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Variance decomposition of MRI-based covariance maps using genetically informative samples and structural equation modeling

J. Eric Schmitt, Rhoshel K. Lenroot, Sarah E. Ordaz, Gregory L. Wallace, Jason P. Lerch, Alan C. Evans, Elizabeth C. Prom, Kenneth S. Kendler, Michael C. Neale, Jay N. Giedd
<span title="">2009</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
Using these tools, we produced correlational maps of genetic and environmental (i.e. nongenetic) relationships between several regions of interest and the cortical surface in a large pediatric sample of  ...  Further, using specific gyri with known high heritabilities as seed regions, we found a consistent pattern of high bilateral genetic correlations between structural homologues, with environmental correlations  ...  Acknowledgments This research was supported by NIH grants MH-65322, MH-20030, and DA-18673. Reference List  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2008.06.039">doi:10.1016/j.neuroimage.2008.06.039</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18672072">pmid:18672072</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2996833/">pmcid:PMC2996833</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/m2gyx4eod5gr3onfm6f2fgyo6m">fatcat:m2gyx4eod5gr3onfm6f2fgyo6m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20120206064252/http://www.vipbg.vcu.edu/vipbg/Articles/NEURO-2009-41_VDecompMRICovMaps.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3a/5c/3a5c4f4280c474046c536cd915fc920f1795be9e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2008.06.039"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996833" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Correlation and heritability in neuroimaging datasets: A spatial decomposition approach with application to an fMRI study of twins

Joonkoo Park, Kerby Shedden, Thad A. Polk
<span title="">2012</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
In this work, we develop a statistical method to estimate phenotypic variance and covariance at each location in a spatial process, which in turn can be used to estimate the heritability of a spatial dataset  ...  The method is based on a dimensionally-reduced model of spatial variation in paired images, in which adjusted least squares estimates can be used to estimate the key model parameters.  ...  These values can then be fed into a maximum-likelihood model-fitting algorithm using structural equation modeling (SEM) implemented in Mx in order to estimate genetic and environmental components of phenotypic  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2011.06.066">doi:10.1016/j.neuroimage.2011.06.066</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21763433">pmid:21763433</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3219840/">pmcid:PMC3219840</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mlv7gixgcrbglgfazpw5ttwi2a">fatcat:mlv7gixgcrbglgfazpw5ttwi2a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208064556/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3219840&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/43/78/437846af3ab2995ffdd255ae375ad00a35242e4b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2011.06.066"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219840" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Quantitative Trait Loci: Heritability, Linkage and Association [article]

J. Eric Schmitt
<span title="2017-10-10">2017</span> <i title="Figshare"> Figshare </i> &nbsp;
Talk given during the "Introduction to Imaging Genetics" workshop at the 2012 Organization for Human Brain Mapping (OHBM) conference in in Beijing, 10-14 June.  ...  GOALS AND OBJECTIVES • DEFINE CORE QUANTITATIVE GENETIC CONCEPTS • Provide examples of classic twin and family modeling and several extensions of basic models. • Demonstrate flexibility of likelihood-based  ...  c 2 Covariances also can be used with continuous data • General framework for customizable statistical analysis and hypothesis testing. • Expectations for observed variances, covariances, and means can  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.6084/m9.figshare.5484643">doi:10.6084/m9.figshare.5484643</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yuchh3inozd6jake6jx53vrqiq">fatcat:yuchh3inozd6jake6jx53vrqiq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200213105219/https://s3-eu-west-1.amazonaws.com/pfigshare-u-files/9486262/03_Schmitt_QuantTrait.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/22/3c/223c9795f079381bc3cc1a2b92a49ec9a0d6c8c0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.6084/m9.figshare.5484643"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> figshare.com </button> </a>

The genetics of cortical myelination in young adults and its relationships to cerebral surface area, cortical thickness, and intelligence: A magnetic resonance imaging study of twins and families

