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Long-term correlations in solar proxies and solar wind parameters [article]

Raffaele Reda, Tommaso Alberti, Francesco Berrilli, Piermarco Giobbi, Luca Giovannelli, Valentina Penza
2021 Zenodo  
Solar variability related to its magnetic activity can be quantified by using synthetic indices (e.g. sunspots number) or physical ones (e.g. chromospheric proxies). In order to connect the long-term solar activity variations to solar wind properties, we use Ca II K index and solar wind OMNI data in the time interval between 1965 and 2019, which almost entirely cover the last 5 solar cycles. A time lag in the correlation between the parameters is found. This time shift seems to show a temporal
more » ... volution over the different solar cycles. The advantage to use a chromospheric proxy opens the possibility to extend the relation found for the Sun to link stellar variability and stellar wind properties in Sun-like stars.
doi:10.5281/zenodo.4565516 fatcat:npbsgnt5ovas7ge7q7binndi3e

The Integrated Environment for Learning Objects Design and Storing in Semantic Web

Valentina Dagiene, Daina Gudoniene, Reda Bartkute
2018 International Journal of Computers Communications & Control  
There is a variety of tools and environments for Learning Objects (LOs) design and delivery as well as learning object repositories (LOR) but the researchers could not find a repository that includes both functions: creation and storing of LOs. A number of different integrated learning systems are suggested for users that demonstrate the variety of e-learning methods and semantic capabilities. LO repository oer.ndma.lt/lor, that we are going to present, is very friendly and interoperable to use
more » ... and assure LO design, search in semantic web, adaptation of the re-used objects and storing. There are no more existing LO repositories with the functionality presented by researchers. Transformation of closed education into open one without existence of well-structured, multifunctional and integrated environment becomes problematic. Authors will present an integrated environment for the LO design, search in semantic web, adaptation and storing of newly designed or re-designed LO. Measures will support the transformation of closed education into open and will assure effective design, re-usability and adaptation of LO in the integrated environment.
doi:10.15837/ijccc.2018.1.3074 fatcat:dlxpkshpk5agpkbf3cimntbyua

Impact of uteroplacental insufficiency on postnatal rat male gonad

Valentina Pampanini, Daniela Germani, Antonella Puglianiello, Jan-Bernd Stukenborg, Ahmed Reda, Iuliia Savchuk, Kristín Rós Kjartansdóttir, Stefano Cianfarani, Olle Söder
2017 Journal of Endocrinology  
Valentina Pampanini received grant support from the Sällskapet Barnavård foundation. Figure 1 1 TaqMan Low-Density Array analysis of gene expression in IUGR and sham animals at 5, 20 and 40 dpp.  ... 
doi:10.1530/joe-16-0418 pmid:27885054 pmcid:PMC5184772 fatcat:szdbnf2dezgsza5egp3mz4h6ma

Effect of ethanol on the visual‑evoked potential in rat:dynamics of ON and OFF responses

Redas Dulinskas, Rokas Buisas, Valentina Vengeliene, Osvaldas Ruksenas
2017 Acta Neurobiologiae Experimentalis  
The effect of acute ethanol administration on the flash visual-evoked potential (VEP) was investigated in numerous studies. However, it is still unclear which brain structures are responsible for the differences observed in stimulus onset (ON) and offset (OFF) responses and how these responses are modulated by ethanol. The aim of our study was to investigate the pattern of ON and OFF responses in the visual system, measured as amplitude and latency of each VEP component following acute
more » ... ation of ethanol. VEPs were recorded at the onset and offset of a 500 ms visual stimulus in anesthetized male Wistar rats. The effect of alcohol on VEP latency and amplitude was measured for one hour after injection of 2 g/kg ethanol dose. Three VEP components -N63, P89 and N143 -were analyzed. Our results showed that, except for component N143, ethanol increased the latency of both ON and OFF responses in a similar manner. The latency of N143 during OFF response was not affected by ethanol but its amplitude was reduced. Our study demonstrated that the activation of the visual system during the ON response to a 500 ms visual stimulus is qualitatively different from that during the OFF response. Ethanol interfered with processing of the stimulus duration at the level of the visual cortex and reduced the activation of cortical regions.
doi:10.21307/ane-2017-051 fatcat:vkbmk6slwzb5tcikb5gycemtru

The exoplanetary magnetosphere extension in Sun-like stars based on the solar wind - solar UV relation [article]

