Filters








128 Hits in 7.3 sec

A Two-Step Scaffolding Model for Mitotic Chromosome Assembly

Kazuhiro Maeshima, Ulrich K. Laemmli
2003 Developmental Cell  
TopoII␣ and 13S folding-loop model.  ...  Switzerland What then is the process at mitosis that carves out chromosomal bodies from the dispersed chromatin mass of the interphase nucleus?  ...  The model proposes that the centric chromatin serves in prophase as a seed/sink that drives the assembly of interspersed, heterochromatic attachment fragment into the topoII␣-marked chain; it is unclear  ... 
doi:10.1016/s1534-5807(03)00092-3 pmid:12689587 fatcat:2teatmzs4rhmfghu35bsnjza24

Bayesian Nonparametric Models for Biomedical Data Analysis [article]

Tianjian Zhou
2017 arXiv   pre-print
In the same context of using mutation pairs, in order to recover the phylogenetic relationship of subclones, we then develop a Bayesian treed feature allocation model.  ...  Finally, we propose a nonparametric Bayesian approach to monotone missing data in longitudinal studies with non-ignorable missingness.  ...  So the current genome centric definition of tumor heterogeneity could be extended by incorporation of methylation, DNA mutation, and RNA expression data in an integromics model.  ... 
arXiv:1710.09890v1 fatcat:kvjysjkjirgt5dvmusedegibdq

Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches

Vojtech Franc, Jing Zhu, Albert J. R. Heck
2018 Journal of the American Society for Mass Spectrometry  
By placing the observed PTMs in structural models of free C8 and C8 embedded in the MAC, it may be speculated that some of the newly identified modifications may play a role in the MAC formation.  ...  Here, we charted in detail the structural micro-heterogeneity within C8, purified from human plasma, combining high-resolution native mass spectrometry and (glyco)peptide-centric proteomics.  ...  // creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide  ... 
doi:10.1007/s13361-018-1901-6 pmid:29532326 pmcid:PMC6003997 fatcat:sx4wbzndwzdwdlwvmwm75sxlji

A global screen for assembly state changes of the mitotic proteome by SEC-SWATH-MS [article]

Moritz Heusel, Max Frank, Mario Koehler, Sabine Amon, Fabian Frommelt, George Rosenberger, Isabell Bludau, Simran Aulakh, Monika I. Linder, Yansheng Liu, Ben C. Collins, Gstaiger Matthias (+2 others)
2019 bioRxiv   pre-print
The results recall key hallmarks of mitotic complex remodeling and discover new events, such as a new model of nuclear pore complex disassembly, validated by orthogonal methods.  ...  Here, we describe the implementation of an integrated technique to quantify cell state-specific changes in the physical arrangement of protein complexes, concurrently for thousands of proteins and hundreds  ...  In order to minimize time-sensitive artifacts 986 of complex disassembly under dilution, samples were processed independently to achieve a 987 fixed processing time-to-column of 1.5-2 h.  ... 
doi:10.1101/633479 fatcat:5mr4tdeszje3vnlsmtr5cyf3dy

Runtime Adaptation for Autonomic Heterogeneous Computing

Thomas R.W. Scogland, Wu-Chun Feng
2014 2014 14th IEEE/ACM International Symposium on Cluster, Cloud and Grid Computing  
This work has resulted in runtime schedulers capable of automatically detecting and mitigating heterogeneity in physically homogeneous systems through MPI and adaptive coscheduling for physically heterogeneous  ...  This dissertation has also benefitted greatly from the involvement of all current and former members of the SyNeRGy lab. In particular I would like to thank Dr.  ...  We first presented an approach to detecting the symptoms of heterogeneity in homogeneous MPI applications.  ... 
doi:10.1109/ccgrid.2014.23 dblp:conf/ccgrid/ScoglandF14 fatcat:eat26fkykvebnfeqpuuwhhbfbu

Islands of complex DNA are widespread in Drosophila centric heterochromatin

M H Le, D Duricka, G H Karpen
1995 Genetics  
We have investigated the molecular structure of the 1 Mb of centric heterochromatin in the Drosophila minichromosome Dp1187.  ...  Major gaps exist in our knowledge of the nature and overall organization of DNA sequences present in heterochromatin.  ...  processes is minimal.  ... 
pmid:8536977 pmcid:PMC1206727 fatcat:hnvh3pq2tzdozawq3z5li32sgi

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig (+7 others)
2021 Genome Biology  
Our work illustrates the complexity through which genetic variation can drive phenotypic variability between individuals and thereby contribute to complex disease.  ...  in canonical translation initiation and reinitiation rates.  ...  Peer review information Anahita Bishop was the primary editor of this article and managed its editorial process and peer review in collaboration with the rest of the editorial team.  ... 
doi:10.1186/s13059-021-02397-w pmid:34183069 fatcat:b2q3n7vuznaulk4om52gbphewa

The Significance of G Protein-Coupled Receptor Crystallography for Drug Discovery

