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Vertebral landmarks for the identification of spinal cord segments in the mouse

Megan Harrison, Aine O'Brien, Lucy Adams, Gary Cowin, Marc J. Ruitenberg, Gulgun Sengul, Charles Watson
2013 NeuroImage  
Accurate identification of spinal cord segments in relation to vertebral landmarks is essential to surgery aimed at experimental spinal cord injury.  ...  We have analyzed a complete series of high-resolution magnetic resonance (MR) images from the mouse spine in order to delineate the boundaries of spinal cord segments in relation to vertebral landmarks  ...  This work was supported in part by funding from the Queensland Nuclear Magnetic Resonance Network and from an Enabling Grant from the National Health and Medical Research Council of Australia (NHMRC) to  ... 
doi:10.1016/j.neuroimage.2012.11.048 pmid:23246856 fatcat:tpm65m45knhgtpo5uxe2ykug64

Sacral Spinal Cord Transection and Isolated Sacral Cord Preparation to Study Chronic Spinal Cord Injury in Adult Mice

Carmelo Bellardita, Maite Marcantoni, Peter Löw, Ole Kiehn
2018 Bio-protocol  
of the spinal cord.  ...  We generated a mouse model of chronic spinal cord injury that reliably reproduces spasticity observed after SCI, while at the same time allows study of motor impairments in vivo and in an in vitro preparation  ...  The authors declare that they have no conflicts or competing interests.  ... 
doi:10.21769/bioprotoc.2784 pmid:29795778 pmcid:PMC5961933 fatcat:rpknmzg6vfhhldfnkh2wa4hqkq

A novel approach for assigning levels to monkey and human lumbosacral spinal cord based on ventral horn morphology

Cassandra Gross, Brian Ellison, Aron S. Buchman, Ei Terasawa, Veronique G. VanderHorst, Norbert Weidner
2017 PLoS ONE  
Acknowledgments The authors would like to thank Lauren Broom for proofreading the manuscript. Author Contributions  ...  Results Identification of rostral and caudal lumbosacral landmarks in monkey and human spinal cord In monkeys, retrogradely (CTb) labeled motoneurons innervating the iliopsoas muscle formed the most  ...  Fig 1 . 1 Identification of rostral and caudal landmarks in the lumbosacral enlargement in rhesus monkey and humans.  ... 
doi:10.1371/journal.pone.0177243 pmid:28542213 pmcid:PMC5443490 fatcat:3laqr3zngfattdhonqb3pljjfa

Identification of Apical Vertebra for Grading of Idiopathic Scoliosis using Image Processing

H. Anitha, G. K. Prabhu
2011 Journal of digital imaging  
Precise measurement of apical vertebral rotation in terms of grading is most valuable for the determination of reference value in normal and pathological conditions for better understanding of scoliosis  ...  Scoliosis is a 3-D deformity of spinal column, characterized by both lateral curvature and vertebral rotation.  ...  In case of pedicle screw misplacement that incur risks of spinal cord injury.  ... 
doi:10.1007/s10278-011-9394-x pmid:21725622 pmcid:PMC3264723 fatcat:5skbsv7tvvhvfbmzutzscezz3y

Spinal vertebrae localization and analysis on disproportionality in curvature using radiography—a comprehensive review

Joddat Fatima, Muhammad Usman Akram, Amina Jameel, Adeel Muzaffar Syed
2021 EURASIP Journal on Image and Video Processing  
of curvature deformity of the vertebrae in the spinal cord.  ...  The spinal cord assists the overall communication network of the human anatomy through the brain.  ...  I would also like to acknowledge the support provided by my university.  ... 
doi:10.1186/s13640-021-00563-5 fatcat:khzxpnubxjdnto4zdcpbxqxvnu

Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration

Gary J. Cowin, Tim J. Butler, Nyoman D. Kurniawan, Charles Watson, Robyn H. Wallace
2011 NeuroImage  
These results demonstrate the usefulness of MRM in visualising the ultrastructure of the mouse spinal cord.  ...  MRM signal intensity was increased exclusively in the ventral motor nerve roots of the lumbar spinal cord of ALS-affected SOD1 mice compared to wildtype littermates.  ...  Acknowledgements Funding provided by the Ross Maclean Fellowship, Peter Goodenough Bequest and the Queensland Nuclear Magnetic Resonance Network. Jane Ellis for assistance with histology. References  ... 
doi:10.1016/j.neuroimage.2011.06.003 pmid:21689764 fatcat:75a3z6lklrhw3pfsoovrouf7du

Transmitter-phenotypes of commissural interneurons in the lumbar spinal cord of newborn mice

Carlos Ernesto Restrepo, Line Lundfald, Gabor Szabó, Ferenc Erdélyi, Hanns Ulrich Zeilhofer, Joel C. Glover, Ole Kiehn
2009 Journal of Comparative Neurology  
Our results suggest that glycinergic, GABAergic, and glutamatergic CINs are the principal CIN phenotypes in the CPG region of the lumbar spinal cord in the newborn mouse.  ...  In this study we describe the relative proportions and anatomical locations of putative inhibitory and excitatory CINs in the lumbar spinal cord of newborn mice.  ...  ACKNOWLEDGMENTS We thank Mette Kirkegaard for comments on a previous version of the article, and Lovisa Kä llman and Anna Eriksson for caretaking and breeding of the different transgenic lines used in  ... 
doi:10.1002/cne.22144 pmid:19731323 fatcat:eutp5jmpzjc3hmqxql2axtw33a

The transneuronal spread phenotype of herpes simplex virus type 1 infection of the mouse hind footpad

J P Engel, T C Madigan, G M Peterson
1997 Journal of Virology  
The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection.  ...  regions of the spinal cord on days 5 and 6 p.i.  ...  in the nucleus proprius and the nucleus dorsalis regions of the spinal cord gray matter at the segment of entry and two to three segments rostral and caudal to the entry segment and (ii) the long fibers  ... 
pmid:9032380 pmcid:PMC191353 fatcat:6mgxbodq6vebtddtxfol7c62ay

The transneuronal spread phenotype of herpes simplex virus type 1 infection of the mouse hind footpad

J P Engel, T C Madigan, G M Peterson
1997 Journal of Virology  
The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection.  ...  regions of the spinal cord on days 5 and 6 p.i.  ...  in the nucleus proprius and the nucleus dorsalis regions of the spinal cord gray matter at the segment of entry and two to three segments rostral and caudal to the entry segment and (ii) the long fibers  ... 
doi:10.1128/jvi.71.3.2425-2435.1997 fatcat:ugijjf64hfhyhpoziuryvqvfyy

Segmental pattern of development of the hindbrain and spinal cord of the zebrafish embryo

E Hanneman, B Trevarrow, W K Metcalfe, C B Kimmel, M Westerfield
1988 Development  
Young neurones within both the hindbrain and spinal cord were identified in live embryos using Nomarski optics, and histochemically by labelling for acetylcholinesterase activity and expression of an antigen  ...  A continuous longitudinal column of developing neurones appears in the spinal cord, whereas an alternating series of large and small clusters of neurones is present in the hindbrain.  ...  The work was supported by NIH grants NS17963, NS21132, NS01O65, GMO7257, GMO7413 and HD22486.  ... 
pmid:3197633 fatcat:rxflafqse5aojaxmwai2xjqtyy

