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Vascular smooth muscle cells remodel collagen matrices by long-distance action and anisotropic interaction
2012
Medical and Biological Engineering and Computing
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We studied the remodeling of collagen matrices by individual vascular smooth muscle cells (SMCs), clusters and monolayers. ...
This process involved both 'hauling up' of matrix by the cells and local matrix compaction at a distance from the cells, up to 200 lm. ...
and the source are credited. ...
doi:10.1007/s11517-012-0916-6
pmid:22674440
pmcid:PMC3382645
fatcat:ci62rkbcjvakxgtdmjfxh75gfq
Engineering thick tissues - the vascularisation problem
2007
European Cells and Materials
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Approaches that aim to create vasculature in vitro include the use of biological extracellular matrices such as collagen hydrogels, porous biodegradable polymeric scaffolds with macro-and micro-lumens ...
and micro-channels, co-culture of cells, incorporation of growth factors, culture in dynamic bioreactor environments, and combinations of these. ...
John Whitelock (University of New South Wales) for discussions on collagen processing, and Prof. ...
doi:10.22203/ecm.v014a01
fatcat:yhtaemeevzdijgyknhdou35niu
Engineering thick tissues--the vascularisation problem
2007
European Cells & Materials
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Approaches that aim to create vasculature in vitro include the use of biological extracellular matrices such as collagen hydrogels, porous biodegradable polymeric scaffolds with macro- and micro-lumens ...
and micro-channels, co-culture of cells, incorporation of growth factors, culture in dynamic bioreactor environments, and combinations of these. ...
John Whitelock (University of New South Wales) for discussions on collagen processing, and Prof. ...
pmid:17654452
fatcat:54g55hdglvg73mgxter3hutaiy
Tissue-Engineered Heart Valves
[chapter]
2013
Heart Valves
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acid, have been seeded with autologous differentiated, progenitor or stem cells. ...
Therefore, efforts are being made to prepare bioartificial heart valves with an autologous biological component by methods of tissue engineering. ...
Three-dimensional matrices prepared from type I collagen, fibrin or a mixture of collagen and fibrin in a 1:1 ratio with embedded rat aortic smooth muscle cells exhibited a different stress-strain profile ...
doi:10.1007/978-1-4614-6144-9_11
fatcat:6dhng7oqknfbbk26fdskxhqmci
Cell-microenvironment interactions and architectures in microvascular systems
2016
Biotechnology Advances
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In fact, mutual interactions among endothelial cells (ECs), supporting mural cells and organ-specific cells, as well as between ECs and the extracellular matrix, are key driving forces for vascularization ...
Various approaches currently being applied to study cell-cell/cell-matrix interactions, as well as biochemical/biophysical cues promoting vascularization and their impact on microvascular network formation ...
in smooth muscle cells. ...
doi:10.1016/j.biotechadv.2016.07.002
pmid:27417066
pmcid:PMC5003740
fatcat:cqdaryg6kve7zhmbsurereu2im
Mimicking the physical cues of the ECM in angiogenic biomaterials
2019
Regenerative Biomaterials
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Here, we will review biomaterials that seek to imitate the physical cues that are natively provided by the ECM to encourage the formation of microvasculature in engineered constructs and ischemic tissue ...
A functional microvascular system is imperative to build and maintain healthy tissue. Impaired microvasculature results in ischemia, thereby limiting the tissue's intrinsic regeneration capacity. ...
Funding This work was supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (grant number EB007507, awarded to C.O.C.) and the American ...
doi:10.1093/rb/rbz003
pmid:30967961
pmcid:PMC6447000
fatcat:zhn2kay2gvg4npwusrf4p6vnjy
Nanotopography-guided tissue engineering and regenerative medicine
2013
Advanced Drug Delivery Reviews
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These uni-directionally aligned hierarchical nanostructures provide sufficient compliance for dynamic action and mechanical impact by inter-fiber sliding which is aided by deformation of the proteoglycan ...
Due to multilevel, hierarchical, and staggered organization, ligaments and tendons dissipate abruptly applied mechanical force by slippage between collagen molecules or fibers. ...
Zorlutuna et al. cultured vascular smooth muscle cells (VSMCs) on collagen films having 332.5 nm, 500 nm, and 650 nm-wide nanogrooves [306] . ...
doi:10.1016/j.addr.2012.07.014
pmid:22921841
pmcid:PMC5444877
fatcat:e62tlaasgjbq7nny5uv5thohgu
Biomaterial strategies for alleviation of myocardial infarction
2011
Journal of the Royal Society Interface
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[5] physically immobilized vascular endothelial growth factor (VEGF) onto heparinized collagen matrices. ...
