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Ultrashort echo time (UTE) magnetic resonance imaging of the short T2 components in white matter of the brain using a clinical 3T scanner

Jiang Du, Guolin Ma, Shihong Li, Michael Carl, Nikolaus M. Szeverenyi, Scott VandenBerg, Jody Corey-Bloom, Graeme M. Bydder
2014 NeuroImage  
In this study we used ultrashort echo time (UTE) sequences to investigate the ultrashort T2 components in white matter of the brain and quantify their T2*s and relative proton densities (RPDs) (relative  ...  These are not detectable using clinical magnetic resonance imaging (MRI) sequences with conventional echo times (TEs).  ...  Acknowledgments The authors thank grants support from GE Healthcare and 1R21 AR063894-01A1.  ... 
doi:10.1016/j.neuroimage.2013.10.053 pmid:24188809 pmcid:PMC4091919 fatcat:dfauovic3bddvhhqdrujacszza

Direct magnitude and phase imaging of myelin using ultrashort echo time (UTE) pulse sequences: A feasibility study

Qun He, Yajun Ma, Shujuan Fan, Hongda Shao, Vipul Sheth, Graeme M. Bydder, Jiang Du
2017 Magnetic Resonance Imaging  
T2* values of ∼300 μs were comparable for myelin paste phantoms and the short T2* component in white matter of the brain in vivo.  ...  In this paper, we aimed to investigate the feasibility of direct visualization of myelin, including myelin lipid and myelin basic protein (MBP), using two-dimensional ultrashort echo time (2D UTE) sequences  ...  Acknowledgments This study was supported by the National Institutes of Health (R01NS092650).  ... 
doi:10.1016/j.mri.2017.02.009 pmid:28219648 pmcid:PMC5503674 fatcat:2dwp6ykhcbelfbdwi5scskv56e

Ultrashort Echo Time Magnetic Resonance Fingerprinting (UTE-MRF) for Simultaneous Quantification of Long and Ultrashort T2 Tissues [article]

Qing Li, Xiaozhi Cao, Huihui Ye, Congyu Liao, Hongjian He, Jianhui Zhong
2019 arXiv   pre-print
Purpose: To demonstrate an ultrashort echo time magnetic resonance fingerprinting (UTE-MRF) method that can simultaneously quantify tissue relaxometries for muscle and bone in musculoskeletal systems and  ...  tissue components in brain and therefore can synthesize pseudo-CT images.  ...  Acknowledgments The authors would like to acknowledge Dr. Kang Wang and Dr. Jin Jin from the First Affiliated Hospital of Zhejiang University for the help and discussions on the patient scans. 19  ... 
arXiv:1812.08067v2 fatcat:yxi64k2g5ngwjpfrflxgjcrune

Ultrashort echo time (UTE) magnetic resonance imaging of myelin: technical developments and challenges

Ya-Jun Ma, Hyungseok Jang, Eric Y. Chang, Annie Hiniker, Brian P. Head, Roland R. Lee, Jody Corey-Bloom, Graeme M. Bydder, Jiang Du
2020 Quantitative Imaging in Medicine and Surgery  
Acknowledgments Funding: This study was supported by the National Institutes of Health (R01NS092650).  ...  (A) Illustration of the contrast mechanisms in imaging ultrashort T 2 components (such as myelin) in white matter (WM S ) using a IR-UTE sequence with an inversion time (TI) set for nulling of signals  ...  Editorial Ultrashort echo time (UTE) magnetic resonance imaging of myelin: technical developments and challenges Direct assessment of the integrity of myelin in the CNS and PNS may be important for the  ... 
doi:10.21037/qims-20-541 pmid:32550129 pmcid:PMC7276362 fatcat:zyqzhrwwzbb2vc4x524npyy73m

Ultrashort echo time and zero echo time MRI at 7T

Peder E. Z. Larson, Misung Han, Roland Krug, Angela Jakary, Sarah J. Nelson, Daniel B. Vigneron, Roland G. Henry, Graeme McKinnon, Douglas A. C. Kelley
2015 Magnetic Resonance Materials in Physics, Biology and Medicine  
Object-Zero echo time (ZTE) and ultrashort echo time (UTE) pulse sequences for MRI offer unique advantages of being able to detect signal from rapidly decaying short-T2 tissue components.  ...  In this paper, we applied 3D zero echo time (ZTE) and ultrashort echo time (UTE) pulse sequences at 7T to assess differences between these methods.  ...  Acknowledgments We would like to thank the volunteers who participated in this study, as well as Kim Butts Pauly, Rob Peters and Michael Carl for helpful comments and discussions on the methods and images  ... 
doi:10.1007/s10334-015-0509-0 pmid:26702940 pmcid:PMC4892974 fatcat:hzshe6pvmbg5pcy4r72mlmztcm

