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The Growing Potential of Neurophysiology in Multiple Sclerosis
2016
Journal of Multiple Sclerosis
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Neurophysiological techniques have a long history of clinical and research use in the setting of Multiple Sclerosis. ...
With the output of evoked potential and electroencephalographic recordings being a direct consequence of the underlying functional integrity and activity of the nervous system it is unsurprising there ...
Ruck T, Bittner S, Simon OJ, Göbel K, Wiendl H, et al. (2014) Long-term effects of dalfampridine in patients with multiple sclerosis. J Neurol Sci 337: 18-24. 56. ...
doi:10.4172/2376-0389.1000190
fatcat:jzjguhsu4rdijb2nx7i2wty4pa
Genome-wide association study of severity in multiple sclerosis
2011
Genes and Immunity
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Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system with a strong genetic component. ...
Several lines of evidence support a strong role for genetic factors influencing both disease susceptibility and clinical outcome in MS. ...
All study participants were recruited in agreement with protocols of the institutional review board at each institution. For a full list of members of the IMSGC, see http://www.imsgc.org/. ...
doi:10.1038/gene.2011.34
pmid:21654844
pmcid:PMC3640650
fatcat:wygha3tjpffe3c23tyvpcpkjly
Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis
2016
International Journal of Molecular Sciences
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Importantly, the analysis of changes in gene connectivity in MS patients provides new evidence of association for genes already implicated in MS by single-nucleotide polymorphism studies and that do not ...
Differential gene expression analyses to investigate multiple sclerosis (MS) molecular pathogenesis cannot detect genes harboring genetic and/or epigenetic modifications that change the gene functions ...
The GEO datasets under analysis include a different number of samples from healthy controls and multiple sclerosis patients. ...
doi:10.3390/ijms17060936
pmid:27314336
pmcid:PMC4926469
fatcat:guafoc77qzgfddt4ajnzqvceiq
Longitudinal Stability of Cognition in Early-Phase Relapsing-Remitting Multiple Sclerosis
2018
International Journal of MS Care
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Up to 70% of people with multiple sclerosis (MS) experience cognitive impairment. Some remain cognitively intact despite advanced disease. ...
Sample homogeneity in terms of disease stage and CR may explain these findings. ...
Financial Disclosures: The authors declare no conflicts of interest. Funding/Support: This study was funded by the Multiple Sclerosis Society of Canada. ...
doi:10.7224/1537-2073.2016-073
pmid:30150901
pmcid:PMC6107342
fatcat:gnqw5oprkvhrtke4gt4uoy6mly
Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat
2021
Proceedings of the National Academy of Sciences of the United States of America
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This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients. ...
The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood. ...
Transcriptional Profiles Obtained from COVID-19 and Multiple Sclerosis Patient Samples. ...
doi:10.1073/pnas.2110455118
pmid:34907015
pmcid:PMC8713789
fatcat:lrtndro3ifb37fntxgujroebiq
Application of Item Response Theory to Modeling of Expanded Disability Status Scale in Multiple Sclerosis
2016
AAPS Journal
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In this study, we report the development of the first item response theory (IRT) model within a pharmacometrics framework to characterize the disease progression in multiple sclerosis (MS), as measured ...
KEY WORDS: cladribine tablets; disease progression model; expanded disability status scale; item response theory; multiple sclerosis. Alain Munafo's affiliation is part of Merck Serono S.A. ...
The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and the International Conference on Harmonization Tripartite Guidelines for Good Clinical Practice. ...
doi:10.1208/s12248-016-9977-z
pmid:27634384
fatcat:zp3murvvsvd3phyppts5plkomi
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection
2021
Frontiers in Immunology
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To validate our in-silico analysis, we measured plasma protein levels of two autoantigens, MPO and PRTN3, in severe and asymptomatic COVID-19. ...
Immune homeostasis is disturbed during severe viral infections, which can lead to loss of tolerance to self-peptides and result in short- or long-term autoimmunity. ...
(22, 23) , vasculitis (24, 25) , and multiple sclerosis (26) . ...
doi:10.3389/fimmu.2021.686462
fatcat:znh3qwpbezh6ri4pud7ucggkfq
Reverse Engineering of the Pediatric Sepsis Regulatory Network and Identification of Master Regulators
2021
Biomedicines
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We identified a set of 15 TFs as potential master regulators of pediatric sepsis, which were divided into two main clusters. ...
Sepsis remains a leading cause of death in ICUs all over the world, with pediatric sepsis accounting for a high percentage of mortality in pediatric ICUs. ...