J. A. Salon, D. T. Lodowski, K. Palczewski
2011 Pharmacological Reviews  
Authorship Contributions Wrote or contributed to the writing of the manuscript: Salon, Lodowski, and Palczewski.  ...  Of additional importance is the 904 SALON ET AL. target-centric modus operandi of the R&D process.  ...  Because the process is target-centric, the content of these libraries reflects the history of prior campaigns.  ... 
doi:10.1124/pr.110.003350 pmid:21969326 pmcid:PMC3186081 fatcat:cote3wvlzvaj7f2ynmitq3eugi

Implementation of Fog computing for reliable E-health applications

Razvan Craciunescu, Albena Mihovska, Mihail Mihaylov, Sofoklis Kyriazakos, Ramjee Prasad, Simona Halunga
2015 2015 49th Asilomar Conference on Signals, Systems and Computers  
in the 1970s.  ...  In addition, we will improve on the performance of such Coded ALOHA protocols in terms of the resource efficiency.  ...  In particular, the device locations are modeled by a modified Thomas cluster process in which the cluster centers are modeled by a PHP instead of a homogeneous PPP.  ... 
doi:10.1109/acssc.2015.7421170 dblp:conf/acssc/CraciunescuMMKP15 fatcat:qm6mki5z6bcvrfimkmqjyrxaxm

Ping-pong beam training for reciprocal channels with delay spread

Elisabeth de Carvalho, Jorgen Bach Andersen
2015 2015 49th Asilomar Conference on Signals, Systems and Computers  
A major challenge lies in the lack of precise knowledge of the process noise parameters.  ...  The processing of streams of data characterizes a wide range of application areas, including signal processing, video coding, image analytics, cryptography, network routing, and network packet processing  ...  In particular, the device locations are modeled by a modified Thomas cluster process in which the cluster centers are modeled by a PHP instead of a homogeneous PPP.  ... 
doi:10.1109/acssc.2015.7421451 dblp:conf/acssc/CarvalhoA15 fatcat:mqokuvnh3zg45licnfbgxyvxfu

Genetics of the ST serotype system in Tetrahymena pyriformis, syngen 1

F S Grass
1972 Genetics  
The time of differentiation is very early in the clonal life cycle, and the output ratio is eccentric.  ...  The pattern of development of the St locus places it in a category with the mating type and H serotype loci.  ...  Presumably a majority of the subnuclei in the macronuclei of the F; hetero- zygotes differentiated so that the St? allele was expressed.  ... 
pmid:4624603 pmcid:PMC1212754 fatcat:t6jvovtmcrdavji667y6so4lya

GENETICS OF THE ST SEROTYPE SYSTEM IN TETRAHYMENA PYRIFORMIS, SYNGEN 1

Frank S Grass
1972 Genetics  
The time of differentiation is very early in the clonal life cycle, and the output ratio is eccentric.  ...  The pattern of development of the St locus places it in a category with the mating type and H serotype loci.  ...  Presumably a majority of the subnuclei in the macronuclei of the F; hetero- zygotes differentiated so that the St? allele was expressed.  ... 
doi:10.1093/genetics/70.4.521 fatcat:h26ik3pfrnczxcsldclb65kzvy

Proximate units in word production: Phonological encoding begins with syllables in Mandarin Chinese but with segments in English

Padraig G. O'Seaghdha, Jenn-Yeu Chen, Train-Min Chen
2010 Cognition  
In this article, we extend the evidence for the language difference by showing that failure to prepare onsets in Mandarin (Experiment 1) applies even to simple monosyllables (Experiments 2-4), and confirm  ...  The language difference arises because syllables are proximate units in Mandarin Chinese, whereas segments are proximate in English and other Indo-European languages.  ...  Acknowledgments The research was supported by the National Science Council of Taiwan NSC-96-2752-H-006-001-PAE and by NIDCD grant R01DC006948.  ... 
doi:10.1016/j.cognition.2010.01.001 pmid:20149354 pmcid:PMC2854551 fatcat:blr7uuylhnazxls4v2ytxrucnu

Defense Advanced Research Projects Agency (Darpa) Fiscal Year 2016 Budget Estimates

Department Of Defense Comptroller's Office
2015 Zenodo  
The Defense Advanced Research Projects Agency (DARPA) FY2016 amounted to $2.868 billion in the President's request to support high-risk, high-reward research.  ...  The Basic Research part of this program focused on the development of new hetero-integration processes and capabilities that were demonstrated in application-specific circuits and transferred into the  ...  -Initiate development of new model-form uncertainty approaches that outperform traditional methods such as the Gaussian Process approach for accurate estimation of Quantities of Interest in physical systems  ... 
doi:10.5281/zenodo.1215366 fatcat:cqn5tyfixjanzp5x3tgfkpedri

Domain-specific languages for modeling and simulation

Tom Warnke
2020
This thesis explores the potential of employing DSLs in modeling and simulation.  ...  Simulation models and simulation experiments are increasingly complex.  ...  With her knowledge and inspiring enthusiasm, she always had the right advice to help me overcome any obstacle on my way to a finished thesis.  ... 
doi:10.18453/rosdok_id00002966 fatcat:44xl3g5wbjgs5gvqcz6tqb5osa
« Previous Showing results 1 — 15 out of 128 results