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Investigation of the T-cells effect to the prediction of the atherosclerotic plaque development in carotid arteries

Dimitrios S. Pleouras, Michalis D. Mantzaris, Panagiotis K. Siogkas, Vassiliki T. Potsika, Vasilis D. Tsakanikas, Fragiska Sigala, Dimitrios I. Fotiadis
2022 Zenodo  
To this aim, this study investigates the role of T-cells in the atherosclerotic plaque growth process through the implementation of a computational model in realistic carotid arteries.  ...  In brief, T-cells mediate in the inflammatory process by secreting interferon-γ that enhances the activation of macrophages.  ...  This model is separated in three modeling levels: i) simulation of the blood flow, ii) simulations of the biological processes within the arterial wall and iii) simulation of wall thickening.  ... 
doi:10.5281/zenodo.6457637 fatcat:igiuf6tvnjgjnbxzumma3uqfly

Inflammatory processes in cardiovascular disease: a route to targeted therapies

Neil Ruparelia, Joshua T. Chai, Edward A. Fisher, Robin P. Choudhury
2016 Nature Reviews Cardiology  
The specific targeting of these processes in experimental models has been shown to attenuate myocardial and arterial injury, reduce disease progression, and promote healing.  ...  As interest in this field has expanded, one of the main challenges has been the use of the term 'inflammation' to cover a wide variety of processes and observations, some of which are very poorly defined  ...  As discussed above, the underlying pathogenesis of AMI is a complex interaction between multiple biological processes.  ... 
doi:10.1038/nrcardio.2016.185 pmid:27905474 pmcid:PMC5525550 fatcat:z3qdoq3zorgohpoz2wlbodt3ye

GPX-Macrophage Expression Atlas: a database for expression profiles of macrophages challenged with a variety of pro-inflammatory, anti-inflammatory, benign and pathogen insults

Graeme R Grimes, Stuart Moodie, John S Beattie, Marie Craigon, Paul Dickinson, Thorsten Forster, Andrew D Livingston, Muriel Mewissen, Kevin A Robertson, Alan J Ross, Garwin Sing, Peter Ghazal
2005 BMC Genomics  
The macrophage cell is therefore an experimentally and clinically amenable biological system for the mapping of biological pathways.  ...  The GPX Macrophage Expression Atlas (GPX-MEA) is an online resource for gene expression based studies of a range of macrophage cell types following treatment with pathogens and immune modulators.  ...  Their function as a mobile unicellular system make them an ideal biological model for taking a systems perspective to pathway analysis, and in silico models of the macrophage cell and signalling pathway  ... 
doi:10.1186/1471-2164-6-178 pmid:16343346 pmcid:PMC1351201 fatcat:3en4go5v3vatdbdrwv5cvmimy4

Recent progress and perspectives on the mechanisms underlying Asbestos toxicity

Akio Kuroda
2021 Genes and Environment  
Further studies using live-cell imaging techniques will be critical to fully understanding the mechanisms underlying asbestos toxicity.  ...  Based on epidemiological and genetic studies, a carcinogenic model has been proposed in which BRCA1-associated protein 1 mutations are able to suppress cell death in mesothelial cells and increase genomic  ...  Acknowledgements The author thanks Mr. T. Nishimura for the electron microscope image of amosite and Dr. T. Ishida for editing Video 1.  ... 
doi:10.1186/s41021-021-00215-0 pmid:34641979 fatcat:loragt3wbbgc3k7ppi56wd76nm

Atherosclerosis and Nanotechnology: Diagnostic and Therapeutic Applications

Jeremy D. Kratz, Ashish Chaddha, Somnath Bhattacharjee, Sascha N. Goonewardena
2016 Cardiovascular Drugs and Therapy  
Over the past several decades, tremendous advances have been made in the understanding, diagnosis, and treatment of coronary artery disease (CAD).  ...  This review highlights nanotechnology applications for imaging and therapeutic advancements in CAD.  ...  G. was supported by a Samuel and Jean Frankel Cardiovascular Center Inaugural Grant and by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award number K08HL123621  ... 
doi:10.1007/s10557-016-6649-2 pmid:26809711 pmcid:PMC4791194 fatcat:vbxjz3uhybhavmqybsft6svrvq

Two-photon excited imaging of photosensitizers in tissues

Mariah L. Coleno, Vincent P. Wallace, Chung-Ho Sun, Andrew K. Dunn, Michael W. Berns, Bruce J. Tromberg, Daniel L. Farkas, Robert C. Leif, Bruce J. Tromberg
1999 Optical Diagnostics of Living Cells II  
The principal objective of this study was to develop a model system for understanding the impact of photodynamic therapy on cellular and extracellular matrix remodeling in biological tissues.  ...  An artificial tissue model (RAFT) composed of collagen, embedded fibroblasts, and macrophage cells has been developed for this purpose.  ...  EXPERIMENTAL DESIGN One of our goals is to develop an artificial tissue model that can be used to image cells and extracellular matrix material involved in the wound healing process.  ... 
doi:10.1117/12.349217 fatcat:gupvnd3nwfcmfjsyoprw5m4oyy

In Silico Modeling of Biologically Complex Membranes

Helgi I. Ingolfsson, Manuel N. Melo, Svetlana Baoukina, Tsjerk A. Wassenaar, Xavier Periole, Alex H. de Vries, D. Peter Tieleman, Siewert J. Marrink
2016 Biophysical Journal  
In this study we evaluated the influence of anticancer drug colchicine on the disorder and complexity of the macrophage membrane from atomic force microscope (AFM) images.  ...  Processing of AFM images and calculations were done with custom MATLAB code.  ... 
doi:10.1016/j.bpj.2015.11.505 fatcat:236lz7cfvnh35carelmfmys2fe

