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Tumor Cell Load and Heterogeneity Estimation From Diffusion-Weighted MRI Calibrated With Histological Data: an Example From Lung Cancer

Yi Yin, Oliver Sedlaczek, Benedikt Muller, Arne Warth, Margarita Gonzalez-Vallinas, Bernd Lahrmann, Niels Grabe, Hans-Ulrich Kauczor, Kai Breuhahn, Irene E. Vignon-Clementel, Dirk Drasdo
2018 IEEE Transactions on Medical Imaging  
between the diffusion coefficient (D value) estimated from DWI and tumor cellularity from serial histological slides of a resected non-small cell lung cancer (NSCLC) tumor.  ...  In order to link low-resolution clinical cross-sectional data with high-resolution histological information, we developed an image processing and analysis chain, which was used to study the correlation  ...  ACKNOWLEDGMENT We thank Johannes Lotz and Janine Olesch for providing us with the registered images ( [38] ). We also thank the reviewers for their useful comments.  ... 
doi:10.1109/tmi.2017.2698525 pmid:28463188 fatcat:dspd2rifpvhlhgjsrpc6cuyxby

Diffusion-weighted MRI-guided needle biopsies permit quantitative tumor heterogeneity assessment and cell load estimation [article]

Yi Yin, Kai Breuhahn, Hans-Ulrich Kauczor, Oliver Sedlaczek, Irene E. Vignon-Clementel, Dirk Drasdo
2021 arXiv   pre-print
It was recently shown by us that such information can be inferred from the diffusion parameter D derived from the diffusion-weighted MRI (DWI) if a relation between D and cell density can be established  ...  Quantitative information on tumor heterogeneity and cell load could assist in designing effective and refined personalized treatment strategies.  ...  The parametric Dmap is generated by estimating the voxel-wise diffusion coefficient from DWI data. (b) Tumor cell load and heterogeneity estimation from biopsies.  ... 
arXiv:2103.00714v1 fatcat:63atequxgjezbmoydb4drpqpuy

Vessel calibre—a potential MRI biomarker of tumour response in clinical trials

Kyrre E. Emblem, Christian T. Farrar, Elizabeth R. Gerstner, Tracy T. Batchelor, Ronald J. H. Borra, Bruce R. Rosen, A. Gregory Sorensen, Rakesh K. Jain
2014 Nature Reviews Clinical Oncology  
1) . 3, 4, 20, 21 Consequently, the tumour vascular bed is spatially and temporally heterogeneous with regard to multiple vessel parameters, not least vessel calibre, which creates an irregular microenvironment  ...  The preferred method for in vivo imaging of most solid cancers is MRI, and the concept of vessel-calibre MRI has evolved since its initial inception in the early 1990s.  ...  The authors acknowledge funding support from the National Cancer Institute, NIH, US Department of Human and Health Services (grants NCT00254943 to K.E.E., T32-CA009502 to C.T.F., NCT00756106 to E.R.G.,  ... 
doi:10.1038/nrclinonc.2014.126 pmid:25113840 pmcid:PMC4445139 fatcat:icxppdra7fhelaqgff3qu4gjua

Diminished aqueous microviscosity of tumors in murine models measured with in vivo radiofrequency electron paramagnetic resonance

H J Halpern, G V Chandramouli, E D Barth, C Yu, M Peric, D J Grdina, B A Teicher
1999 Cancer Research  
The effect of this microviscosity differences may be the basis of several physiological differences between tumors and normal tissues which could confer a growth rate advantage to tumor tissue.  ...  EPR spectra from dissolved nitroxide spin probes report the solvent microviscosity.  ...  ACKNOWLEDGMENTS Technical assistance was provided by Janet Riley, Joseph Teicher, and Lawrence Dunn. Drs. Samuel Hellman and Colin Mailer provided extremely useful discussion and insight.  ... 
pmid:10582707 fatcat:byajukticza6hoqp3hz6npd56e

Visualization and Quantification of the Extracellular Matrix in Prostate Cancer Using an Elastin Specific Molecular Probe

