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Structural Snapshots of Actively Translating Human Ribosomes

Elmar Behrmann, Justus Loerke, Tatyana V. Budkevich, Kaori Yamamoto, Andrea Schmidt, Pawel A. Penczek, Matthijn R. Vos, Jörg Bürger, Thorsten Mielke, Patrick Scheerer, Christian M.T. Spahn
2015 Cell  
Multiparticle refinement and 3D variability analysis allowed us to visualize a variety of native translation intermediates.  ...  Here, we have used cryo-electron microscopy to image ex-vivo-derived human polysomes as a source of actively translating ribosomes.  ...  ., and C.M.T.S. interpreted electron densities and atomic models. E.B. and J.L. prepared figures. C.M.T.S. designed the study. E.B., J.L., and C.M.T.S. wrote the manuscript.  ... 
doi:10.1016/j.cell.2015.03.052 pmid:25957688 pmcid:PMC4432480 fatcat:57nexbhpibgglaehphsqtvbduy

A characterization of translation-invariant experiments admitting adaptive estimates

Georg Ch Pflug, Wilfried Grossmann
1988 Journal of Multivariate Analysis  
In order to include a large variety of cases, the efftciency is measured in terms of minimax bounds.  ...  It is shown that a necessary and sufficient condition for adaptivity of translation invariant experiments is that the parameter of interest and the nuisance parameter are as. independent w.r.t. the posterior  ...  By the boundedness and continuity of V2E' and F it follows that the limit $0, y, b) := lim,l, A-'(~(2, y, b) -s,,) exists and C.S(O, y, b) = (1 -F&&y + b)) . y.  ... 
doi:10.1016/0047-259x(88)90038-3 fatcat:6tb7t3dbm5e67phksypsq3sxgy

Development and Translation of PEDOT:PSS Microelectrodes for Intraoperative Monitoring

Mehran Ganji, Erik Kaestner, John Hermiz, Nick Rogers, Atsunori Tanaka, Daniel Cleary, Sang Heon Lee, Jospeh Snider, Milan Halgren, Garth Rees Cosgrove, Bob S. Carter, David Barba (+6 others)
2017 Advanced Functional Materials  
However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties.  ...  The dashed black line at 30, 42, and 44 Hz for (a)-(c) mark the frequency at which the c.i.s start to overlap for frequencies >15 Hz.  ...  Pointwise c.i.s were computed using the Matlab pwelch function and the expression for c.i. was equation 5.3.64 on page 280 in Manolakis et al.  ... 
doi:10.1002/adfm.201700232 fatcat:54viqvusonc4tgacqhksrvedz4

7th International Symposium on Molecular Allergology (ISMA 2017)

2018 Clinical and Translational Allergy  
CCD-negative samples as controls and 68 CCD-positive samples, from Correspondence: Mariona Pascal - mpascal@clinic.ub.es which n = 60 showed sufficient CCD inhibition and were included in  ...  of IgE to Bet v 1 and Mal d 1, suggesting that cells, including DCs.  ... 
doi:10.1186/s13601-018-0193-z fatcat:ybzfz3yw2zfj3fgobmzrr6eoza

Full Issue PDF

2018 JACC: Basic to Translational Science  
attract adequate human and financial capital.E x t e r n a l f a c t o r s .  ...  Mann, Editor-in-Chief, JACC: Basic to Translational Science, American College of Cardiology, Heart House, 2400 North Street NW, Washington, DC 20037. E-mail: JACCBTS@acc.org.  ... 
doi:10.1016/s2452-302x(18)30054-8 fatcat:w4cqfykv3bgcvjcsi2t7yvyhtu

Rotation, Strain, and Translation Sensors Performance Tests with Active Seismic Sources

Felix Bernauer, Kathrin Behnen, Joachim Wassermann, Sven Egdorf, Heiner Igel, Stefanie Donner, Klaus Stammler, Mathias Hoffmann, Pascal Edme, David Sollberger, Cédric Schmelzbach, Johan Robertsson (+27 others)
2021 Sensors  
The experiment consisted of two parts: during the first part, the sensors were co-located in a huddle test recording self-noise and signals from small, nearby explosions.  ...  Most of the sensors show a high level of coherency and waveform similarity within a narrow frequency range between 10 Hz and 20 Hz for recordings from a nearby explosion signal.  ...  • In theory, the transfer function of a fiber-optic gyroscope is flat from DC to the Nyquist frequency.  ... 
doi:10.3390/s21010264 pmid:33401539 fatcat:lg5tnpoov5a7pdj3fyc53xxu44

