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Transcriptomics of cortical gray matter thickness decline during normal aging
2013
NeuroImage
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can predict cortical gray matter thickness (GMT) variability during normal cerebral aging. ...
Our findings suggest that normal cerebral aging is the product of a progressive decline in regenerative capacity and increased neuroinflammation. ...
Acknowledgments This research was supported by National Institute of Biomedical. ...
doi:10.1016/j.neuroimage.2013.05.066
pmid:23707588
pmcid:PMC3759649
fatcat:7p4nbcr52zhlbaaacbdwzu4egu
Psychiatric polygenic risk associates with cortical morphology and functional organization in aging
2017
Translational Psychiatry
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This study suggested integrating genotype and transcriptome with neuroimage data sheds new light on the mechanisms of aging brain. ...
images, genotypes, and transcriptome data. ...
For cortical thickness analysis, an inner surface was constructed at the boundary between white and gray matter and then propagated to an outer surface at the boundary between gray matter and CSF. ...
doi:10.1038/s41398-017-0036-z
pmid:29225336
pmcid:PMC5802582
fatcat:x5gq2hclqzdhlhzcf7rdantc4m
New insights into the dynamic development of the cerebral cortex in childhood and adolescence: Integrating macro- and microstructural MRI findings
2021
Progress in Neurobiology
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We cover studies of cortical volume, thickness, area, gyrification, T1-weighted (T1w) tissue contrasts such a grey/white matter contrast, T1w/T2w ratio, magnetization transfer and myelin water fraction ...
At the same time, many common mental disorders appear during these critical phases of neurodevelopment. ...
MTR and MWF in cortical gray-matter (Patel et al., 2020) . ...
doi:10.1016/j.pneurobio.2021.102109
pmid:34147583
fatcat:7fjrapj5xnbsjkmltjqblhmwuu
Shaping of Regional Differences in Oligodendrocyte Dynamics by Regional Heterogeneity of the Pericellular Microenvironment
2021
Frontiers in Cellular Neuroscience
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Contrary to the normal brain, demyelinated lesions in the gray matter of multiple sclerosis brains contain more OPCs and OLs and are remyelinated more robustly than those in white matter. ...
than those in gray matter. ...
, and this declines with age (Cantuti-Castelvetri et al., 2018) . ...
doi:10.3389/fncel.2021.721376
pmid:34690700
pmcid:PMC8531270
fatcat:635h7qfvofd5fdacjtln4ejhma
Prediction of Chronological Age in Healthy Elderly Subjects with Machine Learning from MRI Brain Segmentation and Cortical Parcellation
2022
Brain Sciences
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Normal aging is associated with changes in volumetric indices of brain atrophy. A quantitative understanding of age-related brain changes can shed light on successful aging. ...
To investigate the effect of age on global and regional brain volumes and cortical thickness, 3514 magnetic resonance imaging scans were analyzed using automated brain segmentation and parcellation methods ...
Conflicts of Interest: The authors declare no competing interests. ...
doi:10.3390/brainsci12050579
fatcat:sfknoeyeyrfsxg2ew62ddxryaq
Transcriptomic Signatures Associated With Regional Cortical Thickness Changes in Parkinson's Disease
2021
Frontiers in Neuroscience
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To elucidate the molecular underpinnings of cortical thickness changes in PD, we performed an integrated analysis of brain-wide healthy transcriptomic data from the Allen Human Brain Atlas and patterns ...
of cortical thickness based on T1-weighted anatomical MRI data of 149 PD patients and 369 controls. ...
RESULTS
Cortical Thickness Changes Between Parkinson's Disease Patients and Controls We analyzed CT changes between PD patients and healthy controls ( CT) as a measure for gray matter loss ( Figure ...
doi:10.3389/fnins.2021.733501
pmid:34658772
pmcid:PMC8519261
fatcat:qrupqyfdfnbdzcjk5rbetbazni
Sex is a defining feature of neuroimaging phenotypes in major brain disorders
2021
Human Brain Mapping
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We discuss commonalities and sources of variance in study designs, analysis procedures, disease subtype effects, and the impact of these factors on MRI interpretation. ...
Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which are exacerbated in psychiatric and neurological conditions ...
In young adults (ages 20-34 years), VBM has revealed larger total normalized gray matter volume (total gray matter volume/total ICV) but also a faster rate of age-related decline in normalized gray matter ...
doi:10.1002/hbm.25438
pmid:33949018
pmcid:PMC8805690
fatcat:4y3ufbxppjg3bobnvysm7cwd7q
Recessive LAMC3 mutations cause malformations of occipital cortical development
2011
Nature Genetics
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After correction, the cortical thickness was calculated at each point as the shortest distance between the white matter-gray matter boundary and the gray matter-cerebrospinal fluid boundary. ...
periods and declines after infancy. ...
doi:10.1038/ng.836
pmid:21572413
pmcid:PMC3329933
fatcat:5eyfel2fgna77ol7xzddmghus4
Machine Learning Approaches for the Estimation of Biological Aging: The Road Ahead for Population Studies
2019
Frontiers in Medicine
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In recent years, different machine learning algorithms have been developed for the estimation of Biological Age (BA), defined as the hypothetical underlying age of an organism. ...
