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Ultrafast Focus Detection for Automated Microscopy [article]

Maksim Levental, Ryan Chard, Kyle Chard, Ian Foster, Gregg A. Wildenberg
2022 arXiv   pre-print
We present a fast out-of-focus detection algorithm for electron microscopy images collected serially and demonstrate that it can be used to provide near-real-time quality control for neuroscience workflows  ...  We show that our method can detect of out-of-focus conditions within just 20ms.  ...  Rather than focusing the microscope, as auto-focusing algorithms would, our algorithm operates downstream of image acquisition and reports out-of-focus events to the user.  ... 
arXiv:2108.12050v3 fatcat:be32hlkasjbqvjv2irypbkq7va

Industry News – March 2022

2022 Microscopy Today  
Microscopy Facility Map The Royal Microscopy Society has created a map of core microscopy facilities for the UK and beyond.  ...  Located in the Institute imaging facility, the NCofE for Neuro-NanoImaging focuses on how the latest super-resolution microscopy techniques can help in understanding brain cells and their dysfunctions.  ...  Bruker Introduces Fast BioAFM Bruker has released the JPK Nano-Wizard® V BioAFM, which offers a high level of automation and ease of use for life science atomic force microscopy research.  ... 
doi:10.1017/s155192952200027x fatcat:wbr57ccviraxpo5piq7vfvt7ba

2019 Microscopy Today Innovation Awards

2019 Microscopy Today  
High-energy relativistic electrons can minimize space charge for ultrafast microscopy, but traditional round lenses to focus such electrons are bulky and expensive.  ...  The magnetic quadruple lens with asymmetric focusing is used to focus highenergy electrons in accelerators.  ...  High-energy relativistic electrons can minimize space charge for ultrafast microscopy, but traditional round lenses to focus such electrons are bulky and expensive.  ... 
doi:10.1017/s1551929519000828 fatcat:jtaydgqunvfhnjnzlrgaspb35i

Special Section Guest Editorial: Ultrashort Pulsed Laser and Applications Engineering

Marcos Dantus, Gerald C. Manke
2014 Optical Engineering: The Journal of SPIE  
standoff detection of explosives.  ...  His primary focus is the use of laser technology for IR and RF countermeasures and other electronic warfare applications. "High-energy femtosecond 2-μm fiber laser," by P.  ... 
doi:10.1117/1.oe.53.5.051501 fatcat:cbnfxpyjtje3vduomkslxxg5yi

Focus Alignment Method for Laser Manufacturing at Sub-micron Positional Accuracy

Johannes Strauß, Kristian Cvecek, Andreas Gröschl, Ilya Alexeev, Michael Schmidt
2012 Physics Procedia  
The method makes alignment of unique samples precise and time efficient due to ease of automation and provides a reproducibility of surface detection of less than 1μm.  ...  There are a number of methods that allow detection of the surface position, however only few of them use the beam of the processing laser as a basis for the measurement.  ...  For example, beam astigmatism is used for focus positioning in CD/DVD-ROM drives.  ... 
doi:10.1016/j.phpro.2012.10.103 fatcat:a65vkz3ojrdljl2m7vsxnb3x3m

Industry News – May 2022

2022 Microscopy Today  
Introducing the New Home for Remel, Oxoid, and TREK Technical Resources ThermoFisher Scientific will incorporate the Oxoid, Remel, and TREK websites.  ...  In addition, full access to a range of up-to-date tools, resources, and featured content designed for microbiology laboratories will be provided.  ...  with new automation and ease of use for life science atomic force microscopy research.  ... 
doi:10.1017/s1551929522000529 fatcat:r7frqpz3uffpfddqt5isq364da

New Products

2015 Science  
For a fully automated workflow, Verso can integrate with Hamilton automated liquid handling workstations.  ...  Bio-Rad For info: 800-424-6723 www.bio-rad.com/precisionabpr Confocal Raman Imaging Module The newest SWIFT v2 ultrafast confocal Raman imaging module is available for the XploRA PLUS and LabRAM Evolution  ... 
doi:10.1126/science.349.6245.333a fatcat:zgdhtc7eqjgdroxcfc4p7tmb2e

Size Corrections during Ultrafast Laser Induced Refractive Index Changes in Bulk Transparent Materials

Razvan Stoian
2009 Journal of Laser Micro/Nanoengineering  
We discuss here strategies for counteracting wavefront distortion effects which occur during ultrafast laser induced changes of refractive index.  ...  Three-dimensional structuring of bulk dielectric materials usually requires focusing through airdielectric interfaces. Consequently, depth-dependent spherical aberration appears.  ...  Detection of the structures is realized online by optical phase-contrast microscopy (PCM).  ... 
doi:10.2961/jlmn.2009.01.0009 fatcat:x7i6w2ah7vhidpgjsxbq3ijxqu

Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow [article]

