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Unveiling the transport

Jeffrey Mogul, Lawrence Brakmo, David E. Lowell, Dinesh Subhraveti, Justin Moore
2004 Computer communication review  
Traditional application programming interfaces for transport protocols make a virtue of hiding most internal per-connection state.  ...  We advocate a disciplined, portable, and secure interface that gives applications both "get" and "set" access to transport connection state.  ...  Summary We have argued that many interesting applications could use an API that exposes per-connection transport state.  ... 
doi:10.1145/972374.972392 fatcat:dp4cdbmscfavha5ejetq6tpqjq

Unveiling the gating mechanism of ECF Transporter RibU

Jianing Song, Changge Ji, John Z. H. Zhang
2013 Scientific Reports  
The recently reported crystal structure of an ECF transporter RibU provided a foundation for understanding the structure and transport mechanism of ECF transporters.  ...  The Group II transporters share the same AT modules for various S components. In addition, for ECF-transporters, different S components transport different substrates.  ...  C.G.J. is also supported by ''the Fundamental Research Funds for the Central Universities'' and Open Research Fund of the State Key Laboratory of Precision spectroscopy, East China Normal University.  ... 
doi:10.1038/srep03566 pmid:24356467 pmcid:PMC3868957 fatcat:yefnqrscdvdrrjq6tckbpanlj4

The Multiplex Efficiency Index: unveiling the Brazilian Air Transportation Multiplex Network – BATMN [article]

Izabela M. Oliveira, Laura C. Carpi, A.P.F. Atman
2019 arXiv   pre-print
We demonstrate through the combination of the measurement of diversity and multiplex efficiency as the Brazilian air transport network has changed over the years due to the privatization processes of airports  ...  In this work, we use data related to the Brazilian air transport network to introduce a new index, Multiplex Efficiency Index, which allows quantifying the temporal evolution of diversity, particularly  ...  air transportation.  ... 
arXiv:1910.11974v1 fatcat:zdy2wwfvsrd5bjvvule4inothi

Unveiling the Secret Lives of Glutamate Transporters: VGLUTs Engage in Multiple Transport Modes

Alessio Accardi
2014 Neuron  
In the current issue of Neuron, Preobraschenski et al. (2014) show that the VGLUTs, in addition to transporting glutamate, also provide the conductances necessary to maintain the appropriate voltage and  ...  Accumulation of glutamate in synaptic vesicles is mediated by vesicular glutamate transporters called VGLUTs.  ...  These transporters utilize the electrochemical proton gradient (DmH) created by V-ATPases as the driving force for glutamate uptake in the SVs.  ... 
doi:10.1016/j.neuron.2014.12.008 pmid:25521371 pmcid:PMC7263376 fatcat:thrky74osvfynl2suhh4zngj5m

Phonon transport unveils the prevalent point defects in GaN

Ankita Katre, Jesús Carrete, Tao Wang, Georg K. H. Madsen, Natalio Mingo
Here we use an unconventional approach, based on thermal transport modeling, to determine the prevalence of vacancies in previous measurements.  ...  These results also highlight the predictive power of ab initio phonon transport modeling, and its value for understanding and quantifying defects in semiconductors.  ...  The authors acknowledge the support from the Air  ... 
doi:10.1103/physrevmaterials.2.050602 fatcat:swpbqlkypjbfzdjmu7bo6o3yhi

Time-resolved photometry of the young dipper RX J1604.3-2130A: Unveiling the structure and mass transport through the innermost disk [article]

A. Sicilia-Aguilar, C.F. Manara, J. de Boer, M. Benisty, P. Pinilla,, J. Bouvier
2019 arXiv   pre-print
the matter transport from the outer to the inner disk.  ...  The observations reveal details of the structure and matter transport through the inner disk.  ...  that is transported from outer to inner disk.  ... 
arXiv:1911.04938v2 fatcat:hhowvcjutvhhnjwtlo4tdni6vi

Frog Oocytes to Unveil the Structure and Supramolecular Organization of Human Transport Proteins

Marc J. Bergeron, Rajendra Boggavarapu, Marcel Meury, Zöhre Ucurum, Luc Caron, Paul Isenring, Matthias A. Hediger, Dimitrios Fotiadis, Daniel J. Muller
2011 PLoS ONE  
The method was validated for four human and one murine transporter.  ...  This approach will open the way for the structure determination of many human membrane transporters taking full advantage of the Xenopus laevis oocyte expression system that generally yields robust functional  ...  Acknowledgments The authors thank Dr. Gergely Kovacs for his help in recording confocal microscope images.  ... 
doi:10.1371/journal.pone.0021901 pmid:21760919 pmcid:PMC3131388 fatcat:e5hvf65vjnh6fmbqskx4z7obre

Here comes driverless ride sharing: Cruise unveils the origin, a fully autonomous SUV designed for app-controlled urban transportation - [Spectral Lines]

Tekla S. Perry
2020 IEEE spectrum  
HERE COMES DRIVERLESS RIDE SHARING Cruise unveils the Origin, a fully autonomous SUV designed for app-controlled urban transportation  ...  The company estimates that the average urban dweller who relies on Cruise Origin for transportation will cut about US $5,000 a year from personal transportation costs.  ... 
doi:10.1109/mspec.2020.9014442 fatcat:75q3mmqcv5fchmkacm6zhfgzuq

Unveiling the Mechanism of Arginine Transport through AdiC with Molecular Dynamics Simulations: The Guiding Role of Aromatic Residues

