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Using high-resolution quantitative mapping of R1 as an index of cortical myelination

Antoine Lutti, Frederic Dick, Martin I. Sereno, Nikolaus Weiskopf
2014 NeuroImage  
One exciting development is the advent of fast, high-resolution quantitative mapping of basic MR parameters that reflect cortical myeloarchitecture.  ...  An ongoing challenge is to create noninvasive magnetic resonance (MR) imaging techniques that offer sufficient resolution, tissue contrast, accuracy and precision to allow for characterization of cortical  ...  Cross-species comparisons of cortical myelination would be greatly facilitated by high-resolution R1 mapping.  ... 
doi:10.1016/j.neuroimage.2013.06.005 pmid:23756203 fatcat:eqcrzeu6bzfnzecolxfsogz7iy

Structure predicts function: Combining non-invasive electrophysiology with in-vivo histology

Saskia Helbling, Sundeep Teki, Martina F. Callaghan, William Sedley, Siawoosh Mohammadi, Timothy D. Griffiths, Nikolaus Weiskopf, Gareth R. Barnes
2015 NeuroImage  
We present an approach for combining high resolution MRI-based myelin mapping with functional information from electroencephalography (EEG) or magnetoencephalography (MEG).  ...  The myeloarchitecture was estimated indirectly from individual high resolution quantitative multiparameter maps (MPMs) acquired at 800 μm isotropic resolution.  ...  It effectively combines the high spatial resolution and tissue microstructure specificity of MRI with the high temporal resolution of M/EEG.  ... 
doi:10.1016/j.neuroimage.2014.12.030 pmid:25529007 pmcid:PMC4334663 fatcat:qpronflljvf3tcfvgjs3dhlvui

A comparison of in vivo MRI based cortical myelin mapping using T1w/T2w and R1 mapping at 3T

Zahra Shams, David G. Norris, José P. Marques, Peter Lundberg
2019 PLoS ONE  
In this manuscript, we compare two commonly used methods to perform cortical mapping based on myelination of the human neocortex.  ...  Having parcellated cortical myelin maps into VDG11b areas of 4a, 4p, 3a, 3b, 1, 2, V2, and MT, both methods behave identically with R1 showing an increased variability between subjects.  ...  Exploring the high SNR offered by high field imaging, Geyer et al. (2011) obtained high resolution ex-vivo (0.6 mm isotropic) quantitative T1 maps, using the MP2RAGE sequence [19] , to delineate the  ... 
doi:10.1371/journal.pone.0218089 pmid:31269041 pmcid:PMC6609014 fatcat:qpbtt6gxzzdyhln76ecjt3lq4a

Quantitative MRI Provides Markers Of Intra-, Inter-Regional, And Age-Related Differences In Young Adult Cortical Microstructure [article]

Daniel Carey, Francesco Caprini, Micah Allen, Antoine Lutti, Nikolaus Weiskopf, Geraint Rees, Martina F. Callaghan, Frederic Dick
2017 bioRxiv   pre-print
Our findings afford an improved understanding of ontogeny in early adulthood and offer normative quantitative MR data for inter- and intra-cortical composition, which may be used as benchmarks in further  ...  Here, we used a well-validated quantitative MR protocol to measure four parameters (R1, MT, R2*, PD*) that differ in their sensitivity to facets of the tissue microstructural environment (R1, MT: myelin  ...  As outlined above, an important advance made by our age findings is our use of MPMs that index a range of myelin-related tissue processes.  ... 
doi:10.1101/139568 fatcat:juphrglayjg5vawg74pz6fel4i

Quantitative MRI provides markers of intra-, inter-regional, and age-related differences in young adult cortical microstructure

Daniel Carey, Francesco Caprini, Micah Allen, Antoine Lutti, Nikolaus Weiskopf, Geraint Rees, Martina F. Callaghan, Frederic Dick
2017 NeuroImage  
Here, we used a well-validated quantitative  ...  Measuring the structural composition of the cortex is critical to understanding typical development, yet few investigations in humans have charted markers in vivo that are sensitive to tissue microstructural  ...  As outlined above, an important advance made by our age findings is our use of MPMs that index a range of myelin-related tissue processes.  ... 
doi:10.1016/j.neuroimage.2017.11.066 pmid:29203455 pmcid:PMC6189523 fatcat:fuukgeq6tzdfbkltbr7sohqmei