Raffaele Reda, Luca Giovannelli, Tommaso Alberti, Francesco Berrilli, Luca Bertello, Dario Del Moro, Maria Pia Di Mauro, Piermarco Giobbi, Valentina Penza
2022 arXiv   pre-print
Earth's magnetosphere extension is controlled by solar activity level via solar wind properties. Understanding such a relation in the Solar System is useful to predict the condition of exoplanetary magnetosphere near Sun-like stars. We use measurements of a chromospheric proxy, the Ca II K index, and solar wind OMNI parameters to connect the solar activity variations on the decennial time scales to solar wind properties. The dataset span over the time interval 1965-2021, which almost entirely
more » ... vers the last 5 solar cycles. Using both cross-correlation and mutual information analysis, a 3.2-year lag of the solar wind speed with respect to the Ca II K index is found. Analogously, a 3.6-year lag is found with respect to the dynamic pressure. A correlation between the solar wind dynamic pressure and the solar UV emission is therefore found and used to derive the Earth's magnetopause standoff distance. Moreover, the advantage of using a chromospheric proxy, such as the Ca II K index, opens the possibility to extend the relation found for the Sun to Sun-like stars, by linking stellar variability to stellar wind properties. The model is applied to a sample of Sun-like stars as a case study, where we assume the presence of an Earth-like exoplanet at 1 AU. Finally, we compare our results with previous estimates of the magnetosphere extension for the same set of sun-like stars.
arXiv:2203.01554v1 fatcat:hkqs467f3baptcui6636qejdm4

TH2/TH1 Shift Under Ibrutinib Treatment in Chronic Lymphocytic Leukemia

Maria Cristina Puzzolo, Ilaria Del Giudice, Nadia Peragine, Paola Mariglia, Maria Stefania De Propris, Luca Vincenzo Cappelli, Livio Trentin, Gianluigi Reda, Antonio Cuneo, Stefano Molica, Alfonso Piciocchi, Valentina Arena (+3 others)
2021 Frontiers in Oncology  
Ibrutinib may revert the T-helper (Th)2 polarization observed in chronic lymphocytic leukemia (CLL) by targeting the IL-2-inducible kinase, that shows a significant homology with the Bruton tyrosine kinase. In the front-line GIMEMA LLC1114 trial (ibrutinib+rituximab for 6 months, followed by ibrutinib maintenance), we investigated the modulation of T-cell cytokine production in 208 peripheral blood paired samples from 71 CLL patients: 71 samples prior to treatment (Day 0, D0) and at day +14
more » ... ; n=50), at month +8 (M8; 30), +12 (M12; 25), +18 (M18; 22) and +24 (M24; 10) of treatment. We documented a progressive decrease of CD3+CD4+IL-4+ T cells (Th2), that was significant at M8 and at M12 (p=0.019, p=0.002), a relative increase in the CD3+CD4+IFNγ+ T cells (Th1) and a decrease of CD3+CD4+IL-17+ (Th17) cells that was maintained up to M18 (M8 vs D0 p=0.003, M12 vs D0 p=0.003, M18 vs D0 p=0.004) of ibrutinib treatment. The Th2/Th1 ratio significantly decreased already after 14 days of treatment and was maintained thereafter (D14 vs D0 p=0.037, M8 vs D0 p=0.001, M12 vs D0 p=0.005, M18 vs D0 p=0.002). The Th2/Th1 modulation over time was significant only among patients with unmutated IGHV. The Th2/Th1 ratio below a cut-off of 0.088 at M8 was associated with the achievement of a complete response (CR) (p=0.016). Ibrutinib may shape the CLL T-cell profile, limiting Th2 activation and inducing a shift in the Th2/Th1 ratio. The association between the Th2/Th1 ratio decrease and the CR achievement suggests the in vivo generation of a potential host anti-tumor immune activation induced by ibrutinib.
doi:10.3389/fonc.2021.637186 pmid:33937038 pmcid:PMC8082026 fatcat:tg4hsxvnrzabzlpzktoz7zylz4

THE EFFECTIVENESS OF ACTION OBSERVATION TREATMENT (AOT) IN ALZHEIMER'S DISEASE: BENEFIT ON TEMPORAL ORIENTATION AND VISUO-PRASSIC ABILITIES

Paolo Caffarra, Marta Perini, Valentina Reda, Federica Barocco, Giovanni Michelini, Marco Spallazzi, Di Santo Simona Gabriella, Carlo Caltagirone, Luca Rozzini, Alessandro Padovani, Giovanni Buccino, Di Iulio Fulvia (+2 others)
2016 Alzheimer's & Dementia  
FIGURE 2. Daily Action n. 2: Taking a coffee Conclusions • This preliminary results obtained from at interim analysis of the project indicated that AOT seems to be effective in improving both temporal orientation and visuospatial/constructional impairment in AD. • This therapy tapping the mirror neurons system seems to influence both cognitive and visuo-motor coordination processing. Small SL, Buccino G, Solodkin A. 2012 The mirror neuron system and treatment of stroke. Dev Psychobiol.
doi:10.1016/j.jalz.2016.06.1221 fatcat:i4zlulfuszfkxh66dcizgmxrwi

