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Deciphering gene regulatory networks by in silico approaches is a crucial step in the study of the molecular perturbations that occur in diseases. ... Furthermore, given the intrinsic complexity of the data, the development of new tools offering integrated and meaningful visualizations of molecular interactions is necessary to help users drawing new ... The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ...doi:10.1186/1471-2105-13-19 pmid:22292669 pmcid:PMC3395838 fatcat:nzml5gu2gnh2bnuteomu77u5au
We give a comprehensive assessment of the analytical tools of network topology and dynamics. ... The state-of-the-art use of chemical similarity, protein structure, protein-protein interaction, signaling, genetic interaction and metabolic networks in the discovery of drug targets is summarized. ... colleagues for reading the original version of the paper and for valuable suggestions. ...doi:10.1016/j.pharmthera.2013.01.016 pmid:23384594 pmcid:PMC3647006 fatcat:osjkz6kpr5gzxomqlyenla2fvq