Characterization of A11 Neurons Projecting to the Spinal Cord of Mice

Kathrin Koblinger, Tamás Füzesi, Jillian Ejdrygiewicz, Aleksandra Krajacic, Jaideep S. Bains, Patrick J. Whelan, Joohyung Lee
2014 PLoS ONE  
The hypothalamic A11 region has been identified in several species including rats, mice, cats, monkeys, zebrafish, and humans as the primary source of descending dopamine (DA) to the spinal cord.  ...  It has been implicated in the control of pain, modulation of the spinal locomotor network, restless leg syndrome, and cataplexy, yet the A11 cell group remains an understudied dopaminergic (DAergic) nucleus  ...  Example of retrograde labelling in the A11 caudal area following FluoroGold (FG) injections into the lumbar spinal cord between lumbar vertebral segments L4 and L5.  ... 
doi:10.1371/journal.pone.0109636 pmid:25343491 pmcid:PMC4208762 fatcat:6mwsnztvbnhpxcafis4dufntxq

Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons

R Imondi, C Wideman, Z Kaprielian
2000 Development  
We show here that B-class transmembrane ephrins and their receptors are reciprocally expressed on floor plate cells and longitudinally projecting axons in the mouse spinal cord.  ...  In the developing spinal cord, axons project in both the transverse plane, perpendicular to the floor plate, and in the longitudinal plane, parallel to the floor plate.  ...  This work was aided by grants from the Christopher Reeve Paralysis Foundation (KBA9701 and KBR1-9904-1) and the Spinal Cord Research Foundation (1877-01) to Z. K.  ... 
pmid:10704386 fatcat:tgkisuidqnbdbbozy2nidufasy

Chronic in vivo imaging in the mouse spinal cord using an implanted chamber

Matthew J Farrar, Ida M Bernstein, Donald H Schlafer, Thomas A Cleland, Joseph R Fetcho, Chris B Schaffer
2012 Nature Methods  
We developed a chronically implanted spinal chamber and surgical procedure suitable for time-lapse in vivo multiphoton microscopy of mouse spinal cord without the need for repeat surgical procedures.  ...  Understanding and treatment of spinal cord pathology is limited in part by a lack of longitudinal in vivo imaging strategies at the cellular level.  ...  support, and IMRA America, Inc. for the loan of their FCPA μJewel D-400 laser.  ... 
doi:10.1038/nmeth.1856 pmid:22266542 pmcid:PMC3429123 fatcat:ep6r5zvit5bzdnkk77gixrrrwu

A Spinal Cord Window Chamber Model for In Vivo Longitudinal Multimodal Optical and Acoustic Imaging in a Murine Model

Sarah A. Figley, Yonghong Chen, Azusa Maeda, Leigh Conroy, Jesse D. McMullen, Jason I. Silver, Shawn Stapleton, Alex Vitkin, Patricia Lindsay, Kelly Burrell, Gelareh Zadeh, Michael G. Fehlings (+2 others)
2013 PLoS ONE  
However, longitudinal in vivo imaging of the intact spinal cord in rodent models has been challenging, requiring repeated surgeries to expose the cord for imaging or sacrifice of animals at various time  ...  In vivo and direct imaging of the murine spinal cord and its vasculature using multimodal (optical and acoustic) imaging techniques could significantly advance preclinical studies of the spinal cord.  ...  The views expressed in this manuscript do not necessarily reflect those of the Ontario Ministry of Health and Long Term Care (OMHLTC). Dr.  ... 
doi:10.1371/journal.pone.0058081 pmid:23516432 pmcid:PMC3597636 fatcat:6nk45iixebf2fnydg24vtrhaw4

OncoSpineSeg: A Software Tool for a Manual Segmentation of Computed Tomography of the Spine on Cancer Patients [chapter]

Silvia Ruiz-España, David Moratal
2017 Computed Tomography - Advanced Applications  
This chapter presents the design of a MATLAB-based software for the manual segmentation of the spine.  ...  A precise segmentation of the spine is important as a first stage in any automatic diagnosis task.  ...  The authors thank Dr. Estanislao Arana for his collaboration.  ... 
doi:10.5772/intechopen.68552 fatcat:medlsudid5c55lydc6j2kx3en4
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