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PMC18 COMPARISONS OF DATA MINING ALGORITHMS FOR ADVERSE DRUG REACTIONS: AN EMPIRICAL STUDY BASED ONTHE ADVERSE EVENT REPORTING SYSTEM OFTHE FOOD AND DRUG ADMINISTRATION

Y Chen, JJ Guo, NC Patel, M Steinbuch, XD Lin, C Buncher
2008 Value in Health  
PMC18 COMPARISONS OF DATA MINING ALGORITHMS FOR ADVERSE DRUG REACTIONS: AN EMPIRICAL STUDY BASED ON THE ADVERSE EVENT REPORTING SYSTEM OF THE FOOD AND DRUG ADMINISTRATION Chen Y 1 , Guo JJ 2 , Patel  ...  Food and Drug Administration.  ... 
doi:10.1016/s1098-3015(10)70553-2 fatcat:papl3w5tajaetiolpho2mp6yg4

Page 2967 of The Journal of Neuroscience Vol. 14, Issue 5 [page]

1994 The Journal of Neuroscience  
Food intake was limited to 20 gm/d during the self- administration period so that all rats would consume similar amounts of food.  ...  The self-administration paradigm allows the investigator to determine only the dose of drug that is ad- ministered for each lever press, while the animal has control over the number of injections and total  ... 

Detection and Evaluation of Adverse Drug Reaction Signals of Antidepressants Based on FDA Adverse Event Reporting System Database

Chao Ran, Hu Zhou, Chao Tan, Juntao Tan, Zhengyu Zhang, Wenlong Zhao
2020 Open Journal of Depression  
Methods: Reporting Ratio (ROR) method was used to mine the adverse reaction signals of SSRIs in the Adverse Reaction Reporting System (ARES) of the Food and Drug Administration of the United States (FDA  ...  Objective: To detect and analyze the adverse drug reaction (ADR) signals of Selective Serotonin Reuptake Inhibitor (SSRIs) post-marketing and provide references for clinical rational drug use.  ...  Conflicts of Interest The authors declare no conflicts of interest regarding the publication of this paper.  ... 
doi:10.4236/ojd.2020.92002 fatcat:tfefvynly5ft7iglp7eoa6zdqy

Page 2918 of The Journal of Neuroscience Vol. 22, Issue 7 [page]

2002 The Journal of Neuroscience  
Reinstatement of drug seeking induced by a systemic priming injection of cocaine is blocked by intra-mPFC administration of a dopa- mine antagonist.  ...  Nonspecific effects on operant responding by the glutamate and dopamine antagonists used in the reinstatement experiments described above were evaluated by assessing the effect of these drugs on food-reinforced  ... 

Anaphylactic risk related to omalizumab, benralizumab, reslizumab, mepolizumab, and dupilumab

Lisha Li, Zixi Wang, Le Cui, Yingyang Xu, Kai Guan, Bin Zhao
2021 Clinical and Translational Allergy  
This was a retrospective study using data from the US Food and Drug Administration Adverse Event Reporting System database from January 2004 to September 2020.  ...  A total of 2006 reports of anaphylaxis related to benralizumab, dupilumab, mepolizumab, omalizumab, and reslizumab were obtained through data mining.  ...  ACKNOWLEDGEMENTS The authors would like to thank the grant support from the National Natural Science Foundation of China (No. 82070033), and we also thank Editage (www.editage.cn) for English language  ... 
doi:10.1002/clt2.12038 pmid:34123366 pmcid:PMC8175040 fatcat:ktzkm3c5lnfefjvtln43nnkh3y

Application of data mining techniques in pharmacovigilance

Andrew M. Wilson, Lehana Thabane, Anne Holbrook
2003 British Journal of Clinical Pharmacology  
Aims To discuss the potential use of data mining and knowledge discovery in databases for detection of adverse drug events (ADE) in pharmacovig ilance.  ...  Conclusion In view of the importance of ADEs and the development of massive data storage systems and powerful computer systems, the use of data mining techniques in knowledge discovery in medical databases  ...  The US Food and Drug Administration (FDA) uses a data mining algorithm called the Multi-item Gamma Poisson Shrinker (MGPS) to interrogate their spontaneous reporting database, as this has the ability to  ... 
doi:10.1046/j.1365-2125.2003.01968.x pmid:14748811 pmcid:PMC1884444 fatcat:6j7wgbd3mbbqrccrhxhxjwyeoi

Have Current Systems of Pharmacovigilance Had Their Day?

Michael Colacci (Pro), Michael Fralick (Pro), Christine M. Bond (Con)
2020 The Canadian Journal of Hospital Pharmacy  
US Food and Drug Administration; 2018 [cited 2020 Jan 15].  ...  Postmarket safety events among novel therapeutics approved by the US Food and Drug Administration between 2001 and 2010. JAMA. 2017;317(18):1854-63. 3.  ...  The CJHP would be pleased to consider photographs featuring Canadian scenery taken by CSHP members for use on the front cover of the Journal.  ... 
doi:10.4212/cjhp.v73i2.2983 fatcat:72ifttimgzhjhmrpjqjstiku4m

Thrombotic Events Associated with C1 Esterase Inhibitor Products in Patients with Hereditary Angioedema: Investigation from the United States Food and Drug Administration Adverse Event Reporting System Database

Pranav K. Gandhi, William M. Gentry, Michael B. Bottorff
2012 Pharmacotherapy  
Retrospective data mining analysis. Source. The United States Food and Drug Administration (FDA) adverse event reporting system (AERS) database. Measurements and Main Results.  ...  Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting. Diabetes Care 2011;34:1369-71 U.S. Food and Drug Administration.  ... 
doi:10.1002/j.1875-9114.2012.01126 pmid:23033229 fatcat:au7rcigl6vbclo2gvvu5z4eete

