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Male versus female breast cancer: a comparative study of 523 matched cases reveals differences behind similarity

V Speirs, G Ball
2010 Breast Cancer Research  
studies on male breast cancer (MBC) have suff ered from small numbers of cases available from any one centre; thus a signifi cant problem in eff ectively studying this disease is accruing suffi ciently  ...  SPEAKER PRESENTATIONS O1 Male versus female breast cancer: a comparative study of 523 matched cases reveals diff erences behind similarity V Speirs 1 , G Ball 2 , Male Breast Cancer Consortium Retrospective  ...  these cells are more frequently associated with triple-negative breast tumours.  ... 
doi:10.1186/bcr2492 pmcid:PMC2875557 fatcat:ldfk43h5trge7lthunba4w7eyy

Musawah: A Data-Driven AI Approach and Tool to Co-Create Healthcare Services with a Case Study on Cancer Disease in Saudi Arabia

Nala Alahmari, Sarah Alswedani, Ahmed Alzahrani, Iyad Katib, Aiiad Albeshri, Rashid Mehmood
2022 Sustainability  
The case study focuses on cancer disease in Saudi Arabia using Twitter data in the Arabic language.  ...  social media analysis.  ...  The idea of developing cancer-related services from social media analysis is motivated by the well-known science that social media facilitates value co-creation through stakeholder interactions allowing  ... 
doi:10.3390/su14063313 fatcat:mlgdsks4hfcprj4jlh7fwwwasa

Machine Learning Helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer

Arjun P. Athreya, Alan J. Gaglio, Junmei Cairns, Krishna R. Kalari, Richard M. Weinshilboum, Liewei Wang, Zbigniew T. Kalbarczyk, Ravishankar K. Iyer
2018 IEEE Transactions on Nanobioscience  
As a case study, this work uses MDA-MB-231 breast cancer single-cells treated with the antidiabetic drug metformin.  ...  Keywords Unsupervised learning; Single-cell RNASeq; breast cancer; mixture-models; model-based learning; metformin 1 [192*2 cells]*23, 398 ≈ 9M. 2 https://www.genome.gov/27530687/biological-pathways-fact-sheet  ...  This material is based upon work partially supported by a Mayo Clinic and Illinois Alliance  ... 
doi:10.1109/tnb.2018.2851997 pmid:29994716 pmcid:PMC6148350 fatcat:mf6j3wxminhche6rx5oi4juecy

A pathways-based prediction model for classifying breast cancer subtypes

Tong Wu, Yunfeng Wang, Ronghui Jiang, Xinliang Lu, Jiawei Tian
2017 OncoTarget  
We performed a systemic analysis of 698 breast cancer patient samples from The Cancer Genome Atlas project database.  ...  Based on unsupervised clustering analysis, these 136 core genes efficiently categorized breast cancer patients into the appropriate subtypes.  ...  In conclusion, our study provides a comprehensive analysis of breast cancer subtype genes across 698 TCGA samples.  ... 
doi:10.18632/oncotarget.18544 pmid:28938599 pmcid:PMC5601695 fatcat:7njqolwqrnf2ndofeffcnstmn4

Molecular Characterization of Breast Cancer with High-Resolution Oligonucleotide Comparative Genomic Hybridization Array

F. Andre, B. Job, P. Dessen, A. Tordai, S. Michiels, C. Liedtke, C. Richon, K. Yan, B. Wang, G. Vassal, S. Delaloge, G. N. Hortobagyi (+3 others)
2009 Clinical Cancer Research  
NMF class I was characterized by a high rate of triple-negative cancers (64%) and gains of 6p21. VEGFA, E2F3, and NOTCH4 were also gained in 29% to 34% of triple-negative tumors.  ...  Conclusion: The present study identified dysregulated genes that could classify breast cancer and may represent novel therapeutic targets for molecular subsets of cancers.  ...  This region is gained in 34% of triple-negative breast cancer and 10% of non -triple-negative tumors.  ... 
doi:10.1158/1078-0432.ccr-08-1791 pmid:19147748 fatcat:6lfoz3pzkvchdef5s4zuixocrm

