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Liver Vessels Segmentation Using a Hybrid Geometrical Moments/Graph Cuts Method

S. Esneault, C. Lafon, J.-L. Dillenseger
2010 IEEE Transactions on Biomedical Engineering  
This method represents an original way to introduce a data term as a constraint into the widely used Boykov's graph cuts algorithm and hence, to automate the segmentation.  ...  The method is evaluated and compared with others on a synthetic dataset.  ...  In our actual stage of research, the venous trees and the arterial tree were extracted and displayed separately but a non-rigid registration scheme permitting them to mix together, allowing a fully integrated  ... 
doi:10.1109/tbme.2009.2032161 pmid:19783500 pmcid:PMC2831400 fatcat:2wfbn4xdrvfedbkzx6g7h2o4iq

A two-stage approach for fully automatic segmentation of venous vascular structures in liver CT images

Jens N. Kaftan, Hüseyin Tek, Til Aach, Josien P. W. Pluim, Benoit M. Dawant
2009 Medical Imaging 2009: Image Processing  
In surgical planning, vessel segmentation is often used as basis to support the surgeon in the decision about the location of the cut to be performed and the extent of the liver to be removed, respectively  ...  The segmentation of the hepatic vascular tree in computed tomography (CT) images is important for many applications such as surgical planning of oncological resections and living liver donations.  ...  (note that since the initial lesion segmentation is not perfectly accurate, the liver tissue class might contain also other non-vessel regions in whose separation we are not further interested in).  ... 
doi:10.1117/12.812407 dblp:conf/miip/KaftanTA09 fatcat:ajc5epa6yvaozciybfoxuinfvu

Modeling of the contrast-enhanced perfusion test in liver based on the multi-compartment flow in porous media

Eduard Rohan, Vladimír Lukeš, Alena Jonášová
2018 Journal of Mathematical Biology  
The blood flow is characterized at several scales for which different models are used.  ...  For this purpose, we developed a model of dynamic transport of the contrast fluid through the hierarchies of the perfusion trees.  ...  Multicompartment model of Darcy flow We approximate the flow in lower hierarchies of the arterial and venous trees, including perfusion at the level of tissue parenchyma, using a macroscopic model describing  ... 
doi:10.1007/s00285-018-1209-y pmid:29368273 fatcat:eh3i5c5hr5awjjltr7my5i33ba

Image-based multi-scale modelling and validation of radio-frequency ablation in liver tumours

S. Payne, R. Flanagan, M. Pollari, T. Alhonnoro, C. Bost, D. O'Neill, T. Peng, P. Stiegler
2011 Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences  
This is the first time that such a 'loop' of mathematical modelling and experimental validation in vivo has been performed in this context, and such validation enables us to make quantitative estimates  ...  For non-or minimally invasive modalities, such as RFA, considered here, it is difficult to monitor the treatment in vivo.  ...  The research leading to these results has received funding from the European Community's Seventh Framework Programme under grant agreement no. 223877, project IMPPACT.  ... 
doi:10.1098/rsta.2011.0240 pmid:21969674 fatcat:4wyfa5ly6nhnlayef3mgcb3bwa

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

Sonya A. MacParland, Jeff C. Liu, Xue-Zhong Ma, Brendan T. Innes, Agata M. Bartczak, Blair K. Gage, Justin Manuel, Nicholas Khuu, Juan Echeverri, Ivan Linares, Rahul Gupta, Michael L. Cheng (+21 others)
2018 Nature Communications  
The liver is the largest solid organ in the body and is critical for metabolic and immune functions.  ...  Here we report a map of the cellular landscape of the human liver using single-cell RNA sequencing.  ...  Acknowledgements This research was funded in part by the University of Toronto's Medicine by Design initiative, which receives funding from the Canada First Research Excellence Fund (CFREF) to IDM and  ... 
doi:10.1038/s41467-018-06318-7 pmid:30348985 pmcid:PMC6197289 fatcat:372vka7y2bbg7n46s4druiw6ta

Prediction of venous thromboembolism with machine learning techniques in young-middle-aged inpatients