J. Eric Schmitt, Armin Raznahan, Siyuan Liu, Michael C. Neale
<span title="2019-10-31">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
In this study, we use a genetically-informative neuroimaging sample of 1096 young adult subjects from the Human Connectome Project in order to investigate genetic and environmental variation in CM and  ...  Relatively novel MRI-derived measures now enable the investigation of cortical myelination in large samples.  ...  Shared genetic and nongenetic factors between SA and CM were then directly tested using genetically-informative bivariate Cholesky decomposition.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2019.116319">doi:10.1016/j.neuroimage.2019.116319</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31678229">pmid:31678229</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7871660/">pmcid:PMC7871660</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zdnkpunppbh3vb6leynsiicbbm">fatcat:zdnkpunppbh3vb6leynsiicbbm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210527043506/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7871660&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/af/6a/af6a1ac06662c5cf13c018de00a6fbdd269d5afa.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2019.116319"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871660" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twin study

Lisa T. Eyler, Elizabeth Prom-Wormley, Christine Fennema-Notestine, Matthew S. Panizzon, Michael C. Neale, Terry L. Jernigan, Bruce Fischl, Carol E. Franz, Michael J. Lyons, Allison Stevens, Jennifer Pacheco, Michele E. Perry (+7 others)
<span title="2010-06-22">2010</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wtsn7qcbmrhjppax2iuhu4xj2m" style="color: black;">Human Brain Mapping</a> </i> &nbsp;
Understanding patterns of genetic covariation among volumes of subcortical structures may provide insight into the development of individual differences that have consequences for cognitive and emotional  ...  Little is known about genetic influences on the volume of subcortical brain structures in adult humans, particularly whether there is regional specificity of genetic effects.  ...  Most importantly, we gratefully acknowledge the cooperation and participation of the members of the Vietnam Era Twin Registry and their families.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.21054">doi:10.1002/hbm.21054</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20572207">pmid:20572207</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3403693/">pmcid:PMC3403693</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xq4ge5quivcwlml2yyqk7shpja">fatcat:xq4ge5quivcwlml2yyqk7shpja</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20110721091607/http://www.vipbg.vcu.edu/vipbg/Articles/2011_%20Genetic_patterns_correlation_HBM.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fb/3a/fb3aa2de9643acc83cad3420ff4073a2c66ba3e4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.21054"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403693" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Structural brain magnetic resonance imaging of pediatric twins

Jay N. Giedd, James Eric Schmitt, Michael C. Neale
<span title="">2007</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wtsn7qcbmrhjppax2iuhu4xj2m" style="color: black;">Human Brain Mapping</a> </i> &nbsp;
Institute of Mental Health and Virginia Commonwealth University is applying structural equation modeling to brain morphometric data acquired via magnetic resonance imaging from a large sample of monozygotic  ...  factors contribute to the development of the cortex in a regional and age specific manner; and (4) shared genetic effects account for more of the variance than structure specific effects.  ...  The use of a large singleton sample can increase precision in the estimates of neuroanatomic variance due to a greater number of observed covariance statistics , as well as withinsubject covariance in  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.20403">doi:10.1002/hbm.20403</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17437295">pmid:17437295</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/grni7ippe5cbxoq3ciwu7ijtya">fatcat:grni7ippe5cbxoq3ciwu7ijtya</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20120327093744/http://www.vipbg.vcu.edu/vipbg/Articles/HBM-strucbrainmritwins-2007.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e1/22/e1225d384741e28c6eef54356f0769040ca5c83d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/hbm.20403"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a>

Genetic network properties of the human cortex based on regional thickness and surface area measures

