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Host metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation [article]

H. Hendrix, M. Kogadeeva, M. Zimmermann, U. Sauer, J. De Smet, L. Muchez, M. Lissens, I. Staes, M. Voet, J. Wagemans, P-J. Ceyssens, J-P. Noben (+2 others)
2019 bioRxiv   pre-print
Qst represents an exquisite example of intricate reprogramming of the bacterium, which may be exploited towards antibiotic target discovery for this bacterial pathogen.  ...  functional interaction network, which includes enzymes of the central carbon metabolism (CoaC/ThiD) and a novel non-ribosomal peptide synthetase pathway (PA1217), suggests a broader functional context for  ...  Since a functional PqsD enzyme is important for efficient LUZ19 349 357 phage infection.  ... 
doi:10.1101/577908 fatcat:7y4n3nqj2naf3en523cnrkvevy

Habitat and taxon as driving forces of carbohydrate catabolism in marine heterotrophic bacteria: example of the model algae-associated bacterium Zobellia galactanivorans DsijT

Tristan Barbeyron, François Thomas, Valérie Barbe, Hanno Teeling, Chantal Schenowitz, Carole Dossat, Alexander Goesmann, Catherine Leblanc, Frank Oliver Glöckner, Mirjam Czjzek, Rudolf Amann, Gurvan Michel
2016 Environmental Microbiology  
PLoS One 3: e1805. 40 Van de Velde, F. (2008) Structure and function of hybrid carrageenans.  ...  efficient degradation of 24 algal laminarin.  ... 
doi:10.1111/1462-2920.13584 pmid:27768819 fatcat:p7dlrwkofnbbdnoga6rof6iiyq

Endoglucanase activity at a second site in Pyrococcus furiosus triosephosphate isomerase-Promiscuity or compensation for a metabolic handicap?

Prerna Sharma, Purnananda Guptasarma
2017 FEBS Open Bio  
It appears, therefore, that two different sites on PfuTIM are responsible for the observed TIM and endoglucanase activities.  ...  Briefly, during some studies on cellulases being engineered to form 'chimeras', we have to use as a control an enzyme, which was expected to display no detectable endoglucanase/cellulase activity of its  ...  EglA is specific for cellulose [4, 15, 16] , and LamA acts preferentially on laminarins while showing only marginal activity upon cellulose [16] .  ... 
doi:10.1002/2211-5463.12249 pmid:28781953 pmcid:PMC5537068 fatcat:lqtat2k6ordfvfyktjin2uhs2e

Cooperative Multiterminal Radar and Communication: A New Paradigm for 6G Mobile Networks

Leonardo Leyva, Daniel Castanheira, Adao Silva, Atilio Gameiro, Lajos Hanzo
2021 IEEE Vehicular Technology Magazine  
We consider an ultra-dense network (UDN) scenario relying on an active multistatic radar configuration and on cooperation between the access points across the entire coverage area.  ...  Furthermore, the merger of a sensing component into wireless communication networks has raised interest in recent years and it may become a compelling design objective for 6G.  ...  waves used for communication could also be used for radar-type sensing [11] [12] .  ... 
doi:10.1109/mvt.2021.3114138 fatcat:qnxn3yadozhmrmzsbkro4e6dke

G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

Stacy Gelhaus Wendell, Hao Fan, Cheng Zhang
2020 Pharmacological Reviews  
Leukotriene antagonists that block the signaling of cysteinyl leukotriene receptor 1 are used as an add-on therapy to reduce bronchoconstriction and inflammation induced by cysteinyl leukotrienes.  ...  SIGNIFICANCE STATEMENT: Although current treatment methods for asthma are effective for a majority of asthma patients, there are still a large number of patients with poorly controlled asthma who may experience  ...  LAMAs are used in combination with LABAs for increasing the efficacy (Rolla and Brussino, 2018) .  ... 
doi:10.1124/pr.118.016899 pmid:31767622 pmcid:PMC6878000 fatcat:kuanpl3ifbh2zj7eri76dfroua

RELATING TO ZOOLOGY AND BOTANY (PRINCIPALLY INVERTEBRATA AND CRYPTOGAMIA), MICROSCOPY, Etc.*

1907 Journal of the Royal Microscopical Society  
Observations on Life-history of Leucocytes.ll-C. E.  ...  Gerlach finds that two directive mitoses alrvays occur. 111 three-fourths of the cases observed only one polar body was to be seen after maturation.  ...  Yegounow by the use of Velox paper obtains good shadow images, for which he details many obvious uses and advantages over drawings made by hand, especially in representing cultures on Petri dishes, ascertaining  ... 
doi:10.1111/j.1365-2818.1907.tb01917.x fatcat:smrdzq5jejhy5fvqa6ijp5t3wu

2A-induced ribosome stalling

Valèrie Odon, Martin Denis Ryan
2014
In this study, extensive site-directed mutagenesis were performed on several 2A sequences and a series of 'hybrid' 2As comprising different consensus motifs juxtaposed with different upstream contexts  ...  ribosome in a way that a specific peptide bond is skipped between the last glycine of 2A and the proline of 2B, thus providing a discontinuity in translation, resulting in release of discrete proteins from one  ...  Ryan designed the visual system to explore the effect of stress on 2A activity, and suggested expressing the translation-regulating factors in bacteria and expressing 2A in Pichia pastoris.  ... 
doi:10.17630/10023-4894 fatcat:sl5eg75veng6nncufxcdqu3k5e

Study of the Evolutionary Role of Nitric Oxide (NO) in the Cephalochordate Amphioxus, "Branchiostoma lanceolatum"

Filomena Caccavale
2018
The study of the promoter regions of these genes can be very useful to identify possible diversities in regulation that can lead those peculiar expression features.  ...  In the present study, the role of the NO in the embryonic development was investigated in the cephalochordate Branchiostoma lanceolatum (amphioxus) with the purpose of acquiring further knowledge on the  ...  in 70% ethanol for in situ hybridization and immunostaining experiments.  ... 
doi:10.21954/ou.ro.0000d5d2 fatcat:anqneoa5vjdjfobtvvmll4ma5q