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Uncovering the effects of heterogeneity and parameter sensitivity on within-host dynamics of disease: malaria as a case study

Shade Horn, Jacky L. Snoep, David D. van Niekerk
2021 BMC Bioinformatics  
Various models exist to describe within-host dynamics during malaria infection but there is a shortage of clinical data that can be used to quantitatively validate them and establish confidence in their  ...  Background The fidelity and reliability of disease model predictions depend on accurate and precise descriptions of processes and determination of parameters.  ...  Uncertainty, robustness and sensitivity analyses were performed on these within-host models to determine the effect of parameter uncertainty and variability on the predicted disease dynamics, and to test  ... 
doi:10.1186/s12859-021-04289-z fatcat:xhmhz5etlratnkaclvrnoenrym

Seasonality and the dynamics of infectious diseases

Sonia Altizer, Andrew Dobson, Parviez Hosseini, Peter Hudson, Mercedes Pascual, Pejman Rohani
2006 Ecology Letters  
Infectious diseases provide some of the best-studied examples of the role of seasonality in shaping population fluctuations.  ...  Finally, by focusing on well-studied examples of infectious diseases, we hope to highlight general insights that are relevant to other ecological interactions.  ...  In the case of vector-borne diseases like malaria, transmission becomes a function of the relative size of the vector population, vector biting rates and parasite development within vectors (Macdonald  ... 
doi:10.1111/j.1461-0248.2005.00879.x pmid:16623732 fatcat:mwlqodqqwbbxtae7gdoucmzhba

The Role of Single-Cell Technology in the Study and Control of Infectious Diseases

Weikang Nicholas Lin, Matthew Zirui Tay, Ri Lu, Yi Liu, Chia-Hung Chen, Lih Feng Cheow
2020 Cells  
The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale.  ...  The extensive characterization of genomic and phenotypic biomarkers, in addition to host–pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms  ...  Number of Cells and Sequencing Depth As covered earlier in this review, the main applications of scRNA-seq in infectious disease study comprise of the following: (1) studying effect of host cell heterogeneity  ... 
doi:10.3390/cells9061440 pmid:32531928 pmcid:PMC7348906 fatcat:fff6j2cq2bhark72bgsgcwcbki

A Model for Assessing the Quantitative Effects of Heterogeneous Affinity in Malaria Transmission along with Ivermectin Mass Administration

João Sequeira, Jorge Louçã, António M. Mendes, Pedro G. Lind
2020 Applied Sciences  
In particular, we uncover a relationship between the level of heterogeneity and the level of conventional and unconventional anti-malarial drug administration (ivermectin and gametocidal agents), which  ...  heterogeneity in disease transmission and may configure a possible improvement in that setting, upon classical standard measures such as the basic reproductive number.  ...  Acknowledgments: We thank Miguel Prudêncio (IMM-Lisbon) for his help in defining model parameters and for his crucial remarks in discussing the model design.  ... 
doi:10.3390/app10238696 fatcat:eephkkcbfzcrhk6gjlbasmvbgy

Fine-scale spatial patterns of wildlife disease are common and understudied [article]

Gregory F Albery, Amy Sweeny, Daniel Becker, Shweta Bansal
2020 bioRxiv   pre-print
Given the widespread nature of these findings, studies should more frequently record and analyse spatial data, facilitating development and testing of spatial hypotheses in disease ecology.  ...  Parasites of all transmission modes had easily detectable spatial patterns, implying that structured contact networks and susceptibility effects are likely as important in spatially structuring disease  ...  Acknowledgements We would like to extend our profound gratitude to the researchers who generously provided us with their data, and to all those who withstood our numerous emails regardless.  ... 
doi:10.1101/2020.09.01.277442 fatcat:njernr7ysnatlfo2y6o6ex64ei

Aggressive or moderate drug therapy for infectious diseases? Trade-offs between different treatment goals at the individual and population levels [article]

Jérémie Scire, Nathanaël Hozé, Hildegard Uecker
2018 bioRxiv   pre-print
Here, we study the influence of the drug dose on resistance and disease management at the host and population levels.  ...  Recently, several studies have argued that, at least in some cases, low-dose treatments could be more suitable to reduce the within-host emergence of antimicrobial resistance.  ...  The authors are grateful to Pleuni Pennings and Arne Traulsen for valuable comments on the manuscript.  ... 
doi:10.1101/307223 fatcat:dpn3ciqu6vahvmmyjxnq6vtjfq

Aggressive or moderate drug therapy for infectious diseases? Trade-offs between different treatment goals at the individual and population levels

Jérémie Scire, Nathanaël Hozé, Hildegard Uecker, Ted Cohen
2019 PLoS Computational Biology  
Here, we study the influence of the drug dose on resistance and disease management at the host and population levels.  ...  Recently, several studies have argued that, at least in some cases, low-dose treatments could be more suitable to reduce the within-host emergence of antimicrobial resistance.  ...  They are grateful to Pleuni Pennings, Arne Traulsen and Ted Cohen for valuable comments on the manuscript. Author Contributions Conceptualization: Jérémie Scire, Nathanaël Hozé, Hildegard Uecker.  ... 
doi:10.1371/journal.pcbi.1007223 pmid:31404059 pmcid:PMC6742410 fatcat:55fvsuq6i5ebxgkpac4lwlg4va

