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Using neuroimaging to help predict the onset of psychosis

George Gifford, Nicolas Crossley, Paolo Fusar-Poli, Hugo G. Schnack, René S. Kahn, Nikolaos Koutsouleris, Tyrone D. Cannon, Philip McGuire
2017 NeuroImage  
The aim of this review is to assess the potential for neuroimaging measures to facilitate prediction of the onset of psychosis.  ...  Research in this field has mainly involved people at 'ultra-high risk' (UHR) of psychosis, who have a very high risk of developing a psychotic disorder within a few years of presentation to mental health  ...  be useful in predicting the onset of psychosis 110 .  ... 
doi:10.1016/j.neuroimage.2016.03.075 pmid:27039698 fatcat:nylg7ini3zd3lesrhetivcz7gi

Is neuroimaging clinically useful in subjects at high risk for psychosis?

Stefan Borgwardt, André Schmidt
2016 World Psychiatry  
To adequately examine the clinical utility of neuroimaging for the prediction of psychosis onset, a longitudinal analysis of brain changes over time with standardized measures is required.  ...  However, underpowered, cross-sectional study designs without hypothesis-driven strategies have so far impeded the achievement of a neuroimaging-based prediction of psychosis onset.  ...  The goal of the study is to identify multimodal signatures associated with symptom clusters using a data-driven approach that harnesses the power of the collaborative bioresource of the  ... 
doi:10.1002/wps.20333 pmid:27265710 pmcid:PMC4911764 fatcat:3sbr6enyb5copdygubxgq3h5oe

Brain Imaging During the Transition from Psychosis Prodrome to Schizophrenia

Yoonho Chung, Tyrone D. Cannon
2015 Journal of Nervous and Mental Disease  
association with the onset and course of psychosis.  ...  psychosis, effects that can not be explained by exposure to medications or illness chronicity.  ...  Classification and machine learning In addition to its role in investigating dynamic changes in brain structure and function around the time of psychosis onset, neuroimaging may be useful in predicting  ... 
doi:10.1097/nmd.0000000000000286 pmid:25900551 pmcid:PMC4414922 fatcat:k4fl6hbgtvggbbxvm2ejwadyd4

Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice

2019 Schizophrenia Bulletin  
aim of facilitating the prediction of psychosis onset and outcome.  ...  In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with the early stages of psychosis in the hope that these could aid the prediction of onset and clinical  ...  Acknowledgments We would like to thank all participants who took part in the study.  ... 
doi:10.1093/schbul/sbz067 pmid:31424555 pmcid:PMC7043057 fatcat:ooq7qy7ubfh6fd5imkkdn2mixq

The Benefit of Foresight?An Ethical Evaluation of Predictive Testing for Psychosis in Clinical Practice

Natalie M Lane, Stuart A Hunter, Stephen M Lawrie
2020 NeuroImage: Clinical  
Using such models to predict the likelihood of transition to psychosis in individuals known to be at high risk has the potential to meaningfully improve outcomes, principally through facilitating early  ...  We outline the current state of the science of predictive testing for psychosis, with a particular focus on emerging neuroimaging biomarkers.  ...  Neuroimaging biomarkers A number of key neuroimaging biomarkers have been consistently found to predict transition to psychosis.  ... 
doi:10.1016/j.nicl.2020.102228 pmid:32173346 pmcid:PMC7229349 fatcat:mssnihaqzvel7okhbsbiwinbwi

Neuroimaging of schizophrenia: what it reveals about the disease and what it tells us about a patient

Toby T Winton-Brown, Shitij Kapur
2009 Annals of the Academy of Medicine, Singapore  
How do these impact on understanding the patient in front of us? What do they mean for the busy clinician in clinic?  ...  We outline some of the recent findings in neuroimaging research of schizophrenia and consider their potential application in clinical practice.  ...  neurodevelopmental disorder. 6 This has helped build the case for early detection and intervention, where it is thought that vigorous treatment prior to the onset of frank psychosis may ameliorate disease  ... 
pmid:19521645 fatcat:me2brjm5kfcc5jhlvi7z34xl4a

Predictors of schizophrenia spectrum disorders in early-onset first episodes of psychosis: a support vector machine model

Laura Pina-Camacho, Juan Garcia-Prieto, Mara Parellada, Josefina Castro-Fornieles, Ana M. Gonzalez-Pinto, Igor Bombin, Montserrat Graell, Beatriz Paya, Marta Rapado-Castro, Joost Janssen, Inmaculada Baeza, Francisco Del Pozo (+2 others)
2014 European Child and Adolescent Psychiatry  
Acknowledgments The authors would like to thank all participants and their families.  ...  Thus, it makes sense to use this model to investigate the combination of variables at an FEP that would help us to predict a stable diagnostic outcome of SSD.  ...  , and neuroimaging variables (frontal volume) at baseline (i.e. during the FEP) will help us predict a diagnostic outcome of SSD, and (2) the SVM model that includes this combination of variables at baseline  ... 
doi:10.1007/s00787-014-0593-0 pmid:25109600 fatcat:xmnoz3e5tfarvnxdqdcu4abyai

Precision medicine in psychosis: Translating findings from research into clinical practice

S. Galderisi
2021 European psychiatry  
The terminology is increasingly used in psychiatry, and especially in research relevant to the prediction of psychosis onset, response to treatment and functional outcome.  ...  as to the prediction of clinically meaningful outcomes (e.g., psychosis onset, symptomatic and functional outcome, and treatment response).  ...  The terminology is increasingly used in psychiatry, and especially in research relevant to the prediction of psychosis onset, response to treatment and functional outcome.  ... 
doi:10.1192/j.eurpsy.2021.218 fatcat:hiqtn2fr65blbc3z7g3zfafh6m