Anna R. Docherty, Chelsea K. Sawyers, Matthew S. Panizzon, Michael C. Neale, Lisa T. Eyler, Christine Fennema-Notestine, Carol E. Franz, Chi-Hua Chen, Linda K. McEvoy, Brad Verhulst, Ming T. Tsuang, William S. Kremen
<span title="2015-08-20">2015</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/adcuz6lgabeidhngmk32v7egkq" style="color: black;">Frontiers in Human Neuroscience</a> </i> &nbsp;
Biometrical modeling indicated significant shared genetic covariance between size of several of the genetic parcellations.  ...  cortical genetic maps using vertex-wise fuzzy clustering analysis with high spatial resolution.  ...  Univariate ACE Analyses The parcellation-based CT and SA regional measures were analyzed using OpenMx (Boker et al., 2010) , a package for structural equation and other statistical modeling in the R language  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2015.00440">doi:10.3389/fnhum.2015.00440</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26347632">pmid:26347632</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4542323/">pmcid:PMC4542323</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/llmqe5trjrhe5gkozosuded5rm">fatcat:llmqe5trjrhe5gkozosuded5rm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830011615/https://fjfsdata01prod.blob.core.windows.net/articles/files/134229/pubmed-zip/.versions/1/.package-entries/fnhum-09-00440/fnhum-09-00440.pdf?sv=2015-12-11&amp;sr=b&amp;sig=vEVllRizRdIFMWdvaWsaP%2FZhG07vEgeWpH3rQkMqXcU%3D&amp;se=2017-08-30T01%3A16%3A18Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fnhum-09-00440.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/67/b3/67b37aca0f36dd44aa4560e89872e3fa885fb403.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2015.00440"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542323" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The dynamic role of genetics on cortical patterning during childhood and adolescence

J. E. Schmitt, M. C. Neale, B. Fassassi, J. Perez, R. K. Lenroot, E. M. Wells, J. N. Giedd
<span title="2014-04-21">2014</span> <i title="Proceedings of the National Academy of Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nvtuoas5pbdsllkntnhizy4f4q" style="color: black;">Proceedings of the National Academy of Sciences of the United States of America</a> </i> &nbsp;
Using genetically informative latent growth curve modeling of 81,924 measures of cortical thickness, changes in the genetic contributions to cortical development could be visualized across the age range  ...  In the present study we combine these modalities to obtain dynamic anatomical maps of the genetic contributions to cortical thickness through childhood and adolescence.  ...  This work was supported by National Institutes of Health Grants MH-20030 and EB-004311.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1311630111">doi:10.1073/pnas.1311630111</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24753564">pmid:24753564</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4020057/">pmcid:PMC4020057</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uct7s6za5vaztfts4ikql5bhlu">fatcat:uct7s6za5vaztfts4ikql5bhlu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170808070821/http://cerebrum.la/congresomundial/papers/contenido/Jay%20Giedd/Giedd%201.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e3/1c/e31c85484c2c4c4f5e1ac0f74f020d3bcfcde23d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1311630111"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020057" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification of Genetically Mediated Cortical Networks: A Multivariate Study of Pediatric Twins and Siblings

J.E. Schmitt, R.K. Lenroot, G.L. Wallace, S. Ordaz, K.N. Taylor, N. Kabani, D. Greenstein, J.P. Lerch, K.S. Kendler, M.C. Neale, J.N. Giedd
<span title="2008-01-29">2008</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/eeg67t2wzfd3dpiicxsttg3cxi" style="color: black;">Cerebral Cortex</a> </i> &nbsp;
Structural magnetic resonance imaging data from 308 twins, 64 singleton siblings of twins, and 228 singletons were analyzed using structural equation modeling and selected multivariate methods to identify  ...  When covaried for mean global cortical thickness, PCA, cluster analyses, and graph models identified genetically mediated fronto-parietal and occipital networks.  ...  Conflict of Interest : None declared. Address correspondence to Jay N.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/cercor/bhm211">doi:10.1093/cercor/bhm211</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18234689">pmid:18234689</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2790393/">pmcid:PMC2790393</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/a7i73n3jgbephnwburitdkjm3e">fatcat:a7i73n3jgbephnwburitdkjm3e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190226145714/http://pdfs.semanticscholar.org/72df/aef8e85913f1c7c4267ef9d33a7b25f8f5a2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/72/df/72dfaef8e85913f1c7c4267ef9d33a7b25f8f5a2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/cercor/bhm211"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790393" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A multivariate analysis of neuroanatomic relationships in a genetically informative pediatric sample