Avan Kader, Julia Brangsch, Carolin Reimann, Jan O. Kaufmann, Dilyana B. Mangarova, Jana Moeckel, Lisa C. Adams, Jing Zhao, Jessica Saatz, Heike Traub, Rebecca Buchholz, Uwe Karst (+2 others)
2021 Biology  
Two different tumor sizes (500 mm3 and 1000 mm3) were compared and analyzed by MRI in vivo and histologically and analytically ex vivo.  ...  Smaller tumors showed significantly higher signal intensity (p > 0.001), which correlates with the higher proportion of elastin fibers in the histological evaluation than in larger tumors.  ...  Acknowledgments: We are grateful for the financial support from the DFG-German Research Foundation. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/biology10111217 pmid:34827210 pmcid:PMC8615039 fatcat:hn6fznklhre7flcmpyz4fyqige

Investigation of In Vivo Targeting Kinetics of αvβ3-Specific Superparamagnetic Nanoprobes by Time-Resolved MRI

Chase W. Kessinger, Osamu Togao, Chalermchai Khemtong, Gang Huang, Masaya Takahashi, Jinming Gao
2011 Theranostics  
of the accumulation kinetics of nanoprobes in lung, breast and brain cancer preclinical models.  ...  different human cancer cell lines.  ...  The subcutaneous tumor xenografts were formed from non-small cell A549 lung cancer, MDA-MB-231 breast cancer, or U87 glioblastoma cell lines.  ... 
doi:10.7150/thno/v01p0263 pmid:21562632 pmcid:PMC3092449 fatcat:eysxayhstnazzit3lmjbs2zanq

SU-FF-I-79: Java-Based Plugin for Tomographic Reconstruction for SPECT Data

M Andrade, M Costa, A Marques da Silva
2006 Medical Physics (Lancaster)  
Purpose: Digital tomosynthesis (DTS) is a method for reconstructing 3D images from cone-beam projection data acquired with limited angulation (e.g., 40 o ) of an x-ray source, and is much faster and lower  ...  Method and Materials: We simulated the online positioning of an anthropomorphic chest phantom with 6 noncoplanar reference BBs attached. Planning CT data of the phantom were acquired with a G.E.  ...  non-small cell lung cancer (NSCLC).  ... 
doi:10.1118/1.2240759 fatcat:5we2nvgwx5hrxcv2ngufce6obq

Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19 F–MRI and Multispectral Analysis

Yunzhou Shi, Jason Oeh, Anna Hitz, Maj Hedehus, Jeffrey Eastham-Anderson, Franklin V. Peale, Patricia Hamilton, Thomas O'Brien, Deepak Sampath, Richard A.D. Carano
2017 Neoplasia: An International Journal for Oncology Research  
These goals have been successfully met, where an antibody that blocks both murine and human VEGF-A (B20.4.1.1) was found by MS 19 F-MRI to produce a strong anti-vascular response and reduce viable tumor  ...  The first goal of this study was to employ multispectral (MS) 19 F-MRI to noninvasively quantify viable tumor pO 2 and evaluate the ability of a high dose of an antibody to vascular endothelial growth  ...  Acknowledgements The authors would like to thank the in vivo cell culture team and laboratory animal resources at Genentech for their support of these studies.  ... 
doi:10.1016/j.neo.2017.07.010 pmid:28987998 pmcid:PMC5635323 fatcat:o2wiei2sjbeh3jihtbsf5dyj6i

Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success

Thomas E. Yankeelov, Gary An, Oliver Saut, E. Georg Luebeck, Aleksander S. Popel, Benjamin Ribba, Paolo Vicini, Xiaobo Zhou, Jared A. Weis, Kaiming Ye, Guy M. Genin
2016 Annals of Biomedical Engineering  
The top row indicates the apparent diffusion coefficient (ADC) obtained from diffusion weighted MRI data at three time points during therapy.  ...  The top row indicates the apparent diffusion coefficient (ADC) obtained from diffusion weighted MRI data at three time points during therapy.  ... 
doi:10.1007/s10439-016-1691-6 pmid:27384942 pmcid:PMC4983505 fatcat:6uo7f3xvifakzfqnwx2c3r4aiu

Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine

2020 Tomography  
To overcome the translational gap in cancer treatment and prevention, the cancer research community has been transitioning toward using animal models that more fatefully recapitulate human tumor biology  ...  An underlying emphasis in the program is to develop best practices toward reproducible, repeatable, and precise quantitative imaging biomarkers for use in translational cancer imaging and therapy.  ...  GEMMs have shown utility in co-clinical trials of immunotherapy of pancreatic cancer (46) and non-small cell lung cancer (47) .  ... 
doi:10.18383/j.tom.2020.00023 pmid:32879897 pmcid:PMC7442091 fatcat:3yykzm3tijfs5fmhebbipwhyze

