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Comparative (Meta)genomic Analysis and Ecological Profiling of Human Gut-Specific Bacteriophage φB124-14

Lesley A. Ogilvie, Jonathan Caplin, Cinzia Dedi, David Diston, Elizabeth Cheek, Lucas Bowler, Huw Taylor, James Ebdon, Brian V. Jones, Jonathan H. Badger
2012 PLoS ONE  
landscape, identifying a novel and uncharted bacteriophage gene-space in this community. wB124-14 infects only a subset of closely related gut-associated Bacteroides fragilis strains, and the circular genome encodes  ...  Bacteriophage associated with the human gut microbiome are likely to have an important impact on community structure and function, and provide a wealth of biotechnological opportunities.  ...  Block arrows represent individual ORFs and indicate direction of transcription.  ... 
doi:10.1371/journal.pone.0035053 pmid:22558115 pmcid:PMC3338817 fatcat:dzrahhu3pjfgff24vsh4iykq4u

Marine Toxins Targeting Ion Channels

Hugo Arias
2006 Marine Drugs  
A polyamine with analgesic properties obtained from the fishing spider Dolomedes okefinokensii reversibly blocks L-and R-type Ca V channels.  ...  The comparison with the different AChBP structures, which also bind AChR agonists (e.g., ACh, CCh, nicotine, etc.) and competitive antagonists [e.g., α-bungarotoxin (α-BTx), d-tubocurarine, etc.], have  ... 
doi:10.3390/md403037 fatcat:lp2udrquqvfn3gemr4zn5donj4

Antimicrobial Peptides: An Update on Classifications and Databases

Ahmer Bin Hafeez, Xukai Jiang, Phillip J. Bergen, Yan Zhu
2021 International Journal of Molecular Sciences  
They consist of predominantly short cationic peptides with a wide variety of structures and targets.  ...  Pyrrhocoricin can block the molecular chaperones DnaK and GroEL, and also reduce DnaK ATPase activity via competitive inhibition [491, 492] ; drosocin (DnaK and GroEF) [491] and apidaecin (DnaK) [493  ...  Apidaecin has recently been shown to competitively bind with release factors on the A-site of ribosomes, inhibiting the termination step of translation [488] .  ... 
doi:10.3390/ijms222111691 pmid:34769122 pmcid:PMC8583803 fatcat:4ts7nuas7jdanhjgtpn3pntiqy

The Detailed Science Case for the Maunakea Spectroscopic Explorer: the Composition and Dynamics of the Faint Universe [article]

Alan McConnachie, Carine Babusiaux, Michael Balogh, Simon Driver, Pat Côté, Helene Courtois, Luke Davies, Laura Ferrarese, Sarah Gallagher, Rodrigo Ibata, Nicolas Martin, Aaron Robotham, Kim Venn (+149 others)
2016 arXiv   pre-print
MSE is an 11.25m aperture observatory with a 1.5 square degree field of view that will be fully dedicated to multi-object spectroscopy.  ...  MSE is optimized for high throughput, high signal-to-noise observations of the faintest sources in the Universe with high quality calibration and stability being ensured through the dedicated operational  ...  Ultimately, such a survey will allow us to deconstruct a nearby galactic halo into its accreted "building blocks".  ... 
arXiv:1606.00043v1 fatcat:2atxpt2u5zabfc5pjhzd5c5a3e

AAO Observer - August 2011 Edition [article]

Sarah Brough
2011 arXiv   pre-print
components, the measurement of dynamical mass, the examination of the impact of winds and out flows, and the discovery of merging systems via dynamical disturbance.  ...  With the goal of ultimately deriving the distances and peculiar velocities of each of these galaxies, we make use of an important correlation for early-type galaxies, the Fundamental Plane (FP).  ...  Tom was one of the growing band of amateur scientists; making contributions to astronomy through his own personal observations.  ... 
arXiv:1108.4747v1 fatcat:vklfjggdmrf7fknzvlziquci3a

A pharmacological characterisation of death adder (Acanthophis Spp.) venoms and toxins

Janith C. Wickramaratna
Dynamic mechanisms of nonclassical antagonism by competitive ATi receptor antagonists. Trends Pharmacol. Sci., 21, 376-381.  ...  pharmacokinetics and dynamics.  ... 
doi:10.4225/03/59d427590d19b fatcat:kioyy65bo5dt3m5pun627t4jj4


2016 Journal of Thrombosis and Haemostasis  
AMC02 TMEM16F-mediated platelet pro-coagulant activity contributes to infarct progression after ischemic stroke  ...  With the rapid recruitment of inflammatory neutrophils into damaged area, following fibrin net formation and tissue regenerative changes were observed, indicating tight association between endothelial  ...  Background: Preeclampsia contributes significantly to maternal, fetal and neonatal morbidity and mortality, however, its cause is poorly understood.  ... 
doi:10.1111/jth.13325 pmid:27175826 fatcat:zsph726iwfbcff7ghrqnnjheny