Mapping an intrinsic MR property of gray matter in auditory cortex of living humans: A possible marker for primary cortex and hemispheric differences

Irina S. Sigalovsky, Bruce Fischl, Jennifer R. Melcher
2006 NeuroImage  
These results indicate that in vivo R1 mapping can provide new insights into the structure of human cortical gray matter and its relation to function. D  ...  Recently, magnetic resonance properties of cerebral gray matter have been spatially mapped -in vivo -over the cortical surface.  ...  the figures, and Thomas Witzel for assistance with manipulations of the probabilistic atlas.  ... 
doi:10.1016/j.neuroimage.2006.05.023 pmid:16806989 pmcid:PMC1839042 fatcat:pjehpurgd5fdtmai7ujrjznvxi

Studying cyto and myeloarchitecture of the human cortex at ultra-high field with quantitative imaging: R 1 , R 2 * and magnetic susceptibility

José P. Marques, Diana Khabipova, Rolf Gruetter
2017 NeuroImage  
A B S T R A C T In this manuscript, the use of quantitative imaging at ultra-high field is evaluated as a mean to study cyto and myelo-architecture of the cortex.  ...  The quantitative contrasts were computed using high resolution in-vivo (0.65mm isotropic) brain data acquired at 7 T.  ...  for providing freesurfer scripts able to use the high spatial resolution MP2RAGE data and Marc Remy for IT support.  ... 
doi:10.1016/j.neuroimage.2016.12.009 pmid:27939794 fatcat:st7wxajt6rf7ffecu5c2wfco5y

The myelin content of the human precentral hand knob reflects inter-individual differences in manual motor control at the physiological and behavioural level

Raffaele Dubbioso, Kristoffer Hougaard Madsen, Axel Thielscher, Hartwig Roman Siebner
2021 Journal of Neuroscience  
Quantitative structural magnetic resonance imaging (MRI) at 3 Tesla yielded regional R1-maps as a proxy of cortical myelin content. Participants also underwent functional MRI.  ...  Our results identify the degree of myelination as an important structural feature of the neocortex that is tightly linked to the function and behaviour supported by the cortical area.  ...  In addition, a whole-brain multiparameter mapping protocol was run to obtain quantitative R1 maps as an index of regional cortical myelination Lutti et al., 2010) .  ... 
doi:10.1523/jneurosci.0390-20.2021 pmid:33653698 pmcid:PMC8026359 fatcat:ihqgxuzmefdfnbzxypy5w5ybdi

Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)

B. Draganski, J. Ashburner, C. Hutton, F. Kherif, R.S.J. Frackowiak, G. Helms, N. Weiskopf
2011 NeuroImage  
We interpret our findings, based on current biophysical models, as a fingerprint of age-dependent brain atrophy and underlying microstructural changes in myelin, iron deposits and water.  ...  The aim of this study is to explore brain tissue properties in normal ageing using quantitative magnetic resonance imaging (MRI) alongside conventional morphological assessment.  ...  Based on technical developments in recent years, whole-brain high-resolution mapping of R1 and R2* relaxation as well as MT can be performed in clinically feasible acquisition times Weiskopf and Helms  ... 
doi:10.1016/j.neuroimage.2011.01.052 pmid:21277375 pmcid:PMC3093621 fatcat:ff53tqdqdbhp7a4vuozx77gr3e

The R1-weighted connectome: complementing brain networks with a myelin-sensitive measure [article]

Tommy Boshkovski, Ljupco Kocarev, Julien Cohen-Adad, Bratislav Misic, Stéphane Lehericy, Nikola Stikov, Matteo Mancini
2020 bioRxiv   pre-print
Many neurological diseases affect the myelin in the white matter, making myelin-sensitive metrics derived from quantitative MRI of potential interest for early detection and prognosis of those conditions  ...  In this work we weight the connectome by the longitudinal relaxation rate (R1) as a measure sensitive to myelin, and then we assess its added value by comparing it with connectomes weighted by the number  ...  R1 is more directly sensitive to myelin compared to NOS that is considered as an index of microstructural fiber count.  ... 
doi:10.1101/2020.08.06.237941 fatcat:qgvfjpftkrcsxe5z7rjsnk5esy

