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Translational informatics of population health: How large biomolecular and clinical datasets unite
2018
Biocomputing 2019
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This paper summarizes the workshop content on how the integration of large biomolecular and clinical datasets can enhance the field of population health via translational informatics. ...
the translation to clinical practice for improving health outcomes. ...
Colleen Kenost for her organizational contributions with this workshop and proceedings paper. ...
doi:10.1142/9789813279827_0043
fatcat:oplfghfzafdofofkbzeyywjpt4
Traits and types of health data repositories
2014
Health Information Science and Systems
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We review traits of reusable clinical data and offer a typology of clinical repositories with a range of known examples. ...
It would have longitudinal, multi-leveled (environmental through molecular) data on a large population of identified, consenting individuals. ...
Acknowledgements This review was supported by National Jewish Health and the Colorado Clinical and Translational Science Institute, grant UL1RR025780 from NIH. ...
doi:10.1186/2047-2501-2-4
pmid:25825668
pmcid:PMC4340801
fatcat:4f4dcxbdqfg5vkc3yzhumdxdsy
Translational bioinformatics in the era of real-time biomedical, health care and wellness data streams
2016
Briefings in Bioinformatics
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Dr Khader is working at the interface of biomedical informatics, drug repositioning and genomic medicine and pioneering efforts to translate advances in translational bioinformatics to population health ...
The accessibility and clinical utility of such Khader Shameer is a senior biomedical and health care informatics scientist in Dr Joel Dudley's laboratory and the Harris Center for Precision Wellness of ...
(NCI, U54-CA189201-02) to JTD and National Center for Advancing Translational Sciences (NCATS, UL1TR000067) Clinical and Translational Science Awards (CTSA) grant to JTD and KS. ...
doi:10.1093/bib/bbv118
pmid:26876889
pmcid:PMC5221424
fatcat:aqurlfusq5hslpabllsfmygk6m
Genetic data and electronic health records: a discussion of ethical, logistical and technological considerations
2014
JAMIA Journal of the American Medical Informatics Association
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With this explosion of information, questions of what, when, where and how to incorporate genetic data into electronic health records (EHRs) have reached a critical point. ...
Genetic data obtained for clinical purposes, as is true for all results of clinical tests, are expected to be included in patients' medical records. ...
Green and Guyer 69 explained, "Existing clinical informatics architectures are largely incapable of storing genome sequence data in a way that allows the information to be searched, annotated and shared ...
doi:10.1136/amiajnl-2013-001694
pmid:23771953
pmcid:PMC3912723
fatcat:lmbiymqoivahnifwdnxtbghehe
Unlocking Big Data for better health
2017
Nature Biotechnology
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between electronic health record systems and clinical research. ...
Understanding how some of these factors change at a molecular level has been a challenge to the safe translation of medicines from one population to another. ...
doi:10.1038/nbt.3918
pmid:28700551
fatcat:oqiurm5cgzec7lfenvjvlemxoy
Scaling up the Big Health Data Ecosystem: Engaging all Stakeholders!
2020
Journal of the International Society for Telemedicine and eHealth
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For the public to be on board they have to understand much more than most people do about the nature of health data, how it can be used for the benefit of society and what safeguards protect them when ...
Standards exist to achieve this, although more stakeholder engagement is needed in defining practical clinical models and value sets, but the real adoption of interoperability is disappointing and needs ...
of the patient and of that patient population. ...
doi:10.29086/jisfteh.8.e16
fatcat:nudqpunr4bathkmmabnwh6flum
Biobanking in health care: evolution and future directions
2019
Journal of Translational Medicine
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The aim of the present review is to discuss how the promising field of biobanking can support health care research strategies. ...
and Biomolecular Resources Research Infrastructure (BBMRI). ...
Acknowledgements We want to thank all the patients involved in the creation of research biobanks. ...
doi:10.1186/s12967-019-1922-3
pmid:31118074
pmcid:PMC6532145
fatcat:bwgdmvionbd6hm5o4m6liuvhli
Cardiovascular Informatics: building a bridge to data harmony
2021
Cardiovascular Research
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We discuss how and why this interdisciplinary space of Cardiovascular Informatics is particularly relevant to and supportive of current experimental and clinical research. ...