Decision support systems for personalized and participative radiation oncology

Philippe Lambin, Jaap Zindler, Ben G.L. Vanneste, Lien Van De Voorde, Daniëlle Eekers, Inge Compter, Kranthi Marella Panth, Jurgen Peerlings, Ruben T.H.M. Larue, Timo M. Deist, Arthur Jochems, Tim Lustberg (+27 others)
2017 Advanced Drug Delivery Reviews  
/appropriate medical data (clinical, treatment, imaging, biological/genetic, etc.) to achieve the highest possible accuracy with respect to prediction of tumor response and normal tissue toxicity.  ...  In the reasonably near future, decision support systems will be fully integrated within the clinic, with data and knowledge being shared in a standardized, dynamic, and potentially global manner enabling  ...  Acknowledgments The authors acknowledge financial support from the QuIC-ConCePT project, which is partly funded by EFPI A companies and the Innovative  ... 
doi:10.1016/j.addr.2016.01.006 pmid:26774327 fatcat:rpfktbxw3rf4vewbiuj5alsave

Mapping of amide, amine, and aliphatic peaks in the CEST spectra of murine xenografts at 7 T

Kimberly L. Desmond, Firas Moosvi, Greg J. Stanisz
2013 Magnetic Resonance in Medicine  
Conclusions: CEST contrast (particularly the amine peak amplitude) performed especially well in distinguishing areas of apoptosis and/or necrosis from actively progressing tumor, as validated by histology  ...  Methods: CEST spectra of 24 mice with tumor xenografts (20 LLC and 4 MDA) were acquired at three time-points.  ...  They are grateful to Melissa Yin for tumor implantation and Joydeep Chaudhuri for preparation of specimens for histology and for useful discussions.  ... 
doi:10.1002/mrm.24822 pmid:23801344 fatcat:sis453aurfhprfjxsafjykoabu

Radiomics: the process and the challenges

Virendra Kumar, Yuhua Gu, Satrajit Basu, Anders Berglund, Steven A. Eschrich, Matthew B. Schabath, Kenneth Forster, Hugo J.W.L. Aerts, Andre Dekker, David Fenstermacher, Dmitry B. Goldgof, Lawrence O. Hall (+4 others)
2012 Magnetic Resonance Imaging  
The focus of this article will be on images of non-small-cell lung cancer.  ...  Radiomics" refers to the extraction and analysis of large amounts of advanced quantitative imaging features with high throughput from medical images obtained with computed tomography, positron emission  ...  [29] to develop prediction models for classifying non-small-cell lung cancer (NSCLC) tumor types using image features.  ... 
doi:10.1016/j.mri.2012.06.010 pmid:22898692 pmcid:PMC3563280 fatcat:irvoga2qtrbsrbhliher2cyb7e

Proceedings of the World Molecular Imaging Congress 2020, October 7-9, 2020: General Abstracts

2022 Molecular Imaging and Biology  
Fluorescence signal distinguished tumor cells with 90% specificity and 82.5% sensitivity.  ...  EGFR immunohistochemical staining of tumor specimens from 35 HGG patients during 2006-2019 was scored by pathologists and expression levels were compared to that of mouse xenografts and subsequently stratified  ...  Microvascular connectivity (MC) maps (Fig. 1h ) illustrate early stage coherent blood volume fluctuations (i.e. vasodilations and vasoconstrictions) in areas with sprouting tumor vessels (D3-D6), which  ... 
doi:10.1007/s11307-021-01691-0 pmid:34982363 pmcid:PMC8725637 fatcat:ipn7hwekzzh6nbsk6dr2mzuhhm

Manganese-enhanced magnetic resonance imaging of breast cancer cells

Mosa Alhamami
2018 Journal of Clinical & Experimental Oncology  
doses using quantitative MRI (3) utilizing quantitative MRI to demonstrate the role the balance between hydrophilicity and hydrophobicity plays in iii developing CAs for effective T1-weighted MRI of cancer  ...  To further explore the capabilities of intracellular CAs in T1-weighted MRI of breast cancer, this thesis aimed at (1) demonstrating the potential of MnCl2-enhanced MRI to detect and characterize early  ...  We also like to thank Marvin Estrada and Bonny Welsh for their assistance with surgical excision of tumors.  ... 
doi:10.4172/2324-9110-c4-017 fatcat:xnrpahdukff3hlxspagqtrg7zi
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