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Characterization of the cortical myeloarchitecture with inhomogeneous Magnetization Transfer imaging (ihMT)

Fanny Munsch, Gopal Varma, Manuel Taso, Olivier Girard, Arnaud Guidon, Guillaume Duhamel, David C Alsop
2020 NeuroImage  
A recent development of the MT technique, ihMT, has demonstrated greater myelin sensitivity/specificity.  ...  While myelin water imaging and ultra-short TE imaging have not yet been implemented to assess cortical myeloarchitecture, magnetization transfer (MT) shows promise.  ...  This selectivity was further validated by correlation with histological fluorescence microscopy ( Duhamel et al., 2019 ) .  ... 
doi:10.1016/j.neuroimage.2020.117442 pmid:33039620 fatcat:ktx4i6irije4bakqknlwbkqdwm

Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology [article]

Alberto Lazari, Ilona Lipp
2020 bioRxiv   pre-print
single most sensitive strategy to measure myelin with MRI.  ...  Non-invasive microstructural magnetic resonance imaging (MRI) holds the potential to expand and translate these insights to basic and clinical human research, but the sensitivity and specificity of different  ...  We thank Edgar Liberis for his help with curating the online resource, Thomas Wassenaar for his advice on AMSTAR guidelines and Gunther Helms for his input on the macromolecular pool measure.  ... 
doi:10.1101/2020.09.08.286518 fatcat:ouwlfl6jtrbbrm6bqayso3uumy

Magnetization Transfer-Mediated MR Fingerprinting [article]

Daniel J. West, Gastao Cruz, Rui P.A.G. Teixeira, Torben Schneider, Jacques-Donald Tournier, Joseph V. Hajnal, Claudia Prieto, Shaihan J. Malik
2021 arXiv   pre-print
Purpose: Magnetization transfer (MT) and inhomogeneous MT (ihMT) contrasts are used in MRI to provide information about macromolecular tissue content.  ...  In particular, MT is sensitive to macromolecules and ihMT appears to be specific to myelinated tissue.  ...  INTRODUCTION Magnetization transfer (MT) and inhomogeneous MT (ihMT) contrasts are used in MRI to provide information about macromolecular tissue content.  ... 
arXiv:2104.02406v1 fatcat:lh5bbrr4znamvbjzkcuaa5nvey

Mapping the Rest of the Human Connectome: Atlasing the Spinal Cord and Peripheral Nervous System

Andrei Irimia, John Darrell Van Horn
2020 NeuroImage  
Here we recommend a modification to the definition of the human connectome to include the SC and PNS, and argue for the creation of an inclusive atlas to complement current efforts to map the brain's human  ...  However, these efforts are not structured to examine the richness and complexity of the peripheral nervous system (PNS), which arguably forms the (neglected) rest of the connectome.  ...  Other techniques which can be leveraged to image myelin include magnetization transfer imaging (MTI) ( Schmierer et al., 2004 ) , quantitative magnetization transfer MRI (qMT-MRI) ( Ou et al., 2009 )  ... 
doi:10.1016/j.neuroimage.2020.117478 pmid:33160086 pmcid:PMC8485987 fatcat:nje75t2s4bdrpkqpwtouxu73d4

Referee report. For: Silent myelin-weighted magnetic resonance imaging [version 2; peer review: 2 approved, 2 approved with reservations]

Richard Dortch
Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast.  ...  Results: We demonstrated that ihMT ratios comparable to existing, acoustically loud, implementations could be obtained with the silent sequence.  ...  "This variation can at least in part be attributed to the orientation of the head with the main magnetic field. " and "Despite these shortcomings, we showed a strong effect of angle on inverse ihMTR".  ... 
doi:10.21956/wellcomeopenres.17734.r39965 fatcat:msbldl3eqjhltmsfbzoq3jpeki