This analysis measures the enrichment score of the regulatory activity for each regulon, compared with each other, for a set of patients in a cohort. ...
doi:10.3390/biomedicines9101297
pmid:34680414
fatcat:riwagywevbeengc7aksahyuivi
Nintedanib in patients with systemic sclerosis‐associated interstitial lung disease: subgroup analyses by autoantibody status and skin score
2021
Arthritis & Rheumatology
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At baseline, of 576 patients treated, 60.8% were ATA-positive, 51.9% had dcSSc, and 77.5% of 574 patients with mRSS data available had mRSS <18. ...
We used data from the SENSCIS trial to assess the effects of nintedanib versus placebo in subgroups of patients with SSc-ILD based on characteristics associated with progression of SSc-ILD in previous ...
Kuwana had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. ...
doi:10.1002/art.41965
pmid:34514739
fatcat:hijfjsbh7jb3jlnpaxcjv4mkni
Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat
[article]
2021
bioRxiv
pre-print
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This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients. ...
, including multiple sclerosis and COVID-19 vaccination. ...
(H, I) Gene set enrichment analysis of Gene Ontology terms calculated by Fisher's exact test for the turquoise and brown module. ...
doi:10.1101/2021.05.18.444668
fatcat:b7x26sjbvrfrndnbmllgfrl73y
Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management
2017
Journal of Clinical Oncology
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Thus, the intentions of neurosurgeons, pediatric oncologists, and radiotherapists to improve care for pediatric patients with glioma range from increasing quality of life and preventing long-term sequelae ...
The majority of pediatric gliomas present as benign, slowgrowing lesions classified as grade I or II by the WHO classification of CNS tumors. ...
of patients with these tumors may explain some of the long-term survivors seen in HGG clinical trials. 71 More importantly, targeted therapy for this molecularly defined group of patients 72-74 is currently ...
doi:10.1200/jco.2017.73.0242
pmid:28640698
fatcat:pvql52auivgulh7quwkg3ytwlu
Decoding Neuromuscular Disorders Using Phenotypic Clusters Obtained From Co-Occurrence Networks
2021
Frontiers in Molecular Biosciences
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'Elevated serum creatine kinase' was the most specific to NMDs, in agreement with the clinical test of elevated serum creatinine kinase that is conducted on NMD patients. ...
In parallel, a tripartite network based on phenotypes, diseases and genes was used to associate NMD phenotypes with functions, an approach also validated by literature co-mention, with KEGG pathways showing ...
that have not yet been reported by the patient or the clinician, in the comorbidity context of the patient; 3) give researchers clues to perform new experiments to discover the underlying biological mechanisms ...
doi:10.3389/fmolb.2021.635074
pmid:34046427
pmcid:PMC8147726
fatcat:laafcaukefgfrakdxw4q5rmo64
Shared Genetic Etiology of Autoimmune Diseases in Patients from a Biorepository Linked to De-identified Electronic Health Records
2016
Frontiers in Genetics
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Here we performed a targeted genetic association study for cases of multiple sclerosis (MS), rheumatoid arthritis (RA), and Crohn's disease (CD) to assess which common genetic variants contribute individually ...
Joint modeling and pathway analysis combining the three phenotypes were performed to identify common underlying mechanisms of risk of autoimmune conditions. ...
An analysis of ∼15,000 patients in BioVU revealed an average of ∼82 clinic visits per patients with a wide range of one to 1456 clinic visits per patient (Crawford et al., 2015) . ...
doi:10.3389/fgene.2016.00185
pmid:27812365
pmcid:PMC5071319
fatcat:o4pxlbf7xrbb3evbrqm7bpsdd4
Design of the PF-ILD trial: a double-blind, randomised, placebo-controlled phase III trial of nintedanib in patients with progressive fibrosing interstitial lung disease
2017
BMJ Open Respiratory Research
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Selection of patient-reported outcome measures was based on two documents: the US Food and Drug Administration (FDA) reports 'The Voice of the Patient,' 31 and a manuscript from the Outcome Measures in ...
This health status questionnaire was developed in multiple languages specifically for patients with ILD. ...
doi:10.1136/bmjresp-2017-000212
pmid:29018526
pmcid:PMC5604725
fatcat:wby7qz5jqnclva6c3wwvnk3g5m
Cellular Specificity of NF-κB Function in the Nervous System
2019
Frontiers in Immunology
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While the role of NF-κB in processes, such as host immunity and oncogenesis has been more clearly defined, an understanding of the basic functions of NF-κB in the nervous system has lagged behind. ...
In this review, we will focus on the emerging understanding of cell-autonomous regulation of NF-κB signaling as well as the non-cell-autonomous functional impacts of NF-κB activation in the mammalian nervous ...
In addition, a brain-specific tripartite motif protein (TRIM9) with lowered levels in post-mortem brains of PD patients (121) , was recently reported to function as an inhibitor of NF-κB activation by ...
doi:10.3389/fimmu.2019.01043
pmid:31143184
pmcid:PMC6520659
fatcat:cp2fcstxgnb6lel4kmdenh755q
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