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Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?
2021
International Journal of Molecular Sciences
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The understanding of the complex biological scenario of the osteosarcoma will open the way for the identification of new targets for its treatment. ...
However, the drug resistance and the side effects associated with the chemotherapy require the identification of new therapeutic approaches. ...
effect on tumor cells [134, 135] . ...
doi:10.3390/ijms222212586
pmid:34830463
pmcid:PMC8619425
fatcat:2ssyc2h24rhbjklamrq7i3erfq
Osteosarcoma and Metastasis
2021
Frontiers in Oncology
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Toward the goal of elaborating the characteristics and biological behavior of metastatic osteosarcoma, it is essential to combine the diverse investigations that are performed at molecular, cellular, and ...
The aim of this review is to provide an overview of current research advances, with the hope to discovery druggable targets and promising therapy strategies for osteosarcoma metastasis and thus to overcome ...
Our focus was primarily on the biological behavior and underlying mechanisms of metastasis. ...
doi:10.3389/fonc.2021.780264
pmid:34956899
pmcid:PMC8702962
fatcat:l5drh3hbpbesxnhts5litmmr3u
Immune Microenvironment in Osteosarcoma: Components, Therapeutic Strategies and Clinical Applications
2022
Frontiers in Immunology
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Here, we summarize the current knowledge of the classification, features, and functions of the main infiltrating cells, complement system, and exosomes in the osteosarcoma immune microenvironment. ...
To date, the genetic background and oncogenesis mechanisms of osteosarcoma remain unclear, impeding further research. ...
ACKNOWLEDGMENTS We would like to express sincere gratitude to our colleagues in Shanghai Bone Tumor Institution for their kind support and technical help, including Tao Zhang, Yinghua Gao, Zhuoying Wang ...
doi:10.3389/fimmu.2022.907550
pmid:35720360
pmcid:PMC9198725
fatcat:wqdvkhjkfbdxbltwr2wvcziesy
Children's Oncology Group's 2013 blueprint for research: Bone tumors
2012
Pediatric Blood & Cancer
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In the US, approximately 650 children are diagnosed with osteosarcoma and Ewing sarcoma (ES) each year. ...
The outcome of patients with localized ES on the most recent COG Gorlick et al. ...
Analyses that are in process include gene expression studies that have been completed and are currently undergoing bioinformatic analyses, multi-platform analysis of tumor and germline nucleic acids, including ...
doi:10.1002/pbc.24429
pmid:23255238
pmcid:PMC4610028
fatcat:wwxmx4rqrrcvhhtqlhu7igirdi
Extracellular Vesicles in Bone Tumors: How to Seed in the Surroundings Molecular Information for Malignant Transformation and Progression
2021
Frontiers in Oncology
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In this review, we will discuss the main body of literature describing how the cancer cells use the EVs for their growth into the bone and for educating the bone microenvironment to host metastases. ...
These are cell-derived nanosized structures shuttling biologically active molecules, such as nucleic acids and proteins. ...
trials based on the use of EVs. ...
doi:10.3389/fonc.2021.722922
pmid:34616676
pmcid:PMC8488258
fatcat:tymbtupc4nbsnitlsbqp6m3lny
Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine
2021
Pharmaceutics
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Although the development of multifunctional scaffolds and biomaterials is one of the most studied approaches for TERM, all these strategies can be combined among them to develop novel synergistic approaches ...
The increasing demand for organ replacements in a growing world with an aging population as well as the loss of tissues and organs due to congenital defects, trauma and diseases has resulted in rapidly ...
influence on cell behavior. ...
doi:10.3390/pharmaceutics13060792
pmid:34073311
pmcid:PMC8230126
fatcat:qercq4j2mfadbjhbog6nvjtz44
American Society of Pediatric Hematology/Oncology 23rd Annual Meeting: Abstracts
2010
Pediatric Blood & Cancer
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Objectives: To study the effect of FLLL32 and LLL12 on Osteosarcoma cells in vitro and in vivo. ...
Severe side effects associated with zoledronic acid use in adults were not seen, including osteonecrosis of the jaw and renal insufficiency. ...
doi:10.1002/pbc.22516
fatcat:rkvtc7xadra3zarr5ghn2pt7gu
Breast Cancer Familial Risk
[chapter]
2011
Encyclopedia of Cancer
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A B cell, or B lymphocyte, is one of the two major types of lymphocytes. The antigen receptor on B lymphocytes, usually called the B-cell receptor, is a cell-surface immunoglobulin. ...