Frequently lauded as a field with great practical and translational potential, the interface between biomedical informatics and cardiovascular medicine is challenged with staggeringly massive datasets. ...
Acknowledgements The authors thank Samir Akre for assistance with conceptual development of data exploration workflows. ...
doi:10.1093/cvr/cvab067
pmid:33751044
pmcid:PMC9020200
fatcat:wkryk7uhyncyjg2lzrtiasl2lq
Abstracts from Plenary and Keynote Speakers
2018
Public Health Genomics
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Cancers are common diseases which are among the leading causes of death worldwide, and their incidence is increasing as the population ages. ...
Last but not least, combination of cloud-based and manufacturer installable analytic pipelines together with inclusion of RNA and protein information in conjunction with sequencing data are becoming critical ...
One of the biggest challenges will be the translation of the large amounts of genetic data into useful and comprehensible medical information and recommendations. ...
doi:10.1159/000493202
pmid:30219808
fatcat:s7jfdl2q5jhkrpwwotsfnw4tsa
NIAID genomics programs and global health
2011
Genome Biology
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This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health. ...
The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and ...
With G-CODE, we hope to help enable the creation of new disease-centric portals, as well as the widespread use of biomedical informatics tools by basic, clinical and translational researchers, through ...
doi:10.1186/1465-6906-12-s1-i6
fatcat:6bnwkgvlordorcssxmv3sh6lmu
Biobanking for Europe
2007
Briefings in Bioinformatics
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To address these issues, a Biobanking and BioMolecular Resources Infrastructure (BBMRI) is to be developed across Europe, thereby implementing a European 'roadmap' for research infrastructures that was ...
developed by a forum of EU member states and that has been received by the European Commission. ...
Acknowledgements The development of plans we describe for biobanking and biomolecular resources infrastructure has involved a large number of people including those named in Supplementary Table 1 ...
doi:10.1093/bib/bbm050
pmid:17959611
fatcat:ggrkvisrdfc6bauyd366fxbf5u
Applying systems biology to biomedical research and health care: a précising definition of systems medicine
2017
BMC Health Services Research
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states as well as innovative approaches to drug discovery) and health care (i.e. prevention, prediction, diagnosis and treatment) through stratification by means of Systems Biology (i.e. data integration ...
From these we derived the précising definition: Systems Medicine is an approach seeking to improve medical research (i.e. the understanding of complex processes occurring in diseases, pathologies and health ...
Availability of data and materials All data generated or analyzed during this study are included in this published article and its supplementary information files. ...
doi:10.1186/s12913-017-2688-z
pmid:29162092
pmcid:PMC5698952
fatcat:hnfbn6lcpvfljaorjltrqwkelu
Comparative analysis of the vaginal microbiome in health and disease
2011
Genome Biology
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This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health. ...
The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and ...
novo copy number variation, de novo point mutations of large eff ect could explain the majority of all mental retardation cases in the population. ...
doi:10.1186/gb-2011-12-s1-i17
fatcat:nniwcsopi5enhd5ho556rexdce
Innovations in Genomics and Big Data Analytics for Personalized Medicine and Health Care: A Review
2022
International Journal of Molecular Sciences
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Enormously large, rapidly growing collections of biomedical omics-data (genomics, proteomics, transcriptomics, metabolomics, glycomics, etc.) and clinical data create major challenges and opportunities ...
Big data in health care is a fast-growing field and a new paradigm that is transforming case-based studies to large-scale, data-driven research. ...
The use of multimodal data helps in a deeper analysis of large datasets, which improves the understanding of human health and disease by leaps and bound. ...
doi:10.3390/ijms23094645
pmid:35563034
pmcid:PMC9104788
fatcat:yvzczyasqrdh3htmh5tmbpsflu
Pulling the Strands Together: MEGA Steps to Drive European Genomics and Personalised Medicine
2017
Biomedicine Hub
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The availability of genetic data from a large number of individuals increases the ability to investigate questions across many rare and common diseases and in different populations, and also provides more ...
A number of large scale genome sequencing initiatives have been launched in the last few years to try and capitalise on this potential. ...
The authors have no conflicts of interest to declare.
Funding Sources No funding sources. ...
doi:10.1159/000481300
pmid:31988947
pmcid:PMC6945953
fatcat:dn66jws4rfdfpipvgcrrkc6xia
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