Advances in Radiopharmaceutical Sciences for Vascular Inflammation Imaging: Focus on Clinical Applications

Kevin Prigent, Jonathan Vigne
2021 Molecules  
The use of novel radiotracers may help to better understand the underlying pathophysiological processes and overcome some limitations of [18F]FDG PET for the imaging of vascular inflammation.  ...  Molecular imaging techniques to assess cellular processes in vivo have been useful in advancing our understanding of several vascular inflammatory diseases.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/molecules26237111 pmid:34885690 pmcid:PMC8659223 fatcat:2godi2n5ovfpndsliuqdy2tvlu

Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context

W. N. Leonhard, H. Happe, D. J. M. Peters
2016 Journal of the American Society of Nephrology  
Our review addresses the mechanisms by which various biologic processes influence cyst formation and cyst growth, thereby explaining an important part of the inter-and intrafamilial variability in ADPKD  ...  We model these findings in a graphic representation called the cystic probability landscape, providing a robust conceptual understanding of why cells sometimes do or do not form cysts.  ...  Kidneys were harvested and stained with anti-F4/80 (brown), which in mouse studies, is frequently used as a general marker for macrophages.  ... 
doi:10.1681/asn.2016040425 pmid:27493259 pmcid:PMC5118495 fatcat:g3zmxqxrfbgoth7exjr7g56254

Molecular Imaging of Vulnerable Coronary Plaque: A Pathophysiologic Perspective

Sandeep Krishnan, Yuka Otaki, Mhairi Doris, Leandro Slipczuk, Yoav Arnson, Mathieu Rubeaux, Damini Dey, Piotr Slomka, Daniel S. Berman, Balaji Tamarappoo
2017 Journal of Nuclear Medicine  
Other, less available, tracers that target macrophages, endothelial cells, and apoptotic cells have also been tested in small groups of patients.  ...  Two commonly available radiopharmaceuticals-18 F-FDG and 18 F-NaF-have been used in clinical research for imaging coronary artery plaque, and ongoing clinical studies are testing whether there is an association  ...  Although several radiolabeled tracers have proven useful for identifying atherosclerotic plaque in preclinical models of disease, most clinical studies on the imaging of coronary plaque have been performed  ... 
doi:10.2967/jnumed.116.187906 pmid:28183988 fatcat:lyruxi3mkfdjnjnbgk7n5sbq6a

High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo

Viviany R. Taqueti, Farouc A. Jaffer
2013 Integrative Biology  
biological processes has been limited.  ...  longitudinal investigations into the mechanisms and progression of many vascular diseases.  ...  Award, and MGH SPARK Award.  ... 
doi:10.1039/c2ib20194a pmid:23135362 pmcid:PMC3558556 fatcat:yt36mqtc5neujbx57rkwaojxli

How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models

Diego Marescotti
2019 ALTEX: Alternatives to Animal Experimentation  
This finding led to further optimization of the model using rested macrophages; the addition of rested macrophages decreased the basal inflammatory and cell stress status of the co-culture.  ...  This will allow us to gain insight into the steady-state profile of the assembled, complete three-dimensional model using all four cell types and of simpler models of one, two, or three cell types.  ...  Acknowledgements The authors thank Audrey Jehanno for her valuable assistance during the practical work of this study.  ... 
doi:10.14573/altex.1811221 pmid:30753736 fatcat:e236cw6ndfdyxiw75zzz3fjwdq

Molecular Imaging Insights Into Early Inflammatory Stages of Arterial and Aortic Valve Calcification

S. E. P. New, E. Aikawa
2011 Circulation Research  
This review discusses studies that have used molecular imaging methods to advance knowledge of cardiovascular calcification, focusing in particular on the inflammation-dependent mechanisms of arterial  ...  use of molecular imaging.  ...  Reynolds Foundation, and Translational Program of Excellence in Nanotechnology (5-UO1-HL080731). Disclosures None.  ... 
doi:10.1161/circresaha.110.234146 pmid:21617135 pmcid:PMC3139950 fatcat:rntismtmgffnpc25dtk2t7ywkm

How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models_suppl

Diego Marescotti
2019 ALTEX: Alternatives to Animal Experimentation  
This finding led to further optimization of the model using rested macrophages, which decreased the basal inflammatory and cell stress status of the co-culture.  ...  This allowed us to gain insight into the steady-state profile of the assembled, complete three-dimensional model using all four cell types, and of simpler models of one, two, or three cell types.  ...  Acknowledgements The authors thank Audrey Jehanno for her valuable assistance during the practical work of this study.  ... 
doi:10.14573/altex.1811221s fatcat:es6qo6uapbaizlp46xxgeumbdi

Novel Positron Emission Tomography Tracers for Imaging Vascular Inflammation

Andrej Ćorović, Christopher Wall, Justin C. Mason, James H. F. Rudd, Jason M. Tarkin
2020 Current Cardiology Reports  
Use of these novel PET tracers could lead to a better understanding of underlying disease mechanisms and help inform the identification and stratification of patients for newly emerging immune-modulatory  ...  tracer lacks inflammatory cell specificity and is not a practical solution for imaging the coronary vasculature because of avid background myocardial signal.  ...  As a chronic granulomatous disease, macrophages are a key component of the underlying disease process in LVV.  ... 
doi:10.1007/s11886-020-01372-4 pmid:32772188 fatcat:bkoz4hzkuvaztpvbfwqpm5nmza
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