Similarly, we describe ML methods for the estimation of brain age based on structural neuroimaging features. ...
, where BrA was based on cortical/subcortical gray matter measures (40) . ...
doi:10.3389/fmed.2019.00146
pmid:31338367
pmcid:PMC6626911
fatcat:v3yiucqao5dsjcxvu6elssmhga
Epigenetic clock as a correlate of anxiety
2020
NeuroImage: Clinical
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Since MDD is highly correlated with anxiety, we hypothesized that symptoms of anxiety, as well as lower volume of grey matter (GM) in depression-related cortical regions, will be associated with faster ...
) or additional sources of variability in the cohort of adolescents (puberty stages, socioeconomic status, prenatal exposure to maternal smoking during pregnancy). ...
cortical gray matter (GM) and the volumes of GM in the four cerebral lobes. ...
doi:10.1016/j.nicl.2020.102458
pmid:33395955
pmcid:PMC7585143
fatcat:wkbwcodn4zcw5mmlzgufgqdyju
Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophrenia
2012
Schizophrenia Research
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Assess the effect of risperidone formulation on the ICM trajectory during a six-month randomized trial of LAI (RLAI) versus oral (RisO) in first-episode SZ subjects. ...
Insofar as the trajectory of ICM decline in chronic SZ is due to medication non-adherence or pharmacokinetics, it may be modifiable by long acting injection (LAI) formulations. ...
Lu had full access to all of the study data and take responsibility for the integrity of the data and the accuracy of data analysis. ...
doi:10.1016/j.schres.2012.06.036
pmid:22809684
pmcid:PMC3567927
fatcat:u7v2tvywgbdtxjvhabte3is5n4
A Survey of White Matter Neurons at the Gyral Crowns and Sulcal Depths in the Rhesus Monkey
2017
Frontiers in Neuroanatomy
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Since at least some WMNs participate in cortical circuitry, these results raise the possibility of their differential influence on cortical circuitry in the overlying gyral and sulcal locations. ...
or variable across different cortical regions. ...
thickness of cortical gray matter and WM in disease and normal development and aging. ...
doi:10.3389/fnana.2017.00069
pmid:28860975
pmcid:PMC5559435
fatcat:f67iqlugufh3hln6ctwhiciquy
Transcriptomic signatures associated with regional cortical thickness changes in Parkinson's disease
[article]
2020
bioRxiv
pre-print
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To elucidate the molecular underpinnings of cortical thickness changes in Parkinson's disease, we performed an integrated analysis of brain-wide healthy transcriptomic data from the Allen Human Brain Atlas ...
Here, we investigated patterns of cortical thickness using T1-weighted anatomical MRI data of 149 Parkinson's disease patients and 369 controls. ...
Cortical atrophy occurs during the later disease stages and has been associated with cognitive decline, including executive, attentional, memory, and visuospatial deficits (Aarsland et al., 2017; Wilson ...
doi:10.1101/2020.06.19.158808
fatcat:fxjcqtz2ifbgtfbfhv7xkrd4qe
Longitudinal basal forebrain degeneration interacts with TREM2/C3 biomarkers of inflammation in pre-symptomatic Alzheimer's disease
2020
Journal of Neuroscience
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None of these relationships were attributable to degeneration in the whole-brain gray matter volume. ...
Cholinergic inputs originating from the peripheral nervous system regulate the inflammatory immune responses of macrophages during clearance of blood-based pathogens. ...
Each exploratory two group ANOVA covaried for age, sex, education, and, where gray matter volumes were tested, ICV. ...
doi:10.1523/jneurosci.1184-19.2019
pmid:31915256
pmcid:PMC7046458
fatcat:72mimx56mjhlfcdayvxvkocm6q
Editorial: Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age
2019
Frontiers in Aging Neuroscience
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The relativity of the internal perception of time accelerating in aging brains is examined. ...
Collectively, the studies of this book and the associated data sets provide an unprecedented resource for understanding the aging of the brain, the brain networks plasticity, and structure. ...
and other largescale transcriptomic changes in the aging brain (Mostafavi et al., 2018) . ...
doi:10.3389/fnagi.2019.00268
pmid:31680930
pmcid:PMC6803512
fatcat:wg6cokv5m5grdirzcdlqeny5vm
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