Terence T. W. Wong , Matthew Y. H. Tang, Antony C. S. Chan , Godfrey C. F. Chan The University of Hong Kong, Hong Kong These authors contributed equally to this work)
2013 arXiv   pre-print
We here demonstrate a new imaging approach, called asymmetric-detection time-stretch optical microscopy (ATOM), which can deliver ultrafast label-free high-contrast flow imaging with well delineated cellular  ...  Accelerating imaging speed in optical microscopy is often realized at the expense of image contrast, image resolution, and detection sensitivity- a common predicament for advancing high-speed and high-throughput  ...  Mak for preparing the MIHA, BEL-7402 and HeLa cell lines for us. This  ... 
arXiv:1309.5579v1 fatcat:plwhhgjhmfdg5iczo3p2e33d44

Screening of protein crystallization trials by second order nonlinear optical imaging of chiral crystals (SONICC)

Levi M. Haupert, Garth J. Simpson
2011 Methods  
Second order nonlinear optical imaging of chiral crystals (SONICC) is a promising new method for the sensitive and selective detection of protein crystals.  ...  Instrumentation and methods for SONICC measurements are described and critically assessed in terms of performance trade-offs.  ...  Acknowledgments L.M.H and G.J.S are grateful for support from the NIH Roadmap Initiative grant P50 GM073197, NIH-RO1RR026273, and NSF-MRI 0722558.  ... 
doi:10.1016/j.ymeth.2011.11.003 pmid:22101350 pmcid:PMC3264792 fatcat:npogr7ihjbh4bpnr6jcyudokei

Improvement of axial resolution and contrast in temporally focused widefield two-photon microscopy with structured light illumination

Heejin Choi, Elijah Y. S. Yew, Bertan Hallacoglu, Sergio Fantini, Colin J. R. Sheppard, Peter T. C. So
2013 Biomedical Optics Express  
We implemented a structured light illumination for TFM and have shown that it can effectively reject the out-of-focus scattered emission photons improving image contrast.  ...  Although temporally focused wide-field two-photon microscopy (TFM) can perform depth resolved wide field imaging, it cannot avoid the image degradation due to scattering of excitation and emission photons  ...  supported by NIH 9P41EB015871-26A1, 5R01EY017656-02, 5R01 NS051320, 4R44EB012415-02, NSF CBET-0939511, the Singapore-MIT Alliance 2, the MIT SkolTech initiative, the Hamamatsu Corp. and the Koch Institute for  ... 
doi:10.1364/boe.4.000995 pmid:23847726 pmcid:PMC3704103 fatcat:fvdjajourzai7dh47mv4jocxvm

Who Should Decide How Effective Cervical Cancer Screening Will Be?

R. Marshall Austin
1999 Acta Cytologica  
A number of such designs have been im- plemented for ultrafast laser scanning microscopy and for microlithography.  ...  One may solve it by resetting for best focus at each scan field. One may establish a focus map for each slide, in a pipeline fashion, by a sequential prescan by a second objective.  ... 
doi:10.1159/000330535 pmid:9987442 fatcat:h2usdxauwfennhnmn4i56adltq

New Products

2015 Science  
For a fully automated workflow, Verso can integrate with Hamilton automated liquid handling workstations.  ...  Bio-Rad For info: 800-424-6723 www.bio-rad.com/precisionabpr Confocal Raman Imaging Module The newest SWIFT v2 ultrafast confocal Raman imaging module is available for the XploRA PLUS and LabRAM Evolution  ... 
doi:10.1126/science.349.6245.333-a fatcat:6miyjz45ofgkrp5tbuodyrsrxa

New Products

2015 Science  
Go to www.sciencemag.org/products/newproducts.dtl for more information. 1274 sciencemag.org/products SCIENCE Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers  ...  PerkinElmer For info: 800-762-4000 www.perkinelmer.com EMCCD Spectroscopy Camera The new Synapse EM is a deep-cooled EMCCD Scientific camera for low-light and ultrafast spectroscopy experiments.  ...  A number of sample automation and detector options are available to suit many applications.  ... 
doi:10.1126/science.348.6240.1274-a fatcat:syqu2tbvq5gg7p7hotf6aq7bya

An Overview of Non-Destructive Testing Methods for Integrated Circuit Packaging Inspection

Pouria Aryan, Santhakumar Sampath, Hoon Sohn
2018 Sensors  
The review identifies various types of the defects and the capabilities of most common NDT methods employed for defect detection.  ...  The current methods such as, X-ray, scanning acoustic microscopy (SAM), infrared thermography (IRT), magnetic current imaging (MCI) and surface acoustic waves (SAW) are explicitly reviewed.  ...  Infrared Microscopy (IRM) Infrared Microscopy (IRM) denotes a microscopy achieved at infrared wavelengths.  ... 
doi:10.3390/s18071981 pmid:29933589 pmcid:PMC6068802 fatcat:hqxyvgkosjeplkejmsvgshcweu
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