J. Eric Schmitt, Gregory L. Wallace, Michael A. Rosenthal, Elizabeth A. Molloy, Sarah Ordaz, Rhoshel Lenroot, Liv S. Clasen, Jonathan D. Blumenthal, Kenneth S. Kendler, Michael C. Neale, Jay N. Giedd
<span title="">2007</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
We performed a multivariate statistical genetic analysis on volumetric MRI measures (cerebrum, cerebellum, lateral ventricles, corpus callosum, thalamus, and basal ganglia) from a pediatric sample of 326  ...  Prior twin studies have demonstrated that much of individual differences in human anatomy are caused by genetic differences, but information is limited on whether different structures share common genetic  ...  and structural equation modeling.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2006.04.232">doi:10.1016/j.neuroimage.2006.04.232</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17208460">pmid:17208460</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/a7mbrvkto5e7ta4f6imovbvbea">fatcat:a7mbrvkto5e7ta4f6imovbvbea</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20150209031625/http://www.vipbg.vcu.edu:80/vipbg/Articles/Neuroimage-geninfped-2007.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0b/d6/0bd6c80a3d1fe7a7f507cbc6ddeb05ecba637e9a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2006.04.232"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a>

The P-factor and its genomic and neural equivalents: an integrated perspective

Emma Sprooten, Barbara Franke, Corina U. Greven
<span title="2021-02-01">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ywuy2l3c7ngernsmmsbttqvzna" style="color: black;">Molecular Psychiatry</a> </i> &nbsp;
Recently, genetic and neuroimaging studies also derived general dimensions that reflect densely correlated genomic and neural effects on behaviour and psychopathology.  ...  This perspective calls for an update of the traditional endophenotype framework, and encourages methodological innovations to improve models of gene-brain-environment relationships in all their complexity  ...  The other authors (ES and CUG) have no conflicts of interest to disclose.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41380-021-01031-2">doi:10.1038/s41380-021-01031-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33526822">pmid:33526822</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8960404/">pmcid:PMC8960404</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/a2hul2k5fvhyzoxoo3ooyynhpu">fatcat:a2hul2k5fvhyzoxoo3ooyynhpu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210207211802/https://www.nature.com/articles/s41380-021-01031-2.pdf?error=cookies_not_supported&amp;code=dbe33c6d-2462-4b34-b577-7a505ce32157" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fc/92/fc9276a3a471e46ad63def5ac5969ef85deec70b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41380-021-01031-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960404" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genetic Correlations Between Brain Volumes and the WAIS-III Dimensions of Verbal Comprehension, Working Memory, Perceptual Organization, and Processing Speed

Daniëlle Posthuma, Wim F. C. Baaré, Hilleke E. Hulshoff Pol, René S. Kahn, Dorret I. Boomsma, Eco J. C. De Geus
<span title="2003-04-01">2003</span> <i title="Cambridge University Press (CUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/byx25tjh45bfdjauet2kqelfcm" style="color: black;">Twin research</a> </i> &nbsp;
Two overlapping samples provided 135 subjects from 60 extended twin families for whom both MRI scans and WAIS III data were available.  ...  W e recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors .  ...  Using Structural Equation Modelling to Decompose the (co-)variance into Genetic and Environmental Components Decomposition of the variances and covariances into genetic (A) and environmental (E) components  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1375/136905203321536254">doi:10.1375/136905203321536254</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/12723999">pmid:12723999</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/r6m3254usrgnhhp64kf7bvadre">fatcat:r6m3254usrgnhhp64kf7bvadre</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170818042138/http://dare.ubvu.vu.nl/bitstream/handle/1871/18181/Posthuma_Twin%20Research_6(2)_2003_u.pdf?sequence=2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b9/36/b9367f03303e85283f24cc9c3b370091de6d38ee.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1375/136905203321536254"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Genetic Correlations Between Brain Volumes and the WAIS-III Dimensions of Verbal Comprehension, Working Memory, Perceptual Organization, and Processing Speed