Structural-functional relationships in the human thrombin A-chain [article]

Isis Sarah Rosemary Carter
Contrary to expectation, autolysis of the A13 peptide at the N-terminus of the thrombin A-chain was very slow, with a half life of 46 minutes.  ...  While originally considered to be simply an activation remnant with little physiological function, mutations in the prothrombin A-chain region lead to bleeding disorders.  ...  K 301 deletion mutation resulted in a prothrombin that was activated to thrombin with the prothrombinase homolog Taipan snake venom (TSV).  ... 
doi:10.14288/1.0072069 fatcat:duplk3fqxnfrhkga3lb45ghyp4

A Genomic and Proteomic Investigation Into the Clostridium botulinum Neurotoxin Complex

Philip Matthew Ashton
A relationship between OrfX-encoding strains and infant botulism was also uncovered in clinical strains from the UK. Hypotheses to explain this association are explored.  ...  Here, the proteins from the lesser-studied toxin complex type (the OrfX type) are shown for the first time to share sequence similarity and synteny with clusters of proteins that are co-localised with  ...  Competitive antagonists of these carbohydrate receptors blocked intoxication via the oral route in mice (Lee et al., 2013) .  ... 
doi:10.21954/ fatcat:utmcnx25k5favp57v3d4wm66zm

MRAP : marketing military innovation [article]

Hasik, James M., 1966-
Troops were modifying their patrol vehicles in the field with their own scavenged steel plating, deemed hillbilly armor.  ...  Fairly, at that point, the Army was installing add-on armor to Humvees in the United States, and longtime supplier AM General was assembling, each month, 450 even more robust Humvees with factory-installed  ...  Five firms responded: Oshkosh (with its armoring partner Ceradyne), Force Dynamics (the partnership of Force Protection and General Dynamics), General Dynamics on its own, PVI (with assistance from Israeli  ... 
doi:10.15781/t28k74z27 fatcat:kfjsg2ag6zfydbm5cefrvaqzle

Legitimacy dynamics of accounting standards setting: the case of Indonesia

Aviandi Okta Maulana
This research builds upon the works of Suchman (1995) on legitimacy to explore and compare legitimacy dynamics between conventional and Islamic accounting standards, particularly in cognitive biases embedded  ...  Indonesia is selected as case study due to its unique accounting standards infrastructure, with the existence of dual and parallel standards setter for conventional and Islamic accounting standards development  ...  Historically, accountants were required to assist the nation towards economic competitiveness.  ... 
doi:10.48683/1926.00087829 fatcat:p6cpt4vkozbqvjdd2qwmrl3mmq

Quaderni di Linguistica e Studi Orientali / Working Papers in Linguistics and Oriental Studies, Vol. 2, 2016. Full Issue

Coronals block the harmonizing process, in spite of being traditionally dealt with as consonants transparent to the vocalic harmonies.  ...  This in turn leads Asbury to propose that there is competition for morphological realization.  ...  were disgusted with me.'  ... 
doi:10.13128/qulso-2421-7220-18760 fatcat:fllpdrnq7jdtpdcbpvw5fch5ge

Love your country on Nanjing Road : The British and the May Fourth Movement in Shanghai

Tiina Helena Airaksinen
Accordingly, the focus is also on the dynamics of interaction between the British and Chinese and its impact on the development of the May Fourth Movement.  ...  This research is based on previously closed materials held in the Shanghai Municipal Archives and they are supplemented with sources from Bri [...]  ...  events o f 1919 not only reflected the world's changing dynamics in Great Power relations in Europe.  ... 
doi:10.25501/soas.00028871 fatcat:3ilc446mrnee3jucagqxu2t4hy

The question of cross-cultural understanding in the transcultural travel narratives in post-1949 China

Leilei Chen
Ultimately, this is a friendship between human beings who are capable of building connections with one another. J.  ...  Difference also becomes an asset, with which each contributes to the conversation in one's unique way.  ... 
doi:10.7939/r34p7n fatcat:lghjohjpffb3hj2so4tjvp3vce

Teachers, collaboration, praxis: A case study of a participatory action research project in a rural school of Bangladesh [article]

Safayet Alam, University Of Canterbury
However existing professional development programmes and in-service teacher training are centrally developed and top-down and do not fully align with the rural teacher's needs.  ...  The study argued that it is unlikely that current teaching practices will enable Bangladeshi students to either contribute to global economic competitiveness or build national solidarity and critical consciousness  ...  Then, however, they felt their intentions were blocked by frustration with the shortcomings in their students and the sense of their personal inadequacy.  ... 
doi:10.26021/9313 fatcat:plsjiog2gvh4zh4dbl7btnvif4
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