Eva-Maria Krammer, Kassem Ghaddar, Bruno André, Martine Prévost, Dimitrios Fotiadis
2016 PLoS ONE  
The substrate is then released and the transporter returns to its original conformation.  ...  They reveal that transport occurs, as in other secondary transporters, via alternating access to the substrate binding site, caused by conformational changes to either side of the membrane [28] .  ...  Gibbons for having performed some of the conventional MD simulations.  ... 
doi:10.1371/journal.pone.0160219 pmid:27482712 pmcid:PMC4970712 fatcat:m7ew6sgu3vdgvfuh7nnsva7t2m

Rigorous sampling of docking poses unveils binding hypothesis for the halogenated ligands of L-type Amino acid Transporter 1 (LAT1)

Natesh Singh, Bruno O. Villoutreix, Gerhard F. Ecker
2019 Scientific Reports  
L-type Amino acid Transporter 1 (LAT1) plays a significant role in the growth and propagation of cancer cells by facilitating the cross-membrane transport of essential nutrients, and is an attractive drug  ...  Collectively, the results highlight the dual nature of the ligand-protein binding mode characterized by backbone hydrogen bond interactions of the amino acid moiety of the ligands and residues I63, S66  ...  Acknowledgements We thank the Région Hauts-de-France, University of Lille, Inserm institute for financial supports.  ... 
doi:10.1038/s41598-019-51455-8 pmid:31636293 pmcid:PMC6803698 fatcat:pcr4gvpgejhsrp75wijnuok6ni

Unveiling the carrier transport mechanism in epitaxial graphene for forming wafer-scale, single-domain graphene

Sang-Hoon Bae, Xiaodong Zhou, Seyoung Kim, Yun Seog Lee, Samuel S. Cruz, Yunjo Kim, James B. Hannon, Yang Yang, Devendra K. Sadana, Frances M. Ross, Hongsik Park, Jeehwan Kim
2017 Proceedings of the National Academy of Sciences of the United States of America  
domain | single crystal | carrier transport S ince the first discovery of graphene (1), its outstanding properties have drawn a great deal of attention (2-11).  ...  Here, we revealed the role of each parameter affecting carrier transport in epitaxial graphene by performing a layer-resolved graphene transfer (LRGT) process.  ...  the carrier transport through the monolayer and bilayer regions connected in series.  ... 
doi:10.1073/pnas.1620176114 pmid:28373575 pmcid:PMC5402461 fatcat:f2gi354agzcotkdaxkw7nwko5q

Mobile Phone Data in Urban Commuting: A Network Community Detection-Based Framework to Unveil the Spatial Structure of Commuting Demand

Qing Yu, Weifeng Li, Dongyuan Yang, Haoran Zhang, Giuseppe Musolino
2020 Journal of Advanced Transportation  
The results generated by the methodology proposed can be referenced by policymakers to support urban transportation planning and promote urban livability and sustainability.  ...  As the outcomes of rapid urbanization, the spatial separation of homes and workplaces extends the commuting distance and complicates the commuting demand of residents.  ...  Acknowledgments is work was supported by the National Key R&D Program of China (No. 2018YFB1601100). Journal of Advanced Transportation  ... 
doi:10.1155/2020/8835981 fatcat:q57kvd5o3rh2veojoewauu44ea

New insights into the Acetate Uptake Transporter (AceTr) Family: unveiling amino acid residues critical for specificity and activity

Toni Rendulić, João Alves, João Azevedo-Silva, Isabel Soares-Silva, Margarida Casal
2021 Computational and Structural Biotechnology Journal  
Aiming at improving the transport of biotechnologically relevant carboxylic acids in engineered microbial cell factories, the focus of this work was to study plasma membrane transporters belonging to the  ...  Acetate Uptake Transporter (AceTr) family.  ...  these alterations in the transporter function were not unveiled.  ... 
doi:10.1016/j.csbj.2021.08.002 pmid:34471488 pmcid:PMC8379382 fatcat:6rpwmdfpv5faholibcu6dtulq4

Membrane Proteomics Analysis of the Candida glabrata Response to 5-Flucytosine: Unveiling the Role and Regulation of the Drug Efflux Transporters CgFlr1 and CgFlr2

Pedro Pais, Carla Pires, Catarina Costa, Michiyo Okamoto, Hiroji Chibana, Miguel C. Teixeira
2016 Frontiers in Microbiology  
The deletion of CgFLR1 or CgFLR2 was seen to increase the intracellular accumulation of 5-FC, or 5-FC and clotrimazole, suggesting that these transporters play direct roles in drug extrusion.  ...  associated to cell wall assembly, lipid metabolism, amino acid/nucleotide metabolism, ribosome components and translation machinery, mitochondrial function, glucose metabolism, and multidrug resistance transport  ...  Among the obtained results, the concentration of the DHA transporter CgFlr1 was seen to increase in 5-FC challenged cells.  ... 
doi:10.3389/fmicb.2016.02045 pmid:28066366 pmcid:PMC5174090 fatcat:fvwrdfqu2rf25pafndnfycnnim

Transition of yeast Can1 transporter to the inward-facing state unveils an α-arrestin target sequence promoting its ubiquitylation and endocytosis

Christos Gournas, Elie Saliba, Eva-Maria Krammer, Céline Barthelemy, Martine Prévost, Bruno André, Sandra Lemmon
2017 Molecular Biology of the Cell  
They also show that the mutants altered in the 70-81 region and resistant to Arg-induced endocytosis are competent for Arg transport.  ...  Thus, the mutant in residues 82-EVQN-86 could be resistant to Arg-induced endocytosis either because it is part of the cluster of residues 70-81, or because of its low Arg transport.  ... 
doi:10.1091/mbc.e17-02-0104 pmid:28814503 pmcid:PMC5638585 fatcat:x6tq7wh64zfvhoxjb53jwyes6e
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