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Transcranial magnetic stimulation of the precuneus enhances memory and neural activity in prodromal Alzheimer's disease

Giacomo Koch, Sonia Bonnì, Maria Concetta Pellicciari, Elias P. Casula, Matteo Mancini, Romina Esposito, Viviana Ponzo, Silvia Picazio, Francesco Di Lorenzo, Laura Serra, Caterina Motta, Michele Maiella (+5 others)
2018 NeuroImage  
Analysis of TMS-EEG signal revealed an increase of neural 11 activity in patients' PC, an enhancement of brain oscillations in the beta band and a modification of 12 functional connections between the  ...  Using a multimodal approach we investigated in a two-week, randomized, 5 sham-controlled, double-blinded trial the effects of high-frequency repetitive transcranial magnetic 6 stimulation (rTMS) of the  ...  for the 19 treatment of Alzheimer's disease.  ... 
doi:10.1016/j.neuroimage.2017.12.048 pmid:29277405 fatcat:hgojiwalzncr3i7pn73p6mrv34

Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease

Nicolai Franzmeier, Marco Duering, Michael Weiner, Martin Dichgans, Michael Ewers
2017 Neurology  
At higher levels of gLFC connectivity, the association between precuneus FDG-PET hypometabolism and lower memory performance was attenuated (p 5 0.027).  ...  In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity 3 FDG-PET hypometabolism on episodic memory were tested.  ...  current stimulation, or drugs to enhance compensatory brain mechanisms and to slow down the cognitive decline in AD.  ... 
doi:10.1212/wnl.0000000000003711 pmid:28188306 pmcid:PMC5384837 fatcat:d4degv6jgnanlk5cczzupxyjfy

Theta-burst transcranial magnetic stimulation induced cognitive task-related decrease in activity of default mode network: an exploratory study

Novakova Lubomira, Gajdos Martin, Rektorova Irena
2020 Brain Stimulation  
Disruption of both task-positive and task-negative networks is a common finding in many diseases including Alzheimer's disease (AD) [1] .  ...  Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive tool that was shown to influence the underlying brain region and also distant brain areas.  ...  This research was financially supported by the Ministry of Education, Youth and Sports of the Czech Republic within CEITEC 2020 (LQ1601) project.  ... 
doi:10.1016/j.brs.2020.01.015 pmid:32289683 fatcat:baswi2gbqbhytk4imyrwwnjgei

Neurophysiological Hallmarks of Neurodegenerative Cognitive Decline: The Study of Brain Connectivity as A Biomarker of Early Dementia

Paolo Maria Rossini, Francesca Miraglia, Francesca Alù, Maria Cotelli, Florinda Ferreri, Riccardo Di Iorio, Francesco Iodice, Fabrizio Vecchio
2020 Journal of Personalized Medicine  
If the risk factors favoring degenerative mechanisms are modified during early stages (i.e., in the prodromal), the degenerative process and the loss of abilities in daily living activities will be delayed  ...  Neurodegenerative processes of various types of dementia start years before symptoms, but the presence of a "neural reserve", which continuously feeds and supports neuroplastic mechanisms, helps the aging  ...  in the primary motor cortex (M1) by single-pulse transcranial magnetic stimulation (spTMS) [144] .  ... 
doi:10.3390/jpm10020034 pmid:32365890 pmcid:PMC7354555 fatcat:srfn4n6ohnhovcxql26exo7vly

Non-pharmacological intervention for memory decline

Orazio Zanetti
2014 Neurobiology of Aging  
Moreover, several studies have reported enhanced cognitive performance in patients with neurological disease, following non-invasive brain stimulation [i.e., repetitive transcranial magnetic stimulation  ...  The present review provides an overview of memory rehabilitation in individuals with mild cognitive impairment and in patients with Alzheimer's disease with particular regard to cognitive rehabilitation  ...  ACKNOWLEDGMENTS This work was supported by a grant from the Alzheimer's Association (NIRG-11-205099).  ... 
doi:10.1016/j.neurobiolaging.2014.01.130 fatcat:snplwtur3vb65d6xdjtqv73y3e

