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Using Voxel-Based Morphometry to Examine Atrophy-Behavior Correlates in Alzheimer's Disease and Frontotemporal Dementia [chapter]

Michael P. Lin, Christian Devita, James C. Gee, Murray Grossman
2002 Lecture Notes in Computer Science  
This comparative work represents an important advance in the diagnostic armamentarium for neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), where no definitive  ...  Voxel-Based Morphometry (VBM) VBM is a voxel-wise comparison of gray matter intensity, where groups of images are normalized, segmented, smoothed, and then compared using voxel-wise statistical parametric  ...  [9] Frontotemporal Dementia (FTD) Frontotemporal dementia, also known as frontotemporal lobar degeneration or Pick's disease, refers to one important form of non-Alzheimer's dementia.  ... 
doi:10.1007/3-540-45786-0_95 fatcat:ssjh5ciqkvatxlcmfmymdenjq4

TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia

J. D. Rohrer, F. Geser, J. Zhou, E. D. Gennatas, M. Sidhu, J. Q. Trojanowski, S. J. DeArmond, B. L. Miller, W. W. Seeley
2010 Neurology  
Voxel-based morphometry was used to assess regional gray matter atrophy in relation to a group of 50 cognitively normal control subjects.  ...  Behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease were seen in type 2 or type 3 pathology.  ...  disorders, and Treatment of Alzheimer's and related diseases with an antibody; and receives research support from the NIH (NIA P01 AG 09215-20 [ Figure 3 3 Figure 3 Voxel-based morphometry analysis  ... 
doi:10.1212/wnl.0b013e318202038c pmid:21172843 pmcid:PMC3013589 fatcat:kkongz5kyjdqljf2scbp45qjsy

Right temporal variant frontotemporal dementia with motor neuron disease

Elizabeth A. Coon, Jennifer L. Whitwell, Joseph E. Parisi, Dennis W. Dickson, Keith A. Josephs
2012 Journal of clinical neuroscience  
Keywords Frontotemporal dementia; Motor neuron disease; TDP-43; Voxel based morphometry (VBM); positron emission tomography (PET  ...  Patterns of atrophy in frontotemporal dementia (FTD) correlate with the clinical subtypes of behavioral variant FTD (bvFTD), semantic dementia, progressive non-fluent aphasia (PNFA) and FTD with motor  ...  The authors would like to acknowledge Dr. Clifford R. Jack, Jr. for the use of his laboratory to perform the VBM analysis.  ... 
doi:10.1016/j.jocn.2011.06.007 pmid:22051030 pmcid:PMC3248959 fatcat:6v5oymc46vb6jnsalr6tick2da

Alzheimer's disease and frontotemporal dementia exhibit distinct atrophy-behavior correlates

James Gee, Lijun Ding, Zhiyong Xie, Michael Lin, Christian DeVita, Murray Grossman
2003 Academic Radiology  
Voxel-based morphometry (VBM) was performed to characterize at the voxel level the neuroanatomic changes that occur in AD and FTD based on high-resolution T1-weighted three-dimensional (3D) spoiled-gradient  ...  The purpose of this study was to test the hypothesis that distinct patterns of gray matter atrophy are responsible for unique interruptions of the naming process in Alzheimer's disease (AD) and frontotemporal  ...  Figure 1 . 1 Gray Matter Atrophy in Alzheimer's Disease and Frontotemporal Dementia. (a) Atrophy in AD relative to healthy seniors; (b) Atrophy in FTD relative to healthy seniors.  ... 
doi:10.1016/s1076-6332(03)00543-9 pmid:14697007 fatcat:v36erxebgnamlpbc2jyo6gofc4

Grey and white matter correlates of disinhibition in behavioural variant frontotemporal dementia and Alzheimer's disease

Michael Hornberger, John Hodges
2011 Alzheimer's & Dementia  
Hayling and CBI scores were entered as covariates in a grey matter voxel-based morphometry (VBM), as well as in a white matter diffusion tensory imaging (DTI) analysis to determine the grey and white matter  ...  P4-099 GREY AND WHITE MATTER CORRELATES OF DISINHIBITION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA AND ALZHEIMER'S DISEASE Michael Hornberger 1 , John Hodges 1 , 1 Neuroscience Research Australia,  ... 
doi:10.1016/j.jalz.2011.05.2120 fatcat:2rfsfwygkbf2zfh42ihhu7vbea

Neuroanatomical Correlates of Emotional Blunting in Behavioral Variant Frontotemporal Dementia and Early-Onset Alzheimer's Disease