Magnetic resonance imaging of myelin using ultrashort Echo time (UTE) pulse sequences: Phantom, specimen, volunteer and multiple sclerosis patient studies

Vipul Sheth, Hongda Shao, Jun Chen, Scott Vandenberg, Jody Corey-Bloom, Graeme M. Bydder, Jiang Du
2016 NeuroImage  
Here we show that protons in myelin can be directly imaged using ultrashort echo time (UTE) free induction decay (FID) and imaging sequences on a clinical 3T MR scanner.  ...  Clinical magnetic resonance imaging of multiple sclerosis (MS) has focused on indirect imaging of myelin in white matter by detecting signal from protons in the water associated with myelin.  ...  Acknowledgments Funding The authors acknowledge grant support from the NIH (1R01 NS092650). VS was supported by the UCSD Clinician Scientist Program and NIBIB T32-EB005970.  ... 
doi:10.1016/j.neuroimage.2016.05.012 pmid:27155128 pmcid:PMC4914437 fatcat:2l4t3kofina7bdinllpdwwblqm

Short T2 contrast with three-dimensional ultrashort echo time imaging

Jiang Du, Mark Bydder, Atsushi M. Takahashi, Michael Carl, Christine B. Chung, Graeme M. Bydder
2011 Magnetic Resonance Imaging  
In this paper, we describe the use of three-dimensional ultrashort echo time (3D UTE) sequences with TEs down to 8 μs for imaging of these species.  ...  The feasibility of using these approaches was demonstrated in in vitro and in vivo imaging of calcified cartilage, aponeuroses, menisci, tendons, ligaments and cortical bone with a 3-T clinical MR scanner  ...  Acknowledgments This study was supported, in part, by GE Healthcare, the RSNA (the Agfa Heathcare/RSNA Research Scholar) and NIAMS 1R21AR057901-01A1.  ... 
doi:10.1016/j.mri.2010.11.003 pmid:21440400 pmcid:PMC4123532 fatcat:txejqbcrxjaldabk5mor3ewsim

Inversion recovery ultrashort echo time magnetic resonance imaging: A method for simultaneous direct detection of myelin and high signal demonstration of iron deposition in the brain – A feasibility study

Vipul R. Sheth, Shujuan Fan, Qun He, Yajun Ma, Jacopo Annese, Robert Switzer, Jody Corey-Bloom, Graeme M. Bydder, Jiang Du
2017 Magnetic Resonance Imaging  
In this study we tested the hypothesis that the inversion recovery ultrashort echo time (IR-UTE) pulse sequence can directly and simultaneously image myelin and iron deposition using a clinical 3T scanner  ...  The IR-UTE signal from white matter of the brain of healthy volunteers shows a rapid signal decay with a short T2* of ∼300 μs, consistent with the T2* values of myelin protons in the synthetic myelin phantom  ...  Acknowledgments The authors acknowledge grant support from NIH (1R01 NS092650). VS was supported by the UCSD Clinician Scientist Program and NIBIB T32-EB005970.  ... 
doi:10.1016/j.mri.2016.12.025 pmid:28038965 pmcid:PMC5503675 fatcat:gsf7zr56ifbjbo4bg5fftcdabq

MR-Based PET Attenuation Correction using a Combined Ultrashort Echo Time/Multi-Echo Dixon Acquisition [article]

Paul Kyu Han, Debra E. Horng, Kuang Gong, Yoann Petibon, Kyungsang Kim, Quanzheng Li, Keith A. Johnson, Georges El Fakhri, Jinsong Ouyang and Chao Ma
2020 arXiv   pre-print
We propose a magnetic resonance (MR)-based method for estimation of continuous linear attenuation coefficients (LAC) in positron emission tomography (PET) using a physical compartmental model and ultrashort  ...  echo time (UTE)/multi-echo Dixon (mUTE) acquisitions.  ...  Acknowledgements This work was supported in part by the National Institutes of Health (T32EB013180, R01CA165221, R01HL118261, R21EB021710, and P41EB022544) and the Federal Share of Program Income earned  ... 
arXiv:2004.01212v1 fatcat:zfthk53q75cjhih4puc5jugv6q

Measurement of T1 of the Ultrashort T2* Components in White Matter of the Brain at 3T

Jiang Du, Vipul Sheth, Qun He, Michael Carl, Jun Chen, Jody Corey-Bloom, Graeme M. Bydder, Christian Beaulieu
2014 PLoS ONE  
Adiabatic inversion recovery prepared dual echo ultrashort echo time (IR-dUTE) sequences can be used to selectively image the ultrashort T2* components in white matter of the brain using a clinical whole  ...  Recent research demonstrates that white matter of the brain contains not only long T2 components, but a minority of ultrashort T2* components.  ...  Acknowledgments The authors would like to thank the volunteers who participated in the study and Richard Znamirowski for his support in data collection. Author Contributions  ... 
doi:10.1371/journal.pone.0103296 pmid:25093859 pmcid:PMC4122467 fatcat:rl3o4xluznbvdfstfht73jtawq

