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Trade-off between Responsiveness and Noise Suppression in Biomolecular System Responses to Environmental Cues

Alexander V. Ratushny, Ilya Shmulevich, John D. Aitchison, Andrey Rzhetsky
2011 PLoS Computational Biology  
TFA revealed remarkably distinct network behaviors in terms of trade-offs in responsiveness and noise suppression that are appropriately tuned to each biological response.  ...  The wild type galactose network was found to be highly responsive while the oleate network has greater noise suppression ability.  ...  Saleem, and T. Knijnenburg for helpful discussions; S. Ramsey for providing original Dizzy and MATLAB files for the GAL and LPS-induced network models; K. Deutsch and P.  ... 
doi:10.1371/journal.pcbi.1002091 pmid:21738459 pmcid:PMC3127798 fatcat:iss5qrzyfffdrjou2676wctyya

Receptor downregulation and desensitization enhance the information processing ability of signalling receptors

Harish Shankaran, H Steven Wiley, Haluk Resat
2007 BMC Systems Biology  
Frequency response analysis indicates that upstream elements of the EGFR and GPCR networks behave like low-pass filters with the system being able to faithfully transduce inputs below a critical frequency  ...  Receptor downregulation and desensitization increase the filter bandwidth thereby enabling the receptor systems to decode inputs in a wider frequency range.  ...  Acknowledgements The research described in this paper was funded by the National Institutes of Health Grant 5R01GM072821-02 to H.R. and by the Biomolecular Systems Initiative LDRD Program at the Pacific  ... 
doi:10.1186/1752-0509-1-48 pmid:17996096 pmcid:PMC2228318 fatcat:uuodryknnrh5lanivjncppoo4a

Uncovering system-specific stress signatures in primate teeth with multimodal imaging

Christine Austin, Tanya M. Smith, Ramin M. Z. Farahani, Katie Hinde, Elizabeth A. Carter, Joonsup Lee, Peter A. Lay, Brendan J. Kennedy, Babak Sarrafpour, Rosalind J. Wright, Robert O. Wright, Manish Arora
2016 Scientific Reports  
However, the response to adverse stimuli involves complex neurobiological mechanisms, and current approaches do not identify the biological systems or pathways impacted by external stressors.  ...  leaving individuals vulnerable to infections and other chronic health disorders 13,14 , and increased susceptibility to neurodevelopmental deficits from environmental chemicals 15 .  ...  M.A. is supported by a National Institute of Environmental Health Sciences grant 4R00ES019597 and 1DP2ES025453. C.A. and M.A. are supported by NHMRC grant APP1028372.  ... 
doi:10.1038/srep18802 pmid:26727334 pmcid:PMC4698674 fatcat:jr2b2ewr7fcllfwormu2xiw6la

Temperature Control of Fimbriation Circuit Switch in Uropathogenic Escherichia coli: Quantitative Analysis via Automated Model Abstraction

Hiroyuki Kuwahara, Chris J. Myers, Michael S. Samoilov, Mustafa Khammash
2010 PLoS Computational Biology  
increase) of the ON-to-OFF fim switching rate via temperature-dependent suppression of competing dynamics mediated by recombinase FimE.  ...  Given this panoptic physiological role of temperature during UTI progression and notable empirical challenges to its direct in vivo studies, in silico modeling of corresponding biochemical and biophysical  ...  Acknowledgments The authors would like to thank Adam Arkin for helpful discussions and support in the course of this research.  ... 
doi:10.1371/journal.pcbi.1000723 pmid:20361050 pmcid:PMC2845655 fatcat:djspr22ugrcbhmhtdmo4buelta

Temporal integration of loudness as a function of level

Mary Florentine, So/ren Buus, Torben Poulsen
1995 Journal of the Acoustical Society of America  
The control mn is used to estimate the ambient noise processes on long-term scales. Maps of the anthropogenic signal to the ambient noise ratio of the climate system can then be constructed.  ...  Work is in progress to compare the efficiency of different measurement systems such as satellite altimeters, drifters, and traditional measurements to that of acoustic thermometry. 9:30 laAO6.  ...  This ratio is only 20 (between 0.5 and 10 cm 2) for the "compact" versus "diffuse" axis (from/a/to/i/).  ... 
doi:10.1121/1.411567 fatcat:h52442zdrnc6zmr4ephlixbspu

Temporal integration of loudness as a function of level

Mary Florentine, So/ren Buus, Torben Poulsen
1996 Journal of the Acoustical Society of America  
The control mn is used to estimate the ambient noise processes on long-term scales. Maps of the anthropogenic signal to the ambient noise ratio of the climate system can then be constructed.  ...  Work is in progress to compare the efficiency of different measurement systems such as satellite altimeters, drifters, and traditional measurements to that of acoustic thermometry. 9:30 laAO6.  ...  This ratio is only 20 (between 0.5 and 10 cm 2) for the "compact" versus "diffuse" axis (from/a/to/i/).  ... 
doi:10.1121/1.415236 pmid:8819858 fatcat:tsiit3akb5e4tkzxdzrilpsfzy

Application of the PE method to up‐slope sound propagation

Marta Galindo, Karsten Bo Rasmussen
1995 Journal of the Acoustical Society of America  
The control mn is used to estimate the ambient noise processes on long-term scales. Maps of the anthropogenic signal to the ambient noise ratio of the climate system can then be constructed.  ...  Work is in progress to compare the efficiency of different measurement systems such as satellite altimeters, drifters, and traditional measurements to that of acoustic thermometry. 9:30 laAO6.  ...  This ratio is only 20 (between 0.5 and 10 cm 2) for the "compact" versus "diffuse" axis (from/a/to/i/).  ... 
doi:10.1121/1.411728 fatcat:bvxtg4xt7zcljo4rpxldvug444

