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Transcriptomics of cortical gray matter thickness decline during normal aging

P. Kochunov, J. Charlesworth, A. Winkler, L.E. Hong, T.E. Nichols, J.E. Curran, E. Sprooten, N. Jahanshad, P.M. Thompson, M.P. Johnson, J.W. Kent, B.A. Landman (+10 others)
2013 NeuroImage  
can predict cortical gray matter thickness (GMT) variability during normal cerebral aging.  ...  Our findings suggest that normal cerebral aging is the product of a progressive decline in regenerative capacity and increased neuroinflammation.  ...  Acknowledgments This research was supported by National Institute of Biomedical.  ... 
doi:10.1016/j.neuroimage.2013.05.066 pmid:23707588 pmcid:PMC3759649 fatcat:7p4nbcr52zhlbaaacbdwzu4egu

Psychiatric polygenic risk associates with cortical morphology and functional organization in aging

Annie Lee, Mojun Shen, Anqi Qiu
2017 Translational Psychiatry  
This study suggested integrating genotype and transcriptome with neuroimage data sheds new light on the mechanisms of aging brain.  ...  images, genotypes, and transcriptome data.  ...  For cortical thickness analysis, an inner surface was constructed at the boundary between white and gray matter and then propagated to an outer surface at the boundary between gray matter and CSF.  ... 
doi:10.1038/s41398-017-0036-z pmid:29225336 pmcid:PMC5802582 fatcat:x5gq2hclqzdhlhzcf7rdantc4m

New insights into the dynamic development of the cerebral cortex in childhood and adolescence: Integrating macro- and microstructural MRI findings

Linn B. Norbom, Lia Ferschmann, Nadine Parker, Ingrid Agartz, Ole A. Andreassen, Tomáš Paus, Lars T. Westlye, Christian K. Tamnes
2021 Progress in Neurobiology  
We cover studies of cortical volume, thickness, area, gyrification, T1-weighted (T1w) tissue contrasts such a grey/white matter contrast, T1w/T2w ratio, magnetization transfer and myelin water fraction  ...  At the same time, many common mental disorders appear during these critical phases of neurodevelopment.  ...  MTR and MWF in cortical gray-matter (Patel et al., 2020) .  ... 
doi:10.1016/j.pneurobio.2021.102109 pmid:34147583 fatcat:7fjrapj5xnbsjkmltjqblhmwuu

Shaping of Regional Differences in Oligodendrocyte Dynamics by Regional Heterogeneity of the Pericellular Microenvironment

Amin Sherafat, Friederike Pfeiffer, Akiko Nishiyama
2021 Frontiers in Cellular Neuroscience  
Contrary to the normal brain, demyelinated lesions in the gray matter of multiple sclerosis brains contain more OPCs and OLs and are remyelinated more robustly than those in white matter.  ...  than those in gray matter.  ...  , and this declines with age (Cantuti-Castelvetri et al., 2018) .  ... 
doi:10.3389/fncel.2021.721376 pmid:34690700 pmcid:PMC8531270 fatcat:635h7qfvofd5fdacjtln4ejhma

Prediction of Chronological Age in Healthy Elderly Subjects with Machine Learning from MRI Brain Segmentation and Cortical Parcellation

Jaime Gómez-Ramírez, Miguel A. Fernández-Blázquez, Javier J. González-Rosa
2022 Brain Sciences  
Normal aging is associated with changes in volumetric indices of brain atrophy. A quantitative understanding of age-related brain changes can shed light on successful aging.  ...  To investigate the effect of age on global and regional brain volumes and cortical thickness, 3514 magnetic resonance imaging scans were analyzed using automated brain segmentation and parcellation methods  ...  Conflicts of Interest: The authors declare no competing interests.  ... 
doi:10.3390/brainsci12050579 fatcat:sfknoeyeyrfsxg2ew62ddxryaq

Transcriptomic Signatures Associated With Regional Cortical Thickness Changes in Parkinson's Disease

Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Jacobus J. van Hilten, Marcel J. T. Reinders, Ahmed Mahfouz
2021 Frontiers in Neuroscience  
To elucidate the molecular underpinnings of cortical thickness changes in PD, we performed an integrated analysis of brain-wide healthy transcriptomic data from the Allen Human Brain Atlas and patterns  ...  of cortical thickness based on T1-weighted anatomical MRI data of 149 PD patients and 369 controls.  ...  RESULTS Cortical Thickness Changes Between Parkinson's Disease Patients and Controls We analyzed CT changes between PD patients and healthy controls ( CT) as a measure for gray matter loss ( Figure  ... 
doi:10.3389/fnins.2021.733501 pmid:34658772 pmcid:PMC8519261 fatcat:qrupqyfdfnbdzcjk5rbetbazni

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Lauren E Salminen, Meral A Tubi, Joanna Bright, Sophia I Thomopoulos, Alyssa Wieand, Paul M Thompson
2021 Human Brain Mapping  
We discuss commonalities and sources of variance in study designs, analysis procedures, disease subtype effects, and the impact of these factors on MRI interpretation.  ...  Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which are exacerbated in psychiatric and neurological conditions  ...  In young adults (ages 20-34 years), VBM has revealed larger total normalized gray matter volume (total gray matter volume/total ICV) but also a faster rate of age-related decline in normalized gray matter  ... 
doi:10.1002/hbm.25438 pmid:33949018 pmcid:PMC8805690 fatcat:4y3ufbxppjg3bobnvysm7cwd7q

Recessive LAMC3 mutations cause malformations of occipital cortical development

Tanyeri Barak, Kenneth Y Kwan, Angeliki Louvi, Veysi Demirbilek, Serap Saygı, Beyhan Tüysüz, Murim Choi, Hüseyin Boyacı, Katja Doerschner, Ying Zhu, Hande Kaymakçalan, Saliha Yılmaz (+15 others)
2011 Nature Genetics  
After correction, the cortical thickness was calculated at each point as the shortest distance between the white matter-gray matter boundary and the gray matter-cerebrospinal fluid boundary.  ...  periods and declines after infancy.  ... 
doi:10.1038/ng.836 pmid:21572413 pmcid:PMC3329933 fatcat:5eyfel2fgna77ol7xzddmghus4

Machine Learning Approaches for the Estimation of Biological Aging: The Road Ahead for Population Studies

Alessandro Gialluisi, Augusto Di Castelnuovo, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, the Moli-sani Study Investigators
2019 Frontiers in Medicine  
In recent years, different machine learning algorithms have been developed for the estimation of Biological Age (BA), defined as the hypothetical underlying age of an organism.  ...  Similarly, we describe ML methods for the estimation of brain age based on structural neuroimaging features.  ...  , where BrA was based on cortical/subcortical gray matter measures (40) .  ... 
doi:10.3389/fmed.2019.00146 pmid:31338367 pmcid:PMC6626911 fatcat:v3yiucqao5dsjcxvu6elssmhga

Epigenetic clock as a correlate of anxiety

Klára Marečková, Anna Pačínková, Anja Klasnja, Jean Shin, Lenka Andrýsková, Kateřina Stano-Kozubík, Zdenka Pausová, Milan Brázdil, Tomáš Paus
2020 NeuroImage: Clinical  
Since MDD is highly correlated with anxiety, we hypothesized that symptoms of anxiety, as well as lower volume of grey matter (GM) in depression-related cortical regions, will be associated with faster  ...  ) or additional sources of variability in the cohort of adolescents (puberty stages, socioeconomic status, prenatal exposure to maternal smoking during pregnancy).  ...  cortical gray matter (GM) and the volumes of GM in the four cerebral lobes.  ... 
doi:10.1016/j.nicl.2020.102458 pmid:33395955 pmcid:PMC7585143 fatcat:wkbwcodn4zcw5mmlzgufgqdyju

Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophrenia

George Bartzokis, Po H. Lu, Erika P. Raven, Chetan P. Amar, Nicole R. Detore, Alexander J. Couvrette, Jim Mintz, Joseph Ventura, Laurie R. Casaus, John S. Luo, Kenneth L. Subotnik, Keith H. Nuechterlein
2012 Schizophrenia Research  
Assess the effect of risperidone formulation on the ICM trajectory during a six-month randomized trial of LAI (RLAI) versus oral (RisO) in first-episode SZ subjects.  ...  Insofar as the trajectory of ICM decline in chronic SZ is due to medication non-adherence or pharmacokinetics, it may be modifiable by long acting injection (LAI) formulations.  ...  Lu had full access to all of the study data and take responsibility for the integrity of the data and the accuracy of data analysis.  ... 
doi:10.1016/j.schres.2012.06.036 pmid:22809684 pmcid:PMC3567927 fatcat:u7v2tvywgbdtxjvhabte3is5n4

A Survey of White Matter Neurons at the Gyral Crowns and Sulcal Depths in the Rhesus Monkey

Farzad Mortazavi, Samantha E. Romano, Douglas L. Rosene, Kathleen S. Rockland
2017 Frontiers in Neuroanatomy  
Since at least some WMNs participate in cortical circuitry, these results raise the possibility of their differential influence on cortical circuitry in the overlying gyral and sulcal locations.  ...  or variable across different cortical regions.  ...  thickness of cortical gray matter and WM in disease and normal development and aging.  ... 
doi:10.3389/fnana.2017.00069 pmid:28860975 pmcid:PMC5559435 fatcat:f67iqlugufh3hln6ctwhiciquy

Transcriptomic signatures associated with regional cortical thickness changes in Parkinson's disease [article]

Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Jacobus J. van Hilten, Marcel Reinders, Ahmed Mahfouz
2020 bioRxiv   pre-print
To elucidate the molecular underpinnings of cortical thickness changes in Parkinson's disease, we performed an integrated analysis of brain-wide healthy transcriptomic data from the Allen Human Brain Atlas  ...  Here, we investigated patterns of cortical thickness using T1-weighted anatomical MRI data of 149 Parkinson's disease patients and 369 controls.  ...  Cortical atrophy occurs during the later disease stages and has been associated with cognitive decline, including executive, attentional, memory, and visuospatial deficits (Aarsland et al., 2017; Wilson  ... 
doi:10.1101/2020.06.19.158808 fatcat:fxjcqtz2ifbgtfbfhv7xkrd4qe

Longitudinal basal forebrain degeneration interacts with TREM2/C3 biomarkers of inflammation in pre-symptomatic Alzheimer's disease

T.W. SCHMITZ, H SOREQ, J POIRIER, R.N. SPRENG, for the Alzheimer's Disease Neuroimaging Initiative
2020 Journal of Neuroscience  
None of these relationships were attributable to degeneration in the whole-brain gray matter volume.  ...  Cholinergic inputs originating from the peripheral nervous system regulate the inflammatory immune responses of macrophages during clearance of blood-based pathogens.  ...  Each exploratory two group ANOVA covaried for age, sex, education, and, where gray matter volumes were tested, ICV.  ... 
doi:10.1523/jneurosci.1184-19.2019 pmid:31915256 pmcid:PMC7046458 fatcat:72mimx56mjhlfcdayvxvkocm6q

Editorial: Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age

Philip P. Foster, Carryl L. Baldwin, James Campbell Thompson, Thomas Espeseth, Xiong Jiang, Pamela M. Greenwood
2019 Frontiers in Aging Neuroscience  
The relativity of the internal perception of time accelerating in aging brains is examined.  ...  Collectively, the studies of this book and the associated data sets provide an unprecedented resource for understanding the aging of the brain, the brain networks plasticity, and structure.  ...  and other largescale transcriptomic changes in the aging brain (Mostafavi et al., 2018) .  ... 
doi:10.3389/fnagi.2019.00268 pmid:31680930 pmcid:PMC6803512 fatcat:wg6cokv5m5grdirzcdlqeny5vm
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