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Vascular smooth muscle cells remodel collagen matrices by long-distance action and anisotropic interaction

Jeroen van den Akker, Bilge Guvenc Tuna, Adrian Pistea, Arie J. J. Sleutel, Erik N. T. P. Bakker, Ed van Bavel
2012 Medical and Biological Engineering and Computing  
We studied the remodeling of collagen matrices by individual vascular smooth muscle cells (SMCs), clusters and monolayers.  ...  This process involved both 'hauling up' of matrix by the cells and local matrix compaction at a distance from the cells, up to 200 lm.  ...  and the source are credited.  ... 
doi:10.1007/s11517-012-0916-6 pmid:22674440 pmcid:PMC3382645 fatcat:ci62rkbcjvakxgtdmjfxh75gfq

Engineering thick tissues - the vascularisation problem

HCH Ko, BK Milthorpe, CD McFarland
2007 European Cells and Materials  
Approaches that aim to create vasculature in vitro include the use of biological extracellular matrices such as collagen hydrogels, porous biodegradable polymeric scaffolds with macro-and micro-lumens  ...  and micro-channels, co-culture of cells, incorporation of growth factors, culture in dynamic bioreactor environments, and combinations of these.  ...  John Whitelock (University of New South Wales) for discussions on collagen processing, and Prof.  ... 
doi:10.22203/ecm.v014a01 fatcat:yhtaemeevzdijgyknhdou35niu

Engineering thick tissues--the vascularisation problem

Henry C H Ko, Bruce K Milthorpe, Clive D McFarland
2007 European Cells & Materials  
Approaches that aim to create vasculature in vitro include the use of biological extracellular matrices such as collagen hydrogels, porous biodegradable polymeric scaffolds with macro- and micro-lumens  ...  and micro-channels, co-culture of cells, incorporation of growth factors, culture in dynamic bioreactor environments, and combinations of these.  ...  John Whitelock (University of New South Wales) for discussions on collagen processing, and Prof.  ... 
pmid:17654452 fatcat:54g55hdglvg73mgxter3hutaiy

Tissue-Engineered Heart Valves [chapter]

Jillian B. Schmidt, Robert T. Tranquillo
2013 Heart Valves  
acid, have been seeded with autologous differentiated, progenitor or stem cells.  ...  Therefore, efforts are being made to prepare bioartificial heart valves with an autologous biological component by methods of tissue engineering.  ...  Three-dimensional matrices prepared from type I collagen, fibrin or a mixture of collagen and fibrin in a 1:1 ratio with embedded rat aortic smooth muscle cells exhibited a different stress-strain profile  ... 
doi:10.1007/978-1-4614-6144-9_11 fatcat:6dhng7oqknfbbk26fdskxhqmci

Cell-microenvironment interactions and architectures in microvascular systems

Simone Bersini, Iman K. Yazdi, Giuseppe Talò, Su Ryon Shin, Matteo Moretti, Ali Khademhosseini
2016 Biotechnology Advances  
In fact, mutual interactions among endothelial cells (ECs), supporting mural cells and organ-specific cells, as well as between ECs and the extracellular matrix, are key driving forces for vascularization  ...  Various approaches currently being applied to study cell-cell/cell-matrix interactions, as well as biochemical/biophysical cues promoting vascularization and their impact on microvascular network formation  ...  in smooth muscle cells.  ... 
doi:10.1016/j.biotechadv.2016.07.002 pmid:27417066 pmcid:PMC5003740 fatcat:cqdaryg6kve7zhmbsurereu2im

Mimicking the physical cues of the ECM in angiogenic biomaterials

Cody O Crosby, Janet Zoldan
2019 Regenerative Biomaterials  
Here, we will review biomaterials that seek to imitate the physical cues that are natively provided by the ECM to encourage the formation of microvasculature in engineered constructs and ischemic tissue  ...  A functional microvascular system is imperative to build and maintain healthy tissue. Impaired microvasculature results in ischemia, thereby limiting the tissue's intrinsic regeneration capacity.  ...  Funding This work was supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (grant number EB007507, awarded to C.O.C.) and the American  ... 
doi:10.1093/rb/rbz003 pmid:30967961 pmcid:PMC6447000 fatcat:zhn2kay2gvg4npwusrf4p6vnjy

Nanotopography-guided tissue engineering and regenerative medicine

Hong Nam Kim, Alex Jiao, Nathaniel S. Hwang, Min Sung Kim, Do Hyun Kang, Deok-Ho Kim, Kahp-Yang Suh
2013 Advanced Drug Delivery Reviews  
These uni-directionally aligned hierarchical nanostructures provide sufficient compliance for dynamic action and mechanical impact by inter-fiber sliding which is aided by deformation of the proteoglycan  ...  Due to multilevel, hierarchical, and staggered organization, ligaments and tendons dissipate abruptly applied mechanical force by slippage between collagen molecules or fibers.  ...  Zorlutuna et al. cultured vascular smooth muscle cells (VSMCs) on collagen films having 332.5 nm, 500 nm, and 650 nm-wide nanogrooves [306] .  ... 
doi:10.1016/j.addr.2012.07.014 pmid:22921841 pmcid:PMC5444877 fatcat:e62tlaasgjbq7nny5uv5thohgu

Biomaterial strategies for alleviation of myocardial infarction

J. R. Venugopal, M. P. Prabhakaran, S. Mukherjee, R. Ravichandran, K. Dan, S. Ramakrishna
2011 Journal of the Royal Society Interface  
[5] physically immobilized vascular endothelial growth factor (VEGF) onto heparinized collagen matrices.  ...  Moreover, PLACL/collagen allows for cell-cell interaction without attenuating the functional activity of cells and cardiacspecific protein expression.  ... 
doi:10.1098/rsif.2011.0301 pmid:21900319 pmcid:PMC3223634 fatcat:rgckiefbmnexbnefa3rjycno4y