Adverse Event Profile of Tigecycline: Data Mining of the Public Version of the U.S. Food and Drug Administration Adverse Event Reporting System

Kaori Kadoyama, Toshiyuki Sakaeda, Akiko Tamon, Yasushi Okuno
2012 Biological and Pharmaceutical Bulletin  
Food and Drug Administration (FDA) were analyzed after a revision of arbitrary drug names and the deletion of duplicated submissions.  ...  The recent emergence of multidrug-resistant pathogens and/or pharmacokinetics-pharmacodynamics considerations may result in off-label use of a certain class of antibacterials, including tigecycline.  ...  Acknowledgment This study was partially supported by the Funding Program for Next Generation World-Leading Researchers.  ... 
doi:10.1248/bpb.35.967 pmid:22687540 fatcat:lkptxhq4kffr3numpenm3xudtq

Platinum Agent-Induced Hypersensitivity Reactions: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS

Toshiyuki Sakaeda, Kaori Kadoyama, Hiroaki Yabuuchi, Satoshi Niijima, Kyoko Seki, Yukinari Shiraishi, Yasushi Okuno
2011 International Journal of Medical Sciences  
Objective: Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm the platinum agent-associated mild, severe, and lethal hypersensitivity reactions  ...  Conclusion: The FDA's adverse event reporting system, AERS, with optimized data mining tools is useful to authorize potential associations between platinum agents and hypersensitivity reactions.  ...  In this study, adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm the platinum agent-associated mild, severe, and lethal hypersensitivity reactions  ... 
doi:10.7150/ijms.8.332 pmid:21611115 pmcid:PMC3100741 fatcat:fuot5hvdvzhzfhk7nvoxx77z44

Case series of reports of pruritus and sipuleucel-T submitted to the Food and Drug Administration Adverse Event Reporting System

Graça M. Dores, Silvia Perez-Vilar, Manette T. Niu
2019 Journal of Pharmaceutical Health Care and Sciences  
Food and Drug Administration Adverse Event Reporting System (FAERS) received a report of pruritus without rash following the second dose of sipuleucel-T in a patient who had otherwise not started any new  ...  In data mining analyses, pruritus following sipuleucel-T was not reported more frequently than expected when compared to all other adverse event-drug/biologic combinations in FAERS.  ...  Acknowledgements The opinions and information in this article are those of the authors, and do not represent the views and/or policies of the U.S. Food and Drug Administration.  ... 
doi:10.1186/s40780-019-0156-0 pmid:31890238 pmcid:PMC6923907 fatcat:ek46raxsijcllpuy22is6u7ygq

Adverse Events Associated with Use of Digoxin Immune Fab Reported to the US Food and Drug Administration Adverse Event Reporting System, 1986–2019

Shaokui Wei, Manette T. Niu, Graça M. Dores
2021 Drugs - Real World Outcomes  
Although approved by the US Food and Drug Administration (FDA) in 1986 (DigiBind) and 2001 (DigiFab), there remains a paucity of literature describing the safety of these products in the postmarketing  ...  Empirical Bayes geometric means (EBGMs) and their 90% confidence intervals were computed to identify disproportionate (i.e., at least twice the expected) reporting of DigiBind and DigiFab.  ...  Note: The opinions and information in this article are those of the authors and do not represent the views or policies of the US Food and Drug Administration.  ... 
doi:10.1007/s40801-021-00242-x pmid:33721285 fatcat:gf3psfliyvbn7ginmlipcidyki

Page 129 of British Journal of Clinical Pharmacology Vol. 57, Issue 2 [page]

2004 British Journal of Clinical Pharmacology  
However, spontaneous reporting databases do contain large amounts of data, for example the Food and Drug Administration (FDA) spontaneous reporting data- base contains over 2 million reports over a period  ...  Selecticn of data-base To ensure the database contains at The combination of a linked administrative database and electronic medical or databases least the minimum required variables records Data cleaning  ... 

A 2012 Workshop: Vaccine and Drug Ontology in the Study of Mechanism and Effect (VDOSME 2012)

Yongqun He, Luca Toldo, Gully Burns, Cui Tao, Darrell R Abernethy
2012 Journal of Biomedical Semantics  
The workshop covered two main areas: (i) ontologies of vaccines, of drugs, and of studies thereof; and (ii) analysis of administration, mechanism and effect in terms of representations based on such ontologies  ...  events), vaccine and drug adverse event text mining, and ontology-based Semantic Web applications.  ...  This article has been published as part of Journal of Biomedical Semantics 'Vaccine and Drug Ontology in the Study of Mechanism and Effect (VDOSME)' thematic series.  ... 
doi:10.1186/2041-1480-3-12 pmid:23249650 pmcid:PMC3554582 fatcat:zzkqbjxgavhszp4ku6m6ug2u3q

Big Data Mining and Adverse Event Pattern Analysis in Clinical Drug Trials

Callie Federer, Minjae Yoo, Aik Choon Tan
2016 Assay and drug development technologies  
We performed data mining and pattern analysis of drug-AEs in our database.  ...  We extracted the information from ClinicalTrials.gov using a set of python scripts, and then used regular expressions and a drug dictionary to process and structure relevant information into a relational  ...  This work is partly supported by the National Institutes of Health P50CA058187, P30CA046934, Cancer League of Colorado, and the David F. and Margaret T. Grohne Family Foundation.  ... 
doi:10.1089/adt.2016.742 pmid:27631620 pmcid:PMC5175440 fatcat:lid5udwxtbalvnnety7gmsoixe
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