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Intrinsic functional connectivity of the central extended amygdala

Rachael M. Tillman, Melissa D. Stockbridge, Brendon M. Nacewicz, Salvatore Torrisi, Andrew S. Fox, Jason F. Smith, Alexander J. Shackman
2017 Human Brain Mapping  
The central extended amygdala (EAc)-including the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce)-plays a key role in orchestrating states of fear and anxiety and is  ...  The only regions showing stronger functional connectivity with the Ce were located in the anterior hippocampus and dorsal amygdala.  ...  Functional heterogeneity in the bed nucleus of the stria terminalis.  ... 
doi:10.1002/hbm.23917 pmid:29235190 fatcat:2rfmxwbuibf6xg233zc6jc6lha

Intrinsic functional connectivity of the central extended amygdala [article]

Rachael M. Tillman, Melissa D. Stockbridge, Brendon M. Nacewicz, Salvatore Torrisi, Andrew S. Fox, Jason F. Smith, Alexander Joseph Shackman
2017 bioRxiv   pre-print
The central extended amygdala (EAc) -- including the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce) -- plays a key role in orchestrating states of fear and anxiety and  ...  The only regions showing stronger functional connectivity with the Ce were located in the anterior hippocampus and dorsal amygdala.  ...  Phasic and sustained brain responses in the amygdala and the bed nucleus of the stria terminalis during threat anticipation. Human Brain Mapping, 37, 1091-1102. Holmes, A. J., Hollinshead, M.  ... 
doi:10.1101/178533 fatcat:w3ci6dwk7fen5dzeu3ya2mzpo4

A functional MRI study of human amygdala responses to facial expressions of fear versus anger

Paul J. Whalen, Lisa M. Shin, Sean C. McInerney, Håkan Fischer, Christopher I. Wright, Scott L. Rauch
2001 Emotion  
The bed nucleus of the stria terminalis (BNST) is an example of such a nucleus.  ...  They were naive to the face stimuli used and to our hypotheses pertaining to the emotional expressions of faces.  ...  Allow 4-6 weeks for delivery of the first issue. Call for international rates. SEND THIS ORDER FORM TO: American Psychological Association  ... 
doi:10.1037/1528-3542.1.1.70 pmid:12894812 fatcat:p6mzlbvcnbbtfcejcsotumaisi

The Neurobiology of Dispositional Negativity and Attentional Biases to Threat: Implications for Understanding Anxiety Disorders in Adults and Youth

Alexander J. Shackman, Melissa D. Stockbridge, Rachael M. Tillman, Claire M. Kaplan, Do P. M. Tromp, Andrew S. Fox, Matthias Gamer
2016 Journal of Experimental Psychopathology  
Here we review recent work highlighting the importance of neural circuits centered on the amygdala.  ...  Converging lines of epidemiological, neurophysiological, and mechanistic evidence indicate that the amygdala supports stable individual differences in dispositional negativity across the lifespan and contributes  ...  and 5 in females-between the ages of 10 and 65, peaking in adolescence (Soto, John, Gosling, & Potter, 2011) .  ... 
doi:10.5127/jep.054015 pmid:27917284 pmcid:PMC5130287 fatcat:ryy7kzfhazagzjhwhgln4t6uaa

Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework [chapter]

Juyoen Hur, Melissa D. Stockbridge, Andrew S. Fox, Alexander J. Shackman
2019 Progress in Brain Research  
Here, we review new insights into the nature and biological bases of dispositional negativity, a fundamental dimension of childhood temperament and adult personality and a prominent risk factor for the  ...  Collectively, these observations provide an integrative translational framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing  ...  more ventral basal regions of the amygdala shown at the lower left toward the central (Ce) nucleus of the amygdala (magenta) and the neighboring bed nucleus of the stria terminalis (BST) at the upper  ... 
doi:10.1016/bs.pbr.2019.03.012 pmid:31196442 pmcid:PMC6578598 fatcat:qnzyq5n4lffrxklfrkl6zbfjny

Tracking dynamic threat imminence [article]

Christian T. Meyer, Srikanth Padmala, Luiz Pessoa
2017 bioRxiv   pre-print
To address these gaps, in the current functional MRI study involving healthy adult human volunteers, we investigated interactions between proximity, direction, and speed during a dynamic threat-of-shock  ...  Taken together, our study refines our understanding of the brain mechanisms involved during aversive anticipation in human brain.  ...  (B) For the right amygdala, activity decreased as a function of proximity during approach, but changed little Figure 9 . 9 Proximity effect in the bed nucleus of the stria terminalis (BST) ROI analysis  ... 
doi:10.1101/183798 fatcat:cctidpvrfvhqvi4gagw2ojqwvm

Dynamic Threat Processing

Christian Meyer, Srikanth Padmala, Luiz Pessoa
2018 Journal of Cognitive Neuroscience  
In the right bed nucleus of the stria terminalis, we observed an effect of threat proximity, whereas in the right periaqueductal gray/midbrain we observed an effect of threat direction and a proximity  ...  Together, our study refines our understanding of the brain mechanisms involved during aversive anticipation in the human brain.  ...  of the fMRI data, and Nicole Friedman and Jessica Berman for help with participant recruitment.  ... 
doi:10.1162/jocn_a_01363 pmid:30513044 pmcid:PMC6545600 fatcat:6bi2u4t6wnao5fkfxbm4bcdjky

