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Flow field around bubbles on formation of air embolism in small vessels

Zhongnan Li, Guiling Li, Yongjian Li, Yuexin Chen, Jiang Li, Haosheng Chen
2021 Proceedings of the National Academy of Sciences of the United States of America  
However, it is still unclear how a moving bubble is stopped in the blood flow to form an air embolism in small vessels.  ...  An air embolism is induced by intravascular bubbles that block the blood flow in vessels, which causes a high risk of pulmonary hypertension and myocardial and cerebral infarction.  ...  Howard A. Stone for helpful discussions.  ... 
doi:10.1073/pnas.2025406118 pmid:34155104 pmcid:PMC8255810 fatcat:y3qokhxinjdcladww2jbzyu4ee

Hemodynamics Challenges for the Navigation of Medical Microbots for the Treatment of CVDs

Erica Doutel, Francisco J. Galindo-Rosales, Laura Campo-Deaño
2021 Materials  
This paper presents a critical analysis of the state-of-the-art literature related to pulsatile blood flow around microbots.  ...  arteries (i.e., bifurcations and tortuosity of vessels of some regions) in the determination of the dynamic performance of microbots are of paramount importance.  ...  The formation of atherosclerotic plaques in arterial walls reduces their diameter, causes a limitation in blood supply to vital organs, and could lead to a blocked clot causing fatal accidents.  ... 
doi:10.3390/ma14237402 pmid:34885556 fatcat:fyayy36f2fbrthu4mu2izsyxjy

Diastolic timed Vibro-Percussion at 50 Hz delivered across a chest wall sized meat barrier enhances clot dissolution and remotely administered Streptokinase effectiveness in an in-vitro model of acute coronary thrombosis

Andrew Hoffmann, Harjit Gill
2012 Thrombosis Journal  
Results: LFVP -HS only samples (vs. controls) showed; a) development of clot length fluid channels absent in the control group (p < 0.0002); b) enhanced dissolved clot mixing scores ( 5.0 vs. 0.8, p <  ...  However LFVP on a clotted coronary like vessel given engagement over a chest wall sized barrier (to resemble non-invasive heart attack therapy) requires study.  ...  Ultrasound further harbors a propensity, especially at higher intensities, to lead to increased platelet adhesion [9] , damage blood vessels [10] [11] [12] [13] [14] [15] and burn the overlying skin  ... 
doi:10.1186/1477-9560-10-23 pmid:23146079 pmcid:PMC3534480 fatcat:xycedarcoza5jn4oxwcjhgxkcq

Sonothrombolysis [chapter]

Kenneth B. Bader, Guillaume Bouchoux, Christy K. Holland
2016 Advances in Experimental Medicine and Biology  
In this chapter, the use of ultrasound to accelerate clot breakdown alone or in combination with thrombolytic drugs will be reported.  ...  Mechanisms for ultrasound enhancement of thrombolysis, including thermal heating, radiation force, and cavitation, will be reviewed.  ...  In contrast, a meta-analysis by Ricci et al. (2012) of seven randomized control trials found an increased risk of hemorrhage in connection with microbubbles and ultrasound, when both symptomatic and  ... 
doi:10.1007/978-3-319-22536-4_19 pmid:26486347 pmcid:PMC4933511 fatcat:jsrlo3dyjfd6tj6qto4ogjigii

Real-Time Feedback of Histotripsy Thrombolysis Using Bubble-Induced Color Doppler

Xi Zhang, Ryan M. Miller, Kuang-Wei Lin, Albert M. Levin, Gabe E. Owens, Hitinder S. Gurm, Charles A. Cain, Zhen Xu
2015 Ultrasound in Medicine and Biology  
Histotripsy thrombolysis is a noninvasive, drug-free and image-guided therapy that fractionates blood clots using well-controlled acoustic cavitation alone.  ...  Bubble-induced color Doppler (BCD) monitors the motion following cavitation generated by each histotripsy pulse, which has been shown in gel and ex vivo liver tissue to be correlated with histotripsy fractionation  ...  Charles A. Cain and Zhen Xu have financial interest and/or other relationship with HistoSonics Inc.  ... 
doi:10.1016/j.ultrasmedbio.2014.12.006 pmid:25623821 pmcid:PMC4398659 fatcat:xfcpeahxezcnfmzm3va3dkhed4

Ultrasound-mediated drug delivery [chapter]

Yufeng Zhou
2015 Nano based drug delivery  
However, large air bubbles disappeared within a few seconds following intravenous injection due to the high solubility of air in the blood, and the inability of the bubbles to pass through pulmonary capillaries  ...  Angiogenesis Angiogenesis is the physiological process by which new blood vessels form from pre-existing vessels; this process is mostly responsible for blood vessel growth during development and in disease  ... 
doi:10.5599/obp.8.19 fatcat:bpeogggervh75n3rcdg7mytq4y

A novel ultrasound-based method to evaluate hemostatic function of whole blood

Francesco Viola, F. William Mauldin, Xiefan Lin-Schmidt, Doris M. Haverstick, Michael B. Lawrence, William F. Walker
2010 Clinica Chimica Acta  
Sonorheometry uses the phenomenon of acoustic radiation force to measure the dynamic changes in blood viscoelasticity during clot formation and clot dissolution.  ...  Methods: We describe a novel ultrasound-based technology, named sonorheometry, which can assess hemostasis function from a small sample of blood.  ...  Skalak for his thoughtful critique of this manuscript.  ... 
doi:10.1016/j.cca.2009.10.017 pmid:19861121 pmcid:PMC2791922 fatcat:p2v2furuojf7lapcdenvaipmeu

Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery

Klazina Kooiman, Silke Roovers, Simone A.G. Langeveld, Robert T. Kleven, Heleen Dewitte, Meaghan A. O'Reilly, Jean-Michel Escoffre, Ayache Bouakaz, Martin D. Verweij, Kullervo Hynynen, Ine Lentacker, Eleanor Stride (+1 others)
2020 Ultrasound in Medicine and Biology  
Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for beneficial tissue bio-effects are actively under development.  ...  Successful implementation of ultrasound and cavitation nuclei-mediated drug delivery has the potential to change the way drugs are administered systemically, resulting in more effective therapeutics and  ...  However, Kleven et al. (2019) observed more than 60% fractional clot width loss for highly retracted human whole blood clots exposed to rt-PA, Definity and 220 kHz pulsed or continuous wave (CW) ultrasound  ... 
doi:10.1016/j.ultrasmedbio.2020.01.002 pmid:32165014 fatcat:pd3sf4vbdjenjp77tiafiaibqi


2010 Cerebrovascular Diseases  
blood vessels in real-time regime.  ...  Transcranial Dopplerography (TCD) is well known technique based on the recording of the ultrasound waves reflection from cerebral blood flow with pulse-wave Doppler technology to record velocities in intracranial  ...  Methods: Our in-vitro model consisted of a flow-rig circulating a blood-mimicking fluid through silicon tubing connected to an air compressor supplying a micro-pipette capable of creating bubbles of controlled  ... 
doi:10.1159/000315331 fatcat:hr65yin5bjhedcujexbhd7ygfm


2012 Cerebrovascular Diseases  
Amazingly dissections often occur in clusters involving more than one cervical artery in rapid sequence or in a temporarily overlapping mode, a strong arguement for a generalized arteriopathy initiated  ...  For flow information colour-coded mean velocities are added to the B-mode images to eliminate aliasing effects in high flow situations.  ...  Conclusion: Occurrence of MES during TLT, apparently, is connected with influence of fibrinolytic agent on blood clot (embolus) in a gleam of the amazed artery.  ... 
doi:10.1159/000338951 pmid:22652633 fatcat:tvkmom7mpze5zn4tsvsm7tlmje

Poster Presentations

2007 Cerebrovascular Diseases  
Aim: To study the relationship between carotid pathology and risk factors (RF) for cerebrovascular diseases (CVDs).  ...  Methods and patients: Color duplex sonography of carotid arteries was performed in 924 patients: 368 with RF for CVDs, 126 with transient ischemic attacks (TIAs), 287 with chronic unilateral infarction  ...  Methods: Clots from 0.5 ml venous blood were placed into a model which comprised of the US probe (SONOS 5500, S4), a container for the clot within a water bath and a human temporal bone between them.  ... 
doi:10.1159/000104181 fatcat:prxow23hnvc5vk2bmwjo3n2giq

Measurement Science in the Circulatory System

Casey M. Jones, Sandra M. Baker-Groberg, Flor A. Cianchetti, Jeremy J. Glynn, Laura D. Healy, Wai Yan Lam, Jonathan W. Nelson, Diana C. Parrish, Kevin G. Phillips, Devon E. Scott-Drechsel, Ian J. Tagge, Jaime E. Zelaya (+2 others)
2013 Cellular and Molecular Bioengineering  
Together, this review provides an overview of the utility of measurement science techniques to study the spatial systems of the circulatory system in health and disease.  ...  In this review, we discuss measurement techniques that have been developed to characterize the physical and mechanical parameters of the circulatory system across length scales ranging from the tissue  ...  Acknowledgments We are grateful to Juliana Porter for technical assistance.  ... 
doi:10.1007/s12195-013-0317-4 pmid:24563678 pmcid:PMC3928977 fatcat:wgwqyfl6nfep7cp7k64gbdy4fm

Monitoring during paediatric cardiac anaesthesia

Jonathan P. Purday
1994 Canadian Journal of Anesthesia  
The use of the current monitors of cerebral function still remains controversial despite the need for a monitor of adequate brain perfusion, reflecting the need for a great deal of further research in  ...  The purpose of this review is to give a comprehensive update of published material related to both routine and specialized cardiac monitoring.  ...  Medical Illustration, British Columbia Children's Hospital for help in the preparation of this manuscript.  ... 
doi:10.1007/bf03011590 pmid:7955000 fatcat:awijxmbamfgr3eiwntuq6exl7q

Neurosonology of emboli detection and monitoring

Mehmet Akif Topcuoglu, Ethem Murat Arsava
2012 Türk Beyin Damar Hastalıkları Dergisi  
Albeit no uniform picture has emerged from the studies, presence and amount of MES can identify a high-risk status in the setting of potential arterial or cardiac sources of cerebral embolism.  ...  The potential of MES detection in improvement of patient care is usually acknowledged, even though several aspects remain yet to be scientifically established.  ...  MEBR of aerogenic MES is higher than same sized solid MES because scattering of more ultrasound from gas bubbles, which are assumed as deformable spheres, compared to atheroma or thrombus of the same size  ... 
doi:10.5505/tbdhd.2012.80775 fatcat:oyl6d6gzlbe7zhigmdrcuylmzi

Recent advances in the application of computational mechanics to the diagnosis and treatment of cardiovascular disease

Juan C Del Alamo, Alison L Marsden, Juan C Lasheras
2009 Revista Española de Cardiología  
In general, research was driven by the need to provide answers to questions of critical importance for disease management.  ...  opportunity for numerical simulations and complex experimental techniques to make a contribution to improving the diagnosis and clinical management of many forms of cardiovascular disease.  ...  , a baffle is constructed to connect the inferior vena cava (IVC) to the pulmonary arteries resulting in a modified T-shaped junction.  ... 
pmid:19709514 pmcid:PMC6089365 fatcat:kw6aoncesna4nnihuoi7z2wche
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