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Usage of network analysis to investigate Periodic Sharp Wave Complexes in EEGs of patients with sporadic CJD

Paolo Lo Giudice, Nadia Mammone, Francesco Carlo Morabito, Domenico Ursino, Umberto Aguglia, Vittoria Cianci, Edoardo Ferlazzo, Sara Gasparini
2017 Sistemi Evoluti per Basi di Dati  
Electroencephalography (EEG) is one of the main methods to perform clinical diagnosis of CJD, mainly because of Periodic Sharp Wave Complexes (PSWCs).  ...  Furthermore, network motifs are able to detect what the most active and/or connected brain areas are in the tracing segments with PSWCs.  ...  In fact, in the EEG of patients with sCJD, it is often possible to observe three-phase periodic spikes with sharp waves known as "Periodic Sharp Wave Complexes" (hereafter, PSWCs).  ... 
dblp:conf/sebd/GiudiceMMUACFG17 fatcat:66ep6dk4u5dojesps7amgpgxhi

The Epidemiological, Clinical, and Laboratory Features of Sporadic Creutzfeldt-Jakob Disease Patients in China: Surveillance Data from 2006 to 2010

Chen Gao, Qi Shi, Chan Tian, Cao Chen, Jun Han, Wei Zhou, Bao-Yun Zhang, Hui-Ying Jiang, Jin Zhang, Xiao-Ping Dong, Andrew Francis Hill
2011 PLoS ONE  
About 2/3 of probable sCJD cases showed positive 14-3-3 in CSF and/or periodic sharp wave complexes (PSWC) in electroencephalography (EEG).  ...  The epidemiological, clinical and laboratory analysis data were consistent with the characteristics of sporadic CJD, which provide insight into the features of CJD in China.  ...  Acknowledgments We thank all staff working for China CJD surveillance from China CDC, 12 provincial CDCs and 15 sentinel hospitals. Author Contributions  ... 
doi:10.1371/journal.pone.0024231 pmid:21904617 pmcid:PMC3164193 fatcat:wg52zecikfbd5hx2issth5ylou

Clinical and laboratory features of 14 young Chinese probable sCJD patients

Qi Shi, Kang Xiao, Cao Chen, Wei Zhou, Chen Gao, Jing Wang, Bao-Yun Zhang, Yuan Wang, Xiao-Ping Dong
2017 Prion  
Due to low rate of brain autopsy in China, performances of other CJD-associated examinations as much as possible are extremely important for the distinguish diagnosis of young probable sCJD patients.  ...  Special sCJD-associated abnormalities on EEG and MRI were noticed in 7 and 10 cases. CSF 14-3-3 was positive in 7 cases. CSF RT-QuIC showed positive reactive curves in 9 cases, with short lag phases.  ...  As shown in Fig. 2B , periodic sharp wave complexes (PSWC) were noted in 7 (58.33%) patients out of 12 who received EEG examinations. sCJD-associated abnormalities (high signal abnormalities in caudate  ... 
doi:10.1080/19336896.2017.1287656 pmid:28278113 pmcid:PMC5399906 fatcat:mxukpemsinc6fd22bo2q3z64za

The importance of ongoing international surveillance for Creutzfeldt–Jakob disease

Neil Watson, Jean-Philippe Brandel, Alison Green, Peter Hermann, Anna Ladogana, Terri Lindsay, Janet Mackenzie, Maurizio Pocchiari, Colin Smith, Inga Zerr, Suvankar Pal
2021 Nature Reviews Neurology  
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal and transmissible neurodegenerative disease associated with the accumulation of misfolded prion protein in the CNS.  ...  In this Review, we provide an up-to-date overview of the transmission of prion diseases in human populations and argue that CJD surveillance remains vital both from a public health perspective and to support  ...  Acknowledgements This work was carried out on behalf of the European Creutzfeldt-Jakob Disease Surveillance Network, which is funded by European Centre for Disease Prevention and Control.  ... 
doi:10.1038/s41582-021-00488-7 pmid:33972773 pmcid:PMC8109225 fatcat:xeeasfqtljclhjnbj7df4vygdu