Systematic Review and Meta-Analyses of Neural Structural and Functional Differences in Generalized Anxiety Disorder and Healthy Controls using Magnetic Resonance Imaging

Tiffany A. Kolesar, Elena Bilevicius, Alyssia D. Wilson, Jennifer Kornelsen
2019 NeuroImage: Clinical  
reduced volume, and the dlPFC (central executive network) and ACC have reduced FC with the amygdala in GAD.  ...  Although few whole-brain resting state studies were conducted, key nodes of resting state networks have altered physiology: the hippocampus (default network), ACC and amygdala (salience network), have  ...  Functional MRI of the amygdala and bed nucleus of the stria terminalis during conditions of uncertainty in generalized anxiety disorder.  ... 
doi:10.1016/j.nicl.2019.102016 pmid:31835287 pmcid:PMC6879983 fatcat:t4qpog3kfraq5kj7honvolh6ka

UNDERSTANDING THE CONTRIBUTION OF THE CENTRAL EXTENDED AMYGDALA TO DISPOSITIONAL NEGATIVITY

Rachael Tillman
2017
The central extended amygdala (EAc; an anatomical concept encompassing the bed nucleus of the stria terminalis [BST] and central nucleus of the amygdala [Ce]) is implicated in the development and maintenance  ...  Yet, the functional architecture of the human EAc and its relation to individual differences in DN remains poorly understood.  ...  Bed Nucleus of the Stria Terminalis (BST) and Central Nucleus of the Amygdala (Ce) Seeds. Figure 4 . 4 Figure 4.  ... 
doi:10.13016/m2q28w fatcat:nmpgnke52vh27pb57s4p4rhi3a

Understanding the anxiolytic effects of alcohol on the central extended amygdala in humans

Claire Marjorie Kaplan
2017
Focal analyses of the central extended amygdala revealed significant activation during threat in the right, but not left, hemisphere for both the central nucleus [Ce] and bed nucleus of the stria terminalis  ...  Remarkably little is known, however, about the neural circuitry underlying anxiolytic effects of alcohol in humans.  ...  Finally, I would like to thank my laboratory teammates, Rachael Tillman and Kathryn DeYoung, for their support and aid at various stages of the study.  ... 
doi:10.13016/m2f76674x fatcat:vc2loga3szds3gnewtlw4msrn4

Understanding the Relevance of Extended Amygdala Reactivity to Dispositional Negativity

Shannon Elizabeth Grogans
2021
Prior work suggests that DN reflects heightened threat-elicited reactivity in the extended amygdala (EAc), a circuit encompassing the central nucleus (Ce) and the bed nucleus of the stria terminalis (BST  ...  Follow-up analyses revealed that the threat paradigms are not interchangeable probes of EAc function.  ...  of the neighboring bed nucleus of the stria terminalis (BST)-represents an integrative macrocircuit (Alheid & Heimer, 1988 ).  ... 
doi:10.13016/moro-w6i8 fatcat:xexg3pnrpbau5ekw5wq5cbu2py

Impact of Social Threat on Extended Amygdala Function in Adolescent Social Anxiety [article]

Rachael Tillman
2021
The central extended amygdala (EAc)—including the bed nucleus of the stria terminalis (BST) and the dorsal amygdala in the region of the central nucleus (Ce)—plays a key role in prominent neuroscientific  ...  threat processes during adolescence.  ...  Abbreviations-BST, bed nucleus of the stria terminalis; Ce, central nucleus of the amygdala; L, left hemisphere; R, right hemisphere.  ... 
doi:10.13016/gybi-18oa fatcat:scgngkxadbbpxoipwshpmqdphe

Amygdala resting state functional connectivity in alcohol dependence

Csaba Orban, Anne Lingford-Hughes, John McGonigle, Medical Research Council (Great Britain)
2018
In this thesis, spontaneous amygdala network function was examined in abstinent alcohol dependent patients (ADP) using functional magnetic resonance imaging within the framework of a multi-site neuroimaging  ...  Voxelwise comparison of amygdala RSFC between each drug session and placebo, did not reveal differential effects of receptor blockade on ADP and HC.  ...  , nucleus accumbens, CeA and Bed Nucleus of the Stria Terminalis (BNST; Ledoux, 2007; Janak & Tye, 2015) .  ... 
doi:10.25560/59191 fatcat:sjalx4og4vailmytqam4ov3w7e

On the harmonious meeting of visual perception and memory circuitries

P Klaver
2010
Acknowledgements We wish to thank Karsten Specht and Uta Noppeney for their assistance in MRI analysis, and Markus Reuber for his invaluable comments on an earlier version of the manuscript.  ...  We wish to thank Horst Urbach for providing the MR images and Pascal Fries and Ole Jensen for comments on earlier drafts of the manuscript.  ...  The medial amygdala projects to the bed nucleus of the stria terminalis and via the lateral septum to the hippocampus. In humans the role of oxytocin in memory is not clear.  ... 
doi:10.5167/uzh-40149 fatcat:4tudiwhoezcqzda5mtc6dq5vd4