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Transcriptome bioinformatic analysis identifies potential therapeutic mechanism of pentylenetetrazole in down syndrome

Abhay Sharma
2010 BioData Mining  
Methods: In a comparative transcriptomics approach, I have analyzed the available microarray data in order to identify potential therapeutic mechanism of PTZ in DS.  ...  Pentylenetetrazole (PTZ) has recently been found to ameliorate cognitive impairment in rodent models of Down syndrome (DS).  ...  Acknowledgements The research was supported by NWP0034 grant of Council of Scientific and Industrial Research (CSIR), Government of India.  ... 
doi:10.1186/1756-0381-3-7 pmid:21029440 pmcid:PMC2987760 fatcat:ngiuyv5eejeilpbm5b5sdov2b4

_Drosophila_ and human transcriptomic data mining provides evidence for therapeutic mechanism of pentylenetetrazole in Down syndrome

Abhay Sharma
2010 Nature Precedings  
Pentylenetetrazole (PTZ) has recently been found to ameliorate cognitive impairment in rodent models of Down syndrome (DS). The mechanism underlying PTZ's therapeutic effect is however not clear.  ...  In a comparative transcriptomics approach, I have analyzed the available microarray data in order to identify potential mechanism of PTZ action in DS.  ...  The mechanism underlying PTZ's potential therapeutic effect in DS is however unclear.  ... 
doi:10.1038/npre.2010.4330.1 fatcat:y4rcdeopqjb3hfxnhrq7s6h3l4

The GABRG2 F343L allele causes spontaneous seizures in a novel transgenic zebrafish model that can be treated with suberanilohydroxamic acid (SAHA)

Dingding Shen, Juan Chen, Dong Liu, Mi Shen, Xin Wang, Youjia Wu, Shuan Ke, Robert L. Macdonald, Qi Zhang
2020 Annals of Translational Medicine  
More specifically, protein network analysis indicated histone deacetylases (HDACs) as potential therapeutic targets, and suberanilohydroxamic acid (SAHA), a broad HDACs inhibitor, alleviated seizure-like  ...  Real-time quantitative PCR and in situ hybridization identified a significant up-regulation of c-fos in the mutant transgenic zebrafish, which has a well-established role in epileptogenesis.  ...  The animal experiments in this study were approved by the Ethics Committee of Nantong University (Approval ID: 20180202-001), in compliance with Nantong University guidelines for the care and use of animals  ... 
doi:10.21037/atm-20-3745 pmid:33437759 pmcid:PMC7791267 fatcat:gac7ar2g5jh73i44gd3nqikrfq

Mitochondrial Abnormalities in Down Syndrome: Pathogenesis, Effects and Therapeutic Approaches [chapter]

Antonella Izzo, Nunzia Mollo, Rita Cicatiello, Rita Genesio, Simona Paladino, Anna Conti, Lucio Nitsch
2018 Advances in Research on Down Syndrome  
Down syndrome (DS) consists of a complex phenotype with constant features, such as mental retardation and hypotonia, and variable features, including heart defects and susceptibility to Alzheimer's disease  ...  In this review, we first provide a basic overview of mitochondrial alterations in DS in terms of mitochondrial bioenergetics, biogenesis and morphology.  ...  Transcriptome analysis of human fetal heart tissues from DS subjects has shown a global significant downregulation of NEMGs.  ... 
doi:10.5772/intechopen.71059 fatcat:nanu33t5jbdtvcow6yg64ertai

Genomics of model organisms

2008 Genomic Medicine  
Furthermore, ER binding site analysis showed an enrichment of binding sites in the human homolog of zebrafish estrogen responsive genes, suggesting the conservation of regulatory mechanisms and potential  ...  Fly systems model offers a unique opportunity to identify disease, drug target, biomarker and pharmacogenomic candidates, and to screen potential therapeutic agents. 555: Investigating the influence of  ... 
doi:10.1007/s11568-009-9094-5 pmid:19479362 pmcid:PMC2694879 fatcat:27m7o25lqjd7hbok5xpsqn3ub4

Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity

Uriya Bekenstein, Nibha Mishra, Dan Z. Milikovsky, Geula Hanin, Daniel Zelig, Liron Sheintuch, Amit Berson, David S. Greenberg, Alon Friedman, Hermona Soreq
2017 Proceedings of the National Academy of Sciences of the United States of America  
pathway genes, implicating this miR in the avoidance of seizures.  ...  We identified miR-211 as a putative attenuator of cholinergicmediated seizures by intersecting forebrain miR profiles that were Argonaute precipitated, synaptic vesicle target enriched, or differentially  ...  This search identified miRs that are directly or consequentially affected by epileptic perturbations, and that potentially function in the synapse.  ... 
doi:10.1073/pnas.1701201114 pmid:28584127 pmcid:PMC5488936 fatcat:mdluiaeuojbkneiueqe7s23ghy

Single-Target Versus Multi-Target Drugs Versus Combinations of Drugs With Multiple Targets: Preclinical and Clinical Evidence for the Treatment or Prevention of Epilepsy

Wolfgang Löscher
2021 Frontiers in Pharmacology  
as potential therapeutic solutions for diseases of complex etiology and diseases with significant drug-resistance problems.  ...  Yet, cenobamate was discovered purely by phenotype-based screening and its presumed dual mechanism of action was only described recently.  ...  Brodie, Pavel Klein and Stanisław Czuczwar for critical reading of a previous version of this review.  ... 
doi:10.3389/fphar.2021.730257 pmid:34776956 pmcid:PMC8580162 fatcat:5erilgsdyvekxmlgckl64p3xey

Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery

Lu Qian, Julia TCW
2021 International Journal of Molecular Sciences  
A high-throughput drug screen identifies potentially promising therapeutics for clinical trials.  ...  In particular, iPSC-based three-dimensional (3D) tissue engineering that appears as a promising vehicle of in vitro disease modeling provides more sophisticated tissue architectures and micro-environmental  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms22031203 pmid:33530458 fatcat:aabsmwpkqzdkzggsvowfilqury

Human fetal ventral midbrain in standard culture versus organoids

Marcella Birtele, Alessandro Fiorenzano, Jenny Nelander, Malin Parmar
2019 Zenodo  
Our analysis confirmed that the 3D condition preserve the neuronal composition of the tissue more than standard culture where instead, over a long period of time, the majority of the cells are non-neuronal  ...  Parkinson disease (PD) is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc).  ...  DIRECT GENERATION OF HUMAN NAÏVE INDUCED PLURIPOTENT STEM CELLS FROM SOMATIC CELLS IN MICROFLUIDICS  ... 
doi:10.5281/zenodo.3358629 fatcat:svr6h5ghyzc4bdmzasks2lzgma

Power of a Metabonomic Approach to Investigate an Unknown Nervous Disease [chapter]

Celine Domange, Alain Paris, Henri Schroeder, Nathalie Priymenko
2011 Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring  
In case of the lack of any behavioural manifestation in animals, the conclusion isn't that there is a lack of effect but only that there is an impossibility to give an interpretation of this lack of effect  ...  because of an inadequate "observation window" as in delayed toxicity of some contaminants for example.  ...  In the drug discovery process, metabolomics brings some biochemical information about drug candidates, their mechanism of action and their therapeutic potential.  ... 
doi:10.5772/30963 fatcat:cyme4xg5uba2lhpycuoidft4na

2015 Golden Helix Symposium - Next Generation Pharmacogenomics. March 11-13, 2015, Kuala Lumpur, Malaysia: Abstracts

2015 Public Health Genomics  
Data were analyzed using Expression console software, Transcriptome Analysis Console (TAC) and IPA software.  ...  Conclusion: Findings from these two studies lay the groundwork to target AMPK as potential therapeutics to enhance the coronary collateral growth in patients with metabolic syndrome. 2015 Golden Helix  ...  The microarray data were processed and the transcriptomic changes were further enriched via pathway enrichment analysis.  ... 
doi:10.1159/000381430 pmid:25823950 fatcat:3lluvaoguzhjvbs7oi6aqhtfna

Deciphering next-generation pharmacogenomics: an information technology perspective

G. Potamias, K. Lakiotaki, T. Katsila, M. T. M. Lee, S. Topouzis, D. N. Cooper, G. P. Patrinos
2014 Open Biology  
emerge as potential therapeutic candidates.  ...  Data were analyzed using Expression console software, Transcriptome Analysis Console (TAC) and IPA software.  ...  The microarray data were processed and the transcriptomic changes were further enriched via pathway enrichment analysis.  ... 
doi:10.1098/rsob.140071 pmid:25030607 pmcid:PMC4118603 fatcat:xy235o2vqbbghj6dngqtrjse3m

https://dergipark.org.tr/anatomy/issue/44888/558887
Abstracts for the 17th Turkish Neuroscience Congress, 4–7 April 2019, Trabzon, Turkey

2019 Anatomy (International Journal of Experimental and Clinical Anatomy)  
In IS DOWNin our mind.  ...  track down.  ... 
doi:10.2399/ana.19.001s fatcat:cxihq27bmbcdzddf4xvqyudqsq

Calcium channel subunit α2δ4 is regulated by early growth response 1 and facilitates epileptogenesis

Karen M.J. van Loo, Christine K. Rummel, Julika Pitsch, Johannes Alexander Müller, Arthur F. Bikbaev, Erick Martinez Chavez, Sandra Blaess, Dirk Dietrich, Martin Heine, Albert J. Becker, Susanne Schoch
2019 Journal of Neuroscience  
However, epileptogenesis involves complex and dynamic transcriptomic alterations; and so far, our understanding of the transcriptional control mechanism of gene regulatory networks that act in the same  ...  Recently, transcriptional control mechanisms for individual genes involved in converting neurons hyperexcitable have been identified, including early growth response 1 (Egr1), which activates transcription  ...  Materials and Methods Bioinformatic analysis.  ... 
doi:10.1523/jneurosci.1731-18.2019 pmid:30792272 pmcid:PMC6788814 fatcat:mbpcscpwirfkblbaouyswxeh2e

Abstracts from the 13th International Conference on Cerebral Vascular Biology (CVB 2019)

2019 Fluids and Barriers of the CNS  
Functional annotation of identified proteins was analyzed by DAVID Bioinformatics Resources 6.8.  ...  Functional annotation of identified proteins was analyzed by DAVID Bioinformatics Resources 6.8.  ...  A better understanding of the common mechanisms that underlie impaired neurovascular function may help in the development of new potential therapeutic strategies to reinstate BBB function and proper signaling  ... 
doi:10.1186/s12987-019-0135-8 fatcat:efb3m5hoajczbjg3anycabovva
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