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Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?

Viviana De Martino, Michela Rossi, Giulia Battafarano, Jessica Pepe, Salvatore Minisola, Andrea Del Fattore
2021 International Journal of Molecular Sciences  
The understanding of the complex biological scenario of the osteosarcoma will open the way for the identification of new targets for its treatment.  ...  However, the drug resistance and the side effects associated with the chemotherapy require the identification of new therapeutic approaches.  ...  effect on tumor cells [134, 135] .  ... 
doi:10.3390/ijms222212586 pmid:34830463 pmcid:PMC8619425 fatcat:2ssyc2h24rhbjklamrq7i3erfq

Osteosarcoma and Metastasis

Gaohong Sheng, Yuan Gao, Yong Yang, Hua Wu
2021 Frontiers in Oncology  
Toward the goal of elaborating the characteristics and biological behavior of metastatic osteosarcoma, it is essential to combine the diverse investigations that are performed at molecular, cellular, and  ...  The aim of this review is to provide an overview of current research advances, with the hope to discovery druggable targets and promising therapy strategies for osteosarcoma metastasis and thus to overcome  ...  Our focus was primarily on the biological behavior and underlying mechanisms of metastasis.  ... 
doi:10.3389/fonc.2021.780264 pmid:34956899 pmcid:PMC8702962 fatcat:l5drh3hbpbesxnhts5litmmr3u

Immune Microenvironment in Osteosarcoma: Components, Therapeutic Strategies and Clinical Applications

Tianyi Zhu, Jing Han, Liu Yang, Zhengdong Cai, Wei Sun, Yingqi Hua, Jing Xu
2022 Frontiers in Immunology  
Here, we summarize the current knowledge of the classification, features, and functions of the main infiltrating cells, complement system, and exosomes in the osteosarcoma immune microenvironment.  ...  To date, the genetic background and oncogenesis mechanisms of osteosarcoma remain unclear, impeding further research.  ...  ACKNOWLEDGMENTS We would like to express sincere gratitude to our colleagues in Shanghai Bone Tumor Institution for their kind support and technical help, including Tao Zhang, Yinghua Gao, Zhuoying Wang  ... 
doi:10.3389/fimmu.2022.907550 pmid:35720360 pmcid:PMC9198725 fatcat:wqdvkhjkfbdxbltwr2wvcziesy

Children's Oncology Group's 2013 blueprint for research: Bone tumors

Richard Gorlick, Katherine Janeway, Stephen Lessnick, R. Lor Randall, Neyssa Marina
2012 Pediatric Blood & Cancer  
In the US, approximately 650 children are diagnosed with osteosarcoma and Ewing sarcoma (ES) each year.  ...  The outcome of patients with localized ES on the most recent COG Gorlick et al.  ...  Analyses that are in process include gene expression studies that have been completed and are currently undergoing bioinformatic analyses, multi-platform analysis of tumor and germline nucleic acids, including  ... 
doi:10.1002/pbc.24429 pmid:23255238 pmcid:PMC4610028 fatcat:wwxmx4rqrrcvhhtqlhu7igirdi

Extracellular Vesicles in Bone Tumors: How to Seed in the Surroundings Molecular Information for Malignant Transformation and Progression

Alfredo Cappariello, Nadia Rucci
2021 Frontiers in Oncology  
In this review, we will discuss the main body of literature describing how the cancer cells use the EVs for their growth into the bone and for educating the bone microenvironment to host metastases.  ...  These are cell-derived nanosized structures shuttling biologically active molecules, such as nucleic acids and proteins.  ...  trials based on the use of EVs.  ... 
doi:10.3389/fonc.2021.722922 pmid:34616676 pmcid:PMC8488258 fatcat:tymbtupc4nbsnitlsbqp6m3lny

Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine

Nicolas Muzzio, Sergio Moya, Gabriela Romero
2021 Pharmaceutics  
Although the development of multifunctional scaffolds and biomaterials is one of the most studied approaches for TERM, all these strategies can be combined among them to develop novel synergistic approaches  ...  The increasing demand for organ replacements in a growing world with an aging population as well as the loss of tissues and organs due to congenital defects, trauma and diseases has resulted in rapidly  ...  influence on cell behavior.  ... 
doi:10.3390/pharmaceutics13060792 pmid:34073311 pmcid:PMC8230126 fatcat:qercq4j2mfadbjhbog6nvjtz44

American Society of Pediatric Hematology/Oncology 23rd Annual Meeting: Abstracts

2010 Pediatric Blood & Cancer  
Objectives: To study the effect of FLLL32 and LLL12 on Osteosarcoma cells in vitro and in vivo.  ...  Severe side effects associated with zoledronic acid use in adults were not seen, including osteonecrosis of the jaw and renal insufficiency.  ... 
doi:10.1002/pbc.22516 fatcat:rkvtc7xadra3zarr5ghn2pt7gu

Breast Cancer Familial Risk [chapter]