Quality of life and physicians' perception in myelodysplastic syndromes

Esther Natalie Oliva, Carlo Finelli, Valeria Santini, Antonella Poloni, Vincenzo Liso, Daniela Cilloni, Stefana Impera, Adelmo Terenzi, Alessandro Levis, Agostino Cortelezzi, Riccardo Ghio, Pellegrino Musto (+12 others)
2012 American Journal of Blood Research  
To detect factors associated with quality of life (QOL) of patients with myelodysplastic syndrome (MDS) and to compare the MDS patients' self-assessed QOL with that perceived by their physicians. In an observational, non-interventional, prospective, multicentre study, QOL was evaluated in 148 patients with newly diagnosed low- and intermediate-risk IPSS MDS. QOL measures (QOL-E v.2, LASA and EQ-5D) and patient-related candidate determinants of QOL were assessed for up to 18 months. Patients'
more » ... scores were compared with those obtained by appointed hematologists' assessment and with ECOG performance status (PS). Fatigue was not prevalent at diagnosis, though physical QOL and energy levels were low. Transfusion-dependent patients had worse QOL scores. In multivariate analysis, Hb levels and comorbidities were a major determinant of QOL. Physicians' perception of patients' well-being correlated with patients' QOL. Physicians underestimated the impact of disturbances on patients' QOL, mainly in the MDS-specific components. ECOG PS did not discriminate patients according to QOL status. In conclusion, the association of anemia with QOL is confirmed, while co-morbidities emerge as an independent predictor of QOL in MDS. Fatigue is not a major concern. ECOG PS is not a valuable surrogate of patient's QOL, thus highlighting that physician's judgment of patient's well-being must not substitute patient-reported outcomes. Appropriate questionnaires should be used to assess MDS patients' QOL in order to improve communication and therapeutic choice.
pmid:22762033 pmcid:PMC3384400 fatcat:qyv3llchsbbybfrgkxdklkwtqq

Linked Open Data Validity -- A Technical Report from ISWS 2018 [article]

Tayeb Abderrahmani Ghor, Esha Agrawal, Mehwish Alam, Omar Alqawasmeh, Claudia D'amato, Amina Annane, Amr Azzam, Andrew Berezovskyi, Russa Biswas, Mathias Bonduel, Quentin Brabant, Cristina-iulia Bucur, Elena Camossi, Valentina Anita Carriero, Shruthi Chari (+48 others)
2019 arXiv   pre-print
+ Wikidata Sport q1 0 42 Movies q2 3 6 Culture q3 0 31 Drugs q4 0 482 Life Sciences q5 0 9 Amina Annane, Amr Azzam, Ilkcan Keles, Ludovica Marinucci, Amanda Pacini de Moura, Omar Qawasmeh, Roberto Reda  ...  Using The Force to Solve Linked Data Incompleteness Valentina Anita Carriero, David Chaves Fraga, Arnaud Grall, Lars Heling, Subhi Issa, Thomas Minier, Alberto Moya Loustaunau, Maria-Esther Vidal Following  ... 
arXiv:1903.12554v1 fatcat:e25yvjsucvghzol4uo3omflh7i

Do age, fitness and concomitant medications influence management and outcomes of CLL patients treated with ibrutinib?

Alessandra Tedeschi, Anna Maria Frustaci, Francesca Romana Mauro, Annalisa Chiarenza, Marta Coscia, Stefania Ciolli, Gianluigi Reda, Luca Laurenti, Marzia Varettoni, Roberta Murru, Claudia Baratè, Paolo Sportoletti (+19 others)
2021 Blood Advances  
Gilead: Honoraria, Membership on an entity's Board of Directors or advisory committees -Karyopharm Therapeutics: Research Funding Stefania Ciolli: -Janssen: Honoraria -Abbvie: Research Funding Gianluigi Reda  ... 
doi:10.1182/bloodadvances.2021004824 pmid:34525181 pmcid:PMC8714729 fatcat:5f5n4th4xffipamhmlwqvwhsuy

Development of an International Odor Identification Test for Children: The Universal Sniff Test

