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The Growing Potential of Neurophysiology in Multiple Sclerosis

Canham LJW, Western DG, Walsh P
2016 Journal of Multiple Sclerosis  
Neurophysiological techniques have a long history of clinical and research use in the setting of Multiple Sclerosis.  ...  With the output of evoked potential and electroencephalographic recordings being a direct consequence of the underlying functional integrity and activity of the nervous system it is unsurprising there  ...  Ruck T, Bittner S, Simon OJ, Göbel K, Wiendl H, et al. (2014) Long-term effects of dalfampridine in patients with multiple sclerosis. J Neurol Sci 337: 18-24. 56.  ... 
doi:10.4172/2376-0389.1000190 fatcat:jzjguhsu4rdijb2nx7i2wty4pa

Genome-wide association study of severity in multiple sclerosis

2011 Genes and Immunity  
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system with a strong genetic component.  ...  Several lines of evidence support a strong role for genetic factors influencing both disease susceptibility and clinical outcome in MS.  ...  All study participants were recruited in agreement with protocols of the institutional review board at each institution. For a full list of members of the IMSGC, see  ... 
doi:10.1038/gene.2011.34 pmid:21654844 pmcid:PMC3640650 fatcat:wygha3tjpffe3c23tyvpcpkjly

Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis

Teresa Creanza, Maria Liguori, Sabino Liuni, Nicoletta Nuzziello, Nicola Ancona
2016 International Journal of Molecular Sciences  
Importantly, the analysis of changes in gene connectivity in MS patients provides new evidence of association for genes already implicated in MS by single-nucleotide polymorphism studies and that do not  ...  Differential gene expression analyses to investigate multiple sclerosis (MS) molecular pathogenesis cannot detect genes harboring genetic and/or epigenetic modifications that change the gene functions  ...  The GEO datasets under analysis include a different number of samples from healthy controls and multiple sclerosis patients.  ... 
doi:10.3390/ijms17060936 pmid:27314336 pmcid:PMC4926469 fatcat:guafoc77qzgfddt4ajnzqvceiq

Longitudinal Stability of Cognition in Early-Phase Relapsing-Remitting Multiple Sclerosis

Roxana M. Barbu, Jason A. Berard, Louise M. Gresham, Lisa A.S. Walker
2018 International Journal of MS Care  
Up to 70% of people with multiple sclerosis (MS) experience cognitive impairment. Some remain cognitively intact despite advanced disease.  ...  Sample homogeneity in terms of disease stage and CR may explain these findings.  ...  Financial Disclosures: The authors declare no conflicts of interest. Funding/Support: This study was funded by the Multiple Sclerosis Society of Canada.  ... 
doi:10.7224/1537-2073.2016-073 pmid:30150901 pmcid:PMC6107342 fatcat:gnqw5oprkvhrtke4gt4uoy6mly

Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat

Vijayendran Chandran, Mei-Ling Bermúdez, Mert Koka, Brindha Chandran, Dhanashri Pawale, Ramana Vishnubhotla, Suresh Alankar, Raj Maturi, Balachundhar Subramaniam, Senthilkumar Sadhasivam
2021 Proceedings of the National Academy of Sciences of the United States of America  
This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients.  ...  The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood.  ...  Transcriptional Profiles Obtained from COVID-19 and Multiple Sclerosis Patient Samples.  ... 
doi:10.1073/pnas.2110455118 pmid:34907015 pmcid:PMC8713789 fatcat:lrtndro3ifb37fntxgujroebiq

Application of Item Response Theory to Modeling of Expanded Disability Status Scale in Multiple Sclerosis

A. M. Novakovic, E. H. J. Krekels, A. Munafo, S. Ueckert, M. O. Karlsson
2016 AAPS Journal  
In this study, we report the development of the first item response theory (IRT) model within a pharmacometrics framework to characterize the disease progression in multiple sclerosis (MS), as measured  ...  KEY WORDS: cladribine tablets; disease progression model; expanded disability status scale; item response theory; multiple sclerosis. Alain Munafo's affiliation is part of Merck Serono S.A.  ...  The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and the International Conference on Harmonization Tripartite Guidelines for Good Clinical Practice.  ... 
doi:10.1208/s12248-016-9977-z pmid:27634384 fatcat:zp3murvvsvd3phyppts5plkomi

Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection

Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Samrein B. M. Ahmed, Suad Hannawi, Rifat Hamoudi, Qutayba Hamid, Rabih Halwani
2021 Frontiers in Immunology  
To validate our in-silico analysis, we measured plasma protein levels of two autoantigens, MPO and PRTN3, in severe and asymptomatic COVID-19.  ...  Immune homeostasis is disturbed during severe viral infections, which can lead to loss of tolerance to self-peptides and result in short- or long-term autoimmunity.  ...  (22, 23) , vasculitis (24, 25) , and multiple sclerosis (26) .  ... 
doi:10.3389/fimmu.2021.686462 fatcat:znh3qwpbezh6ri4pud7ucggkfq

Reverse Engineering of the Pediatric Sepsis Regulatory Network and Identification of Master Regulators

Raffael Azevedo de Carvalho Oliveira, Danilo Oliveira Imparato, Vítor Gabriel Saldanha Fernandes, João Vitor Ferreira Cavalcante, Ricardo D'Oliveira Albanus, Rodrigo Juliani Siqueira Dalmolin
2021 Biomedicines  
We identified a set of 15 TFs as potential master regulators of pediatric sepsis, which were divided into two main clusters.  ...  Sepsis remains a leading cause of death in ICUs all over the world, with pediatric sepsis accounting for a high percentage of mortality in pediatric ICUs.  ...  This analysis measures the enrichment score of the regulatory activity for each regulon, compared with each other, for a set of patients in a cohort.  ... 
doi:10.3390/biomedicines9101297 pmid:34680414 fatcat:riwagywevbeengc7aksahyuivi

Nintedanib in patients with systemic sclerosis‐associated interstitial lung disease: subgroup analyses by autoantibody status and skin score

Masataka Kuwana, Yannick Allanore, Christopher P Denton, Jörg HW Distler, Virginia Steen, Dinesh Khanna, Marco Matucci‐Cerinic, Maureen D Mayes, Elizabeth R Volkmann, Corinna Miede, Martina Gahlemann, Manuel Quaresma Lic (+2 others)
2021 Arthritis & Rheumatology  
At baseline, of 576 patients treated, 60.8% were ATA-positive, 51.9% had dcSSc, and 77.5% of 574 patients with mRSS data available had mRSS <18.  ...  We used data from the SENSCIS trial to assess the effects of nintedanib versus placebo in subgroups of patients with SSc-ILD based on characteristics associated with progression of SSc-ILD in previous  ...  Kuwana had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.  ... 
doi:10.1002/art.41965 pmid:34514739 fatcat:hijfjsbh7jb3jlnpaxcjv4mkni

Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat [article]

Vijayendran Chandran, Mei-Ling Bermudez, Mert Koka, Dhanashri Pawale, Ramana Vishnubhotla, Suresh Alankar, Raj Maturi, Balachundhar Subramaniam, Senthilkumar Sadhasivam
2021 bioRxiv   pre-print
This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients.  ...  , including multiple sclerosis and COVID-19 vaccination.  ...  (H, I) Gene set enrichment analysis of Gene Ontology terms calculated by Fisher's exact test for the turquoise and brown module.  ... 
doi:10.1101/2021.05.18.444668 fatcat:b7x26sjbvrfrndnbmllgfrl73y

Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management

Dominik Sturm, Stefan M. Pfister, David T.W. Jones
2017 Journal of Clinical Oncology  
Thus, the intentions of neurosurgeons, pediatric oncologists, and radiotherapists to improve care for pediatric patients with glioma range from increasing quality of life and preventing long-term sequelae  ...  The majority of pediatric gliomas present as benign, slowgrowing lesions classified as grade I or II by the WHO classification of CNS tumors.  ...  of patients with these tumors may explain some of the long-term survivors seen in HGG clinical trials. 71 More importantly, targeted therapy for this molecularly defined group of patients 72-74 is currently  ... 
doi:10.1200/jco.2017.73.0242 pmid:28640698 fatcat:pvql52auivgulh7quwkg3ytwlu