Comparison of the pathologic and pathogenic features in six different regions of postmortem brains of three patients with fatal familial insomnia

2012 International Journal of Molecular Medicine  
In all 3 brain specimens, reactive astrogliosis was found to be more severe in the thalamus than in the cortex regions.  ...  In addition, the transcriptional levels of glial fibrillary acidic protein (GFAP) and NSE-specific mRNAs were coincident with the expression of these proteins.  ...  Grab (Johns Hopkins university) for reading our manuscript prior to submission. This study was supported by the China Mega-Project for Infectious Disease  ... 
doi:10.3892/ijmm.2012.1194 pmid:23175354 fatcat:vd3qpu2ecnbmfnv5kb5yryg2ui

Poster Sessions

2011 Epilepsia  
Conclusion: This study demonstrates that a clinical and, to a lesser degree, EEG response to an acute trial of IV BDZs are predictive of subsequent outcome in patients with suspected NCSE, and warrant  ...  NFLE patients with video-EEG recording of at least one hypermotor/asymmetric tonic 24 seizure or two paroxysmal arousals; relatives of patients with NFLE: at least seven members of the proband family;  ...  Acknowledgments: Thanks to the University of Ngaoundere for its support.  ... 
doi:10.1111/j.1528-1167.2011.03207.x fatcat:77ayxa5tcbannis7zksyeo57ju

Proteomics Analyses for the Global Proteins in the Brain Tissues of Different Human Prion Diseases

Qi Shi, Li-Na Chen, Bao-Yun Zhang, Kang Xiao, Wei Zhou, Cao Chen, Xiao-Mei Zhang, Chan Tian, Chen Gao, Jing Wang, Jun Han, Xiao-Ping Dong
2015 Molecular & Cellular Proteomics  
In the study, the proteomics patterns of cortex and cerebellum of brain tissues of sporadic Creutzfeldt-Jakob disease, fatal familial insomnia, and G114V genetic CJD were analyzed with isobaric tags for  ...  relative and absolute quantitation combined with multidimensional liquid chromatography and MS analysis, with the brains from three normal individuals as controls.  ...  Typical periodic sharp-waves (PSW) were detected in electroencephalogram (EEG). Magnetic resonance imaging (MRI) did not reveal a specific abnormality.  ... 
doi:10.1074/mcp.m114.038018 pmid:25616867 pmcid:PMC4390265 fatcat:narhoms5uvcsdjcwruvtpfv64u

37th Meeting of the Canadian Congress of Neurological Sciences

2002 Canadian Journal of Neurological Sciences  
compared with a RR of 1.0 (0.6-1.9) in the low ASPECTS group.  ...  Conclusions: Patients with a baseline ASPECT score greater than seven have a five-fold increased chance of an independent functional outcome with intra-arterial prourokinase compared to those with an ASPECT  ...  EEG showed periodic sharp and slow-waves discharges. MRI showed diffuse T2 signal hyperintensity in periventricular and subcortical white matter with bilateral insular involvement.  ... 
doi:10.1017/s0317167100049775 fatcat:j5rigejlgbhpzgev3esb4cq4em

40th Meeting of the Canadian Congress of Neurological Sciences

2005 Canadian Journal of Neurological Sciences  
The majority of cases were sporadic CJD (89.0%), with 4.4% GSS, 3.8% inherited, 2.2% iatrogenic, 0.6% variant CJD [the patient with variant CJD had been multiple stays in the UK during the peak of bovine  ...  Serial electroencephalography demonstrated periodic sharp waves in couplets at a frequency of 2 Hz on a slowed and poorly organized background.  ...  Conclusions: This is the first reported case of CJD in Canada associated with Tutoplast Dura.  ... 
doi:10.1017/s0317167100003310 fatcat:7cedlythjvcf3lbsol3ugogfy4


