching neural circuit governing both mate preference and copulatory behavior. We show that
doi:10.1038/s41467-017-02797-2
pmid:29374161
pmcid:PMC5786055
fatcat:smwlrknlcrcrlmtnxz7fvmgwli
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... le odors detected in the vomeronasal organ activate kisspeptin neurons in female mice. Classical kisspeptin/Kiss1R signaling subsequently triggers olfactory-driven mate preference. In contrast, copulatory behavior is elicited by kisspeptin neurons in a parallel circuit independent of Kiss1R involving nitric oxide signaling. Consistent with this, we find that kisspeptin neurons impinge onto nitric oxide-synthesizing neurons in the ventromedial hypothalamus. Our data establish kisspeptin neurons as a central regulatory hub orchestrating sexual behavior in the female mouse brain.
Gliotransmission by Prostaglandin E2: A Prerequisite for GnRH Neuronal Function?
2011
Frontiers in Endocrinology
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et al., 2003b Prevot et al., , 2005 . ...
et al., 1998 (Prevot et al., , 1999 . ...
doi:10.3389/fendo.2011.00091
pmid:22649391
pmcid:PMC3355930
fatcat:mqx5f6p6yvbefmdm4u4zelzdle
Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life
2016
Cell Reports
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Graphical Abstract Highlights d Autonomic innervation of pancreatic islets develops during mid-gestation in mice d Leptin is required for normal parasympathetic innervation of pancreatic b cells d Acute leptin injections in embryos cause lifelong disturbances in glucose homeostasis d Leptin acts directly on the hindbrain to modulate cholinergic axon growth SUMMARY The autonomic nervous system plays a critical role in glucose metabolism through both its sympathetic and parasympathetic branches,
doi:10.1016/j.celrep.2016.02.088
pmid:27052164
pmcid:PMC4982372
fatcat:rwmbnupq75djtivjanrir7lg3q
more »
... ut the mechanisms that underlie the development of the autonomic innervation of the pancreas remain poorly understood. Here, we report that cholinergic innervation of pancreatic islets develops during mid-gestation under the influence of leptin. Leptin-deficient mice display a greater cholinergic innervation of pancreatic islets beginning in embryonic life, and this increase persists into adulthood. Remarkably, a single intracerebroventricular injection of leptin in embryos caused a permanent reduction in parasympathetic innervation of pancreatic b cells and long-term impairments in glucose homeostasis. These developmental effects of leptin involve a direct inhibitory effect on the outgrowth of preganglionic axons from the hindbrain. These studies reveal an unanticipated regulatory role of leptin on the parasympathetic nervous system during embryonic development and may have important implications for our understanding of the early mechanisms that contribute to diabetes.
Développement des neurones à GnRH dans le cerveau d'embryons humains
2017
M S.Médecine Sciences
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