Lifespan maturation and degeneration of human brain white matter

Jason D. Yeatman, Brian A. Wandell, Aviv A. Mezer
2014 Nature Communications  
Quantitative measurements of macromolecule tissue volume (MTV) confirm that R1 is an accurate index of the growth of new brain tissue.  ...  The amount of R1 change during development differs between white-matter fascicles, but in each fascicle the rate of development and decline are mirror-symmetric; the rate of R1 development as the brain  ...  Measurements of macromolecule tissue volume (MTV) confirm that R1 is an accurate index of tissue creation and loss.  ... 
doi:10.1038/ncomms5932 pmid:25230200 pmcid:PMC4238904 fatcat:gxmnthwiwfghjh7lhawnxmhpa4

Individual variability in the human connectome maintains selective cross-modal consistency and shares microstructural signatures [article]

Esin Karahan, Luke Tait, Ruoguang Si, Aysegul Ozkan, Maciek Szul, Jiaxiang Zhang
2021 bioRxiv   pre-print
Variability in connectivity is associated with cortical myelin content and microstructural properties of connections.  ...  Here, by using multimodal imaging data including diffusion MRI, functional MRI and MEG, we show the consistency of interindividual variation of connectivity across modalities.  ...  To relate with microstructure of gray matter, we measured quantitative R1 values as a proxy to myelination on an independent cohort.  ... 
doi:10.1101/2021.04.01.438129 fatcat:o2qdo7lqtfbhdcv7vppknpzwu4

Fast Whole-Brain Three-dimensional Macromolecular Proton Fraction Mapping in Multiple Sclerosis

Vasily L. Yarnykh, James D. Bowen, Alexey Samsonov, Pavle Repovic, Angeli Mayadev, Peiqing Qian, Beena Gangadharan, Bart P. Keogh, Kenneth R. Maravilla, Lily K. Jung Henson
2015 Radiology  
Conclusion: MPF mapping enables quantitative assessment of demyelination in normal-appearing brain tissues and shows primary clinical relevance of GM damage in MS.  ...  Mean MPF, R1, and MT ratio in normal-appearing white matter (WM), gray matter (GM), and lesions were compared between subject groups by using analysis of variance.  ...  An R1 map, an MT-weighted image normalized to a reference image, and field maps are used as input data for the second step (B ).  ... 
doi:10.1148/radiol.14140528 pmid:25208343 pmcid:PMC4314118 fatcat:pft3eqdaozfy7dqbg3ynmppeva

The R1-weighted connectome: complementing brain networks with a myelin-sensitive measure

Tommy Boshkovski, Ljupco Kocarev, Julien Cohen-Adad, Bratislav Mišić, Stéphane Lehéricy, Nikola Stikov, Matteo Mancini
2020 Network Neuroscience  
Additionally, the rank-based analysis shows that R1 can be used to separate transmodal regions (responsible for higher-order functions) from unimodal regions (responsible for low-order functions).  ...  of streamlines (NOS).  ...  The R1-weighted connectome  ... 
doi:10.1162/netn_a_00179 pmid:34189369 pmcid:PMC8233108 fatcat:mpypkv4yl5ds7o4t35i7kqhhti

Multivariate combination of magnetization transfer, T 2 * and B0 orientation to study the myelo-architecture of the in vivo human cortex

G. Mangeat, S.T. Govindarajan, C. Mainero, J. Cohen-Adad
2015 NeuroImage  
The goal of this study was thus to combine MTR and T 2 * using multivariate statistics in order to gain insights into cortical myelin content.  ...  The combination of MTR, T 2 *, CT and B0 orientation may be a useful means to study cortical myeloarchitecture with more specificity than using any of the individual methods.  ...  Recently, (Sereno et al., 2013) have computed high resolution quantitative R1 (inverse of T1) maps from PDw and T1w images according to the formalism developed by Helms et al. (2008) and including  ... 
doi:10.1016/j.neuroimage.2015.06.033 pmid:26095090 pmcid:PMC4564318 fatcat:egqd4gnprvechofdg33kon4udi
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