Non-Pharmacological Intervention for Memory Decline

Maria Cotelli, Rosa Manenti, Orazio Zanetti, Carlo Miniussi
2012 Frontiers in Human Neuroscience  
Moreover, several studies have reported enhanced cognitive performance in patients with neurological disease, following non-invasive brain stimulation [i.e., repetitive transcranial magnetic stimulation  ...  The present review provides an overview of memory rehabilitation in individuals with mild cognitive impairment and in patients with Alzheimer's disease with particular regard to cognitive rehabilitation  ...  ACKNOWLEDGMENTS This work was supported by a grant from the Alzheimer's Association (NIRG-11-205099).  ... 
doi:10.3389/fnhum.2012.00046 pmid:22408614 pmcid:PMC3297818 fatcat:rou46h2aufezvgebfdr6zfbwty

Past, Present, and Future of Non-invasive Brain Stimulation Approaches to Treat Cognitive Impairment in Neurodegenerative Diseases: Time for a Comprehensive Critical Review

Clara Sanches, Chloé Stengel, Juliette Godard, Justine Mertz, Marc Teichmann, Raffaella Migliaccio, Antoni Valero-Cabré
2021 Frontiers in Aging Neuroscience  
Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation, two of the most popular NIBS technologies, use electrical fields generated non-invasively in the brain to long-lastingly enhance  ...  Research should also integrate novel knowledge on the mechanisms and constraints guiding the impact of electrical and magnetic fields on cerebral tissues and brain activity, and incorporate the principles  ...  ACKNOWLEDGMENTS We thank the FRA foundation for logistic and equipment support and the Naturalia & Biologia Foundation for financial assistance for traveling and attendance to meetings.  ... 
doi:10.3389/fnagi.2020.578339 pmid:33551785 pmcid:PMC7854576 fatcat:2dabsejeubg7ditnrdrlz5a2bu

Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review

Tien-Wei Yu, Hsien-Yuan Lane, Chieh-Hsin Lin
2021 International Journal of Molecular Sciences  
Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for most cases of dementia.  ...  While drug repositioning may accelerate pharmacological development, non-pharmacological interventions, especially repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation  ...  Acknowledgments: All the figures are created with Publication license from BioRender are proof of our publication rights.  ... 
doi:10.3390/ijms22158208 pmid:34360973 pmcid:PMC8348485 fatcat:dqjgtsmmznd5dgwkfa5zyil2b4

Transcranial Magnetic Stimulation in Alzheimer's disease: are we ready?

Marina Weiler, Kevin C. Stieger, Jeffrey M. Long, Peter R. Rapp
2019 eNeuro  
Transcranial magnetic stimulation (TMS) is among a growing family of noninvasive brain stimulation techniques being developed to treat multiple neurocognitive disorders, including Alzheimer's disease (  ...  On the basis of converging evidence from multiple fields, we caution that TMS therapeutic protocols established in young adults may have unexpected detrimental effects in older individuals or in the brain  ...  Prominently including transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, this family of related technologies shares a generally well tolerated safety profile in healthy  ... 
doi:10.1523/eneuro.0235-19.2019 pmid:31848209 pmcid:PMC6948923 fatcat:rxi3cmrgp5dr3izn2azrrzgufm

Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS

Kristin Prehn, Agnes Flöel
2015 Frontiers in Cellular Neuroscience  
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that is increasingly used in research and clinical settings to enhance the effects of cognitive training.  ...  Finally, we will highlight future directions and limitations in this field and emphasize the need to conduct RCTs to establish efficacy of interventions for activities of daily life for a given patient  ...  Acknowledgments This work was supported by grants from the Deutsche Forschungsgemeinschaft (Fl 379-8/1, Fl 379-10/1, Fl 379-11/1, and DFG-Exc 257) and the Bundesministerium für Bildung und Forschung (FKZ  ... 
doi:10.3389/fncel.2015.00355 pmid:26441526 pmcid:PMC4568338 fatcat:e3a5aieyxvcobilqwtv6r7tcou

Non-Invasive Brain Stimulation: A New Strategy in Mild Cognitive Impairment?