2012 Dementia and Geriatric Cognitive Disorders  
To allow comparison with previous studies patients presenting with progressive aphasia were excluded from the analysis.  ...  Patients with FTLD however, can present with a barrage of signs and symptoms and different syndromes, resulting in complex and obscure relationships between clinical and pathological diagnoses.  ...  The case is presented for its rarity of relatively late onset of FTD with possible temporal association with a parasagittal meningioma, and the challenges faced in management.  ... 
doi:10.1159/000342903 pmid:23007027 fatcat:io2rfqz7hndlddkrquqhkjhm7m

Poster Session 2, Monday 27 September

2010 European Journal of Neurology  
In 19 patients with epilepsy EEG showed: focal spikes or biphasic spikes, spike and wave complex 6-7Hz focally or diffuse paroxysmal discharges, spike and wave complex 3-4Hz focally or diffuse paroxysmal  ...  EEG after sleep deprivation showed sharp waves localized in the left frontotemporal region. No seizure occurred during 14day video-EEG monitoring.  ...  We intended to identify the prevalence of each form of CJD from a case series of 40 patients, followed clinically and with complete neuropathological study.  ... 
doi:10.1111/j.1468-1331.2010.03233.x fatcat:lsellp2xyvc77c7gr7qbzu6coi

2nd International Congress on Neurology and Epidemiology

2012 Neuroepidemiology  
EEG in all of the patients revealed epileptiform discharges of sharp wave, spike, or sharp and slow wave complexes in non-paroxysmal bursts.  ...  No significant relationship could be found with analogue technology or after usage periods of ≥15 years.  ...  Material and methods: We have studied efficacy of FR200 in 37 patients with F10.2+CCI, (group I, 40, 7±4, 1 years) during therapy of dysphoric manifestations of WS (week 1) and during post-withdrawal period  ... 
doi:10.1159/000343765 pmid:23128512 fatcat:zlibc2hggzhknbgves2mvspkqi

CGS 39th Annual Scientific Meeting: Book of Abstracts

Various Authors
2019 Canadian Geriatrics Journal  
Employing a grounded theory approach, constant comparative analysis and theoretical sampling was used in semi-structured interviews with directors of care from 10 long-term care facilities in B.C. and  ...  The iterative analysis resulted in adjusting questions as theory emerged. Developing themes were utilized to develop a set of openended questions used in two follow-up focus groups.  ...  EEGs showed periodic slow wave complexes; MRI brain scans showed restricted diffusion in the occipital lobes bilaterally and right frontal & parietal lobes.  ... 
doi:10.5770/cgj.22.385 fatcat:zgrnjyy4uzdaphz6ahcmob5q4i

42nd Annual Congress Canadian Neurological Sciences Federation

2007 Canadian Journal of Neurological Sciences  
findings of periodic sharp wave complexes are suggestive of a clinical diagnosis of sporadic Creutzfelt Jacob Disease (sCJD).  ...  Analysis of CSF for protein 14-3-3 and cranial imaging with MRI may aid in the diagnosis of CJD.  ...  The Benefits of Becoming a Reviewer: • An annual record of all your refereeing contributions for academic promotional purposes. • Your name included in the "Thank you to Reviewers" list in the February  ... 
doi:10.1017/s0317167100017054 fatcat:7kj4qzqunnhabhfrthsyx3wpje

3rd International Congress on Neurology and Epidemiology. Abu Dhabi, UAE, November 21–23, 2013: Abstracts

2013 Neuroepidemiology  
COMPARATIVE STUDY OF COMPLEXITY ANALYSIS OF EPILEPTIC SCALP EEG RECORDS Objectives: A wavelet based method is proposed for measuring the complexity of EEG records of epileptic patients since wavelets are  ...  To identify the predominant ictal onset frequencies with wide spectrum EEG frequency analysis.  ...  Next, we provided the patients with treatment, and then followed-up for a period of 6 months.  ... 
doi:10.1159/000356326 fatcat:cwvmef3j4bgbxctcrlbsfml4da
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