Complexity in biomaterials for tissue engineering

Elsie S. Place, Nicholas D. Evans, Molly M. Stevens
2009 Nature Materials  
Centre/bottom: new blood vessels form initially by endothelial cell organization into tubes, which are later stabilized by smooth muscle cells and pericytes.  ...  longe vity of vascular networks 127, 140, 141 .  ...  of cell surface cadherin proteins, biotin-avidin interactions have been used to artificially aggregate cells 28 . f, A range of responses, such as cell adhesion, viability and differentiation, can be  ... 
doi:10.1038/nmat2441 pmid:19458646 fatcat:2pf6rxw6kvgxzhjalry6tiiy2y

How to Make a Heart Valve: From Embryonic Development to Bioengineering of Living Valve Substitutes

D. MacGrogan, G. Luxan, A. Driessen-Mol, C. Bouten, F. Baaijens, J. L. de la Pompa
2014 Cold Spring Harbor Perspectives in Medicine  
The CNIC is supported by the Ministerio de Ciencia e Innovacion (MICINN) and the Pro-CNIC Foundation.  ...  J.L.d.l.P. is funded by Grants SAF2010-17555, RD12/ 0042/0005 (RIC), and RD12/0019/0003 (TER-CEL) from the Spanish Ministry of Economy and Competition (MINECO).  ...  of fibril formation and the distance between adjacent collagen fibrils.  ... 
doi:10.1101/cshperspect.a013912 pmid:25368013 pmcid:PMC4208706 fatcat:ggvxjp6ypbgypks7xnbbfuoesi

Alignment of Cells and Extracellular Matrix Within Tissue- Engineered Substitutes [chapter]

Jean-Michel Bourget, Francois A., Lucie Germain, Maxime Guillemette, Teodor Veres
2013 Advances in Biomaterials Science and Biomedical Applications  
The particular alignment patterns of ECM and cells observed in tissues and organs such as the corneal stroma, vascular smooth muscle cells SMCs , tendons, bones and skeletal muscles are crucial for organ  ...  "nnu Rev Cell Dev "iol. -. [ ] Kanda K, Matsuda T. Mechanical stress-induced orientation and ultrastructural change of smooth muscle cells cultured in three-dimensional collagen lattices.  ... 
doi:10.5772/54142 fatcat:ylkogxsdwrgrresxfxhmsjfu2m

Type I Collagen-Fibrin Mixed Hydrogels: Preparation, Properties and Biomedical Applications

Thibaud Coradin, Kun Wang, Thalie Law, Léa Trichet
2020 Gels  
Among the many biomedical applications of such type I collagen-fibrin mixed gels, those requiring the co-culture of two cell types with distinct affinity for these proteins, such as vascularization of  ...  Type I collagen and fibrin are two essential proteins in tissue regeneration and have been widely used for the design of biomaterials.  ...  Acknowledgments: T.C. and L.T. thank the Centre National de la Recherche Scientifique (CNRS) for supporting their research in this field.  ... 
doi:10.3390/gels6040036 pmid:33092154 pmcid:PMC7709698 fatcat:pyv7qiq6m5fqve6clzmnk5p4qm

Striated muscle function, regeneration, and repair

I. Y. Shadrin, A. Khodabukus, N. Bursac
2016 Cellular and Molecular Life Sciences (CMLS)  
These layers predominantly consist of Type I, II and III collagens synthesized by fibroblasts.  ...  In the heart, Collagen I is the main ECM protein made by cardiac fibroblasts that until recently were believed to be the most dominant cell type in the heart, with different abundances reported in different  ...  EC, endothelial cell. MC, mural cell. SMC, smooth muscle cell.  ... 
doi:10.1007/s00018-016-2285-z pmid:27271751 pmcid:PMC5056123 fatcat:q52gg6622bcp3h4nlcte43fjoi

3D bioprinting for cardiovascular regeneration and pharmacology

Haitao Cui, Shida Miao, Timothy Esworthy, Xuan Zhou, Se-jun Lee, Chengyu Liu, Zu-xi Yu, John P. Fisher, Muhammad Mohiuddin, Lijie Grace Zhang
2018 Advanced Drug Delivery Reviews  
aggregates, cell-laden hydrogels, microcarriers, and decellularized matrices) through a syringe needle in a controlled, filamentous manner to fabricate a 3D architecture [16] .  ...  It has been widely used to create bone, cartilage, neural, and vascularized tissues, cancer models, and, even 4D transformative constructs [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37  ...  Acknowledgment This work is financially supported by NIH Director's New Innovator Award 1DP2EB020549-01.  ... 
doi:10.1016/j.addr.2018.07.014 pmid:30053441 pmcid:PMC6226324 fatcat:sm6h77qaingkrgqyuztqbefeae

Tissue constructs: platforms for basic research and drug discovery

Elliot L. Elson, Guy M. Genin
2015 Interface Focus  
However, interpretation of three-dimensional FPM data is also challenging, especially at low cell concentrations, because anisotropic ECM remodelling gives cells long-range interactions that effectively  ...  ) phenotype is in the direction of smooth muscle cells as suggested by functional and structural criteria Tomasek et al  ...  This work was supported in part by the NIH through grant no. R01 HL109505, and jointly by the NSF and NIH through multiscale modelling grant no. U01EB016422.  ... 
doi:10.1098/rsfs.2015.0095 pmid:26855763 pmcid:PMC4686252 fatcat:pcy76p2phrghxffo43plmpv5hm
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