Barbara Burwinkel, Yang Rongxi
2011 Encyclopedia of Cancer  
A B cell, or B lymphocyte, is one of the two major types of lymphocytes. The antigen receptor on B lymphocytes, usually called the B-cell receptor, is a cell-surface immunoglobulin.  ...  On activation by antigen, B cells differentiate into cells producing antibody molecules of the same antigen specificity as this receptor.  ...  Zoledronic acid was at least as effective as pamidronate according to the primary end point.  ... 
doi:10.1007/978-3-642-16483-5_6695 fatcat:7c34qkrcbvhstf4qm6sd3caxj4

Novel insights based on the plasticity of γδ T cells in the tumor microenvironment

Yue Wang, Yi Xu, Hui Chen, Jianmin Zhang, Wei He
2022 Exploration of Immunology  
(MHC)-independent manner, thereby activating downstream pleiotropic effects. γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance.  ...  This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. Effective immunity of the body is often manifested by counterbalance under mutual restriction.  ...  In one study, a large metagenomic dataset was used to perform bioinformatics analysis of the biopsy samples of 39 cancer patients (including solid tumors, leukemia, and lymphoma) [67] .  ... 
doi:10.37349/ei.2022.00039 fatcat:jou26rsbtzgexf3gkpftvpcc7i

Breast Cancer Genes BRCA1 and BRCA2 [chapter]

Ashok R. Venkitaraman
2011 Encyclopedia of Cancer  
A B cell, or B lymphocyte, is one of the two major types of lymphocytes. The antigen receptor on B lymphocytes, usually called the B-cell receptor, is a cell-surface immunoglobulin.  ...  They are closely related members of the immunoglobulin gene superfamily and both bind to the CD28 molecule on M. Schwab (ed.  ...  Zoledronic acid was at least as effective as pamidronate according to the primary end point.  ... 
doi:10.1007/978-3-642-16483-5_718 fatcat:3jlvfgomsfevtfxahsl4jnpwuu

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Achilleas D. Theocharis, Spyros S. Skandalis, Thomas Neill, Hinke A.B. Multhaupt, Mario Hubo, Helena Frey, Sandeep Gopal, Angélica Gomes, Nikos Afratis, Hooi Ching Lim, John R. Couchman, Jorge Filmus (+4 others)
2015 Biochimica et Biophysica Acta. CR. Reviews on Cancer  
Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis.  ...  The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior.  ...  Acknowledgements This research has been co-financed by the European Union (European Social Fund -ESF) and Greek National Funds through the Operational Program "Education and Lifelong Learning" of the National  ... 
doi:10.1016/j.bbcan.2015.03.006 pmid:25829250 pmcid:PMC4433619 fatcat:aifpardphza2jmxm6rd44nr2pq

Abstracts of the ECTS Congress 2018

2018 Calcified Tissue International  
These consist of osteonal-like remodeled bone covered by a shell formed through apposition of compact multi-layered lamellae oriented parallel to the periosteal surface.  ...  Somatic activating mutations in MAP2K1 have been recently identified as a cause of melorheostosis, a rare skeletal dysostosis characterized by dense hyperostotic lesions.  ...  Due to anti-neoplastic effect, zoledronic acid (Zol) is used in the adjuvant setting even though other anti-resorptive medications might be as bone effective.  ... 
doi:10.1007/s00223-018-0418-0 pmid:29728722 fatcat:zrpx4rp2srcc7aezjeyg376tqa

Osteoporosis [chapter]

2017 Encyclopedia of Cancer  
These results should be viewed in light of the biological effects of antioxidants in cancer cells.  ...  The immune cells appear to have little if any effect on the growing mass of tumor cells, presumably due to the lack of specifically reactive cells.  ...  Cross-References The guidelines for the treatment of other epithelial tumors such as cystadenoma and adenocarcinomas follow those for the corresponding tumors in adults.  ... 
doi:10.1007/978-3-662-46875-3_4287 fatcat:eqvwh4mlezdxhf3yqk66lueg4u

Profiling Cancer Cells by Cell-SELEX: Use of Aptamers for Discovery of Actionable Biomarkers and Therapeutic Applications Thereof

Sarah Shigdar, Lisa Agnello, Monica Fedele, Simona Camorani, Laura Cerchia
2021 Pharmaceutics  
In this review, we discuss the potential of cell-SELEX for increasing the currently limited repertoire of actionable cancer cell-surface biomarkers and focus on the use of the selected aptamers as components  ...  Thanks to the simplicity, versatility and effectiveness of its application, cell-SELEX (Systematic Evolution of Ligands by Exponential Enrichment) technology is a valid complement to the present strategies  ...  Specifically, dandelion-like tailorable NPs were generated by using an acid-responsive linker to increase their size, which were loaded with the macrophage conditioning agent zoledronic acid and decorated  ... 
doi:10.3390/pharmaceutics14010028 pmid:35056924 pmcid:PMC8781458 fatcat:y6gopujurbavpmcrsqy4n6nv6y

Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight

Anne-Sophie Lamort, Ioanna Giopanou, Ioannis Psallidas, Georgios T. Stathopoulos
2019 Cells  
The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.  ...  On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis.  ...  The bold font indicates the regulation process demonstrated in the lung. Antagonistic effects depending on cell type and disease.  ... 
doi:10.3390/cells8080815 pmid:31382483 pmcid:PMC6721491 fatcat:fm64jupayrdm7i72hlq5sowdza
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