Grace J. Lee, Po H. Lu, Michelle J. Mather, Jill Shapira, Elvira Jimenez, Alex D. Leow, Paul M. Thompson, Mario F. Mendez
2014 Journal of Alzheimer's Disease  
The two groups were compared on SEB ratings and MRIderived brain volume using tensor-based morphometry (TBM).  ...  Background-Emotional blunting is a characteristic feature of behavioral variant frontotemporal dementia (bvFTD) and can help discriminate between patients with bvFTD and other forms of younger-onset dementia  ...  Acknowledgments This work was supported by NIH grants K23-AG028727 and R01-AG034499 from the National Institute of Aging (NIA), the Alzheimer's Disease Research Center grant P50 AG-16570, California Alzheimer's  ... 
doi:10.3233/jad-132219 pmid:24685626 pmcid:PMC4111835 fatcat:zhe3oijcyzbkdhml2iqgis4d7e

Voxel-based morphometry patterns of social cognition in PPA and bvFTD

Blas Couto, Sandra Baez, FAcundo Manes, Pablo Richly, Patricia Montañes, Diana Matallana, Pablo Reyes, Agustín Ibañez
2013 Alzheimer's & Dementia  
We investigated the anatomical structures of brain associated with pentagon drawing in sub-jects with mild to moderate Alzheimer's disease (AD) with voxel-based morphometry (VBM).  ...  A voxel-based multiple regression analysis was used to investigate correlation between gray matter loss and pentagon drawing performance of AD patients.  ... 
doi:10.1016/j.jalz.2013.05.1494 fatcat:cdzhbescqvctlpt5p5sa3hh7em

Comparison of Gray Matter Atrophy in Behavioral Variant Frontal Temporal Dementia and Amyotrophic Lateral Sclerosis: A Coordinate-Based Meta-Analysis

Chunyan Luo, Na Hu, Yuan Xiao, Wenjing Zhang, Qiyong Gong, Su Lui
2020 Frontiers in Aging Neuroscience  
The aim of this study was to delineate the common and different patterns of gray matter atrophy associated with bvFTD and with ALS by pooling together the results of previous voxel-based morphometry (VBM  ...  There is growing evidence supporting behavioral variant frontotemporal dementia (bvFTD) and amyotrophic lateral sclerosis (ALS) as extreme points of a disease spectrum.  ...  What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration.  ... 
doi:10.3389/fnagi.2020.00014 pmid:32116647 pmcid:PMC7026505 fatcat:ukrrhbvkk5gutec3m6a4pgs2sy

Neural networks associated with body composition in frontotemporal dementia

Rebekah M. Ahmed, Ramon Landin‐Romero, Cheng T. Liang, Julia M. Keogh, Elana Henning, Cherie Strikwerda‐Brown, Emma M. Devenney, John R. Hodges, Matthew C. Kiernan, I. Sadaf Farooqi, Olivier Piguet
2019 Annals of Clinical and Translational Neurology  
Frontotemporal dementia (FTD) is associated with complex changes in eating behavior and metabolism, which potentially affect disease pathogenesis and survival.  ...  It is currently not known if body composition changes and changes in fat deposition also exist in FTD, the relationship of these changes in eating behavior and appetite, and whether these changes are centrally  ...  Sadaf Farooqi and Olivier Piguet have no disclosures.  ... 
doi:10.1002/acn3.50869 pmid:31461580 pmcid:PMC6764740 fatcat:uh6bjnalfnfkxfbw5uuedya7ty

Ecological Validity and Neuroanatomical Correlates of the NIH EXAMINER Executive Composite Score

Katherine L. Possin, Amanda K. LaMarre, Kristie A. Wood, Dan M. Mungas, Joel H. Kramer
2013 Journal of the International Neuropsychological Society  
In addition, we investigated the neuroanatomical correlates of the Executive Composite using voxel-based morphometry in a sample of 37 participants diagnosed with dementia, mild cognitive impairment, or  ...  The NIH EXAMINER battery was designed to assess executive functions comprehensively and efficiently.  ...  ., for his guidance on the voxel-based morphometry methods, and our research participants for their generous time and efforts. We have no conflicts of interest to report.  ... 
doi:10.1017/s1355617713000611 pmid:23764015 pmcid:PMC4059410 fatcat:klrinbb35ve3hohxgyyegqqmfm

Structural explanation of poor prognosis of amyotrophic lateral sclerosis in the non-demented state

