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Understanding the fabric of protein crystals: computational classification of biological interfaces and crystal contacts
2015
Bioinformatics
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Since the mid-1990s, several approaches have been applied to obtain high-accuracy classification of crystal contacts and biological protein-protein interfaces. ...
A key issue linked to protein interface classification is the identification of the biological assembly of a crystal structure and the analysis of its symmetry. ...
Research Program of the National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health (support to S.B.). Conflict of Interest: none declared. ...
doi:10.1093/bioinformatics/btv622
pmid:26508758
pmcid:PMC4743631
fatcat:y5taf2mmlfgtxjjqjb7ghiqvxu
Thermotropic Liquid Crystal-Assisted Chemical and Biological Sensors
2017
Materials
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In this review article, we analyze recent progress in the application of liquid crystal-assisted advanced functional materials for sensing biological and chemical analytes. ...
We review trends in implementing LC sensing techniques and identify common problems related to the stability and reliability of the sensing materials as well as to experimental set-ups. ...
., E.K.M. and A.J. were supported in part by a NSF DMR-0907055 and 1506018. P.P., E.K.M. and A.J. were additionally supported by NSF I-Corps grant. P. ...
doi:10.3390/ma11010020
pmid:29295530
pmcid:PMC5793518
fatcat:earsvgxlxbfnhln6ojsmwpqxsu
Introduction to protein crystallization
2004
Methods
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The crystallization of proteins, nucleic acids and large biological complexes, such as viruses, depends on the creation of a solution that is supersaturated in the macromolecule but exhibits conditions ...
Protein crystallization was discovered by chance about 150 years ago and was developed in the late 19th century as a powerful purification tool and as a demonstration of chemical purity. ...
In these cases the antibody fragment enhanced the solubility of the otherwise insoluble protein and provided additional lattice contacts in the resultant crystals. ...
doi:10.1016/j.ymeth.2004.03.019
pmid:15325645
fatcat:ou5ddllubzfx7llybkeabiugta
Introduction to protein crystallization
2013
Acta Crystallographica Section F Structural Biology Communications
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The crystallization of proteins, nucleic acids and large biological complexes, such as viruses, depends on the creation of a solution that is supersaturated in the macromolecule but exhibits conditions ...
Protein crystallization was discovered by chance about 150 years ago and was developed in the late 19th century as a powerful purification tool and as a demonstration of chemical purity. ...
In these cases the antibody fragment enhanced the solubility of the otherwise insoluble protein and provided additional lattice contacts in the resultant crystals. ...
doi:10.1107/s2053230x13033141
pmid:24419610
pmcid:PMC3943105
fatcat:r5oxmbkjazgljbqmu6zaouk43y
What's in a Drop? Correlating Observations and Outcomes to Guide Macromolecular Crystallization Experiments
2011
Crystal Growth & Design
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The methods and rationale are broadly and generally applicable in any crystallization laboratory. ...
Through a combination of incomplete factorial sampling of crystallization cocktails, standard outcome classifications, visualization of outcomes as they relate chemically, and application of a simple phase ...
J.R.L. and E.H.S. would like to acknowledge NIH for funding support through U54 GM074899 and ...
doi:10.1021/cg1013945
pmid:21643490
pmcid:PMC3106348
fatcat:qxxvpzd575a5dlielz7isgdrmi
Modeling Complex Liquid Crystals Mixtures: From Polymer Dispersed Mesophase to Nematic Nanocolloids
[article]
2013
arXiv
pre-print
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and order fluctuations, (v) the formation of novel material architectures such as colloidal crystals, (vi) the particle rich phase behaviour in liquid crystal nanocomposites, (vii) the use of topological ...
The novelties of incorporating mesophases into blends, solutions, dispersions and mixtures is revealed by using theory, modelling, computation, and visualization. ...
Acknoeldegements This work is based on the research performed by A. ...
arXiv:1310.8645v1
fatcat:e7lecb5ou5efvo4af7y57646wq
Crystal Quartz Microbalance for Protein Adsorption Measurement
[chapter]
2016
Encyclopedia of Membranes
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Despite wide applications, cadmium is known to be a toxic element, and the occupational exposure is by inhalation of fumes and ingestion of soluble cadmium compounds. ...
Cadmium separation by liquid membranes: Cadmium occurs as a minor component in the zinc ores. It has many common industrial applications. ...
In the case of crystallization of proteins, ligands and cofactors can be exploited to stabilize the protein or to increase its conformational purity. ...
doi:10.1007/978-3-662-44324-8_1524
fatcat:jbqz25jxtjgsljzy5v63uagiee
Photonic crystal enhanced microscopy for imaging of live cell adhesion
2013
The Analyst
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A form of microscopy based on the unique optical properties of a photonic crystal (PC) biosensor provides both label-free (LF) and enhanced fluorescence (EF) imaging modalities for the study of cell-surface ...