Moreover, PLACL/collagen allows for cell-cell interaction without attenuating the functional activity of cells and cardiacspecific protein expression. ...
doi:10.1098/rsif.2011.0301
pmid:21900319
pmcid:PMC3223634
fatcat:rgckiefbmnexbnefa3rjycno4y
Complexity in biomaterials for tissue engineering
2009
Nature Materials
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Centre/bottom: new blood vessels form initially by endothelial cell organization into tubes, which are later stabilized by smooth muscle cells and pericytes. ...
longe vity of vascular networks 127, 140, 141 . ...
of cell surface cadherin proteins, biotin-avidin interactions have been used to artificially aggregate cells 28 . f, A range of responses, such as cell adhesion, viability and differentiation, can be ...
doi:10.1038/nmat2441
pmid:19458646
fatcat:2pf6rxw6kvgxzhjalry6tiiy2y
How to Make a Heart Valve: From Embryonic Development to Bioengineering of Living Valve Substitutes
2014
Cold Spring Harbor Perspectives in Medicine
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The CNIC is supported by the Ministerio de Ciencia e Innovacion (MICINN) and the Pro-CNIC Foundation. ...
J.L.d.l.P. is funded by Grants SAF2010-17555, RD12/ 0042/0005 (RIC), and RD12/0019/0003 (TER-CEL) from the Spanish Ministry of Economy and Competition (MINECO). ...
of fibril formation and the distance between adjacent collagen fibrils. ...
doi:10.1101/cshperspect.a013912
pmid:25368013
pmcid:PMC4208706
fatcat:ggvxjp6ypbgypks7xnbbfuoesi
Alignment of Cells and Extracellular Matrix Within Tissue- Engineered Substitutes
[chapter]
2013
Advances in Biomaterials Science and Biomedical Applications
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The particular alignment patterns of ECM and cells observed in tissues and organs such as the corneal stroma, vascular smooth muscle cells SMCs , tendons, bones and skeletal muscles are crucial for organ ...
"nnu Rev Cell Dev "iol. -. [ ] Kanda K, Matsuda T. Mechanical stress-induced orientation and ultrastructural change of smooth muscle cells cultured in three-dimensional collagen lattices. ...
doi:10.5772/54142
fatcat:ylkogxsdwrgrresxfxhmsjfu2m
Type I Collagen-Fibrin Mixed Hydrogels: Preparation, Properties and Biomedical Applications
2020
Gels
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Among the many biomedical applications of such type I collagen-fibrin mixed gels, those requiring the co-culture of two cell types with distinct affinity for these proteins, such as vascularization of ...
Type I collagen and fibrin are two essential proteins in tissue regeneration and have been widely used for the design of biomaterials. ...
Acknowledgments: T.C. and L.T. thank the Centre National de la Recherche Scientifique (CNRS) for supporting their research in this field. ...
doi:10.3390/gels6040036
pmid:33092154
pmcid:PMC7709698
fatcat:pyv7qiq6m5fqve6clzmnk5p4qm
Striated muscle function, regeneration, and repair
2016
Cellular and Molecular Life Sciences (CMLS)
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These layers predominantly consist of Type I, II and III collagens synthesized by fibroblasts. ...
In the heart, Collagen I is the main ECM protein made by cardiac fibroblasts that until recently were believed to be the most dominant cell type in the heart, with different abundances reported in different ...
EC, endothelial cell. MC, mural cell. SMC, smooth muscle cell. ...
doi:10.1007/s00018-016-2285-z
pmid:27271751
pmcid:PMC5056123
fatcat:q52gg6622bcp3h4nlcte43fjoi
3D bioprinting for cardiovascular regeneration and pharmacology
2018
Advanced Drug Delivery Reviews
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aggregates, cell-laden hydrogels, microcarriers, and decellularized matrices) through a syringe needle in a controlled, filamentous manner to fabricate a 3D architecture [16] . ...
It has been widely used to create bone, cartilage, neural, and vascularized tissues, cancer models, and, even 4D transformative constructs [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37 ...
Acknowledgment This work is financially supported by NIH Director's New Innovator Award 1DP2EB020549-01. ...
doi:10.1016/j.addr.2018.07.014
pmid:30053441
pmcid:PMC6226324
fatcat:sm6h77qaingkrgqyuztqbefeae
Tissue constructs: platforms for basic research and drug discovery
2015
Interface Focus
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However, interpretation of three-dimensional FPM data is also challenging, especially at low cell concentrations, because anisotropic ECM remodelling gives cells long-range interactions that effectively ...
) phenotype is in the direction of smooth muscle cells as suggested by functional and structural criteria Tomasek et al ...
This work was supported in part by the NIH through grant no. R01 HL109505, and jointly by the NSF and NIH through multiscale modelling grant no. U01EB016422. ...
doi:10.1098/rsfs.2015.0095
pmid:26855763
pmcid:PMC4686252
fatcat:pcy76p2phrghxffo43plmpv5hm
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