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From bacterial killing to immune modulation: Recent insights into the functions of lysozyme

Stephanie A. Ragland, Alison K. Criss, James B. Bliska
2017 PLoS Pathogens  
This review will highlight recent advances in our understanding of the diverse mechanisms that bacteria use to protect themselves against lysozyme, the intriguing immunomodulatory function of lysozyme,  ...  and the relationship between these features in the context of infection.  ...  Acknowledgments We would like to thank the 2 reviewers, both of whom provided critical, thoughtful feedback to shape the direction of this manuscript.  ... 
doi:10.1371/journal.ppat.1006512 pmid:28934357 pmcid:PMC5608400 fatcat:ujlqk2l2ljbkxce3qj6nnm7she

Cell Wall-active Bacteriocins and Their Applications Beyond Antibiotic Activity

Clara Roces, Ana Rodríguez, Beatriz Martínez
2012 Probiotics and Antimicrobial Proteins  
Bera A, Herbert S, Jakob A, Vollmer W, Götz F (2005) Why are pathogenic 527 staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is 528 48.  ...  Gründling A, Schneewind O (2006) Cross-linked peptidoglycan mediates lysostaphin 660 binding to the cell wall envelope of Staphylococcus aureus. J Bacteriol 188 (7):2463-661 2472 662 56.  ...  This is the case of PG O-acetylation 192 accounting for resistance to lysozyme [8, 31, 50] or the presence of D-lactate, D-Ser or Gly 193 instead of D-Ala in the last position of the pentapeptide in some  ... 
doi:10.1007/s12602-012-9116-9 pmid:26782186 fatcat:r2vb3bbz3vfr7mpxpq6c7ln6em

Lipid Intermediates in the Biosynthesis of Bacterial Peptidoglycan

J. van Heijenoort
2007 Microbiology and Molecular Biology Reviews  
Perhaps lipid II-antibiotic complexes could be useful tools in these matters, as illustrated by their recent use in the study of the dynamic assembly of peptidoglycan in B. subtilis (49, 171) .  ...  The impact of the presence of the vanA mechanism on the structure of peptidoglycan was investigated in an S. aureus ␤-lactam-resistant strain by analysis of the cytoplasmic precursor pools and the muropeptide  ... 
doi:10.1128/mmbr.00016-07 pmid:18063720 pmcid:PMC2168651 fatcat:rbc7o2q2tjcgfgqxvg27zfbasy

Identification of MltG as a potential terminase for peptidoglycan polymerization in bacteria

Rachel Yunck, Hongbaek Cho, Thomas G. Bernhardt
2015 Molecular Microbiology  
Acknowledgements The authors would like to thank all members of the Bernhardt and Rudner labs for advice and helpful discussions.  ...  We would also like to thank Dana Boyd for initial help with the bioinformatic analysis of MltG conservation. We are also grateful to Suzanne Walker and her  ...  O-Acetylated peptidoglycan: Controlling the activity of bacterial autolysins and lytic enzymes of innate immune systems.  ... 
doi:10.1111/mmi.13258 pmid:26507882 pmcid:PMC4752859 fatcat:xerkt3ykcbggtgjunfqd3o2bxa

A Continuum of Anionic Charge: Structures and Functions of D-Alanyl-Teichoic Acids in Gram-Positive Bacteria

F. C. Neuhaus, J. Baddiley
2003 Microbiology and Molecular Biology Reviews  
The research in the laboratory of FCN was supported by AI-04615 and GM-51621.  ...  ACKNOWLEDGMENTS We thank our many colleagues and coworkers for their valuable contributions toward understanding the structure-function relationships of TAs from the time of their discovery to the present  ...  This relationship may be determined in part by the intercalation of the poly(Gro-P) moiety of LTA into the peptidoglycan matrix as well as by the bridging of the growing peptidoglycan chains between the  ... 
doi:10.1128/mmbr.67.4.686-723.2003 pmid:14665680 pmcid:PMC309049 fatcat:h2zth72mpfguhkuntly3dm53gi

Abstracts of the 29th Annual Symposium of The Protein Society

2015 Protein Science  
Finally, 19F-NMR was used to study solvent exposure of the complex and its dynamics in solution through relaxation dispersion of the 19F-nucleus at different temperatures.  ...  However, protein NMR can be complicated by the overlap of 1H and other resonances, hence the resolution needed to assign spectra precisely can be hard to achieve [1]. 19F-NMR is increasingly being used  ...  The structure of the C-terminal domain until residue 1629 has been solved by crystallography, while the structure and function of the remaining 130 residues remained undetermined [2].  ... 
doi:10.1002/pro.2823 pmid:26452528 pmcid:PMC4632850 fatcat:ejmksoqj3zbsrkabl4jyp7emgi

The presence of pMRC01 promotes greater cell permeability and autolysis in lactococcal starter cultures

Vincenzo Fallico, Olivia McAuliffe, Gerald F. Fitzgerald, Colin Hill, R. Paul Ross
2009 Journal of food microbiology  
Plasmid biology of natural Lactococcus lactis strains and molecular mechanisms of bacteriophage-host interaction. PhD Thesis, University College Cork.  ...  Rights © 2011, Vincenzo Fallico http://creativecommons.org/licenses/by-nc-nd/3.0/ Item downloaded from http://hdl.handle.Abstract vi CHAPTER 1 The potential of lacticin 3147, enterocin AS-48, lacticin  ...  The information in this database allows rapid prediction of relationships structure/function and target organisms of these antimicrobial peptides.  ... 
doi:10.1016/j.ijfoodmicro.2009.04.029 pmid:19560223 fatcat:4ouq5cjr2bazlg54nnr24pwepe