Third-generation neuroimaging in early schizophrenia: Translating research evidence into clinical utility

Stefan Borgwardt, Paolo Fusar-Poli
2012 British Journal of Psychiatry  
Psychiatric imaging needs to move away from simple investigations of the neurobiology underlying the early phases of schizophrenia to translate imaging findings in the clinical field, targeting clinical  ...  outcomes including transition, remission and response to preventive interventions.  ...  This clinical strategy aims at identifying neural changes occurring prior to the onset of schizophrenia and may improve the ability of neuroimaging to predict clinical outcomes in schizophrenia (for a  ... 
doi:10.1192/bjp.bp.111.103234 pmid:22474231 fatcat:fzjzgi5n4ffdxpbktlmrmjeidm

Magnetic Resonance Imaging and the Prediction of Outcome in First-Episode Schizophrenia: A Review of Current Evidence and Directions for Future Research

P. Dazzan, C. Arango, W. Fleischacker, S. Galderisi, B. Glenthoj, S. Leucht, A. Meyer-Lindenberg, R. Kahn, D. Rujescu, I. Sommer, I. Winter, P. McGuire
2015 Schizophrenia Bulletin  
Conclusion: Neuroimaging data, possibly in combination with other biomarkers of disease, could help stratifying patients with psychoses to generate patient clusters clinically meaningful, and useful to  ...  This article reviewed studies that examined brain structure at illness onset as a predictor of outcome, discusses the limitations of the findings, and highlights the challenges that would need to be addressed  ...  Acknowledgments This work was funded by a grant from the European Commission within the 7th Program (HEALTH-F2-2010-242114). We would also like to thank Prof S.  ... 
doi:10.1093/schbul/sbv024 pmid:25800248 pmcid:PMC4393706 fatcat:nkvj4wohovftxdihtxi6eci7nq

Treatment of Early Onset Schizophrenia: Recent Trends, Challenges and Future Considerations

Nora S. Vyas, Nitin Gogtay
2012 Frontiers in Psychiatry  
Indeed, early detection, identification of relevant biomarkers, coupled with advancing knowledge of the neurochemical and neuroanatomic pathways may help design informed and novel treatment strategies.  ...  Early onset schizophrenia (onset before adulthood) is a rare, severe, and chronic form of schizophrenia.The clinical presentation of schizophrenia at this unusually early age of onset has been associated  ...  There is limited evidence that management and symptom specific treatment of help-seeking prodromal patients may delay or prevent the onset of psychosis; however the uncertainty of course prediction adds  ... 
doi:10.3389/fpsyt.2012.00029 pmid:22485097 pmcid:PMC3317175 fatcat:lteajje6xba6fek4jkp2y5bpeu

Brain Biomarkers of Vulnerability and Progression to Psychosis

Tyrone D. Cannon
2015 Schizophrenia Bulletin  
Identifying predictors and elucidating the fundamental mechanisms underlying onset of psychosis are critical for the development of targeted preemptive interventions.  ...  This article presents a selective review of findings on risk prediction algorithms and potential mechanisms of onset in youth at clinical high-risk for psychosis, focusing principally on recent findings  ...  processes and help to correct this unbalanced cascade. 80 Summary and Conclusion In summary, the CHR paradigm appears to be useful for elucidating predictors and mechanisms of onset of psychosis and  ... 
doi:10.1093/schbul/sbv173 pmid:26656880 pmcid:PMC4960430 fatcat:umkdu25z4fhchk7vttvavpegfm

Progressive Changes in the Development Toward Schizophrenia: Studies in Subjects at Increased Symptomatic Risk

S. J. Wood, C. Pantelis, D. Velakoulis, M. Yucel, A. Fornito, P. D. McGorry
2007 Schizophrenia Bulletin  
In this review, we summarize the extant neuroimaging and neuropsychological studies of people at clinical high risk for psychosis.  ...  Further, a better understanding of the transition period may help the development of novel therapies.  ...  Summary and Conclusions As yet, there are no convincing, replicated, reports of neuroimaging measures that predict the subsequent onset of psychosis.  ... 
doi:10.1093/schbul/sbm149 pmid:18199631 pmcid:PMC2632412 fatcat:4k3nlar3f5asdle2ntfzziivnq

Editorial: Psychosis and Personality Disorders: Do We Need Early Diagnosis for Successful Treatment?

Silvio Bellino, Paola Rocca
2020 Frontiers in Psychiatry  
A core issue of studies of young individuals at risk for psychosis is to improve the ability to detect these subjects at an early phase, before the onset of a first psychotic episode.  ...  the predictive value of specific clinical, neuropsychological, and neuroimaging factors on prognosis.  ... 
doi:10.3389/fpsyt.2020.00584 pmid:32612548 pmcid:PMC7308528 fatcat:6ydannxcnnh6plpfs3ep2rhrde

Predictors of outcome in early-onset psychosis: a systematic review

Covadonga M Díaz-Caneja, Laura Pina-Camacho, Alberto Rodríguez-Quiroga, David Fraguas, Mara Parellada, Celso Arango
2015 npj Schizophrenia  
Given the global burden of psychotic disorders, the identification of patients with early-onset psychosis (EOP; that is, onset before the age of 18) at higher risk of adverse outcome should be a priority  ...  Higher risk of attempting suicide was predicted by greater severity of psychotic illness and of depressive symptoms at the first episode of psychosis.  ...  obscure the predictive value of age at onset.  ... 
doi:10.1038/npjschz.2014.5 pmid:27336027 pmcid:PMC4849440 fatcat:trkwdolirne3bno2o4q6f4a2ye
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