Agustina Birba, Agustín Ibáñez, Lucas Sedeño, Jesica Ferrari, Adolfo M. García, Máximo Zimerman
2017 Frontiers in Aging Neuroscience  
Recently, they have been applied in patients with mild cognitive impairment (MCI) and subjective cognitive impairment (SCI) to prevent or delay the development of Alzheimer's disease (AD).  ...  Thus, the impact of NIBS on cognitive performance in MCI and SCI remains to be determined.  ...  atDCS, anodal transcranial direct current stimulation; rTMS, repetitive transcranial magnetic stimulation; AD, Alzheimer's disease; MCI, mild cognitive impairment; VMCI, vascular mild cognitive impairment  ... 
doi:10.3389/fnagi.2017.00016 pmid:28243198 pmcid:PMC5303733 fatcat:inicfbjaabfzrmalkopbz36r2y

Repetitive Transcranial Magnetic Stimulation in the Treatment of Alzheimer's Disease and Other Dementias

Athina-Maria Aloizou, Georgia Pateraki, Konstantinos Anargyros, Vasileios Siokas, Christos Bakirtzis, Markos Sgantzos, Lambros Messinis, Grigorios Nasios, Eleni Peristeri, Dimitrios P. Bogdanos, Triantafyllos K. Doskas, Georgios Tzeferakos (+1 others)
2021 Healthcare  
Repetitive transcranial magnetic stimulation (rTMS) is a safe, non-invasive form of brain stimulation that utilizes a magnetic coil to generate an electrical field and induce numerous changes in the brain  ...  There are several diseases belonging to the dementia spectrum, most prominently Alzheimer's disease (AD), vascular dementia (VD), Lewy body dementia (LBD) and frontotemporal dementia (FTD).  ...  Ongoing studies on the use of repetitive transcranial magnetic stimulation in dementia.  ... 
doi:10.3390/healthcare9080949 fatcat:v46ojagzpvax5nterkqulxcw6q

Advances in neurocognitive rehabilitation research from 1992 to 2017: The ascension of neural plasticity

Bruce Crosson, Benjamin M. Hampstead, Lisa C. Krishnamurthy, Venkatagiri Krishnamurthy, Keith M. McGregor, Joe R. Nocera, Simone Roberts, Amy D. Rodriguez, Stella M. Tran
2017 Neuropsychology  
has positively impacts neural plasticity, especially for older persons, and (e) enhancement neural plasticity by creating interventions that generalize beyond the boundaries of treatment activities.  ...  Results-The expanding influence of neural plasticity has provided new models and tools for neurocognitive rehabilitation in neural injuries and disorders, as well as methods for measuring neural plasticity  ...  for aging (grant number P30AG053760) The views presented in this work do not necessarily represent the views of the United States Government or the Department of Veterans Affairs.  ... 
doi:10.1037/neu0000396 pmid:28857600 pmcid:PMC5788715 fatcat:xp6lfvwiofbrdbhxqxc2axdmtu

Noninvasive brain stimulation in Alzheimer's disease: Systematic review and perspectives for the future

Catarina Freitas, Helena Mondragón-Llorca, Alvaro Pascual-Leone
2011 Experimental Gerontology  
A number of studies have applied transcranial magnetic stimulation (TMS) to physiologically characterize Alzheimer's disease (AD) and to monitor effects of pharmacological agents, while others have begun  ...  Five studies focused on the enhancement of cognitive function in AD.  ...  Conflict of interest APL serves on the scientific advisory board for Nexstim, Neuronix, Starlab, and Neosync, and holds IP for the combination of TMS with EEG.  ... 
doi:10.1016/j.exger.2011.04.001 pmid:21511025 pmcid:PMC3589803 fatcat:mhmyqwf4zbgyvbnrcu66x62rjq

Attempted and Successful Compensation in Preclinical and Early Manifest Neurodegeneration – A Review of Task fMRI Studies

Elisa Scheller, Lora Minkova, Mathias Leitner, Stefan Klöppel
2014 Frontiers in Psychiatry  
For compensation to be termed successful, the temporary disruption of a specific region by, e.g., transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) should yield  ...  Patients diagnosed with amnestic MCI are prone to convert to manifest Alzheimer's disease (53, 54) and constitute the most studied subtype of MCI before the revised definition of prodromal AD was published  ...  Conflict of Interest  ... 
doi:10.3389/fpsyt.2014.00132 pmid:25324786 pmcid:PMC4179340 fatcat:a6s3f7jv3bgyhjid2sspz5gvcy
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