Hua Liu, Hua Yuan, Yongmei Wang, Weiwei Huang, Hui Xue, Xiuying Zhang
2021 Scientific Reports  
The aim of this study was to develop and externally validate a new prediction model for young-middle-aged people using machine learning methods.  ...  Clinical data sets of young and middle-aged inpatients can be used to accurately predict the risk of VTE with a support vector machine model.  ...  Acknowledgements We are very grateful to all the patient participants for agreeing to take part in this study, and to the clinical research teams at China-Japan Union Hospital (Jilin University, Changchun  ... 
doi:10.1038/s41598-021-92287-9 pmid:34145330 fatcat:7szhymlg5zhklhualurrvapfpm

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

P. Ramachandran, R. Dobie, J. R. Wilson-Kanamori, E. F. Dora, B. E. P. Henderson, N. T. Luu, J. R. Portman, K. P. Matchett, M. Brice, J. A. Marwick, R. S. Taylor, M. Efremova (+16 others)
2019 Nature  
We identify a scar-associated TREM2+CD9+ subpopulation of macrophages, which expands in liver fibrosis, differentiates from circulating monocytes and is pro-fibrogenic.  ...  Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available.  ...  In particular we used SNN graph-based clustering, where the SNN graph was constructed using from 2 to 11 principal components as determined by dataset variability shown in principal components analysis  ... 
doi:10.1038/s41586-019-1631-3 pmid:31597160 pmcid:PMC6876711 fatcat:qtsru747mff37i5uv2vwoxbmnm

Exploitation of Clustering Techniques in Transactional Healthcare Data

Naeem Ahmad Mahoto, Faisal Karim Shaikh, Abdul Qadir Ansari
2014 Mehran University Research Journal of Engineering and Technology  
The challenging issue in this domain is to select adequate data mining algorithm for optimal results.  ...  The best solution of cluster sets among the exploited algorithms is evaluated using clustering quality indexes and is selected to identify the possible subgroups of patients having similar treatment patterns  ...  ACKNOWLEDGEMENTS The authors wish to thank Giulia Bruno and Silvia Chiusano for their fruitful discussions.  ... 
doaj:5ed457d2db484bbe995d4b757ef9d4c9 fatcat:kj7og23pn5anvnlyw3d3xacomu

From whole-organ imaging to in-silico blood flow modeling: A new multi-scale network analysis for revisiting tissue functional anatomy

Pol Kennel, Jules Dichamp, Corinne Barreau, Christophe Guissard, Lise Teyssedre, Jacques Rouquette, Julien Colombelli, Anne Lorsignol, Louis Casteilla, Franck Plouraboué, Andrew D. McCulloch
2020 PLoS Computational Biology  
the vascular graph.  ...  We show how the use of Light-Sheet Fluorescence Microscopy (LSFM) permits whole-organ micro-vascular imaging, analysis and modelling.  ...  Acknowledgments The authors thank P. Weiss, L. Risser, R. Guibert, for helpful discussions. Author Contributions  ... 
doi:10.1371/journal.pcbi.1007322 pmid:32059013 fatcat:rcf5nfa2mnbufmneidmsvvzsra

Analysis of diabetic patients through their examination history

Dario Antonelli, Elena Baralis, Giulia Bruno, Tania Cerquitelli, Silvia Chiusano, Naeem Mahoto
2013 Expert systems with applications  
To measure the relevance of specific examinations for a given disease complication, patient examination data has been represented in the Vector Space Model using the TF-IDF method.  ...  Abstract The analysis of medical data is a challenging task for health care systems since a huge amount of interesting knowledge can be automatically mined to effectively support both physicians and health  ...  Acknowledgments The authors wish to thank Dr. Baudolino Mussa and Dr. Dario Bellomo for their advice and fruitfull discussions.  ... 
doi:10.1016/j.eswa.2013.02.006 fatcat:oavisp4e3fcezbnrch73e2crkm

Contrast enhanced delayed myocardial enhancement in patients with end stage liver cirrhosis – further evidence for cirrhotic cardiomyopathy