Ecological Theory to Enhance Infectious Disease Control and Public Health Policy

Katherine F. Smith, Andrew P. Dobson, F. Ellis McKenzie, Leslie A. Real, David L. Smith, Mark L. Wilson
2005 Frontiers in Ecology and the Environment  
B y the second half of the 20th century, improved hygiene, advances in diagnostic methods, and the development of new drugs and vaccines allowed industrialized nations to greatly reduce the prevalence  ...  Yet today, infectious diseases remain the leading cause of death in the world.  ...  and Synthesis, a center funded by NSF (Grant #DEB-0072909), The University of California, and UC Santa Barbara.  ... 
doi:10.2307/3868442 fatcat:mqve543j7ngejdk5ah3b5zpl4u

The research and development process for multiscale models of infectious disease systems

Winston Garira
2020 PLoS Computational Biology  
Multiscale modelling of infectious disease systems falls within the domain of complexity science-the study of complex systems.  ...  in the discourse for multiscale modelling of infectious disease dynamics.  ...  is considered negligible/insignificant and its effects on disease dynamics in the multiscale model can be ignored.  ... 
doi:10.1371/journal.pcbi.1007734 pmid:32240165 pmcid:PMC7156109 fatcat:3jqb3hxebbe2hny3ytsensqgby

Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis

Edwin Michael, Brajendra K. Singh
2016 BMC Medicine  
Guinea, reflecting different ecological and vector characteristics, to investigate the impacts and implications of transmission heterogeneity and complexity on filarial infection dynamics, system robustness  ...  The current WHO-led initiative to eradicate the macroparasitic disease, lymphatic filariasis (LF), based on single-dose annual mass drug administration (MDA) represents one of the largest health programs  ...  While impacts of heterogeneities in ecological and environmental factors on the transmission dynamics of vector-bone parasitic diseases, including malaria, filariasis, schistosomiasis and onchocerciasis  ... 
doi:10.1186/s12916-016-0557-y pmid:26822124 pmcid:PMC4731922 fatcat:4fr4covinnbwdlyrooknnmt63u

Ecological theory to enhance infectious disease control and public health policy

Katherine F. Smith, Andrew P. Dobson, F Ellis McKenzie, Leslie A. Real, David L. Smith, Mark L. Wilson
2005 Frontiers in Ecology and the Environment  
eliminate, and in one case eradicate infectious diseases.  ...  Here, we discuss these theoretical advances and describe a number of cases where theoretical ecology has influenced the construction of initiatives to prevent or control infectious diseases around the  ...  and Synthesis, a center funded by NSF (Grant #DEB-0072909), The University of California, and UC Santa Barbara.  ... 
doi:10.1890/1540-9295(2005)003[0029:etteid]2.0.co;2 pmid:19838319 pmcid:PMC2762229 fatcat:45eyx3ykkrf55fpuq6clkz36wm

Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach

João Sequeira, Jorge Louçã, António M. Mendes, Pedro G. Lind
2019 Journal of Theoretical Biology  
Our mathematical framework enables to uncover the critical values of the parameters characterizing the effect of each drug therapy.  ...  In the agent model, the main properties of human-mosquito interactions are implemented as parameters and the model is validated by comparing simulations with real data of malaria incidence collected in  ...  Acknowledgments We thank Miguel Prudêncio (IMM -Lisbon) for his help in defining model parameters, and for his crucial remarks in discussing the model design.  ... 
doi:10.1016/j.jtbi.2019.110030 pmid:31568789 fatcat:7z53ita6bvg4xfdkazuxlabwua

Differential and enhanced response to climate forcing in diarrheal disease due to rotavirus across a megacity of the developing world

Pamela P. Martinez, Aaron A. King, Mohammad Yunus, A. S. G. Faruque, Mercedes Pascual
2016 Proceedings of the National Academy of Sciences of the United States of America  
Here, we focus on the transmission dynamics of rotavirus, the main diarrheal disease in infants and young children, within the megacity of Dhaka, Bangladesh.  ...  Spatial demographic, socioeconomic, and environmental heterogeneity can create reservoirs of infection and enhance the sensitivity of disease systems to climate forcing, especially in the populated cities  ...  The case data used in this paper were collected with the support of the ICDDR,B and its donors, who provide unrestricted support  ... 
doi:10.1073/pnas.1518977113 pmid:27035949 pmcid:PMC4839397 fatcat:hvtiasf6hbal3c2qshbllsw4bu

Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach [article]

João Sequeira, Jorge Louçã, António M. Mendes, Pedro G. Lind
2019 arXiv   pre-print
Our mathematical framework enables to uncover the critical values of the parameters characterizing the effect of each drug therapy.  ...  In the agent model, the main properties of human-mosquito interactions are implemented as parameters and the model is validated by comparing simulations with real data of malaria incidence collected in  ...  Acknowledgments We thank Miguel Prudêncio (IMM -Lisbon) for his help in defining model parameters, and for his crucial remarks in discussing the model design.  ... 
arXiv:1903.04353v1 fatcat:xip625p7enb7tgrazxub7fpsee

Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes

Tsukushi Kamiya, Megan A. Greischar, David S. Schneider, Nicole Mideo, Benjamin M. Althouse
2020 PLoS Computational Biology  
Our work demonstrates that the reaction norm approach provides a useful quantitative framework for examining the impact of a continuous external factor on within-host infection processes.  ...  In many disease systems, the initial infection dose impacts host morbidity and mortality.  ...  We are also grateful to the community of Stan developers and users, who were extremely generous with their time on The Stan Forums https://discourse.mc-stan.org/.  ... 
doi:10.1371/journal.pcbi.1008211 pmid:33031367 fatcat:s4o3jcpgifcizpgpxxvdukm344
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