Second International Meeting of ISEV 2013: Boston, USA, April 17th-20th, 2013

2013 Journal of Extracellular Vesicles  
Among these, Staphylococcus aureus is one of the most important bacterium, and methicillin-resistant S. aureus (MRSA) is a serious and growing threat in hospitals and also communities.  ...  This study aims to characterise the proteome of drugresistant and drug-resistive breast cancer cells and their MPs in order to understand the molecular basis for the acquisition and dominance of the donor  ...  Metagenomics, sequencing of DNA from an environmental sample, offers a powerful means to better understand the complex relationships between hosts and their bacterial inhabitants.  ... 
doi:10.3402/jev.v2i0.20826 pmid:26082317 pmcid:PMC3760629 fatcat:fzccutscpnasrkcokd4wuckeba

Abstracts

2011 Journal of Vascular Research  
An in vitro angiogenesis (Matrigel) assay was used to compare the effect of serum from CLI patients and controls (n=5/group) on endothelial tubule formation.  ...  Manipulating these cellular and molecular endogenous responses may represent a novel therapeutic target for the revascularisation of ischaemic tissue. 24 Cell dynamics and migration are highly complex  ...  This research was supported by and UrB of RAS (project 10-1-SP-257). J. Allen, J. R Frame and A. Murray Physiol.  ... 
doi:10.1159/000332604 fatcat:egmxzxdg6bcyhn7iuw3qmwnjmi

Coronavirus [chapter]

Jan W. Gooch
2011 Encyclopedic Dictionary of Polymers  
Toxic Shock syndrome (TSS) Condition caused by infection with certain toxigenic strains of Staphylococcus aureus; often associated with the use of super absorbent but abrasive tampons.  ...  Plaque Assay A viral assay used to determine viral yield by culturing viruses on a bacterial lawn and counting plaques.  ...  to NADPH; it is thus coupled to the oxidation of H 2 O and the reduction of NADP þ .  ... 
doi:10.1007/978-1-4419-6247-8_13476 fatcat:btluws7qzvahvjm4g3abak2zh4

Radioisotope [chapter]

Jan W. Gooch
2011 Encyclopedic Dictionary of Polymers  
Toxic Shock syndrome (TSS) Condition caused by infection with certain toxigenic strains of Staphylococcus aureus; often associated with the use of super absorbent but abrasive tampons.  ...  Plaque Assay A viral assay used to determine viral yield by culturing viruses on a bacterial lawn and counting plaques.  ...  to NADPH; it is thus coupled to the oxidation of H 2 O and the reduction of NADP þ .  ... 
doi:10.1007/978-1-4419-6247-8_14640 fatcat:kebxan2fczapph46wnsudadjc4

Antimicrobial Drug Discovery Emerging Strategies

George Tegos, Eleftherios Mylonakis, Paul Hyman, Stephen Abedon
Advances in Molecular and Cellular Microbiology   unpublished
The series is edited by researchers active in the application of molecular and cellular microbiology to human disease states.  ...  Through the application of molecular and cellular microbiology, we now recognize the diversity and dominance of microbial life forms on our planet, which exist in all environments.  ...  Research conducted in the Hamblin Laboratory was supported by the NIH (R01 AI050875 to Michael R. Hamblin) and the US Air Force MFEL Program (FA9550-04-1-0079).  ... 
fatcat:3ggdi4h6nzgito7kxnwuueqjxu

SPECIAL ISSUE ON BIOPHYSICS IN INDIA GUEST EDITORS

Md Hassan
unpublished
To understand the structure-function relationship of lysozyme resistance in S. aureus by peptidoglycan O-acetylation, we adapted an integrated computational and in vitro technique.  ...  Staphylococcus aureus (S. aureus), an opportunistic commensal pathogen, is highly resistant to lysozyme, because of the O-acetylation of peptidoglycan by O-acetyl transferase (OatA).  ...  of protein "Lysozyme" by means of molecular dynamic (MD) simulations under different temperature and concentration regime.  ... 
fatcat:7gngicns5nfltnba2jqucgci2y

Functional analysis of the DNA-binding domain of the Staphylococcus aureus master virulence transcription factor AgrA

Sophie Nicod, Sivaramesh Wigneshweraraj, Christoph Tang, Biotechnology And Biological Sciences Research Council (Great Britain)
2016
The accessory gene regulator A (AgrA) in Staphylococcus aureus (S. aureus) is the master TF responsible for the activation of transcription at the agr operon, a key regulatory locus involved in the switch  ...  AgrA is an LDCTF and the only one for which the crystal structure of the LytTR domain in complex with DNA is available.  ...  peptide sensing and resistance in Staphylococcus aureus.  ... 
doi:10.25560/33244 fatcat:mf3surwttvd73o43jt2tw3rl2u

Characterization of Staphylococcus aureus extracellular nuclease activity CHARACTERIZATION OF STAPHYLOCOCCUS AUREUS EXTRACELLULAR NUCLEASE ACTIVITY

Megan Kiedrowski, Megan Kiedrowski, Alexander Horswill
2012 unpublished
The goal of this dissertation was to characterize extracellular nuclease activity of S. aureus to better understand the contributions of Nuc and Nuc2 to the S. aureus life cycle.  ...  Initially, little was understood about the biological and physiological roles of Nuc and Nuc2 in S. aureus.  ...  SLUSH hemolytic peptides, fibrinogen binding protein Fbl, a vWF-binding protein for adherence to host cells and platelets, and a peptidoglycan O-acetyltransferase conferring lysozyme resistance Nuc Nuc2  ... 
fatcat:etr4rerssrbttptcggoacr2xna
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