Valentin A. Schriever, Eduardo Agosin, Aytug Altundag, Hadas Avni, Helene Cao Van, Carlos Cornejo, Gonzalo de los Santos, Gad Fishman, Claudio Fragola, Marco Guarneros, Neelima Gupta, Robyn Hudson (+24 others)
2018 Journal of Pediatrics  
Objective: The measurement of olfactory function in children is challenging and at present, there is no test that is commonly used. Our objective was to assess olfactory function in children and to create and validate an odor identification test to diagnose olfactory dysfunction in children, which we called the "Universal-Sniff (U-Sniff)" test. Study design: This is a multicenter study involving 19 countries. The "U-Sniff" was developed in three phases including 1760 children age 5-7 years.
more » ... e 1: Identification of potentially recognizable odors; Phase 2: Selection of odorants for the odor identification test; and Phase 3: Evaluation of the test and acquisition of normative data. Test-retest reliability was evaluated in a subgroup of children (n=27) and the test was validated using children with congenital anosmia (n=14). Results: Twelve odors were familiar to children and therefore included in the "U-Sniff". Children scored a mean±SD of 9.88±1.80 points out of 12. Normative data was obtained and reported for each country. The "U-Sniff" demonstrated a high test-retest reliability (r 27 =0.83, p<0.001) and enabled discrimination between normosmia and children with congenital anosmia with a sensitivity of 100% and specificity of 86%. Conclusion: The "U-Sniff" is a valid and reliable method of testing olfaction in children and can be used internationally.
doi:10.1016/j.jpeds.2018.03.011 pmid:29730147 fatcat:x5rkwncrgbb5pc6yum4ttthll4

EFFICACY OF IDELALISIB AND RITUXIMAB IN RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA TREATED OUTSIDE OF CLINICAL TRIALS. A REPORT OF THE GIMEMA WORKING GROUP

Gian Matteo Rigolin, Francesco Cavazzini, Alfonso Piciocchi, Valentina Arena, Andrea Visentin, Gianluigi Reda, Giulia Zamprogna, Francesca Cibien, Orsola Vitagliano, Marta Coscia, Lucia Farina, Gianluca Gaidano (+18 others)
2021 Hematological Oncology  
Alfonso Piciocchi, Valentina Arena, Gian Matteo Rigolin, Francesco Cavazzini, Marco Vignetti, Antonio Cuneo, and Robin Foà analyzed and interpreted the data.  ...  Andrea Visentin, speaker's bureau from Janssen, Abbvie, Italfarmaco, Gilead, Gianluigi Reda, honoraria from AbbVie, Gilead, Janssen.  ... 
doi:10.1002/hon.2861 pmid:33739461 fatcat:twr3rywxyjaqzlrqlvdex2rgim

The landscape of MOOCs and Higher Education in Europe and the USA

Valentina Goglio
2019 Zenodo  
Also framed as a potential tool contributing to build European identity (De Rosa and Reda 2013) MOOCs for credit and CPD USA • emerging trend of micro-credentials and professional short degrees  ...  MOOCs, framed in the "Fear of Missing Out" syndrome (FOMO) Europe • high expectations, but combined with less enthusiasm: a mix of over-caution and fear for the unknown consequences of MOOCs (De Rosa and Reda  ... 
doi:10.5281/zenodo.3232949 fatcat:pz76ujmr2rcq7eoc4ubfvn5d3y

La rivoluzione dei MOOCs: un'analisi di policy framework su scala europea / The MOOCs' (R)evolution. A policy framework analysis at a European level

Rosanna De Rosa Valentina Reda
2014
Academic institutions all over the world, as well as active stakeholders in the field of education and supporting services, are exploring Moocs to try and understand how learning and teaching environments are changing, the outcomes of such a novelty for different countries and audiences, to what extent the Moocs revolution can represent both a unique opportunity to open up education and a new business model. Born to help universities and academic institutions to innovate pedagogical models,
more » ... s are developing along different routes. Using a policy framework analysis approach, this article presents the results of a European survey that questioned both public and private stakeholders on Moocs policy design, objectives and expected outcomes.
doi:10.13128/lea-1824-484x-13850 fatcat:bun5d4xl65brzb5bv6hcbfjw4i

Novi sintaksoni i nomenklaturne preinake u Hrvatskoj (2019.-2020.)

Nenad Jasprica, Željko Švorc
2021 Glasnik Hrvatskog botaničkog društva  
Za vegetacju Hrvatske opisani su za znanost dva nova razreda (Pinetea halepensis i Dittrichietea viscosae), dva reda (Junipero communis-Pinetalia nigrae i Dittrichietalia viscosae), četiri sveze (Salvio  ...  Sveza Phalaridion arundinaceae Kopecký 1961 isključena je iz reda Nasturtio-Glycerietalia Pignatti 1953 jer joj nedostaju dijagnostičke vrste.  ...  Andrija, Viški arhipelag) opisana je zajednica Artemisia arborescens-Coronilla valentina koja je priključena svezi Artemisio arborescentis-Capparidion spinosae.  ... 
doi:10.46232/glashbod.8.2.7 fatcat:hxslmagvpvbtfneewu7wexdcia
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