Statistical relations among architectural features and objective acoustical measurements of concert halls

Gary W. Siebein, Wei‐hwa Chiang, Gary S. Madaras, Harold W. Doddington, Wilhelm K. Schwab, John S. Bradley, A. C. Gade
1993 Journal of the Acoustical Society of America  
The manikin was used to record impulse responses in eight northeastern United States concert halls as part of the recent Concert Hall Research Group Study. The placement of the manikin's l/2-in.  ...  Spaces (ARIAS) system and manikin developed at the University of Florida and the BRAM software system developed at NRC Canada with a B&K dummy head and torso.  ...  Now by forward modeling the trade-off between scattering and intrinsic attenuation in seafloor models with both surface roughness and volume heterogeneities can be studied.  ... 
doi:10.1121/1.406641 fatcat:2ulfax5x7rg3nogxaiinu4epfe

Comparisons of auditorium acoustics measurements as a function of location in halls

John S. Bradley, A. C. Gade, Gary W. Siebein
1993 Journal of the Acoustical Society of America  
The manikin was used to record impulse responses in eight northeastern United States concert halls as part of the recent Concert Hall Research Group Study. The placement of the manikin's l/2-in.  ...  Spaces (ARIAS) system and manikin developed at the University of Florida and the BRAM software system developed at NRC Canada with a B&K dummy head and torso.  ...  Now by forward modeling the trade-off between scattering and intrinsic attenuation in seafloor models with both surface roughness and volume heterogeneities can be studied.  ... 
doi:10.1121/1.406637 fatcat:qm3xseekvjgtpaucjdpbkm3o2y

Acoustical measurements on stages of nine U.S. concert halls

A. C. Gade, John S. Bradley
1993 Journal of the Acoustical Society of America  
The manikin was used to record impulse responses in eight northeastern United States concert halls as part of the recent Concert Hall Research Group Study. The placement of the manikin's l/2-in.  ...  Spaces (ARIAS) system and manikin developed at the University of Florida and the BRAM software system developed at NRC Canada with a B&K dummy head and torso.  ...  Now by forward modeling the trade-off between scattering and intrinsic attenuation in seafloor models with both surface roughness and volume heterogeneities can be studied.  ... 
doi:10.1121/1.406640 fatcat:omothtjqojcofd5ypx2oubadsy

Synthetic Biology and the Gut Microbiome

Jennifer Dou, Matthew R. Bennett
2017 Biotechnology Journal  
In this review, we discuss the ways in which synthetic biology has been applied to improve the effectiveness and versatility of said probiotics, and the ways in which it might applied in the future.  ...  The gut microbiome plays a crucial role in maintaining human health, one which scientists have attempted to exploit through the development of genetically modified probiotics that produce and deliver therapeutics  ...  Acknowledgments Funding for this work was provided by the National Institutes of Health, grant number R01GM117138, and by the Gillson Longenbaugh Foundation.  ... 
doi:10.1002/biot.201700159 pmid:28976641 fatcat:zjbndeygp5gapgxckfndqb55hi

Effects of measurement procedure and equipment on average room acoustic measurements

A. C. Gade, John S. Bradley, Gary W. Siebein
1993 Journal of the Acoustical Society of America  
The manikin was used to record impulse responses in eight northeastern United States concert halls as part of the recent Concert Hall Research Group Study. The placement of the manikin's l/2-in.  ...  Spaces (ARIAS) system and manikin developed at the University of Florida and the BRAM software system developed at NRC Canada with a B&K dummy head and torso.  ...  Now by forward modeling the trade-off between scattering and intrinsic attenuation in seafloor models with both surface roughness and volume heterogeneities can be studied.  ... 
doi:10.1121/1.406634 fatcat:rah72seo75gtpgirf4x2ngcg24

The structural acoustic properties of stiffened shells

Yu Luan
2008 Journal of the Acoustical Society of America  
Beyond, this contradiction, specific space analysis models and tools can help to visualize the acoustic interactions between workstations, teams and departments accommodated in the same room.  ...  Daniel Juvé ͑Ecole centrale de Lyon, Modern aeroacoustics started in the early 1950's when Lighthill developed his famous acoustic analogy in an attempt to understand, and reduce, the terrifying noise  ...  This implies that a trade-off needs to be made between avoiding damage and obtaining an acceptable cleaning performance.  ... 
doi:10.1121/1.2932806 fatcat:zohbewf2k5h7fly2hoqzfdk42e

Trends in preference, programming and design of concert halls for symphonic music

Anders C. Gade
2008 Journal of the Acoustical Society of America  
This implies that a trade-off needs to be made between avoiding damage and obtaining an acceptable cleaning performance.  ...  We propose a new method of global synthesis, computationally inexpensive, allowing to design a robust broadband beam pattern with an optimal trade-off between the frequency invariance and the directivity  ...  The response of such systems to a simple forcing that acts on the dominant system has received considerable attention.  ... 
doi:10.1121/1.2932471 fatcat:hhka5ml2fvcszklkzau2lw3gka

Ray tracing in a turbulent, shallow‐water channel

Christian Bjerrum‐Niese, René Lützen, Leif Bjo/rno/
1998 Journal of the Acoustical Society of America  
Squeal noise can be controlled and even suppressed by a secondary feedback system, consisting of a sensor ͑to pick up the wheel oscillation or the squeal noise͒, filter, phase-shifter, amplifier, and transducer  ...  Predicting noise levels from new refinery units is a vital part of environmental assessment and designing units to meet noise limits.  ...  Since matched field processing is sensitive to environmental mismatch, the search space is expanded to include both the scatterer depth and the unknown environmental parameters.  ... 
doi:10.1121/1.422455 fatcat:vqypn7trzberzap3bkznkoddcu
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