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A kiss to set the rhythm

Sonal Shruti, Vincent Prevot
2016 eLife  
Copyright Shruti and Prevot.  ...  Associated Laboratory, Institut National de la Santé et de la Recherche Mé dicale, Université de Lille, Unité Mixte de Recherche 1172, Lille, France Vincent  ... 
doi:10.7554/elife.19823 pmid:27558594 pmcid:PMC4999308 fatcat:ezokxzwkxndotdl5xy7gkgamoe

Les tanycytes hypothalamiques

Églantine Balland, Vincent Prévot
2014 M S.Médecine Sciences  
Prévot, page 624 de ce numéro Églantine Balland, Vincent Prévot Inserm, équipe développement et plasticité du cerveau postnatal, Centre de recherche Jean-Pierre Aubert, Inserm U837, bâtiment Biserte,  ...  Prévot 1 , Fanny Langlet 1Figure 1.  ... 
doi:10.1051/medsci/20143006009 pmid:25014450 fatcat:useznbmoyfg47pdpu6fpoxbxcq

Hypothalamic microRNAs flip the switch for fertility

Andrea Messina, Vincent Prevot
2017 OncoTarget  
Hypothalamic microRNAs flip the switch for fertility Andrea Messina and Vincent Prevot Reproduction, in mammals, is finely regulated by the hypothalamic-pituitary-gonadal axis (HPG) and driven, by a complex  ... 
doi:10.18632/oncotarget.14646 pmid:28099896 pmcid:PMC5354699 fatcat:ceolu7vlfnd47g3r2erwp7kq2m

GnRH Neurons Directly Listen to the Periphery

Vincent Prevot
2011 Endocrinology  
doi:10.1210/en.2011-1544 pmid:21937749 pmcid:PMC3519581 fatcat:5wqxtssbobg6tcroblwui4qwty

Les micro-ARN

Andrea Messina, Fanny Langlet, Vincent Prevot
2017 M S.Médecine Sciences  
Prevot  ... 
doi:10.1051/medsci/20173305014 pmid:28612726 fatcat:ri3qmj5rlfhudcphjcixxoqcva

Reproductive function during chronodisruption: Model of shiftwork in rodents

Valerie Leysen, Vincent Prevot
2020 Endocrinology  
doi:10.1210/endocr/bqaa151 pmid:32853386 pmcid:PMC7640781 fatcat:p44iaj7gtfcntgvy4ofh5c5lsm

L'hormone anti-müllerienne

Sophie Catteau-Jonard, Didier Dewailly, Vincent Prévot, Irène Cimino, Paolo Giacobini
2016 M S.Médecine Sciences  
4. Picard C, Mathieu AL, Hasan U, et al. Inherited anomalies of innate immune receptors in pediatriconset inflammatory diseases. Autoimmun Rev 2015 ; 14 : 1147-53. 5. Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008 ; 134 : 587-98. 2. Hung T, Pratt GA, Sundararaman B, et al. The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression. Science 2015 ; 350 : 455-9. 3. Crow YJ, Manel N.
more » ... s syndrome and the type I interferonopathies. Nat Rev Immunol 2015 ; 15 : 429-40. RÉFÉRENCES 1. Terrier B, Mouthon L. Lupus érythémateux systémique : traitements par anticorps monoclonaux et molécules recombinantes. Med Sci (Paris) 2013 ; 29 : 65-73.
doi:10.1051/medsci/20163205005 pmid:27225911 fatcat:6hymji4o4na3pbvjanrwhv3ht4

L'IRM hypothalamique, un nouvel outil diagnostique dans l'anorexie mentale ?

Vincent Florent, Marc Baroncini, Vincent Prévot
2020 M S.Médecine Sciences  
doi:10.1051/medsci/2020007 pmid:32129746 fatcat:khvlh3x6arfvhlxmp3zmwuz7ve

When Size Matters: How Astrocytic Processes Shape Metabolism

Ariane Sharif, Vincent Prevot
2017 Cell Metabolism  
The hypothalamic control of metabolism appears to be a puzzle that cannot be explained by neuronal function alone. Zhang and colleagues (2017) add a few new pieces by demonstrating that astrocytes critically modulate neural circuits controling energy homeostasis through nutritional-status-dependent morphological plasticity and IKKβ/NF-κB signaling, which modulate extracellular neurotransmitter bioavailability. Main body Key to the regulation of energy homeostasis is the control by hypothalamic
more » ... eurons of numerous neuroendocrine functions that integrate metabolic feedback and adapt the response of the organism to physiological demands (Jais and Bruning, 2017). However, it is
doi:10.1016/j.cmet.2017.04.016 pmid:28467945 fatcat:2yng33n6ojhvnkusunypvkj5qy

Plasticité de la barrière hémato-hypothalamique

Bénédicte Dehouck, Vincent Prévot, Fanny Langlet
2014 M S.Médecine Sciences  
Prévot, page 624 de ce numéro c'est la place des jonctions serrées, qui sont sur les cellules endothéliales ou sur les tanycytes.  ...  Prévot, page 624 de ce numéro Les tanycytes sont la source du VEGFA impliqué dans les fenestrations endothéliales Nos travaux ont montré que les tany- cytes synthétisent et sécrètent le VEGFA qui  ... 
doi:10.1051/medsci/20143006010 pmid:25014451 fatcat:fbn3fzmqr5fqzdjbqwbydzfn4i