Molecular Classification of Triple-Negative Breast Cancer

Sung Gwe Ahn, Seung Jun Kim, Cheungyeul Kim, Joon Jeong
2016 Journal of Breast Cancer  
Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer.  ...  Figure 1 . 1 Distributions of the Vanderbilt subtypes using TNBCtype in Korean women with triple-negative breast cancer (n = 45).  ... 
doi:10.4048/jbc.2016.19.3.223 pmid:27721871 pmcid:PMC5053306 fatcat:gwlxnr74kbehnotjj2i6q2k4b4

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer

Ryoko Kikuchi-Koike, Kazunori Nagasaka, Hitoshi Tsuda, Yasuyuki Ishii, Masaru Sakamoto, Yoshihiro Kikuchi, Shiho Fukui, Yuko Miyagawa, Haruko Hiraike, Takayuki Kobayashi, Takayuki Kinoshita, Yae Kanai (+5 others)
2019 BMC Cancer  
To identify a high-risk group in pN0 invasive breast cancer, we examined copy number alterations (CNAs) of 800 cancer-related genes.  ...  The major component was triple-negative cases (69%, 9 of 13) in group 1, luminal B-like (57%, 13 of 23) and HER2-overexpressing (26%, 6 of 23) subtypes in group 2, and luminal A-like subtype (60%, 9 of  ...  T at the National Cancer Center Hospital for technical assistance.  ... 
doi:10.1186/s12885-019-5737-7 fatcat:akp7edefcbhj3ldsrrc333diz4

Clonality of circulating tumor cells in breast cancer brain metastasis patients

Carlotta Riebensahm, Simon A. Joosse, Malte Mohme, Annkathrin Hanssen, Jakob Matschke, Yvonne Goy, Isabell Witzel, Katrin Lamszus, Jolanthe Kropidlowski, Cordula Petersen, Anja Kolb-Kokocinski, Sascha Sauer (+7 others)
2019 Breast Cancer Research  
The incidence of brain metastases in breast cancer (BCBM) patients is increasing.  ...  These patients have a very poor prognosis, and therefore, identification of blood-based biomarkers, such as circulating tumor cells (CTCs), and understanding the genomic heterogeneity could help to personalize  ...  From case UKE72, a patient diagnosed with triplenegative breast cancer, 13 single CTCs and the primary tumor tissue were analyzed.  ... 
doi:10.1186/s13058-019-1184-2 pmid:31481116 pmcid:PMC6720990 fatcat:5vpfstawxfd77p25jvhzzzfvtq

Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response

Pascal Jézéquel, Delphine Loussouarn, Catherine Guérin-Charbonnel, Loïc Campion, Antoine Vanier, Wilfried Gouraud, Hamza Lasla, Catherine Guette, Isabelle Valo, Véronique Verrièle, Mario Campone
2015 Breast Cancer Research  
Methods: We conducted an unsupervised analysis of microarray gene-expression profiles of 107 triple-negative breast cancer patients and undertook robust functional annotation of the molecular entities  ...  Triple-negative breast cancers need to be refined in order to identify therapeutic subgroups of patients.  ...  of 107 triple-negative breast cancer patients based on fuzzy-clustering partition.  ... 
doi:10.1186/s13058-015-0550-y pmid:25887482 pmcid:PMC4389408 fatcat:il6uyualzzeepm7fwpab5wu2im

Quantitative multiplexed analysis of ErbB family coexpression for primary breast cancer prognosis in a large retrospective cohort

Jennifer M. Giltnane, Christopher B. Moeder, Robert L. Camp, David L. Rimm
2009 Cancer  
Automated quantitative analysis (AQUA) is a new technology that allows quantitative in situ assessment of protein expression.  ...  Methods-We quantitatively assessed the expression of six proteins in four subcellular compartments in 676 patients using breast carcinoma tissue microarrays (TMA).  ...  This group may be defining the so called "triple negative" class (9,24,25) of breast cancer since these cases are low for ER, PR and HER-2.  ... 
doi:10.1002/cncr.24277 pmid:19330842 pmcid:PMC2756449 fatcat:rjoxoppjkraq5c5ucdyzhlwzaq