On activation by antigen, B cells differentiate into cells producing antibody molecules of the same antigen specificity as this receptor. ...
Zoledronic acid was at least as effective as pamidronate according to the primary end point. ...
doi:10.1007/978-3-642-16483-5_6695
fatcat:7c34qkrcbvhstf4qm6sd3caxj4
Novel insights based on the plasticity of γδ T cells in the tumor microenvironment
2022
Exploration of Immunology
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(MHC)-independent manner, thereby activating downstream pleiotropic effects. γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. ...
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. Effective immunity of the body is often manifested by counterbalance under mutual restriction. ...
In one study, a large metagenomic dataset was used to perform bioinformatics analysis of the biopsy samples of 39 cancer patients (including solid tumors, leukemia, and lymphoma) [67] . ...
doi:10.37349/ei.2022.00039
fatcat:jou26rsbtzgexf3gkpftvpcc7i
Breast Cancer Genes BRCA1 and BRCA2
[chapter]
2011
Encyclopedia of Cancer
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A B cell, or B lymphocyte, is one of the two major types of lymphocytes. The antigen receptor on B lymphocytes, usually called the B-cell receptor, is a cell-surface immunoglobulin. ...
They are closely related members of the immunoglobulin gene superfamily and both bind to the CD28 molecule on M. Schwab (ed. ...
Zoledronic acid was at least as effective as pamidronate according to the primary end point. ...
doi:10.1007/978-3-642-16483-5_718
fatcat:3jlvfgomsfevtfxahsl4jnpwuu
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
2015
Biochimica et Biophysica Acta. CR. Reviews on Cancer
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Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. ...
The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. ...
Acknowledgements This research has been co-financed by the European Union (European Social Fund -ESF) and Greek National Funds through the Operational Program "Education and Lifelong Learning" of the National ...
doi:10.1016/j.bbcan.2015.03.006
pmid:25829250
pmcid:PMC4433619
fatcat:aifpardphza2jmxm6rd44nr2pq
Abstracts of the ECTS Congress 2018
2018
Calcified Tissue International
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These consist of osteonal-like remodeled bone covered by a shell formed through apposition of compact multi-layered lamellae oriented parallel to the periosteal surface. ...
Somatic activating mutations in MAP2K1 have been recently identified as a cause of melorheostosis, a rare skeletal dysostosis characterized by dense hyperostotic lesions. ...
Due to anti-neoplastic effect, zoledronic acid (Zol) is used in the adjuvant setting even though other anti-resorptive medications might be as bone effective. ...
doi:10.1007/s00223-018-0418-0
pmid:29728722
fatcat:zrpx4rp2srcc7aezjeyg376tqa
Osteoporosis
[chapter]
2017
Encyclopedia of Cancer
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These results should be viewed in light of the biological effects of antioxidants in cancer cells. ...
The immune cells appear to have little if any effect on the growing mass of tumor cells, presumably due to the lack of specifically reactive cells. ...
Cross-References The guidelines for the treatment of other epithelial tumors such as cystadenoma and adenocarcinomas follow those for the corresponding tumors in adults. ...
doi:10.1007/978-3-662-46875-3_4287
fatcat:eqvwh4mlezdxhf3yqk66lueg4u
Profiling Cancer Cells by Cell-SELEX: Use of Aptamers for Discovery of Actionable Biomarkers and Therapeutic Applications Thereof
2021
Pharmaceutics
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In this review, we discuss the potential of cell-SELEX for increasing the currently limited repertoire of actionable cancer cell-surface biomarkers and focus on the use of the selected aptamers as components ...
Thanks to the simplicity, versatility and effectiveness of its application, cell-SELEX (Systematic Evolution of Ligands by Exponential Enrichment) technology is a valid complement to the present strategies ...
Specifically, dandelion-like tailorable NPs were generated by using an acid-responsive linker to increase their size, which were loaded with the macrophage conditioning agent zoledronic acid and decorated ...
doi:10.3390/pharmaceutics14010028
pmid:35056924
pmcid:PMC8781458
fatcat:y6gopujurbavpmcrsqy4n6nv6y
Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
2019
Cells
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The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples. ...
On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. ...
The bold font indicates the regulation process demonstrated in the lung. Antagonistic effects depending on cell type and disease. ...
doi:10.3390/cells8080815
pmid:31382483
pmcid:PMC6721491
fatcat:fm64jupayrdm7i72hlq5sowdza
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