Building Machine Translation Systems for the Next Thousand Languages [article]

Ankur Bapna, Isaac Caswell, Julia Kreutzer, Orhan Firat, Daan van Esch, Aditya Siddhant, Mengmeng Niu, Pallavi Baljekar, Xavier Garcia, Wolfgang Macherey, Theresa Breiner, Vera Axelrod (+12 others)
2022 arXiv   pre-print
In this paper we share findings from our effort to build practical machine translation (MT) systems capable of translating across over one thousand languages.  ...  We hope that our work provides useful insights to practitioners working towards building MT systems for currently understudied languages, and highlights research directions that can complement the weaknesses  ...  the ASCII character to the "correct" Unicode codepoint.E LIST OF LANGUAGES WITH REGIONS, APPROXIMATE SPEAKER COUNTS AND DATA SIZESInformation about the languages and datasets we found on the web, including  ... 
arXiv:2205.03983v3 fatcat:65fva7qvpbaapemrrmovgkpac4

Srf KO and wild-type mice similarly adapt to endurance exercise

Haidar Djemai, Medhi Hassani, Nissrine Daou, Zhenlin Li, Athanassia Sotiropoulos, Philippe Noirez, Dario Coletti
2019 European Journal of Translational Myology  
Since lack of Srf induces premature sarcopenia, our observations suggest that the modifications due to the absence of Srf take time to occur and that young, Srf KO mice behave similarly to WT in aerobic  ...  Endurance exercise induces local and global effects, resulting in skeletal muscle adaptations to aerobic activity and contributes to an amelioration of muscle performance.  ...  The speed was increased by 1 cm.s -1 every 15 sec. V̇O2 was expressed relatively to lean mass (ml.h -1 .g -1 ).  ... 
doi:10.4081/ejtm.2019.8205 pmid:31354926 pmcid:PMC6615070 fatcat:ds2kr2ukhbgc5oola274jrfj3y

High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial

A. Pearson, E. Smyth, I. S. Babina, M. T. Herrera-Abreu, N. Tarazona, C. Peckitt, E. Kilgour, N. R. Smith, C. Geh, C. Rooney, R. Cutts, J. Campbell (+15 others)
2016 Cancer Discovery  
In a translational clinical trial we show that gastric cancers with high-level clonal FGFR2 amplification have a high response rate to the selective FGFR inhibitor AZD4547, whilst cancers with sub-clonal  ...  Signalling in low-level FGFR1 amplified cancers is more restricted to MAPK signalling, limiting sensitivity to FGFR inhibition.  ...  A substantial fall in FGFR2 expression is seen in the highly FGFR2 amplified but heterogeneous tumour from patient 135 potentially reflecting sub-clonal loss of FGFR2 over-expression tumour clone.E.  ... 
doi:10.1158/2159-8290.cd-15-1246 pmid:27179038 pmcid:PMC5338732 fatcat:razilydc4jclnfu5p4t62lnnbm

A Quantitative Validation of Multi-Modal Image Fusion and Segmentation for Object Detection and Tracking

Nicholas LaHaye, Michael J. Garay, Brian D. Bue, Hesham El-Askary, Erik Linstead
2021 Remote Sensing  
The success here will allow this methodology to be used within use concrete cases and become the basis for future dynamic object tracking across datasets from various remote sensing instruments.  ...  In this paper, we quantitatively validate the methodology against datasets currently being generated and used within the remote sensing community, as well as show the capabilities and benefits of the data  ...  Brodersen, K.H.; Ong, C.S.; Stephan, K.E.; Buhmann, J.M. The Balanced Accuracy and Its Posterior Distribution.  ... 
doi:10.3390/rs13122364 fatcat:xyizarl22zg7jniuijqlmgqwle

Custom-Fitted In- and Around-the-Ear Sensors for Unobtrusive and On-the-Go EEG Acquisitions: Development and Validation