Decoding Neuromuscular Disorders Using Phenotypic Clusters Obtained From Co-Occurrence Networks

Elena Díaz-Santiago, M. Gonzalo Claros, Raquel Yahyaoui, Yolanda de Diego-Otero, Rocío Calvo, Janet Hoenicka, Francesc Palau, Juan A. G. Ranea, James R. Perkins
2021 Frontiers in Molecular Biosciences  
'Elevated serum creatine kinase' was the most specific to NMDs, in agreement with the clinical test of elevated serum creatinine kinase that is conducted on NMD patients.  ...  In parallel, a tripartite network based on phenotypes, diseases and genes was used to associate NMD phenotypes with functions, an approach also validated by literature co-mention, with KEGG pathways showing  ...  that have not yet been reported by the patient or the clinician, in the comorbidity context of the patient; 3) give researchers clues to perform new experiments to discover the underlying biological mechanisms  ... 
doi:10.3389/fmolb.2021.635074 pmid:34046427 pmcid:PMC8147726 fatcat:laafcaukefgfrakdxw4q5rmo64

Shared Genetic Etiology of Autoimmune Diseases in Patients from a Biorepository Linked to De-identified Electronic Health Records

Nicole A. Restrepo, Mariusz Butkiewicz, Josephine A. McGrath, Dana C. Crawford
2016 Frontiers in Genetics  
Here we performed a targeted genetic association study for cases of multiple sclerosis (MS), rheumatoid arthritis (RA), and Crohn's disease (CD) to assess which common genetic variants contribute individually  ...  Joint modeling and pathway analysis combining the three phenotypes were performed to identify common underlying mechanisms of risk of autoimmune conditions.  ...  An analysis of ∼15,000 patients in BioVU revealed an average of ∼82 clinic visits per patients with a wide range of one to 1456 clinic visits per patient (Crawford et al., 2015) .  ... 
doi:10.3389/fgene.2016.00185 pmid:27812365 pmcid:PMC5071319 fatcat:o4pxlbf7xrbb3evbrqm7bpsdd4

Design of the PF-ILD trial: a double-blind, randomised, placebo-controlled phase III trial of nintedanib in patients with progressive fibrosing interstitial lung disease

Kevin R Flaherty, Kevin K Brown, Athol U Wells, Emmanuelle Clerisme-Beaty, Harold R Collard, Vincent Cottin, Anand Devaraj, Yoshikazu Inoue, Florence Le Maulf, Luca Richeldi, Hendrik Schmidt, Simon Walsh (+2 others)
2017 BMJ Open Respiratory Research  
Selection of patient-reported outcome measures was based on two documents: the US Food and Drug Administration (FDA) reports 'The Voice of the Patient,' 31 and a manuscript from the Outcome Measures in  ...  This health status questionnaire was developed in multiple languages specifically for patients with ILD.  ... 
doi:10.1136/bmjresp-2017-000212 pmid:29018526 pmcid:PMC5604725 fatcat:wby7qz5jqnclva6c3wwvnk3g5m

Cellular Specificity of NF-κB Function in the Nervous System

Erica C. Dresselhaus, Mollie K. Meffert
2019 Frontiers in Immunology  
While the role of NF-κB in processes, such as host immunity and oncogenesis has been more clearly defined, an understanding of the basic functions of NF-κB in the nervous system has lagged behind.  ...  In this review, we will focus on the emerging understanding of cell-autonomous regulation of NF-κB signaling as well as the non-cell-autonomous functional impacts of NF-κB activation in the mammalian nervous  ...  In addition, a brain-specific tripartite motif protein (TRIM9) with lowered levels in post-mortem brains of PD patients (121) , was recently reported to function as an inhibitor of NF-κB activation by  ... 
doi:10.3389/fimmu.2019.01043 pmid:31143184 pmcid:PMC6520659 fatcat:cp2fcstxgnb6lel4kmdenh755q
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