Hypothalamic structural and functional imbalances in anorexia nervosa

Vincent Florent, Marc Baroncini, Patrice Jissendi-Tchofo, Renaud Lopes, Matthieu Vanhoutte, Sowmyalakshmi RASIKA, Jean-Pierre Pruvo, Jean Vignau, Stephane Verdun, Jeanette E. Johansen, Marie Pigeyre, Sebastien G. Bouret (+2 others)
2019 Neuroendocrinology  
The hypothalamus contains integrative systems that support life, including physiological processes such as food intake, energy expenditure and reproduction. Here, we show that anorexia nervosa patients, contrary to normal weight and constitutionally lean individuals, respond with a paradoxical reduction in hypothalamic levels of glutamate/glutamine (Glx) upon feeding. This reversal of the Glx response is associated with decreased wiring in the arcuate nucleus and increased connectivity in the
more » ... teral hypothalamic area, which are involved in the regulation on a variety of physiological and behavioral functions including the control of food intake and energy balance. The identification of distinct hypothalamic neurochemical dysfunctions and associated structural variations in anorexia nervosa paves the way for the development of new diagnostic and treatment strategies in conditions associated with abnormal body mass index and a maladaptive response to negative energy balance.
doi:10.1159/000503147 pmid:31484186 fatcat:wbfixh5e5vh77lh3vhriuzi6n4

Female sexual behavior in mice is controlled by kisspeptin neurons

Vincent Hellier, Olivier Brock, Michael Candlish, Elodie Desroziers, Mari Aoki, Christian Mayer, Richard Piet, Allan Herbison, William Henry Colledge, Vincent Prévot, Ulrich Boehm, Julie Bakker
2018 Nature Communications  
Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural circuits driving this orchestration in the brain have, however, remained elusive. Here, we demonstrate that neurons controlling ovulation in the mammalian brain are at the core of a branching neural circuit governing both mate preference and copulatory behavior. We show that
more » ... le odors detected in the vomeronasal organ activate kisspeptin neurons in female mice. Classical kisspeptin/Kiss1R signaling subsequently triggers olfactory-driven mate preference. In contrast, copulatory behavior is elicited by kisspeptin neurons in a parallel circuit independent of Kiss1R involving nitric oxide signaling. Consistent with this, we find that kisspeptin neurons impinge onto nitric oxide-synthesizing neurons in the ventromedial hypothalamus. Our data establish kisspeptin neurons as a central regulatory hub orchestrating sexual behavior in the female mouse brain.
doi:10.1038/s41467-017-02797-2 pmid:29374161 pmcid:PMC5786055 fatcat:smwlrknlcrcrlmtnxz7fvmgwli

Gliotransmission by Prostaglandin E2: A Prerequisite for GnRH Neuronal Function?

Jerome Clasadonte, Ariane Sharif, Marc Baroncini, Vincent Prevot
2011 Frontiers in Endocrinology  
et al., 2003b Prevot et al., , 2005 .  ...  et al., 1998 (Prevot et al., , 1999 .  ... 
doi:10.3389/fendo.2011.00091 pmid:22649391 pmcid:PMC3355930 fatcat:mqx5f6p6yvbefmdm4u4zelzdle

Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life

Sophie Croizier, Vincent Prevot, Sebastien G. Bouret
2016 Cell Reports  
Graphical Abstract Highlights d Autonomic innervation of pancreatic islets develops during mid-gestation in mice d Leptin is required for normal parasympathetic innervation of pancreatic b cells d Acute leptin injections in embryos cause lifelong disturbances in glucose homeostasis d Leptin acts directly on the hindbrain to modulate cholinergic axon growth SUMMARY The autonomic nervous system plays a critical role in glucose metabolism through both its sympathetic and parasympathetic branches,
more » ... ut the mechanisms that underlie the development of the autonomic innervation of the pancreas remain poorly understood. Here, we report that cholinergic innervation of pancreatic islets develops during mid-gestation under the influence of leptin. Leptin-deficient mice display a greater cholinergic innervation of pancreatic islets beginning in embryonic life, and this increase persists into adulthood. Remarkably, a single intracerebroventricular injection of leptin in embryos caused a permanent reduction in parasympathetic innervation of pancreatic b cells and long-term impairments in glucose homeostasis. These developmental effects of leptin involve a direct inhibitory effect on the outgrowth of preganglionic axons from the hindbrain. These studies reveal an unanticipated regulatory role of leptin on the parasympathetic nervous system during embryonic development and may have important implications for our understanding of the early mechanisms that contribute to diabetes.
doi:10.1016/j.celrep.2016.02.088 pmid:27052164 pmcid:PMC4982372 fatcat:rwmbnupq75djtivjanrir7lg3q

Développement des neurones à GnRH dans le cerveau d'embryons humains

Anne-Laure Barbotin, Vincent Prévot, Paolo Giacobini
2017 M S.Médecine Sciences  
doi:10.1051/medsci/20173304003 pmid:28497730 fatcat:jismmlxhnnby5bscm3vcdht4ne
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