Olivier Valentin, Guilhem Viallet, Aidin Delnavaz, Gabrielle Cretot-Richert, Mikaël Ducharme, Hami Monsarat-Chanon, Jérémie Voix
2021 Sensors  
Additionally, late latency results demonstrate EARtrodes' capacity to reliably detect decision-making processes from the ear.  ...  This paper aims to validate the performance and physical design of a wearable, unobtrusive ear-centered electroencephalography (EEG) device, dubbed "EARtrodes", using early and late auditory evoked responses  ...  Acknowledgments: The authors wish to acknowledge the financial support received from the NSERC-EERS Industrial Research Chair in In-Ear Technologies (CRITIAS), as well as from MITACS Elevation program  ... 
doi:10.3390/s21092953 pmid:33922456 fatcat:g2tpdllxh5e7hg4u2utc5gwtru

Quantification of Pharmacokinetic Profiles of PD-1/PD-L1 Antibodies by Validated ELISAs

Sara Zalba, Ana M. Contreras-Sandoval, Eva Martisova, Reno Debets, Christian Smerdou, María Jesús Garrido
2020 Pharmaceutics  
In this study, we have developed and validated two in-house ELISAs to quantify a-PD-1 and a-PD-L1 in plasma collected from tumor-bearing mice.  ...  In this regard, preclinical assays allow the time profiles of antibody plasma concentrations to be characterized rapidly and easily, which may help to increase PK knowledge.  ...  Acknowledgments: The authors want to thank Pedro Berraondo and Sandra Hervás-Stubbs for the donation of the cell lines used in the present study.  ... 
doi:10.3390/pharmaceutics12060595 pmid:32604843 fatcat:4ym3l24fenhs5evuott65vk6jm

2013 Autumn Padua Muscle Days | Padova and Terme Euganee, Italy, November 14-16

The Editors
2013 European Journal of Translational Myology  
Special thanks to Heike Thieme and Med El. Acknowledgements. This work is supported by a grant from Med-El, Innsbruck, Austria.  ...  Pathological evaluation of the condition can be separated by the various components of the functional unit of contractioni.e. the motor unit -and its associated structures.  ...  Age-associated power decline from running, jumping & throwing male master world-records. Exp Aging Res Revision submitted. Translational Myology Lab., Dept.  ... 
doi:10.4081/ejtm.2013.2226 fatcat:zrhswyoyefdynbvpfvp2dafgry

Prognosis Analysis and Validation of m6A Signature and Tumor Immune Microenvironment in Glioma

Shaojian Lin, Houshi Xu, Anke Zhang, Yunjia Ni, Yuanzhi Xu, Tong Meng, Mingjie Wang, Meiqing Lou
2020 Frontiers in Oncology  
In order to construct a more veracious prediction model and identify the potential prognosis-biomarker, we explore the differential expressed m6A RNA methylation regulators in 665 gliomas from TCGA-GBM  ...  Moreover, we also found PDPN and TIMP1 were highly expressed in high-grade glioma from The Human Protein Atlas database and both of them were correlated with m6A and immune cell marker in glioma tissue  ...  Then, the expression of these m6A RNA methylation regulators in gliomas were systematically compared with different clinical outcomes using Gliovis (http://gliovis.bioinfo. cnio.es/) (26) .  ... 
doi:10.3389/fonc.2020.541401 pmid:33123464 pmcid:PMC7571468 fatcat:fmrz4erkvjh2fmkvm6uavvlvya

A pilot study of Arizona Battery for Communication Disorders of Dementia. Validation in Normal Greek Population. [Abstract]

Dionysios Tafiadis, Spyridon Konitsiotis, Grigorios Nasios
2017 Figshare  
The Scale consists of 100 statements to which a "True or False" response is given by the participants. Members-patients and staff were administered the C.O.P.E.S. form R (Real Form).  ...  Results The following diagram represents the profile of C.O.P.E.S. for members (n=17) and staff (n=6) at the "Estia" Day Center. Standard scores above 50 are considered to be an above average score.  ...  A previous study from Turkey %51.1 of schzohrenia patients are shown to have behavior of help seeking from traditional healers(1).  ... 
doi:10.6084/m9.figshare.5263696.v3 fatcat:qncfyymbpjc2tlkik4q2cecdw4
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