Yet more evidence that myelin protons can be directly imaged with UTE sequences on a clinical 3T scanner: Bicomponent T2* analysis of native and deuterated ovine brain specimens

Shu-Juan Fan, Yajun Ma, Yanchun Zhu, Adam Searleman, Nikolaus M. Szeverenyi, Graeme M. Bydder, Jiang Du
2017 Magnetic Resonance in Medicine  
(C) Illustration of the contrast mechanism for imaging white-matter ultrashort T 2 components (WM S ) using IR-UTE with the TI set for nulling of signals from the white-matter long T 2 components (WM L  ...  of these sequences to myelin proton signals by comparing the ultrashort T 2 component (STC) fraction (f S ) and T Ã 2 (T Ã 2S ) seen in fresh and deuterated ovine brain white matter (WM).  ... 
doi:10.1002/mrm.27052 pmid:29271083 fatcat:vixait5sdzgjfhbtbk5utkglfu

Towards quantification of myelin by solid-state MRI of the lipid matrix protons

Alan C. Seifert, Cheng Li, Michael J. Wilhelm, Suzanne L. Wehrli, Felix W. Wehrli
2017 NeuroImage  
echo-time (UTE) and zero echo-time (ZTE) MRI in ovine spinal cord.  ...  Conclusion-In the present implementation, IR-UTE at 9.4T produced similar estimates of myelin concentration in D 2 O-exchanged and non-exchanged spinal cord white matter. 3T data suggest that direct myelin  ...  Acknowledgments This work was supported by the National Institutes of Health Grant R21-NS082953.  ... 
doi:10.1016/j.neuroimage.2017.09.054 pmid:28964929 pmcid:PMC5716915 fatcat:yxp6nf2ogjfnldajz2k5eangia

New options for increasing the sensitivity, specificity and scope of synergistic contrast magnetic resonance imaging (scMRI) using Multiplied, Added, Subtracted and/or FiTted (MASTIR) pulse sequences

Ya-Jun Ma, Hongda Shao, Shujuan Fan, Xing Lu, Jiang Du, Ian R. Young, Graeme M. Bydder
2020 Quantitative Imaging in Medicine and Surgery  
of clinical magnetic resonance imaging (MRI) protocols.  ...  In the brain, when an IR sequence nulling white matter has subtracted from it an IR sequence nulling gray matter to form the subtracted IR (SIR) sequence, increases in the single TP T1 between the two  ...  Introduction In clinical magnetic resonance imaging (MRI), pulse sequences are usually described by the single tissue property (TP) such as T 1 or T 2 most responsible for the contrast they produce using  ... 
doi:10.21037/qims-20-795 pmid:33014733 pmcid:PMC7495319 fatcat:wkwhyjhlcvgctospjh76dxzajy

Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin

Alex L. MacKay, Cornelia Laule, Bernard Zalc
2016 Brain Plasticity  
Myelin water imaging is a magnetic resonance imaging method which can be used to visualize myelination in the brain and spinal cord in vivo.  ...  Multi-echo T 2 relaxation approaches continue to undergo development and whole-brain imaging time now takes less than 10 minutes; the standard analysis method for this type of data acquisition is a non-negative  ...  ACKNOWLEDGMENTS Research by ALM is supported by a Discovery  ... 
doi:10.3233/bpl-160033 pmid:29765849 pmcid:PMC5928546 fatcat:sce5or2unvecxfgzz5cart4dru

Short T2 imaging using a 3D double adiabatic inversion recovery prepared ultrashort echo time cones (3D DIR-UTE-Cones) sequence

Ya-Jun Ma, Yanchun Zhu, Xing Lu, Michael Carl, Eric Chang, Jiang Du
2018 Magnetic Resonance in Medicine   unpublished
Purpose: To investigate high contrast imaging of short T 2 tissues with a three-dimensional double adiabatic inversion recovery prepared ultrashort echo time Cones (3D DIR-UTE-Cones) sequence.  ...  Conclusion: The 3D DIR-UTE-Cones sequence provides robust suppression of long T 2 tissues and allows selective imaging as well as T Ã 2 measurement of short T 2 tissues such as cortical bone, patellar  ...  , and the Achilles tendon ex vivo and in vivo on a clinical 3T scanner.  ... 
fatcat:6uqns3pbzrdqtl72rqmeahmy2i
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