The imaging system utilizes an angle-tunable illumination source, either LED or laser, to achieve highly efficient coupling of ...
PC biosensors are fabricated from inexpensive materials and require only low intensity illumination from beneath the sensor, so no electrical or physical contact between the sensor and the detection system ...
doi:10.1039/c3an01541f
pmid:23971078
fatcat:alb5lwrbzzduhbo6wyyytfj33e
Quantitative imaging of cell membrane-associated effective mass density using Photonic Crystal Enhanced Microscopy (PCEM)
2016
Progress in Quantum Electronics
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fabricated the PC sensors; B.C. and B.H. provided guidance and edited the manuscript. ...
It is followed by the redistribution of cellular materials at the cell membrane or at the cell-surface interface for cells interacting with surfaces, such as basement membranes. ...
The content is solely the responsibility of the authors and does not necessarily represent the official views of the NSF and NIH. Porcine adipose derived stem cells were a gift from Dr. ...
doi:10.1016/j.pquantelec.2016.10.001
pmid:28649149
pmcid:PMC5479321
fatcat:6e5q7xe5hfh7leub7l6psakoau
Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems
2015
Nanoscale
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We present the science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems, targeting an evolution in technology, that might lead to impacts and benefits reaching ...
This roadmap was developed within the framework of the European Graphene Flagship and outlines the main targets and research areas as best understood at the start of this ambitious project. ...
, and the understanding of the interfacial electronic structure of such contacts. ...
doi:10.1039/c4nr01600a
pmid:25707682
fatcat:hzfkhollfbbunbdroujkvqzxke
Fabrication of Massive Sheets of Single Layer Patterned Arrays Using Lipid Directed Reengineered Phi29 Motor Dodecamer
2008
ACS Nano
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Green from University of California at Davis for his technical assistance and valuable comments, as well as the preparation of Figures 1D and 2 . ...
The structural and conformational complexity of biological molecules brings about new avenues and challenges to experimental approaches at the bio/nano interface. 1,4,33Ϫ36 For instance, fabrication ...
The arrangement of the individual dodecamers is dictated by the intermolecular protein contacts and proteinϪ surface interactions. ...
doi:10.1021/nn800409a
pmid:19206255
pmcid:PMC2651733
fatcat:kxregblrb5a3pll6xhrelwqdvi
Biosensors and Biochips for Nanomedical Applications: a Review
2010
Sensors & Transducers
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In the last few decades, a tremendous growth in the field of nanotechnology has been witnessed and its applications to various disciplines are being continuously explored. ...
as an interface mechanism, are also reviewed. ...
The biological events like, antibody/ DNA binding, oxidation/reduction, etc., need to be transduced into a format understandable by a computer (voltage, light, intensity, mass, etc.), for analyzing and ...
doaj:659d1e73fafd474fb7b784b61854140e
fatcat:at4vqgiz25czzn4xa4mtkd27fu
Biomineralization Forming Process and Bio-inspired Nanomaterials for Biomedical Application: A Review
2019
Minerals
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The artificially introducing and utilization of biomineralization, the bio-inspired synthesis of nanomaterials, in biomedical fields was further discussed, mainly in five potential fields: drug and cell-therapy ...
In this review, the regulating roles of temperature, pH, and organics in biominerals forming process were reviewed. ...
Acknowledgments: The authors gratefully acknowledge the financial support from the Natural Science Foundation of Beijing Municipality (Grant No. 17L20128) and Beihang University (No. ...
doi:10.3390/min9020068
fatcat:4c62uxckkrbs5lundpf5tqcnia
Opportunities in theoretical and computational polymeric materials and soft matter
2015
Soft Matter
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CHALLENGES The convergence of new methods for materials synthesis and fabrication, rapidly expanding computational capabilities, and emerging conceptual frameworks for understanding multi---length scale ...
An important part of this challenge is to standardize and validate the methods used to couple models at interfaces between different computational zones. ...
Participant check---in All participants 9:00 - 9:30am Introduction/charge from organizers All participants 9:30---10:20am Introduction Combined session β All participants 5:30pm Dinner and close of day ...
doi:10.1039/c4sm02344g
pmid:25711605
fatcat:4smqrcruhzgs7gl7y4cdxsa3zi
Computational Issues in Biomedical Nanometrics and Nano-Materials
2008
Journal of Nano Research
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It is widely recognized as one of the most potentially beneficial applications of nanotechnology to industry and society to date. ...
computational methods are helping to generate remarkable new insights into how biological systems function, how metabolic processes interrelate, and how new molecular scale machines can operate. ...
Understanding of biological processes on the nano-scale level is a strong driving force behind development of nanotechnology [34] . ...
doi:10.4028/www.scientific.net/jnanor.1.50
fatcat:prlk2t7dhbdifgdfsp76i7kmim
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