Dirk Lossnitzer, Daniel Gotthardt, Stephanie Lehrke, Grigorios Korosoglou, Henning Steen, Peter Sauer, Evangelos Giannitsis, Hugo A Katus
2009 Journal of Cardiovascular Magnetic Resonance  
The use of ICDs in this large patient population is still limited by high costs and possible adverse events including inappropriate discharges and progression of heart failure.  ...  Contrast enhanced cardiovascular magnetic resonance imaging (ceCMR) can detect and quantify myocardial fibrosis in the setting of CMI and might therefore be a valuable tool for a more accurate risk stratification  ...  Conclusion: We presented a robust, accurate and efficient method for the fully automatic delineation of the myocardium contours in LA + SA cine CMR images, which can be used for accurate LV functional  ... 
doi:10.1186/1532-429x-11-s1-p20 fatcat:xhqcck5hyzg2fme57lufknm4w4

Fatty liver in uncomplicated type 2 DM is associated with impaired myocardial HEP metabolism, modulated by myocardial glucose uptake

Jacqueline T Jonker, Rutger Meer, Luuk J Rijzewijk, Adriaan A Lammertsma, Michaela Diamant, Johannes WA Smit, Albert de Roos, Johannes A Romijn, Hildo J Lamb
2009 Journal of Cardiovascular Magnetic Resonance  
Myocardial siderosis is the main cause of morbidity and mortality in thalassaemia major. In the United Kingdom approximately 50% of patients die before reaching 35 years.  ...  The cardiomyopathy is reversible if chelation is commenced early but diagnosis is often delayed due to the late onset of symptoms.  ...  Conclusion: We have demonstrated a rapid method of T2-mapping for quantitative detection of myocardial edema.  ... 
doi:10.1186/1532-429x-11-s1-p93 fatcat:gbghnbwlcjd5jpws5efxrjkqfq

Structural and hemodynamic properties in murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension [article]

Megan J. Chambers, Mitchel J. Colebank, M Umar Qureshi, Rachel Clipp, Mette S. Olufsen
2020 arXiv   pre-print
Each arterial network is modeled as a directed graph representing vessels along the principal pathway to ensure perfusion of all lobes.  ...  Specific attention is devoted to developing a tool that processes CT images, generating subject-specific arterial networks in which 1D fluid dynamics modeling is used to predict blood pressure and flow  ...  Acknowledgements The study was supported in part by the National Science Foundation via awards nsf-dms 1246991 and 1615820, and the American Heart Association Predoctoral fellowship 19PRE34380459.  ... 
arXiv:2002.08416v1 fatcat:gyh5caydwfc7ddzijy2lk7qwme

Chemical Constituents of Sandbox Tree (Hura crepitans Linn.) and Anti-hepatotoxic Activity of the Leaves and Stem Bark Extracts

GK Oloyede, OA Adaramoye, MB Olatinwo
2016 West Indian Medical Journal  
Objectives: The use of natural products derived from plants for therapeutic purpose is as ancient as human civilization. Sandbox tree, Hura crepitans L.  ...  Phytomicrographs of the liver samples were also taken and analyzed.  ...  ALT is majorly found in the liver while AST is found in the liver, kidney and brain.  ... 
doi:10.7727/wimj.2015.247 fatcat:5xeoverk7nbs5gedhe3li32nwm

Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations

Lars Ole Schwen, Arne Schenk, Clemens Kreutz, Jens Timmer, María Matilde Bartolomé Rodríguez, Lars Kuepfer, Tobias Preusser, Manlio Vinciguerra
2015 PLoS ONE  
The goal of this article is to present a methodology to extend whole-body pharmacokinetics models by a detailed liver model, combining different modeling approaches from the literature.  ...  The mammalian liver plays a key role for metabolism and detoxification of xenobiotics in the body.  ...  Acknowledgments The authors would like to thank Benjamin Knowles, Dipen Parekh for providing and processing the MRI data used for the human liver geometry; and Uta Dahmen, Olaf Dirsch, André Homeyer, Serene  ... 
doi:10.1371/journal.pone.0133653 pmid:26222615 pmcid:PMC4519332 fatcat:4sw6obwquvemzizzrtemwcbayu
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