Translational breast cancer research in luminal breast cancer

M Dowsett
2011 Breast Cancer Research  
Initial exciting data suggesting that iniparib improved outcome in patients with triple-negative breast cancer in combination with chemotherapy have not been confi rmed in phase III studies, although there  ...  Based on a series of striking phenotypic similarities between the majority of sporadic triple-negative breast cancers and most cancers that arise in BRCA1 heterozygotes, the hypothesis arose that perhaps  ... 
doi:10.1186/bcr3013 pmcid:PMC3247047 fatcat:usjruem4s5hgrkofcta4indcsm

A clinically relevant gene signature in triple negative and basal-like breast cancer

Achim Rody, Thomas Karn, Cornelia Liedtke, Lajos Pusztai, Eugen Ruckhaeberle, Lars Hanker, Regine Gaetje, Christine Solbach, Andre Ahr, Dirk Metzler, Marcus Schmidt, Volkmar Müller (+2 others)
2011 Breast Cancer Research  
Conclusions We describe a ratio of high B-cell presence and low IL-8 activity as a powerful new prognostic marker for TNBC.  ...  ; RFS: Relapse free survival; TNBC: triple negative breast cancer; VEGF: vascular endothelial growth factor.  ...  Table 3 compares the clinical characteristics of BLBC or non-BLBC triple negative cancers the discovery cohort-A.  ... 
doi:10.1186/bcr3035 pmid:21978456 pmcid:PMC3262210 fatcat:xmcgdo4njvfchnim6jli36lqly

Epidemiology of triple negative breast cancers

Gretchen L. Gierach, Aileen Burke, William F. Anderson, Jennifer Eng-Wong, Jo Anne Zujewski
2011 Breast Disease  
Keywords breast cancer; triple negative breast cancers; breast cancer molecular subtypes; estrogen receptor (ER); progesterone receptor (PR); human epidermal growth factor receptor-2 (HER2); breast cancer  ...  In contrast, ER+PR+ breast cancers rise rapidly then continue to increase at a slower pace. The inflection near age 50 years has been referred to as Clemmesen's hook [32] .  ...  In a case-case analysis of triple negative versus luminal A (Table 4) , only Trivers et al.  ... 
doi:10.3233/bd-2010-0319 pmid:21965309 pmcid:PMC4684941 fatcat:rbuf7ddtqzdofowhfwu437jyhi

Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer

Rulla M. Tamimi, Graham A. Colditz, Aditi Hazra, Heather J. Baer, Susan E. Hankinson, Bernard Rosner, Jonathan Marotti, James L. Connolly, Stuart J. Schnitt, Laura C. Collins
2011 Breast Cancer Research and Treatment  
This analysis included 2,022 invasive breast cancer cases for whom we were able to obtain archived breast cancer tissue specimens.  ...  Methods-We evaluated the association between traditional breast cancer risk factors and risk of previously defined molecular subtypes of breast cancer in the Nurses' Health Study.  ...  Breast feeding for at least four months was associated with a lower risk of triple negative cases (ER-/PR-/HER2-) compared with luminal A.  ... 
doi:10.1007/s10549-011-1702-0 pmid:21830014 pmcid:PMC3237947 fatcat:6n4uskg2r5ablirgjcw2bw76yu

Evolution of the Tumor Microenvironment toward Immune-Suppressive Seclusion during Brain Metastasis of Breast Cancer: Implications for Targeted Therapy

Myung-Giun Noh, Sung Sun Kim, Yeong Jin Kim, Tae-Young Jung, Shin Jung, Joon-Haeng Rhee, Jae-Hyuk Lee, Ji-Shin Lee, Jae-Ho Cho, Kyung-Sub Moon, Hansoo Park, Kyung-Hwa Lee
2021 Cancers  
Despite emerging therapies such as immunotherapy, whether the tumor microenvironment (TME) in breast cancer brain metastasis (BCBM) has potential as a target of new treatments is unclear.  ...  Breast cancer (BC) is the second most common solid malignant tumor that metastasizes to the brain.  ...  Acknowledgments: The English in this document has been checked by at least two professional editors, both native speakers of English.  ... 
doi:10.3390/cancers13194895 pmid:34638378 pmcid:PMC8507988 fatcat:7irzzy3gsrgk3ctirknvindn7y
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