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VIO: ontology classification and study of vaccine responses given various experimental and analytical conditions

Edison Ong, Peter Sun, Kimberly Berke, Jie Zheng, Guanming Wu, Yongqun He
2019 BMC Bioinformatics  
We then evaluated whether the ontological VIO modeling and VIO-based statistical analysis would contribute to the enhanced vaccine investigation studies and a better understanding of vaccine response mechanisms  ...  Different experimental and analysis conditions were likely contributed to the observed differences.  ...  To further address the hypothesis of how different experimental and analysis conditions affect the outcomes of host responses to vaccines, we applied VIO to standardize and analyze the host responses induced  ... 
doi:10.1186/s12859-019-3194-6 pmid:31865910 pmcid:PMC6927110 fatcat:pirn34j6qzdprdgjh3uv6bbzui

COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning [article]

Edison Ong, Mei U Wong, Anthony Huffman, Yongqun He
2020 biorxiv/medrxiv  
Besides the commonly used S protein, the nsp3 protein has not been tested in any coronavirus vaccine studies and was selected for further investigation.  ...  Our predicted vaccine targets provide new strategies for effective and safe COVID-19 vaccine development.  ...  VIO: Ontology classification and study of vaccine responses given various 434 experimental and analytical conditions. BMC Bioinformatics (2019). doi:10.UniProt Consortium.  ... 
doi:10.1101/2020.03.20.000141 pmid:32511333 pmcid:PMC7239068 fatcat:u3cvsck375cklhkenhnld7m6vi

Rational Vaccine Design by Reverse & Structural Vaccinology and Ontology

Edison Ong, University, My
2021
I developed the Vaccine Investigation Ontology (VIO) for standardized metadata representation for high throughput vaccine OMICS data analysis.  ...  The vaccine antigens selected and optimized by Reverse and Structural Vaccinology in this dissertation are subjected to future experimental verification.  ...  The VIO ontology provides a way to standardize the representation of minimal information standards and metadata representation for vaccine investigations, including both experimental and analytic parts  ... 
doi:10.7302/1424 fatcat:khq2a4zisfexbf7cbmcrqr32fu

AASLD Abstract (pp. 162A–266A)

2004 Hepatology  
and 8 leaks plus stricture for an incidence of 34%.  ...  The diagnostic yield of imaging, and pathology were assessed as was treatment modalities and outcomes.  ...  within the liver under the experimental conditions used.  ... 
doi:10.1002/hep.1840400506 fatcat:n5a3zewdefgs3m7pl3rdzfdqdq

Primary Teachers' Understandings Of The Nature Of Science And The Purposes Of Science Education

Stephen Andrew Lunn
2000
1998, a questionnaire survey of a broader sample; and triangulation between case studies and survey.  ...  Various factors that may underlie a teacher's view of the nature of science are proposed - scientism, naive empiricism, new-age-ism, constructivism, pragmatism, and scepticism.  ...  Assessment of Performance Unit  ... 
doi:10.21954/ou.ro.00004d0b fatcat:x6d6w4v26bcl5dtkcpauatbdzm