H.-J. Kim, S.-I. Oh, M. de Leon, X. Wang, K.-W. Oh, J.-S. Park, A. Deshpande, M. Buj, S. H. Kim
2016 European Journal of Neurology  
; PNFA, progressive nonfluent aphasia; AD, Alzheimer's disease; VBM, voxel-based morphometry.  ...  Our aim was to investigate the specific patterns of brain atrophy in sporadic, impaired ALS patients without commonly known genetic mutations using voxel-based morphometry.  ...  Voxel-based morphometry analysis Voxel-based morphometry is a fully automated, whole-brain technique for the detection of regional brain atrophy by voxel-wise comparison of gray and white matter volumes  ... 
doi:10.1111/ene.13163 pmid:27753163 pmcid:PMC5436047 fatcat:jvgzeh334vcr3bkx6o6vw37oee

Structural MRI in Frontotemporal Dementia: Comparisons between Hippocampal Volumetry, Tensor-Based Morphometry and Voxel-Based Morphometry

Miguel Ángel Muñoz-Ruiz, Päivi Hartikainen, Juha Koikkalainen, Robin Wolz, Valtteri Julkunen, Eini Niskanen, Sanna-Kaisa Herukka, Miia Kivipelto, Ritva Vanninen, Daniel Rueckert, Yawu Liu, Jyrki Lötjönen (+2 others)
2012 PLoS ONE  
Objective: To compare FTD with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) with three automatic MRI analysis methods -Hippocampal Volumetry (HV), Tensor-based Morphometry (TBM) and Voxel-based  ...  and Voxel-Based Morphometry.  ...  One of the goals of our study was to investigate the advantages of morphometry methods in Alzheimer's disease and Frontotemporal dementia, by estimating gray matter density (VBM) or the shape of the brain  ... 
doi:10.1371/journal.pone.0052531 pmid:23285078 pmcid:PMC3527560 fatcat:zcldu5lslbfo7df4yz62ji2abq

Fronto-Striatal Atrophy in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease

Maxime Bertoux, Claire O'Callaghan, Emma Flanagan, John R. Hodges, Michael Hornberger
2015 Frontiers in Neurology  
Behavioral variant frontotemporal dementia (bvFTD) has only recently been associated with significant striatal atrophy, whereas the striatum appears to be relatively preserved in Alzheimer's disease (AD  ...  In this study, we establish for the first time a profile of fronto-striatal atrophy in 23 bvFTD and 29 AD patients at presentation, based on the structural connectivity of striatal and cortical regions  ...  Acknowledgments We are thankful to Prof. Roger N. Gunn and Dr. Andri C. Tziortzi who provided us the cortico-striatal maps of the Oxford-GSK-Imanova Striatal Connectivity Atlas. We also thank Prof.  ... 
doi:10.3389/fneur.2015.00147 pmid:26191038 pmcid:PMC4486833 fatcat:mbe2chtarfdlzeeicb3z3dt5oy

Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration

G.D. Rabinovici, W.W. Seeley, E.J. Kim, M.L. Gorno-Tempini, K. Rascovsky, T.A. Pagliaro, S.C. Allison, C. Halabi, J.H. Kramer, J.K. Johnson, M.W. Weiner, M.S. Forman (+4 others)
2008 American Journal of Alzheimers Disease & Other Dementias  
To better define the anatomic distinctions between Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), we retrospectively applied voxel-based morphometry to the earliest magnetic resonance  ...  , hippocampus, and amygdala; and patients with both disorders showed atrophy in dorsolateral and orbital prefrontal cortex and lateral temporal cortex (P FWE-corr < .05).  ...  Acknowledgments The authors would like to thank Victoria Beckman, Clarissa Bush, Erin Clevenger, Danijela Pavlic, Mamta Sattavat, Terry Schuck, and Diana Truran for their invaluable technical and administrative  ... 
doi:10.1177/1533317507308779 pmid:18166607 pmcid:PMC2443731 fatcat:h4mqisn7cranpgm6i2dbkliele

Neural correlates of behavioural symptoms in behavioural variant frontotemporal dementia and Alzheimer's disease: Employment of a visual MRI rating scale

Christopher Go, Eneida Mioshi, Belinda Yew, John R. Hodges, Michael Hornberger
2012 Dementia & Neuropsychologia  
correlates of behavioural symptoms in behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD).  ...  Their behavioural profiles were assessed using the Frontal System Behaviour Scale (FrSBe) and cross-correlated to the atrophy of the sub-regions in the prefrontal cortex using a 5-point visual rating scale  ...  A voxel-based morphometry analysis found a correlation between atrophy in prefrontal and temporal cortex regions and the severity of the apathy and disinhibition FrSBe subscores.  ... 
doi:10.1590/s1980-57642012dn06010003 pmid:29213767 pmcid:PMC5619102 fatcat:gndfpzu3snba7ipbr5fbrjmlca
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