Daniëlle Posthuma, Wim F. C. Baaré, Hilleke E. Hulshoff Pol, René S. Kahn, Dorret I. Boomsma, Eco J. C. De Geus
<span title="">2003</span> <i title="Cambridge University Press (CUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/byx25tjh45bfdjauet2kqelfcm" style="color: black;">Twin research</a> </i> &nbsp;
Two overlapping samples provided 135 subjects from 60 extended twin families for whom both MRI scans and WAIS III data were available.  ...  W e recently showed that the correlation of gray and white matter volume with full scale IQ and the Working Memory dimension are completely mediated by common genetic factors .  ...  Using Structural Equation Modelling to Decompose the (co-)variance into Genetic and Environmental Components Decomposition of the variances and covariances into genetic (A) and environmental (E) components  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1375/twin.6.2.131">doi:10.1375/twin.6.2.131</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/dnkrokkgxvep3kuwbcggvrfxyu">fatcat:dnkrokkgxvep3kuwbcggvrfxyu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170818042138/http://dare.ubvu.vu.nl/bitstream/handle/1871/18181/Posthuma_Twin%20Research_6(2)_2003_u.pdf?sequence=2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b9/36/b9367f03303e85283f24cc9c3b370091de6d38ee.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1375/twin.6.2.131"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

A Fast, Accurate Two-Step Linear Mixed Model for Genetic Analysis Applied to Repeat MRI Measurements [article]

Qifan Yang, Gennady V. Roshchupkin, Wiro J. Niessen, Sarah E. Medland, Alyssa H. Zhu, Paul M. Thompson, Neda Jahanshad
<span title="2019-03-15">2019</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Genetic associations analysis of such datasets requires methods to properly handle relatedness, population structure and other types of biases introduced by confounders.  ...  Second step provides a faster framework to obtain the effect sizes of covariates in regression model.  ...  Acknowledgements This research has been conducted using the UK Biobank Resource under Application Number '11559' and was funded in part by NIH grant U54 EB020403 from the Big Data to Knowledge (BD2K) Program  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1710.10641v4">arXiv:1710.10641v4</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/22zhrm2fxzhntgna6fsdi2objq">fatcat:22zhrm2fxzhntgna6fsdi2objq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200929131125/https://arxiv.org/ftp/arxiv/papers/1710/1710.10641.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1a/2d/1a2de65e3ea834792ea5d14acedce8fcae147d69.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1710.10641v4" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Genetic architecture of subcortical brain regions: common and region-specific genetic contributions

M. E. Rentería, N. K. Hansell, L. T. Strike, K. L. McMahon, G. I. de Zubicaray, I. B. Hickie, P. M. Thompson, N. G. Martin, S. E. Medland, M. J. Wright
<span title="2014-10-08">2014</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/l7foe5kblzc4ncr5rfdkjntp4y" style="color: black;">Genes, Brain and Behavior</a> </i> &nbsp;
pallidum, hippocampus, amygdala and nucleus accumbens) in a genetically informative sample of adolescents and young adults (N = 1038; mean age = 21.6 ± 3.2 years; including 148 monozygotic and 202 dizygotic  ...  structures, particularly those of the thalamus (0.71 out of 0.88), pallidum (0.52 out of 0.75) and putamen (0.43 out of 0.89).  ...  Acknowledgments We thank the twins for their participation, Kori Johnson and the radiographers for MRI scanning and preprocessing the images, Marlene Grace and Ann Eldridge for twin recruitment. The  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/gbb.12177">doi:10.1111/gbb.12177</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25199620">pmid:25199620</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4241157/">pmcid:PMC4241157</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/a4zjb777rbgktno4fgb3osnlf4">fatcat:a4zjb777rbgktno4fgb3osnlf4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170810070452/https://genepi.qimr.edu.au/contents/p/staff/Renteria_GenesBrain%26Behav_821-830.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ca/a4/caa4149ca78b52c6d0121cbf39c968e1a5e9a403.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/gbb.12177"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241157" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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